Yoshino 2021 Science

[[Has title::Yoshino M, Yoshino J, Kayser BD, Patti GJ, Franczyk MP, Mills KF, Sindelar M, Pietka T, Patterson BW, Imai SI, Klein S (2021) Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science 372:1224-29. https://doi.org/10.1126/science.abe9985]]

» [[Has info::PMID: 33888596 Open Access]]

Was written by::Yoshino Mihoko, Was written by::Yoshino Jun, Was written by::Kayser Brandon D, Was written by::Patti Gary J, Was written by::Franczyk Michael P, Was written by::Mills Kathryn F, Was written by::Sindelar Miriam, Was written by::Pietka Terri, Was written by::Patterson Bruce W, Was written by::Imai Shin-Ichiro, Was written by::Klein Samuel (Was published in year::2021) Was published in journal::Science

Abstract: [[has abstract::In rodents, obesity and aging impair nicotinamide adenine dinucleotide (NAD⁺) biosynthesis, which contributes to metabolic dysfunction. Nicotinamide mononucleotide (NMN) availability is a rate-limiting factor in mammalian NAD⁺ biosynthesis. We conducted a 10-week, randomized, placebo-controlled, double-blind trial to evaluate the effect of NMN supplementation on metabolic function in postmenopausal women with prediabetes who were overweight or obese. Insulin-stimulated glucose disposal, assessed by using the hyperinsulinemic-euglycemic clamp, and skeletal muscle insulin signaling [phosphorylation of protein kinase AKT and mechanistic target of rapamycin (mTOR)] increased after NMN supplementation but did not change after placebo treatment. NMN supplementation up-regulated the expression of platelet-derived growth factor receptor β and other genes related to muscle remodeling. These results demonstrate that NMN increases muscle insulin sensitivity, insulin signaling, and remodeling in women with prediabetes who are overweight or obese (clinicaltrial.gov NCT03151239).]]

• Bioblast editor: [[has editor::Plangger M]] • O2k-Network Lab: Was published by MiPNetLab::US MO St Louis Abumrad NA

Labels: MiParea: MiP area::Respiration 

Organism: Organism::Human  Tissue;cell: tissue and cell::Skeletal muscle  Preparation: Preparation::Permeabilized tissue 

Coupling state: Coupling states::LEAK, Coupling states::OXPHOS, Coupling states::ET  Pathway: Pathways::N, Pathways::S, Pathways::NS  HRR: Instrument and method::Oxygraph-2k