MiPschool Obergurgl 2017

MiPschool Obergurgl 2017

[[Has title:: Obergurgl AT, 2017 Jul 23-30. 10th MiPschool 2017 MitoEAGLE and MitoEAGLE Workshop WG1-4.]]

Was written by::Mitochondrial Physiology Society (Was published in year::2017-07-23) Was published in journal::MitoGlobal

Abstract: has abstract::'''2017 Jul 23-30, Obergurgl, AT.'''

Labels:

additional label::2017, additional label::ORO, additional label::MitoFit, additional label::MitoEAGLE, additional label::MiP, additional label::TRACT, additional label::MitoGlobal 

News

Joint terminology review: open for contributions and feedback

• [|Building blocks of mitochondrial physiology]

Date, venue, organization

• 2017 July 23-30

• 2017 July 23-27 Training School jointly organized by the Mitochondrial Physiology Society and COST Action MitoEAGLE
• 2017 July 27-30 MitoEAGLE Workshop: WG1-4

• University Centre Obergurgl, Tyrol, Austria

Minutes MitoAGLE Obergurgl 2017

- Minutes prepared by Zuzana Sumbalova.

Find the WG summaries in the Minutes and also here

Feedback

• Congratulations on a very successful MiPschool in Obergurgl. The organization was excellent. I'm very happy that I could participate in this event. It has been an amazing time, full of great presentations and exciting discussions. I have learned a lot and I think it will bring benefits in my future work. So one more time, great thanks to you and your team. - Karolina Siewiera, Lodz, PL

• It was really a pleasure to be a part of such a great group of people and it gave me a motivation in my work. I enjoyed all presentations which were very interesting and brought new insight into the problematics but especially like the small table sessions with experts. Next thing that I will remember for a long time was working with you and Chuck and Javier and everybody else who participated on writing the common review on mitochondrial terminology. I have never seen such a professionality and group spirit during the manuscript preparation and I like it a lot. Those moments were very fascinating and completely absorbing. - Ondrej Sobotka, Hradec Kralova, CZ

• It was another enjoyable and productive meeting. I am delighted to be a part of this team. My new students have returned from MIPSchool energized and motivated to work on their projects. - Anthony Molina, Winston-Salem, North Carolina, US.
• The 10th MiPschool and the MitoEAGLE workshop in Obergurgl were an amazingly enriching experience for me. Having just recently started working in mitochondrial physiology, these meetings provided critical insight of what are the state-of-the-art techniques and questions related to mitochondria. The program is balanced, although there is certainly space for improvement. And that is a positive thing. I would also like to emphasize that the sense of scientific community built on sharing knowledge and sheer friendship that allowed me to set new, hopefully long and fruitful collaborations. - Luís Crisóstomo, MSc, PhD Student, Porto, PT.

• Thanks a lot, has been an amazing meeting. I have learnt a lot and I have enjoyed each minute spent in the beautiful Obergurgl. Also, working with you (Erich Gnaiger) and with Charles (Hoppel) has been an amazing opportunity to learn and grow as a scientist. - Javier Iglesias-González, PhD, Manchester, UK.

• I just wanted to congratulate and thank you for the exciting and productive MitoEAGLE event. - Brian Irving, PhD, Baton Rouge, La, US

• I would just like to say thank you for the effort and expertise that you brought in this MiP School. I have learned so much from your training that will assist me in my workplace. Thank you very much for your presentation in Oxygraph. For me, it stands out as one of the best training school I have been to. I have come away with much more knowledge and feel far more equipped to deal with related to mitochondrial research issues. It was lovely to meet you and all the other participants within such a great learning environment. Thank you again such an informative and entertaining days of learning. Now, I am able to walk with a new understanding of and strategies in, dealing in research. - Vipin Sharma, Ahemdabad, IN

• Thank you once again for a wonderful meeting! Although I was a bit unwell during portions of the meeting, I enjoyed all the discussions and camaraderie. I have attached some pictures that Raj and I captured during the meeting. We also look forward to many photos/videos taken during the meeting as well. Hope to see you all soon. - Shilpa Iyer, Fayetteville , AR, US

• I am very grateful for having an opportunity to be present at 10th MiPschool and the MitoEAGLE workshop in Obergurgl. For me as a beginner it was great chance to learn a lot about mitochondrial topic, especially those terminology sessions were very enriching. Last but not least, I have met a lot of wonderful people, who are inspiriting and I was my greatest pleasure to spend this time with them. Thank you very much. - Katerina Nozickova, Hradec Kralove, CZ

Programme MiPschool

• The MiPschool will focus on basic concepts on mitochondrial respiratory states and applications of substrate-uncoupler-inhibitor titration (SUIT) protocols. - Last update: 2017-07-22

• • • • 2017-07-23

Arrival MiPschool

16:00 Registration

18:30 Joint dinner

20:30 - 21:30 Welcome by the organizers Verena Laner - General Secretary MiPsociety and Erich Gnaiger - Chair COST Action MitoEAGLE

• • • • 2017-07-24

Session A (morning) Coupling and pathway control in oxidative phosphorylation

08:30-09:10

• Elemental steps towards understanding mitochondrial core energy metabolism: coupling control (Erich Gnaiger, Medical University of Innsbruck, AT).

09:10-09:40

• Biochemical coupling efficiency and ATP/O₂ ratios (Charles L Hoppel, Case Western Reserve University School of Medicine, Ohio, US).

09:40-10:00 Selected oral presentations A.1-2

10:00-10:30 Coffee/tea break - poster viewing

10:30-11:10

• The electron transfer-pathway – Q redox regulation and mitochondrial pathways to oxygen (Anthony L Moore, University of Sussex, UK).

11:10-11:40

• Respiratory pathway control in mitochondrial core energy metabolism: from bioenergetics to mitochondrial physiology (Gnaiger Erich, Medical University of Innsbruck, AT).

11:40-12:00 Selected oral presentations A.3-4

{{#ask:was submitted to event::MiPschool Obergurgl 2017Event::A1 | ?has title=Presentation | ?Event=Session | format=broadtable | limit=500 | offset=0 | sort=Event | order=descending }}

13:00-15:00 Walk&Talk, Run&Fun, Person-to-person poster talks or MIGHT!TM game time

Session B (afternoon) selected abstracts/posters

• B1: ROS signaling, oxidative stress, cancer

15:00-15:20 Selected oral presentations B1.1-2

15:20-16:00 Poster session and general discussion

16:00-16:30 Coffee/tea - Poster session continued

{{#ask:was submitted to event::MiPschool Obergurgl 2017Event::B1 | ?has title=Presentation | ?Event=Session | format=broadtable | limit=500 | offset=0 | sort=Event | order=descending }}

• B2: Life style, degenerative and mitochondrial diseases

16:30-17:30 Selected oral presentations B2.1-6

17:30-18:30 Poster session and general discussion

{{#ask:was submitted to event::MiPschool Obergurgl 2017Event::B2 | ?has title=Presentation | ?Event=Session | format=broadtable | limit=500 | offset=0 | sort=Event | order=descending }}

18:30 Dinner

• After dinner interplay: Anthony L Moore and Erich Gnaiger discuss perspectives on the Q-junction, inviting interactions with the audience.

• • • • 2017-07-25

Session C (morning) OXPHOS protocols and data reporting

08:30-09:10

• Apparent Complex IV excess capacity and biochemical thresholds (Gnaiger Erich, Medical University of Innsbruck, AT).

09:10-09:40

• Substrate-uncoupler-inhibitor titration (SUIT) protocols – fundamental principles (Carolina Doerrier, Oroboros Instruments, AT).

09:40-10:00 Selected oral presentations C.1-2

10:00-10:30 Coffee/tea break - poster viewing

10:30-11:10

• Respiratory control ratios and control factors (Gnaiger Erich, Medical University of Innsbruck, AT).

11:10-11:40

• Discussion: Normalization of respiratory flux and flow.

11:40-11:50 Selected oral presentations C.3-4

{{#ask:was submitted to event::MiPschool Obergurgl 2017Event::C1 | ?has title=Presentation | ?Event=Session | format=broadtable | limit=500 | offset=0 | sort=Event | order=descending }}

13:00-15:00 Walk & Talks, Run & Fun, Person-to-person poster talks or MIGHT!TM game time

Session D (afternoon) Posters and selected abstracts

• D1. Models and mt-preparations in mitochondrial physiology

15:00-16:00 Selected oral presentations D1.1-6

16:00-16:30 Coffee/tea - poster viewing

{{#ask:was submitted to event::MiPschool Obergurgl 2017Event::D1 | ?has title=Presentation | ?Event=Session | format=broadtable | limit=500 | offset=0 | sort=Event | order=descending }}

• D2. Pharmacological intervention, toxicology, and regulation

16:30-17:10 Selected oral presentations D2.1-4

17:10-18:00 Poster session and general discussion

18:00 Dinner

{{#ask:was submitted to event::MiPschool Obergurgl 2017Event::D2 | ?has title=Presentation | ?Event=Session | format=broadtable | limit=500 | offset=0 | sort=Event | order=descending }}

20:00-21:30

Session D3 MitoEAGLE Early Career Investigators forum (organized by Komlòdi Timea, Oroboros Instruments, Innsbruck, AT; and Garcia e Souza Luiz, University Innsbruck, AT): Meet the expert

• • • • 2017-07-26

Session E1 (morning) Clinical mitochondrial physiology

08:30-09:00

• The challenges of functional mitochondrial diagnosis (Charles L Hoppel, Case Western Reserve University School of Medicine, Ohio, US).

09:00-09:30

• Mitochondrial fitness in skeletal muscle (Pablo Garcia-Roves, University of Barcelona, ES).

09:30-10:00

• Scope and limitations of functional mitochondrial diagnosis in blood cells. (Anthony Molina,Department of Internal Medicine, US).

10:00-10:30 Coffee/tea break

10:30-11:00

• The scope of cryopreservation in blood cells for functional mitochondrial diagnosis. (Beata Cizmarova, Pavol Jozef Šafárik University in Kosice, SK)

11:00-11:30

• Mitochondrial physiology in plants, alternative oxidases, and clinical perspectives (Anthony L Moore, University of Sussex, UK).

11:30-12:00

• Pyruvate therapy for mitochondrial diseases (Masashi Tanaka, Tokyo Metropolitan Institute of Gerontology, JP).

{{#ask:was submitted to event::MiPschool Obergurgl 2017Event::E1 | ?has title=Presentation | ?Event=Session | format=broadtable | limit=500 | offset=0 | sort=Event | order=descending }}

13:00-15:00 Walk&Talks, Run&Fun, Person-to-person poster talks, MIGHT!TM game time

Session E2 (afternoon) Mitochondrial physiology: biomedical applications

15:00-15:30

• Mitochondrial function and dysfunction: ROS and Ca²⁺. (Werner Koopman, Radboud University Nijmegen Medical Centre, NL)

15:30-16:00

• Mitochondrial function and dysfunction in cancer (Richard K Porter, Trinity College Dublin, IE).

16:00-16:30 Coffee/tea

16:30-17:00

• The metabolic syndrome - dysmitochondrial syndrome and mitochondrial disruptors (Hong Kyu Lee, Eulji University College of Medicine, Seoul, KR).

17:00-17:30

• Mitochondrial function in aging and regeneration (Pidder Jansen-Duerr, University of Innsbruck, AT).

{{#ask:was submitted to event::MiPschool Obergurgl 2017Event::E2 | ?has title=Presentation | ?Event=Session | format=broadtable | limit=500 | offset=0 | sort=Event | order=descending }}

18:30 Dinner

20:00 Conclusion and social programme with Raphael

• • • • 2017-07-27

Departure MiPschool

Relaxing day for participants staying for the MitoEAGLE WG Workshop

Lecturers

• 

  Doerrier Carolina

• 

  Garcia-Roves Pablo

• 

  Gnaiger Erich

• 

  Hoppel Charles L

• 

  Jansen-Duerr Pidder

• 

  Koopman Werner

• 

  Lee Hong Kyu

• 

  Molina Anthony

• 

  Moore Anthony

• 

  Porter Richard K

• 

  Tanaka Masashi

• 

  Cizmarova Beata

Programme MitoEAGLE Working Groups Workshop

• • • • 2017-07-27

Arrival MitoEAGLE workshop

• • • • 2017-07-28 to 29

MitoEAGLE Workshop: WG1-4

• WG1: Harmonization of nomenclature on mitochondrial respiratory states and control parameters: Status of the consensus paper on a consistent terminology on mitochondrial physiology and bioenergetics; recommendations for the use of a common terminology in mitochondrial physiological research as a milestone towards unification of concepts and nomenclature.

» The protonmotive force and respiratory control: Building blocks of mitochondrial physiology - Manuscript in preparation by the MitoEAGLE Terminology Group.

» Add critical discussion on 'ATP production' (not to be confused with a difference of respiratory fluxes), 'glycolytic flux' (not to be confused with extracellular proton flux), 'reserve capacity' (is the difference of ET capacity and ROUTINE respiratory activity a 'reserve'?), confusion of ET capacity ('State 3u') and OXPHOS capacity, ..

• WG1: Respirometric reference protocols:

1. Standard format for presenting substrate-uncoupler-inhibitor titration (SUIT) protocols for a ‘library of protocols’ applied in mitochondrial respiratory physiology.
2. Criteria for selecting and recommending reference protocols.
3. Documentation of the state-of-the-art standards in designing, conducting, reporting, interpreting, and validating SUIT protocols.
4. Compare: Maelstrom Research program- data repository and harmonization.

• WG2-4: Data repositories

1. Summary of WG2: steps towards database: Summary from Obergurgl, 2017.
2. Summary of WG4 cell lines: WG4 Cell Lines Obergurgl, 2017.
3. Summary of WG4 blood cells:WG4 Blood cells Obergurgl, 2017

• • • • 2017-07-30

Departure MitoEAGLE

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Participants - alphabetical order

(Attendance list)

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Impressions from MiPschool Obergurgl 2017

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Sponsors

The project MitoFit is funded by the Land Tirol within the program K-Regio of Standortagentur Tirol.

• COST Action CA15203 Mitochondrial fitness mapping - MitoEAGLE

Organizers

Georg Kandolf - Abstracts

Verena Laner MiPsociety General Secretary - General conference organization

Marija Beno, MitoEAGLE Administrative Representative - General conference organization

Erich Gnaiger, Chair COST Action MitoEAGLE and Chair MiPsociety - Main organizer

10 years ago

» MiPschool Schroecken AT 2007

Support

This project has received funding from the European Union's Horizon 2020 research and innovation programme supported by COST (European Cooperation in Science and Technology) under grant agreement No OC-2015-2-19984.

Listed under MitoGlobal Events.