Oxalomalic acid is an inhibitor of aconitase (and of cytoplasmic NADP-dependent isocitrate dehydrogenase). Aconitase mediates the isomerization of citrate to isocitrate as the first step in the TCA cycle. Oxalomalic acid has been used at 1 mM concentration and after 45 min of pre-incubation to inhibit aconitase in permeabilized rat Soleus muscle fibres, inhibiting the enzyme by 24% (Osiki 2016 FASEB J).
Reference: Osiki 2016 FASEB J
MitoPedia topics: Inhibitor