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Oxalomalic acid

From Bioblast

high-resolution terminology - matching measurements at high-resolution

Oxalomalic acid


Oxalomalic acid is an inhibitor of aconitase (and of cytoplasmic NADP-dependent isocitrate dehydrogenase). Aconitase mediates the isomerization of citrate to isocitrate as the first step in the TCA cycle. Oxalomalic acid has been used at 1 mM concentration and after 45 min of pre-incubation to inhibit aconitase in permeabilized rat Soleus muscle fibres, inhibiting the enzyme by 24% (Osiki 2016 FASEB J).

Reference: Osiki 2016 FASEB J

MitoPedia topics: Inhibitor