From Bioblast
Description
The N/S pathway control ratio is obtained from SUIT protocols when the N-pathway flux and S-pathway flux are measured in the same coupling control state. The N/S pathway control ratio may be larger or smaller than 1.0, depending on the mitochondrial source and various mitochondrial injuries. The S-pathway control state may be selected preferentially as reference state, if mitochondria are studied with respect to N-pathway injuries.
Abbreviation: N/S
Reference: Gnaiger 2020 BEC MitoPathways
Communicated by Gnaiger E 2020-11-16
Mitochondrial N/S types
- N/S flux ratios vary strongly between tissues and species. In human vastus lateralis, the NP/SP ratio is less than 1, with a wide scatter between studies but a consistent correlation between PM/S and GM/S flux control ratios (PMP ~ GMP). Low N/S flux control ratios indicate defects in the N-pathway upstream of the Q-junction.
- In human cardiac mitochondria, NP/SP ~ 1 in the OXPHOS-state, but NE/SE ~ 2 in the ET-state (high E-P excess capacity specifically for the N-pathway). In contrast, NE/SE is as low as 0.5 in mouse heart mitochondria. The S-pathway is highly dominant in human, mouse, and rat liver mitochondria, but not in trout liver mitochondria.
List of publications: N- and S-pathway control states
- » Listed publications: 1589
Year | Reference | Mammal and model | Tissue and cell | Stress | Diseases | |
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Patil 2024 J Exp Biol | 2024 | Patil YN, Gnaiger E, Landry AP, Leno ZJ, Hand SC (2024) OXPHOS capacity is diminished and the phosphorylation system inhibited during diapause in an extremophile, embryos of Artemia franciscana. J Exp Biol 227:jeb.245828. https://doi.org/10.1242/jeb.245828 | Artemia | Hypoxia | ||
Hunter-Manseau 2024 Insect Sci | 2024 | Hunter-Manseau F, Cormier SB, Strang R, Pichaud N (2024) Fasting as a precursor to high-fat diet enhances mitochondrial resilience in Drosophila melanogaster. Insect Sci [Epub ahead of print]. https://doi.org/10.1111/1744-7917.13355 | Drosophila | |||
Donnelly 2024 Redox Biol | 2024 | Donnelly C, KomlĂłdi T, Cecatto C, Cardoso LHD, Compagnion A-C, Matera A, Tavernari D, Campiche O, Paolicelli RC, Zanou N, Kayser B, Gnaiger E, Place N (2024) Functional hypoxia reduces mitochondrial calcium uptake. Redox Biol 71:103037. https://doi.org/10.1016/j.redox.2024.103037 | Human Mouse | Heart Skeletal muscle | Hypoxia | |
Balmaceda 2024 Biochim Biophys Acta Mol Basis Dis | 2024 | Balmaceda V, Komlodi T, Szibor M, Gnaiger E, Moore AL, Fernandez-Vizarra E, Viscomi C (2024) The striking differences in the bioenergetics of brain and liver mitochondria are enhanced in mitochondrial disease. Biochim Biophys Acta Mol Basis Dis 1870:167033. https://doi.org/10.1016/j.bbadis.2024.167033 | Mouse | Nervous system Liver | Oxidative stress;RONS | |
Ciccone 2024 J Exp Biol | 2024 | Ciccone C, Kante F, Folkow LP, Hazlerigg DG, West AC, Wood SH (2024) Circadian coupling of mitochondria in a deep-diving mammal. J Exp Biol 227:jeb24699. https://doi.org/10.1242/jeb.246990 | Other mammals | Fibroblast | Hypoxia | |
Xiao 2024 Sci Adv | 2024 | Xiao L, Yin Y, Sun Z, Liu J, Jia Y, Yang L, Mao Y, Peng S, Xie Z, Fang L, Li J, Xie X, Gan Z (2024) AMPK phosphorylation of FNIP1 (S220) controls mitochondrial function and muscle fuel utilization during exercise. Sci Adv 10:eadj2752. https://doi.org/10.1126/sciadv.adj2752 | Mouse | Skeletal muscle | ||
Ravasz 2024 Sci Rep | 2024 | Ravasz D, Bui D, Nazarian S, Pallag G, Karnok N, Roberts J, Marzullo BP, Tennant DA, Greenwood B, Kitayev A, Hill C, KomlĂłdi T, Doerrier C, Cunatova K, Fernandez-Vizarra E, Gnaiger E, Kiebish Michael A, Raska A, Kolev K, Czumbel B, Narain NR, Seyfried TN, Chinopoulos C (2024) Residual Complex I activity and amphidirectional Complex II operation support glutamate catabolism through mtSLP in anoxia. Sci Rep 14:1729. https://doi.org/10.1038/s41598-024-51365-4 | Mouse | Heart Liver | Hypoxia | |
Dong 2024 Nat Commun | 2024 | Dong J, Chen L, Ye F, Tang J, Liu B, Lin J, Zhou PH, Lu B, Wu M, Lu JH, He JJ, Engelender S, Meng Q, Song Z, He H (2024) Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease. https://doi.org/10.1038/s41467-023-44057-6 | Mouse | Liver | ||
Tsouka 2024 Commun Med (Lond) | 2024 | Tsouka S, Kumar P, Seubnooch P, Freiburghaus K, St-Pierre M, Dufour JF, Masoodi M (2024) Transcriptomics-driven metabolic pathway analysis reveals similar alterations in lipid metabolism in mouse MASH model and human. Commun Med (Lond) 4:39. https://doi.org/10.1038/s43856-024-00465-3 | Mouse | Liver | Other | |
Al-Sabri 2024 Sci Rep | 2024 | Al-Sabri MH, Ammar N, Korzh S, Alsehli AM, Hosseini K, Fredriksson R, Mwinyi J, Williams MJ, Boukhatmi H, Schiöth HB (2024) Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes. https://doi.org/10.1038/s41598-024-53446-w | Drosophila | Skeletal muscle | ||
Visker 2024 Exp Physiol | 2024 | Visker JR, Leszczynski EC, Wellette-Hunsucker AG, McPeek AC, Quinn MA, Kim SH, Bazil JN, Ferguson DP (2024) Postnatal growth restriction alters myocardial mitochondrial energetics in mice. https://doi.org/10.1113/ep091304 | Mouse | Heart | ||
Hu 2024 Front Endocrinol (Lausanne) | 2024 | Hu Y, Fang B, Tian X, Wang H, Tian X, Yu F, Li T, Yang Z, Shi R (2024) Passive exercise is an effective alternative to HRT for restoring OVX induced mitochondrial dysfunction in skeletal muscle. Front Endocrinol (Lausanne) 15:1356312. https://doi.org/10.3389/fendo.2024.1356312 | Mouse | Skeletal muscle | ||
Abegg 2024 Toxicol Lett | 2024 | Abegg VF, Panajatovic MV, Mancuso RV, Allard JA, Duthaler U, Odermatt A, KrĂ€henbĂŒhl S, Bouitbir J (2024) Mechanisms of hepatocellular toxicity associated with the components of St. John's Wort extract hypericin and hyperforin in HepG2 and HepaRG cells. https://doi.org/10.1016/j.toxlet.2024.01.008 | Human | Liver | ||
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Zvejniece 2023 Biomed Pharmacother | 2023 | Zvejniece L, Svalbe B, Vavers E, Ozola M, Grinberga S, Gukalova B, Sevostjanovs E, Liepinsh E, Dambrova M (2023) Decreased long-chain acylcarnitine content increases mitochondrial coupling efficiency and prevents ischemia-induced brain damage in rats. | Rat | Ischemia-reperfusion | ||
Calabria 2023 Biomedicines | 2023 | Calabria E, Muollo V, Cavedon V, Capovin T, Saccenti L, Passarotti F, Ghiotto L, Milanese C, Gelati M, Rudi D, Salvagno GL, Lippi G, Tam E, Schena F, Pogliaghi S (2023) Type 2 diabetes related mitochondrial defects in peripheral mononucleated blood cells from overweight postmenopausal women. https://doi.org/10.3390/biomedicines11010121 | Human | Blood cells | Diabetes | |
Silaidos 2023 Geroscience | 2023 | Silaidos CV, Reutzel M, Wachter L, Dieter F, Ludin N, Blum WF, Wudy SA, Matura S, Pilatus U, Hattingen E, Pantel J, Eckert GP (2023) Age-related changes in energy metabolism in peripheral mononuclear blood cells (PBMCs) and the brains of cognitively healthy seniors. https://doi.org/10.1007/s11357-023-00810-9 | Human | Blood cells | Aging;senescence | |
Vamesu 2023 JCI Insight | 2023 | Vamesu BM, Nicola T, Li R, Hazra S, Matalon S, Kaminski N, Ambalavanan N, Kandasamy J (2023) Thyroid hormone modulates hyperoxic neonatal lung injury and mitochondrial function. https://doi.org/10.1172/jci.insight.160697 | Mouse | Lung;gill | Other | |
Kankuri 2023 Exp Mol Med | 2023 | Kankuri E, Finckenberg P, Leinonen J, Tarkia M, Björk S, Purhonen J, KallijÀrvi J, Kankainen M, Soliymani R, Lalowski M, Mervaala E (2023) Altered acylcarnitine metabolism and inflexible mitochondrial fuel utilization characterize the loss of neonatal myocardial regeneration capacity. https://doi.org/10.1038/s12276-023-00967-5 | Mouse | Heart | Cardiovascular | |
Frangos 2023 J Biol Chem | 2023 | Frangos SM, DesOrmeaux GJ, Holloway GP (2023) Acidosis attenuates CPT-I supported bioenergetics as a potential mechanism limiting lipid oxidation. https://doi.org/10.1016/j.jbc.2023.105079 | Mouse | Skeletal muscle | ||
Colosio 2023 J Appl Physiol (1985) | 2023 | Colosio M, Brocca L, Gatti M, Neri M, Crea E, Cadile F, Canepari M, Pellegrino MA, Polla B, Porcelli S, Bottinelli R (2023) Structural and functional impairments of skeletal muscle in patients with post-acute sequelae of SARS-CoV-2 infection. https://doi.org/10.1152/japplphysiol.00158.2023 | Human | Skeletal muscle | Infectious | |
Liu 2023 Pharmacol Res | 2023 | Liu S, Yue S, Guo Y, Han JY, Wang H (2023) Sorafenib induces cardiotoxicity through RBM20-mediated alternative splicing of sarcomeric and mitochondrial genes. https://doi.org/10.1016/j.phrs.2023.107017 | Rat | Heart | Cancer | |
Martell 2023 Nat Commun | 2023 | Martell E, Kuzmychova H, Kaul E, Senthil H, Chowdhury SR, Morrison LC, Fresnoza A, Zagozewski J, Venugopal C, Anderson CM, Singh SK, Banerji V, Werbowetski-Ogilvie TE, Sharif T (2023) Metabolism-based targeting of MYC via MPC-SOD2 axis-mediated oxidation promotes cellular differentiation in group 3 medulloblastoma. https://doi.org/10.1038/s41467-023-38049-9 | Human | Nervous system | Cancer | |
Fletcher 2023 Transl Res | 2023 | Fletcher E, Miserlis D, Sorokolet K, Wilburn D, Bradley C, Papoutsi E, Wilkinson T, Ring A, Ferrer L, Haynatzki G, Smith RS, Bohannon WT, Koutakis P (2023) Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of peripheral artery disease. https://doi.org/10.1016/j.trsl.2023.05.002 | Mouse | Skeletal muscle | Myopathy Obesity | |
Nollet 2023 Eur Heart J | 2023 | Nollet EE, Duursma I, Rozenbaum A, Eggelbusch M, WĂŒst RCI, Schoonvelde SAC, Michels M, Jansen M, van der Wel NN, Bedi KC, Margulies KB, Nirschl J, Kuster DWD, van der Velden J (2023) Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration. https://doi.org/10.1093/eurheartj/ehad028 | Human | Heart | Cardiovascular Myopathy | |
Heo 2023 J Cachexia Sarcopenia Muscle | 2023 | Heo J, Schifino AG, McFaline-Figueroa J, Miller DL, Hoffman JR, Noble EE, Greising SM, Call JA (2023) Differential effects of Western diet and traumatic muscle injury on skeletal muscle metabolic regulation in male and female mice. https://doi.org/10.1002/jcsm.13361 | Mouse | Skeletal muscle | Obesity Other | |
Curtabbi 2023 Redox Biol | 2023 | Curtabbi A, GuarĂĄs A, Cabrera-AlarcĂłn JL, Rivero M, Calvo E, Rosa-Moreno M, VĂĄzquez J, Medina M, EnrĂquez JA (2023) Regulation of respiratory complex I assembly by FMN cofactor targeting. https://doi.org/10.1016/j.redox.2023.103001 | Mouse | Fibroblast Kidney | ||
Mu 2023 STAR Protoc | 2023 | Mu C, Shearer J (2023) Protocol for measuring respiratory function of mitochondria in frozen colon tissue from rats. https://doi.org/10.1016/j.xpro.2023.102560 | Rat | Endothelial;epithelial;mesothelial cell | Cryopreservation | |
Gong 2023 Biomed Pharmacother | 2023 | Gong DF, Sun SC, Wang RR, Dawuti A, Kong DW, Liu RQ, Du LD, Wang SB, Lu Y, Yuan TY, Du GH, Fang LH (2023) Salvianolic acid A improve mitochondrial respiration and cardiac function via inhibiting apoptosis pathway through CRYAB in diabetic cardiomyopathy. https://doi.org/10.1016/j.biopha.2023.114382 | Rat | Heart | Cardiovascular Diabetes | |
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Devaux 2023 J Comp Physiol B | 2023 | Devaux JBL, Hedges CP, Birch N, Herbert N, Renshaw GMC, Hickey AJR (2023) Electron transfer and ROS production in brain mitochondria of intertidal and subtidal triplefin fish (Tripterygiidae). https://doi.org/10.1007/s00360-023-01495-4 | Fishes | Nervous system | Oxidative stress;RONS | |
Mayayo-Vallverdu 2023 Redox Biol | 2023 | Mayayo-VallverdĂș C, LĂłpez de Heredia M, Prat E, GonzĂĄlez L, Espino Guarch M, Vilches C, Muñoz L, Asensi MA, Serra C, Llebaria A, Casado M, Artuch R, Garrabou G, Garcia-Roves PM, PallardĂł FV, Nunes V (2023) The antioxidant l-Ergothioneine prevents cystine lithiasis in the Slc7a9-/- mouse model of cystinuria. https://doi.org/10.1016/j.redox.2023.102801 | Mouse | Kidney | Other | |
Arias-Reyes 2023 MitoFit | 2023 | Arias-Reyes C, Aliaga-RaduĂĄn F, Pinto-Aparicio R, Joseph V, Soliz J (2023) Mitochondrial plasticity in the retrosplenial cortex enhances ATP synthesis during acclimatization to hypoxia in mice but not in rats. MitoFit Preprints 2023.6. https://doi.org/10.26124/mitofit:2023-0006 | Mouse Rat | Nervous system | Hypoxia | |
Zhang 2023 Nat Commun | 2023 | Zhang Y, Fan Y, Hu H, Zhang X, Wang Z, Wu Z, Wang L, Yu X, Song X, Xiang P, Zhang X, Wang T, Tan S, Li C, Gao L, Liang X, Li S, Li N, Yue X, Ma C (2023) ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury. https://doi.org/10.1038/s41467-023-43439-0 | Mouse | Liver | ||
Ashok 2023 Mol Cell Biochem | 2023 | Ashok S, Raji SR, Manjunatha S, Srinivas G (2023) Impairment of substrate-mediated mitochondrial respiration in cardiac cells by chloroquine. https://doi.org/10.1007/s11010-023-04740-0 | Mouse | Heart | ||
Mioc 2023 Molecules | 2023 | Mioc M, Mioc A, Racoviceanu R, Ghiulai R, Prodea A, Milan A, Barbu Tudoran L, Oprean C, Ivan V, Èoica C (2023) The antimelanoma biological assessment of triterpenic acid functionalized gold nanoparticles. https://doi.org/10.3390/molecules28010421 | Human | Endothelial;epithelial;mesothelial cell | Cancer | |
Garcia-Roche 2023 PLoS One | 2023 | GarcĂa-Roche M, TalmĂłn D, Cañibe G, Astessiano AL, Mendoza A, Cassina A, Quijano C, Carriquiry M (2023) Hepatic metabolism of grazing cows of two Holstein strains under two feeding strategies with different levels of pasture inclusion. https://doi.org/10.1371/journal.pone.0290551 | Bovines | Liver | ||
Bellar 2023 Clin Transl Med | 2023 | Bellar A, Welch N, Dasarathy J, Attaway A, Musich R, Kumar A, Sekar J, Mishra S, Sandlers Y, Streem D, Nagy LE, Dasarathy S (2023) Peripheral blood mononuclear cell mitochondrial dysfunction in acute alcohol-associated hepatitis. https://doi.org/10.1002/ctm2.1276 | Human | Blood cells | Other | |
Ebanks 2023 PLoS One | 2023 | Ebanks B, Kwiecinska P, Moisoi N, Chakrabarti L (2023) A method to assess the mitochondrial respiratory capacity of complexes I and II from frozen tissue using the Oroboros O2k-FluoRespirometer. https://doi.org/10.1371/journal.pone.0276147 | Mouse Drosophila | Skeletal muscle | Cryopreservation | |
Boykov 2023 Sci Rep | 2023 | Boykov IN, Montgomery MM, Hagen JT, Aruleba RT, McLaughlin KL, Coalson HS, Nelson MA, Pereyra AS, Ellis JM, Zeczycki TN, Vohra NA, Tan SF, Cabot MC, Fisher-Wellman KH (2023) Pan-tissue mitochondrial phenotyping reveals lower OXPHOS expression and function across cancer types. https://doi.org/10.1038/s41598-023-43963-5 | Mouse | Heart Endothelial;epithelial;mesothelial cell | Cancer | |
Sathiaseelan 2023 J Gerontol A Biol Sci Med Sci | 2023 | Sathiaseelan R, Ahn B, Stout MB, Logan S, Wanagat J, Van M Nguyen H, Hord NG, Vandiver AR, Selvarani R, Ranjit R, Yarbrough H, Masingale A, Miller BF, Wolf RF, Austad SN, Richardson A (2023) A genetically heterogeneous rat model with divergent mitochondrial genomes. https://doi.org/10.1093/gerona/glad056 | Rat | Skeletal muscle | ||
Fernando 2023 Commun Biol | 2023 | Fernando R, Shindyapina AV, Ost M, Santesmasses D, Hu Y, Tyshkovskiy A, Yim SH, Weiss J, Gladyshev VN, Grune T, Castro JP (2023) Downregulation of mitochondrial metabolism is a driver for fast skeletal muscle loss during mouse aging. https://doi.org/10.1038/s42003-023-05595-3 | Mouse | Skeletal muscle | Aging;senescence | |
Scandalis 2023 JAMA Cardiol | 2023 | Scandalis L, Kitzman DW, Nicklas BJ, Lyles M, Brubaker P, Nelson MB, Gordon M, Stone J, Bergstrom J, Neufer PD, Gnaiger E, Molina AJA (2023) Skeletal muscle mitochondrial respiration and exercise intolerance in patients with heart failure with preserved ejection fraction. https://doi.org/10.1001/jamacardio.2023.0957 | Human | Skeletal muscle | Cardiovascular | |
Awad-Igbaria 2023 J Transl Med | 2023 | Awad-Igbaria Y, Ferreira N, Keadan A, Sakas R, Edelman D, Shamir A, Francous-Soustiel J, Palzur E (2023) HBO treatment enhances motor function and modulates pain development after sciatic nerve injury via protection the mitochondrial function. https://doi.org/10.1186/s12967-023-04414-x | Rat | Nervous system | Other | |
Dominguez-Lopez 2023 Neuropharmacology | 2023 | Dominguez-Lopez S, Ahn B, Sataranatarajan K, Ranjit R, Premkumar P, Van Remmen H, Beckstead MJ (2023) Long-term methamphetamine self-administration increases mesolimbic mitochondrial oxygen consumption and decreases striatal glutathione. https://doi.org/10.1016/j.neuropharm.2023.109436 | Mouse | Nervous system | ||
Cecatto 2023 MitoFit | 2023 | Cecatto C, Cardoso LHD, Ozola M, Korzh S, Zvejniece L, Gukalova B, Doerrier C, Dambrova M, Gnaiger E, Makrecka-Kuka M, Liepinsh E (2023) Fatty acid ÎČ-oxidation in brain mitochondria: Insights from high-resolution respirometry in mouse, rat and Drosophila brain, ischemia and aging models. MitoFit Preprints 2023.10. https://doi.org/10.26124/mitofit:2023-0010 | Mouse Rat Drosophila | Nervous system Heart Kidney | Ischemia-reperfusion | Aging;senescence |
Davis 2023 MitoFit | 2023 | Davis MS, Barrett MR, Bayly WM, Bolinger A (2023) Effect of selected fluorophores on equine skeletal muscle mitochondrial respiration. MitoFit Preprints 2023.5. https://doi.org/10.26124/mitofit:2023-0005 | Horse | Skeletal muscle | ||
Vilas-Boas 2023 J Biol Chem | 2023 | Vilas-Boas EA, Cabral-Costa JV, Ramos VM, Caldeira da Silva CC, Kowaltowski AJ (2023) Goldilocks calcium concentrations and the regulation of oxidative phosphorylation: too much, too little, or just right. https://doi.org/10.1016/j.jbc.2023.102904 | Mouse | Liver | ||
Menail 2023 FASEB J | 2023 | Menail HA, Cormier SB, LĂ©ger A, Robichaud S, Hebert-Chatelain E, Lamarre SG, Pichaud N (2023) Age-related flexibility of energetic metabolism in the honey bee Apis mellifera. https://doi.org/10.1096/fj.202300654r | Hexapods | Aging;senescence | ||
Czyzowska 2023 Redox Biol | 2023 | CzyĆŒowska A, Brown J, Xu H, Sataranatarajan K, Kinter M, Tyrell VJ, O'Donnell VB, Van Remmen H (2023) Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness. https://doi.org/10.1016/j.redox.2023.102761 | Mouse | Skeletal muscle | Aging;senescence | |
Sucha 2023 Int J Mol Sci | 2023 | Sucha M, Benediktova S, Tichanek F, Jedlicka J, Kapl S, Jelinkova D, Purkartova Z, Tuma J, Kuncova J, Cendelin J (2023) Experimental treatment with edaravone in a mouse model of spinocerebellar ataxia 1. https://doi.org/10.3390/ijms241310689 | Mouse | Nervous system | Neurodegenerative | |
Luptak 2023 Antioxidants (Basel) | 2023 | ÄœuptĂĄk M, FiĆĄar Z, HroudovĂĄ J (2023) Different effects of SSRIs, Bupropion, and Trazodone on mitochondrial functions and monoamine oxidase isoform activity. Antioxidants (Basel) 12:1208. https://doi.org/10.3390/antiox12061208 | Pig | Nervous system | Neurodegenerative | |
Robertson 2023 J Cell Sci | 2023 | Robertson GL, Riffle S, Patel M, Bodnya C, Marshall A, Beasley HK, Garza-Lopez E, Shao J, Vue Z, Hinton A, Stoll MS, de Wet S, Theart RP, Chakrabarty RP, Loos B, Chandel NS, Mears JA, Gama V (2023) DRP1 mutations associated with EMPF1 encephalopathy alter mitochondrial membrane potential and metabolic programs. https://doi.org/10.1242/jcs.260370 | Human | Fibroblast | Neurodegenerative | |
Noone 2023 J Physiol | 2023 | Noone J, Damiot A, Kenny H, Chery I, Zahariev A, Normand S, Crampes F, de Glisezinski I, Rochfort KD, Laurens C, Bareille MP, Simon C, Bergouignan A, Blanc S, O'Gorman DJ (2023) The impact of 60 days of -6° head down tilt bed rest on mitochondrial content, respiration and regulators of mitochondrial dynamics. https://doi.org/10.1113/jp284734 | Human | Skeletal muscle | ||
Airik 2023 Antioxidants (Basel) | 2023 | Airik M, Arbore H, Childs E, Huynh AB, Phua YL, Chen CW, Aird K, Bharathi S, Zhang B, Conlon P, Kmoch S, Kidd K, Bleyer AJ, Vockley J, Goetzman E, Wipf P, Airik R (2023) Mitochondrial ROS triggers KIN pathogenesis in FAN1-deficient kidneys. https://doi.org/10.3390/antiox12040900 | Human | Kidney | Oxidative stress;RONS | Inherited |
Verma 2023 Int J Mol Sci | 2023 | Verma A, Azhar G, Zhang X, Patyal P, Kc G, Sharma S, Che Y, Wei JY (2023) P. gingivalis-LPS induces mitochondrial dysfunction mediated by neuroinflammation through oxidative stress. Int J Mol Sci 24:950. https://doi.org/10.3390/ijms24020950 | Human | Endothelial;epithelial;mesothelial cell | Neurodegenerative | |
Zhang 2023 J Cachexia Sarcopenia Muscle | 2023 | Zhang S, Yan H, Ding J, Wang R, Feng Y, Zhang X, Kong X, Gong H, Lu X, Ma A, Hua Y, Liu H, Guo J, Gao H, Zhou Z, Wang R, Chen P, Liu T, Kong X (2023) Skeletal muscle-specific DJ-1 ablation-induced atrogenes expression and mitochondrial dysfunction contributing to muscular atrophy. https://doi.org/10.1002/jcsm.13290 | Mouse | Skeletal muscle | Parkinson's | |
Gautam 2023 Neurobiol Dis | 2023 | Gautam M, Genç B, Helmold B, Ahrens A, Kuka J, Makrecka-Kuka M, GĂŒnay A, Koçak N, Aguilar-Wickings IR, Keefe D, Zheng G, Swaminathan S, Redmon M, Zariwala HA, Ăzdinler PH (2023) SBT-272 improves TDP-43 pathology in ALS upper motor neurons by modulating mitochondrial integrity, motility, and function. https://doi.org/10.1016/j.nbd.2023.106022 | Rat | Heart Nervous system | Neurodegenerative | |
Batterson 2023 Physiol Rep | 2023 | Batterson PM, McGowan EM, Borowik AK, Kinter MT, Miller BF, Newsom SA, Robinson MM (2023) High-fat diet increases electron transfer flavoprotein synthesis and lipid respiration in skeletal muscle during exercise training in female mice. https://doi.org/10.14814/phy2.15840 | Mouse | Skeletal muscle | ||
Diaz 2023 Front Mol Biosci | 2023 | Diaz EC, Adams SH, Weber JL, Cotter M, BĂžrsheim E (2023) Elevated LDL-C, high blood pressure, and low peak VËO2 associate with platelet mitochondria function in children-The Arkansas Active Kids Study. Front Mol Biosci 10:1136975. https://doi.org/10.3389/fmolb.2023.1136975 | Human | Blood cells Platelet | Aging;senescence | |
Rodriguez 2023 BEC | 2023 | RodrĂguez E, Bettinazzi S, Inwongwan S, Camus MF, Lane N (2023) Harmonizing protocols to measure Drosophila respiratory function in mitochondrial preparations. Bioenerg Commun 2023.3. https://doi.org/10.26124/bec:2023-0003 | Drosophila | |||
Wu 2023 Int Immunopharmacol | 2023 | Wu F, Zhang YT, Teng F, Li HH, Guo SB (2023) S100a8/a9 contributes to sepsis-induced cardiomyopathy by activating ERK1/2-Drp1-mediated mitochondrial fission and respiratory dysfunction. https://doi.org/10.1016/j.intimp.2023.109716 | Mouse | Heart | Cardiovascular Myopathy Sepsis | |
Ismaeel 2023 Physiol Rep | 2023 | Ismaeel A, Valentino TR, Burke B, Goh J, Saliu TP, Albathi F, Owen A, McCarthy JJ, Wen Y (2023) Acetate and succinate benefit host muscle energetics as exercise-associated post-biotics. https://doi.org/10.14814/phy2.15848 | Mouse | Skeletal muscle | ||
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Pharaoh 2019 Mol Neurobiol | 2019 | Pharaoh G, Owen D, Yeganeh A, Premkumar P, Farley J, Bhaskaran S, Ashpole N, Kinter M, Van Remmen H, Logan S (2019) Disparate central and peripheral effects of circulating IGF-1 deficiency on tissue mitochondrial function. Mol Neurobiol 57:1317-31. | Mouse | Skeletal muscle Nervous system Fat | Aging;senescence | |
Calabria 2019 Front Neurosci | 2019 | Calabria Elisa, Scambi Ilaria, Bonafede Roberta, Schiaffino Lorenzo, Peroni Daniele, Potrich Valentina, Capelli Carlo, Schena Federico, Mariotti Raffaella (2019) ASCs-exosomes recover coupling efficiency and mitochondrial membrane potential in an in vitro model of ALS. Front Neurosci 13:1070. | Mouse | Nervous system | Neurodegenerative | |
Hafen 2019 J Appl Physiol (1985) | 2019 | Hafen PS, Abbott K, Bowden JA, Lopiano R, Hancock CR, Hyldahl RD (2019) Daily heat treatment maintains mitochondrial function and attenuates atrophy in human skeletal muscle subjected to immobilization. J Appl Physiol (1985) 127:47-57. https://doi.org/10.1152/japplphysiol.01098.2018 | Human | Skeletal muscle | Temperature | |
Reda 2019 Sci Rep | 2019 | Reda A, Refaat A, Abd-Rabou AA, Mahmoud AM, Adel M, Sabet S, Ali SS (2019) Role of mitochondria in rescuing glycolytically inhibited subpopulation of triple negative but not hormone-responsive breast cancer cells. Sci Rep 9:13748. | Human | Endothelial;epithelial;mesothelial cell | Cancer | |
Hedges 2019 Comp Biochem Physiol A Mol Integr Physiol | 2019 | Hedges CP, Wilkinson RT, Devaux JBL, Hickey AJR (2019) Hymenoptera flight muscle mitochondrial function: Increasing metabolic power increases oxidative stress. Comp Biochem Physiol A Mol Integr Physiol 230:115-21. | Other invertebrates | Skeletal muscle | Oxidative stress;RONS | |
Paradis 2019 Antioxidants (Basel) | 2019 | Paradis S, Charles AL, Georg I, Goupilleau F, Meyer A, Kindo M, Laverny G, Metzger D, Geny B (2019) Aging exacerbates ischemia-reperfusion-induced mitochondrial respiration impairment in skeletal muscle. Antioxidants (Basel) 8:E168. | Mouse | Skeletal muscle | Ischemia-reperfusion | Aging;senescence |
Miranda-Silva 2019 Acta Physiologica | 2019 | Miranda-Silva D, WĂŒst RCI, Conceição G, Gonçalves-Rodrigues P, Gonçalves N, Gonçalves A, Kuster DWD, Leite-Moreira AF, van der Velden J, de Sousa Beleza JM, MagalhĂŁes J, Stienen GJM, FalcĂŁo-Pires I (2019) Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction. Acta Physiol e13378. | Rat | Heart | Cardiovascular Obesity | |
Ahn 2019 J Cachexia Sarcopenia Muscle | 2019 | Ahn B, Ranjit R, Premkumar P, Pharaoh G, Piekarz KM, Matsuzaki S, Claflin DR, Riddle K, Judge J, Bhaskaran S, Satara Natarajan K, Barboza E, Wronowski B, Kinter M, Humphries KM, Griffin TM, Freeman WM, Richardson A, Brooks SV, Van Remmen H (2019) Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fiber branching. J Cachexia Sarcopenia Muscle 10:411-28. | Mouse | Skeletal muscle | Oxidative stress;RONS | |
Latham 2019 J Anim Sci | 2019 | Latham CM, Fenger CK, White SH (2019) Rapid Communication: Differential skeletal muscle mitochondrial characteristics of weanling racing-bred horses. J Anim Sci [Epub ahead of print]. | Horse | Skeletal muscle | ||
Rodriguez-Enriquez 2019 Toxicol Appl Pharmacol | 2019 | RodrĂguez-EnrĂquez S, Pacheco-VelĂĄzquez SC, MarĂn-HernĂĄndez Ă, Gallardo-PĂ©rez JC, Robledo-Cadena DX, HernĂĄndez-ResĂ©ndiz I, GarcĂa-GarcĂa JD, Belmont-DĂaz J, LĂłpez-Marure R, HernĂĄndez-Esquivel L, SĂĄnchez-Thomas R, Moreno-SĂĄnchez R (2019) Resveratrol inhibits cancer cell proliferation by impairing oxidative phosphorylation and inducing oxidative stress. Toxicol Appl Pharmacol 370:65-77. | Rat | Heart Liver | Oxidative stress;RONS | Cancer |
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