User talk:Beno Marija/My sandbox US NC Winston-Salem Molina AJA
From Bioblast
UPBEAT project
- The following webpage summarizes our current Aging Center projects: Aging Center projects
- UPBEAT- Understanding the Physiology and BioEnergetics of Aging
- Age-related bioenergetic decline underlies numerous features of aging, including the development of age-related diseases and disorders. To date, there is a limited understanding of how mitochondrial bioenergetics changes in the context of normal human aging. The goal of UPBEAT is to address this gap in knowledge and to generate a database of bioenergetic profiles from healthy individuals across a spectrum of ages. A key feature of UPBEAT is its design to serve as a healthy control group for ongoing and future research projects. For example, the role of mitochondrial bioenergetics in in several age-related diseases is currently being investigated by comparing data from patients and age-matched UPBEAT participants.
- Highly comprehensive bioenergetic profiling is being achieved by respirometry of circulating cells and biopsied skeletal muscle tissue using complementary approaches and protocols. In addition to standard clinical measures, analyses of physical ability and exercise capacity are being conducted. Current recruitment is focused on healthy older adults; younger age groups will follow.
- Principal Investigator:
- Anthony J.A. Molina. PhD
- Wake Forest School of Medicine
- -This study is supported by the American Heart Association and the National Institute on Aging.
- -Additional support and technical expertise provided by Oroboros Instruments (Innsbruck, Austria).
- To download the UPBEAT project summary press here.
