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Ali 2012 Abstract Bioblast

From Bioblast
Ali SS (2012) Interrogating Egyptian mitochondria! Mitochondr Physiol Network 17.12.

Link: MiPNet17.12 Bioblast 2012 - Open Access

Ali SS (2012)

Event: Bioblast 2012

Sameh Ali

Many neurodegenerative, cardiovascular, cancer, and psychological disorders are known to involve mitochondrial dysfunction and deregulated levels of reactive oxygen species. Aging is associated with a sustained increase in superoxide radical levels, which is associated with a progressive decline in cognitive function and increased prevalence of neurodegeneration. Mitochondria were identified as one source of oxidant production in brain during aging, but several recent studies suggest that an alternative, extra-mitochondrial source of superoxide may also be important to aging-associated pathologic phenotype. In this presentation I will briefly discuss some of our contributions to the field including our studies on the dynamics of mitochondrial superoxide production, and our recent discovery that the superoxide-producing enzyme NADPH-oxidase-2 (Nox2) is induced during aging and remain constitutively active in neurons and synaptosomes from aged brain and from schizophrenia mouse model.

Finally, I’ll present our progress in establishing the Center for Aging and Associated Diseases (CAAD) as part of the newly founded Zewail City of Science and Technology, the Egyptian National Project of Scientific Renaissance. In CAAD, we are focusing primarily on establishing a state-of-the-art facility to study diseases in relevance to the Egyptian people. In one of CAAD’s core facilities, the Oroboros® O2k-MultiSensor system will be combined with the Seahorse XF24 and the Magnettech MS400 EPR spectrometer to study mitochondrial dynamics in the context of aging, metabolic, cardiovascular, and neurodegenerative diseases.

  1. Ali SS, Marcondes MC, Bajova H, Dugan LL, Conti B (2010) Metabolic depression and increased reactive oxygen species production by isolated mitochondria at moderately lower temperatures J Biol Chem 285: 32522-32528. Open Access
  2. Ali SS, Young JW, Wallace CK, Gresack J, Jeste DV, Geyer MA, Dugan LL, Risbrough VB (2011) Initial evidence linking synaptic superoxide production with poor short-term memory in aged mice. Brain Res 1368: 65-70. Open Access
  3. Fridolfsson HN, Kawaraguchi Y, Ali SS, Panneerselvam M, Niesman IR, Finley JC, Kellerhals SE, Migita MY, Okada H, Moreno AL, Jennings M, Kidd MW, Bonds JA, Balijepalli RC, Ross RS, Patel PM, Miyanohara A, Chen Q, Lesnefsky EJ, Head BP, Roth DM, Insel PA, Patel HH (2012) Mitochondria-localized caveolin in adaptation to cellular stress and injury. FASEB J 26: 4637-4649. Open Access

Keywords: Free radicals, Brain, Mitochondria, NADPH oxidase, Neurological disorders, Aging, Electron paramagnetic resonance spectroscopy, Antioxidants

O2k-Network Lab: EG Cairo Ali SS

Labels: Pathology: Aging;senescence  Stress:Oxidative stress;RONS, Mitochondrial disease  Organism: Human, Mouse  Tissue;cell: Nervous system 

Affiliations and author contributions

Sameh S Ali - Email: [email protected]

The Center for Aging and Associated Diseases, Helmy Institute of Medical Sciences, Zewail City of Science and Technology, Giza, Egypt

Department of Medicine, University of California, San Diego, USA