Oxaloacetate: Difference between revisions
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|abbr=Oa | |abbr=Oa | ||
|description=[[File:Oxaloacetic_acid.jpg|left|100px|Oxaloacetic acid]] | |description=[[File:Oxaloacetic_acid.jpg|left|100px|Oxaloacetic acid]] | ||
'''Oxaloacetic acid''', C<sub>4</sub>H<sub>4</sub>O<sub>5</sub>, occurs under physiological conditions as the anion '''oxaloacetate<sup>2-</sup>, Oa'''. Oxaloacetate is formed from malate by [[Malate dehydrogenase|MDH]]. Oa reacts with | '''Oxaloacetic acid''', C<sub>4</sub>H<sub>4</sub>O<sub>5</sub>, occurs under physiological conditions as the anion '''oxaloacetate<sup>2-</sup>, Oa'''. Oxaloacetate is formed from malate by [[Malate dehydrogenase|MDH]]. Oa reacts with acetyl-CoA through [[citrate synthase]] to form citrate, or with [[glutamate]] through transaminase to form [[oxoglutarate]] and aspartate. Oa transport is restricted across the inner [[mitochondrial|mt]]-membrane of various tissues. Oa is a potent inhibitor of [[succinate dehydrogenase]]. | ||
|info=[[Gnaiger 2014 MitoPathways]] | |info=[[Gnaiger 2014 MitoPathways]] | ||
|type=Enzyme | |type=Enzyme |
Revision as of 09:35, 11 September 2020
Description
Oxaloacetic acid, C4H4O5, occurs under physiological conditions as the anion oxaloacetate2-, Oa. Oxaloacetate is formed from malate by MDH. Oa reacts with acetyl-CoA through citrate synthase to form citrate, or with glutamate through transaminase to form oxoglutarate and aspartate. Oa transport is restricted across the inner mt-membrane of various tissues. Oa is a potent inhibitor of succinate dehydrogenase.
Abbreviation: Oa
Reference: Gnaiger 2014 MitoPathways
MitoPedia topics: Substrate and metabolite