Wikstroem Marten KF

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Name Wikström Marten K.F., MD, PhD, Professor Emeritus, Physical Biochemistry (1945-2024)
Institution Institute of Biotechnology
Marten Wikstroem

University of Helsinki


In memoriam, Mårten Wikström (1945-2024)

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City Helsinki
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Country Finland
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Weblink Helsinki Institute of Life Science
O2k-Network Lab FI Helsinki Wikstroem M


Professor Mårten Wikström, a luminary in biophysics and bioenergetics, revolutionized the field with his seminal work on cytochrome oxidases, notably resolving the Michell-Wikström debate on Complex IV as a proton pump, based on his classical publication of 1977. His illustrious career, spanning from pioneering research to academic leadership, earned him international recognition and prestigious awards, including membership in EMBO and the Royal Swedish Academy of Sciences, and the EBEC Peter Mitchell Medal. Wickström's enduring legacy extends beyond scientific achievements, as he is remembered for his intellectual refinement and musical talents. While his passing represents a significant loss, his contributions continue to inspire future generations of researchers, ensuring his impact persists in the scientific community. Several scientists pay a ‘Tribute to Mårten Wikström’ in a series of communications linked to his inspirational scientific and personal contributions.
Communicated by Erich Gnaiger - Tributes to pioneers in bioenergetics
Tributes to pioneers in bioenergetics

Tributes to pioneers in bioenergetics - wandering in the garden of memories

Mitochondria and bioblasts: Made history


Mitochondria and bioblasts: Made history


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Publications

 PublishedReference
Wikstroem 2023 Enzymes2023Wikström M, Pecorilla C, Sharma V (2023) The mitochondrial respiratory chain. Enzymes 54:15-36. https://doi.org/10.1016/bs.enz.2023.05.001
Wikstroem 2023 Biochim Biophys Acta Bioenerg2023Wikström M, Gennis RB, Rich PR (2023) Structures of the intermediates in the catalytic cycle of mitochondrial cytochrome c oxidase. Biochim Biophys Acta Bioenerg 1864:148933. https://doi.org/10.1016/j.bbabio.2022.148933
Wikstroem 2023 FEBS Lett2023Wikström M, Djurabekova A, Sharma V (2023) On the role of ubiquinone in the proton translocation mechanism of respiratory complex I. FEBS Lett 597:224-36. https://doi.org/10.1002/1873-3468.14506
Saura 2022 Proc Natl Acad Sci U S A2022Saura P, Riepl D, Frey DM, Wikström M, Kaila VRI (2022) Electric fields control water-gated proton transfer in cytochrome c oxidase. Proc Natl Acad Sci U S A 119:e2207761119. https://doi.org/10.1073/pnas.2207761119
Kaila 2021 Nat Rev Microbiol2021Kaila VRI, Wikström M (2021) Architecture of bacterial respiratory chains. Nat Rev Microbiol 19:319-30. https://doi.org/10.1038/s41579-020-00486-4
Siletsky 2021 Biochim Biophys Acta Bioenerg2021Siletsky SA, Soulimane T, Belevich I, Gennis RB, Wikström M (2021) Specific inhibition of proton pumping by the T315V mutation in the K channel of cytochrome ba3 from Thermus thermophilus. Biochim Biophys Acta Bioenerg 1862:148450. https://doi.org/10.1016/j.bbabio.2021.148450
Purhonen 2020 Nat Commun2020Purhonen J, Grigorjev V, Ekiert R, Aho N, Rajendran J, Pietras R, Truvé K, Wikström M, Sharma V, Osyczka A, Fellman V, Kallijärvi J (2020) A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice. Nat Commun 11:322.
Wikstroem 2020 Commun Biol2020Wikström M, Springett R (2020) Thermodynamic efficiency, reversibility, and degree of coupling in energy conservation by the mitochondrial respiratory chain. Commun Biol 3:451. https://doi.org/10.1038/s42003-020-01192-w
Warnau 2018 Proc Natl Acad Sci U S A2018Warnau J, Sharma V, Gamiz-Hernandez AP, Di Luca A, Haapanen O, Vattulainen I, Wikström M, Hummer G, Kaila VRI (2018) Redox-coupled quinone dynamics in the respiratory complex I. Proc Natl Acad Sci U S A 115:E8413-20. https://doi.org/10.1073/pnas.1805468115
Wikstroem 2018 Biochim Biophys Acta Bioenerg2018Wikström M, Sharma V (2018) Proton pumping by cytochrome c oxidase - a 40 year anniversary. Biochim Biophys Acta Bioenerg 1859:692-8. https://doi.org/10.1016/j.bbabio.2018.03.009
Wikstroem 2018 Chem Rev2018Wikström M, Krab K, Sharma V (2018) Oxygen activation and energy conservation by cytochrome c oxidase. Chem Rev 118:2469-90. https://doi.org/10.1021/acs.chemrev.7b00664
Siletsky 2017 Biochim Biophys Acta Bioenerg2017Siletsky SA, Belevich I, Belevich NP, Soulimane T, Wikström M (2017) Time-resolved generation of membrane potential by ba3 cytochrome c oxidase from Thermus thermophilus coupled to single electron injection into the O and OH states. Biochim Biophys Acta Bioenerg 1858:915-26. https://doi.org/10.1016/j.bbabio.2017.08.007
Liang 2017 Proc Natl Acad Sci U S A2017Liang R, Swanson JMJ, Wikström M, Voth GA (2017) Understanding the essential proton-pumping kinetic gates and decoupling mutations in cytochrome c oxidase. Proc Natl Acad Sci U S A 114:5924-9. https://doi.org/10.1073/pnas.1703654114
Liang 2016 Proc Natl Acad Sci U S A2016Liang R, Swanson JM, Peng Y, Wikström M, Voth GA (2016) Multiscale simulations reveal key features of the proton-pumping mechanism in cytochrome c oxidase. Proc Natl Acad Sci U S A 113:7420-5. https://doi.org/10.1073/pnas.1601982113
Sharma 2016 Biochim Biophys Acta2016Sharma V, Wikström M (2016) The role of the K-channel and the active-site tyrosine in the catalytic mechanism of cytochrome c oxidase. Biochim Biophys Acta 1857:1111-5. https://doi.org/10.1016/j.bbabio.2016.02.008
Hummer 2016 Biochim Biophys Acta2016Hummer G, Wikström M (2016) Molecular simulation and modeling of complex I. Biochim Biophys Acta 1857:915-21. https://doi.org/10.1016/j.bbabio.2016.01.005
Sharma 2015 Proc Natl Acad Sci U S A2015Sharma V, Enkavi G, Vattulainen I, Róg T, Wikström M (2015) Proton-coupled electron transfer and the role of water molecules in proton pumping by cytochrome c oxidase. Proc Natl Acad Sci U S A 112:2040-5. https://doi.org/10.1073/pnas.1409543112
Wikstroem 2015 Chem Rev2015Wikström M, Sharma V, Kaila VR, Hosler JP, Hummer G (2015) New perspectives on proton pumping in cellular respiration. Chem Rev 115:2196-221. https://doi.org/10.1021/cr500448t
Sharma V 2015 Proc Natl Acad Sci U S A2015Sharma V, Belevich G, Gamiz-Hernandez AP, Róg T, Vattulainen I, Verkhovskaya ML, Wikström M, Hummer G, Kaila VR (2015) Redox-induced activation of the proton pump in the respiratory Complex I. Proc Natl Acad Sci U S A 112:11571-6. https://doi.org/10.1073/pnas.1503761112
Verkhovskaya 2014 Biochim Biophys Acta2014Verkhovskaya M, Wikström M (2014) Oxidoreduction properties of bound ubiquinone in Complex I from Escherichia coli. Biochim Biophys Acta 1837:246-50. https://doi.org/10.1016/j.bbabio.2013.11.001
Kaila 2014 Proc Natl Acad Sci U S A2014Kaila VR, Wikström M, Hummer G (2014) Electrostatics, hydration, and proton transfer dynamics in the membrane domain of respiratory Complex I. Proc Natl Acad Sci U S A 111:6988-93. https://doi.org/10.1073/pnas.1319156111
Sharma 2014 FEBS Lett2014Sharma V, Wikström M (2014) A structural and functional perspective on the evolution of the heme-copper oxidases. FEBS Lett 588:3787-92. https://doi.org/10.1016/j.febslet.2014.09.020
Sharma 2013 Proc Natl Acad Sci U S A2013Sharma V, Karlin KD, Wikström M (2013) Computational study of the activated O(H) state in the catalytic mechanism of cytochrome c oxidase. Proc Natl Acad Sci U S A 110:16844-9. https://doi.org/10.1073/pnas.1220379110
Wikstroem 2012 Proc Natl Acad Sci U S A2012Wikström M, Hummer G (2012) Stoichiometry of proton translocation by respiratory complex I and its mechanistic implications. Proc Natl Acad Sci U S A 109:4431-6.
Babcock 1992 Nature1992Babcock GT, Wikström M (1992) Oxygen activation and the conservation of energy in cell respiration. Nature 356:301-9.
Wikstroem 1979 Biochim Biophys Acta1979Wikstroem MKF, Krab K (1979) Proton-pumping cytochrome c oxidase. Biochim Biophys Acta 549:177-222.
Wikstroem 1977 Nature1977Wikstroem MKF (1977) Proton pump coupled to cytochrome c oxidase in mitochondria. Nature 266:271-3.
Akerman 1976 FEBS Lett1976Akerman KEO, Wikström MKF (1976) Safranine as a probe of the mitochondrial membrane potential. FEBS Lett 68:191-7.

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