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Al-Obeidallah 2021 J Pers Med

From Bioblast
Publications in the MiPMap
Al-Obeidallah M, Jarkovská D, Valešová L, Horák J, Jedlička J, Nalos L, Chvojka J, Švíglerová J, Kuncová J, Beneš J, Matějovič M, Štengl M (2021) SOFA score, hemodynamics and body temperature allow early discrimination between porcine peritonitis-induced sepsis and peritonitis-induced septic shock. J Pers Med 11:164.

» PMID: 33670874 Open Access

Al-Obeidallah Mahmoud, Jarkovska Dagmar, Valesova Lenka, Horak Jan, Jan Jedlička 1 2, Nalos Lukas, Chvojka Jiri, Sviglerova Jitka, Kuncova Jitka, Benes Jan, Matejovic Martin, Stengl Milan (2021) J Pers Med

Abstract: Porcine model of peritonitis-induced sepsis is a well-established clinically relevant model of human disease. Interindividual variability of the response often complicates the interpretation of findings. To better understand the biological basis of the disease variability, the progression of the disease was compared between animals with sepsis and septic shock. Peritonitis was induced by inoculation of autologous feces in fifteen anesthetized, mechanically ventilated and surgically instrumented pigs and continued for 24 h. Cardiovascular and biochemical parameters were collected at baseline (just before peritonitis induction), 12 h, 18 h and 24 h (end of the experiment) after induction of peritonitis. Analysis of multiple parameters revealed the earliest significant differences between sepsis and septic shock groups in the sequential organ failure assessment (SOFA) score, systemic vascular resistance, partial pressure of oxygen in mixed venous blood and body temperature. Other significant functional differences developed later in the course of the disease. The data indicate that SOFA score, hemodynamical parameters and body temperature discriminate early between sepsis and septic shock in a clinically relevant porcine model. Early pronounced alterations of these parameters may herald a progression of the disease toward irreversible septic shock. Keywords: SOFA score, Pig, Sepsis, Septic shock Bioblast editor: Plangger M O2k-Network Lab: CZ Pilsen Kuncova J


Labels: MiParea: Respiration  Pathology: Sepsis 

Organism: Pig 




HRR: Oxygraph-2k 

2021-03