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Fieni 2012 Nat Commun

From Bioblast
Publications in the MiPMap
Fieni F, Lee SB, Jan YN, Kirichok Y (2012) Activity of the mitochondrial calcium uniporter varies greatly between tissues. Nat Commun 3:1317.

Β» PMID: 23271651 Open Access

Fieni F, Lee SB, Jan YN, Kirichok Y (2012) Nat Commun

Abstract: The mitochondrial calcium uniporter is a highly selective channel responsible for mitochondrial Ca2+ uptake. The mitochondrial calcium uniporter shapes cytosolic Ca2+ signals, controls mitochondrial ATP production, and is involved in cell death. Here using direct patch-clamp recording from the inner mitochondrial membrane, we compare mitochondrial calcium uniporter activity in mouse heart, skeletal muscle, liver, kidney and brown fat. Surprisingly, heart mitochondria show a dramatically lower mitochondrial calcium uniporter current density than the other tissues studied. Similarly, in Drosophila flight muscle, mitochondrial calcium uniporter activity is barely detectable compared with that in other fly tissues. As mitochondria occupy up to 40% of the cell volume in highly metabolically active heart and flight muscle, low mitochondrial calcium uniporter activity is likely essential to avoid cytosolic Ca2+ sink due to excessive mitochondrial Ca2+ uptake. Simultaneously, low mitochondrial calcium uniporter activity may also prevent mitochondrial Ca2+ overload in such active tissues exposed to frequent cytosolic Ca2+ activity. β€’ Keywords: Calcium, Mitochondrial Calcium Uniporter, Heart, Skeletal muscle, Liver, Kidney, Brown fat β€’ Bioblast editor: Cecatto C


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Organism: Mouse, Drosophila  Tissue;cell: Heart, Skeletal muscle, Liver, Kidney, Fat 




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