Torres-Quesada 2022 MitoFit Kinase: Difference between revisions
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{{Publication | {{Publication | ||
|title=Torres-Quesada O, Strich S, Stefan E (2022) Kinase perturbations redirect mitochondrial function. https://doi.org/10.26124/mitofit:2022-0011 β ''2022-11-15 published in [https://doi.org//10.26124/bec:2022-0013 '''Bioenerg Commun 2022.13.''']'' | |title=Torres-Quesada O, Strich S, Stefan E (2022) Kinase perturbations redirect mitochondrial function. https://doi.org/10.26124/mitofit:2022-0011 β ''2022-11-15 published in [https://doi.org//10.26124/bec:2022-0013 '''Bioenerg Commun 2022.13.''']'' | ||
|info=MitoFit Prep 2022.11. [[File:MitoFit Preprints pdf.png|left|160px|link=https://wiki.oroboros.at/images/9/91/Torres-Quesada_2022_MitoFit_Kinase.pdf|MitoFit pdf]] [https://wiki.oroboros.at/images/9/91/Torres-Quesada_2022_MitoFit_Kinase.pdf Kinase perturbations redirect mitochondrial function] [[File:WatchThePresentationYoutube_icon.jpg|200px|link=https://www.youtube.com/watch?v=2--Bt1T7Zu0&t=1819s|Β»''Watch the presentation''Β«]]<br/> | |info=MitoFit Prep 2022.11. [[File:MitoFit Preprints pdf.png|left|160px|link=https://wiki.oroboros.at/images/9/91/Torres-Quesada_2022_MitoFit_Kinase.pdf|MitoFit pdf]] [https://wiki.oroboros.at/images/9/91/Torres-Quesada_2022_MitoFit_Kinase.pdf Kinase perturbations redirect mitochondrial function] [[File:WatchThePresentationYoutube_icon.jpg|200px|link=https://www.youtube.com/watch?v=2--Bt1T7Zu0&t=1819s|Β»''Watch the presentation''Β«]]<br/> | ||
|authors= | |authors=MitoFit Prep 2022.11. | ||
|year=2022 | |year=2022 | ||
|journal=MitoFit Prep | |journal=MitoFit Prep | ||
|abstract=[[Torres-Quesada 2022 Abstract Bioblast]]: Protein kinases take the center stage in numerous signaling pathways by phosphorylating compartmentalized protein substrates for controlling cell proliferation, cell cycle and metabolism. Kinase dysfunctions have been linked to numerous human diseases such as cancer. This has led to the development of kinase inhibitors which aim to target oncogenic kinase activities. The specificity of the cancer blockers depends on the range of targeted kinases. Therefore, the question arises of how cell-type-specific off-target effects impair the specificities of cancer drugs. Blockade of kinase activities has been shown to converge on the energetic organelle, the mitochondria. In this review, we highlight examples of selected major kinases which impact mitochondrial signaling. Further, we discuss pharmacological strategies to target kinase activities which are linked to cancer progression and redirecting mitochondrial function. Finally, we propose that cell-based recordings of mitochondrial bioenergetic states might predict off-target or identify specific on-target effects of kinase inhibitors. | |abstract=[[Torres-Quesada 2022 Abstract Bioblast]]: Protein kinases take the center stage in numerous signaling pathways by phosphorylating compartmentalized protein substrates for controlling cell proliferation, cell cycle and metabolism. Kinase dysfunctions have been linked to numerous human diseases such as cancer. This has led to the development of kinase inhibitors which aim to target oncogenic kinase activities. The specificity of the cancer blockers depends on the range of targeted kinases. Therefore, the question arises of how cell-type-specific off-target effects impair the specificities of cancer drugs. Blockade of kinase activities has been shown to converge on the energetic organelle, the mitochondria. In this review, we highlight examples of selected major kinases which impact mitochondrial signaling. Further, we discuss pharmacological strategies to target kinase activities which are linked to cancer progression and redirecting mitochondrial function. Finally, we propose that cell-based recordings of mitochondrial bioenergetic states might predict off-target or identify specific on-target effects of kinase inhibitors. | ||
Β | |keywords=Kinases, signaling, mitochondria, kinase inhibitors, cancer, drug off-target effects | ||
|keywords=Kinases, signaling, mitochondria, kinase inhibitors, cancer, drug off-target effects Β | |||
|editor=Doerrier C | |editor=Doerrier C | ||
|mipnetlab=AT Innsbruck Oroboros | |mipnetlab=AT Innsbruck Oroboros | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|area=Pharmacology;toxicology | |area=Pharmacology;toxicology | ||
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|additional=MitoKIN, Bioblast 2022 | |additional=MitoKIN, Bioblast 2022 | ||
}} | }} | ||
[[File:Bioblast2022 banner.jpg|link=Bioblast_2022]] | |||
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ORC'''ID''': [[File:ORCID.png|20px|link=https://orcid.org/0000-0003-3394-3075]] Torres-Quesada Omar, | |||
[[File:ORCID.png|20px|link=https://orcid.org/0000-0003-3650-4713]] Stefan Eduard |
Revision as of 12:59, 8 January 2023
Torres-Quesada O, Strich S, Stefan E (2022) Kinase perturbations redirect mitochondrial function. https://doi.org/10.26124/mitofit:2022-0011 β 2022-11-15 published in Bioenerg Commun 2022.13. |
Β» MitoFit Prep 2022.11.
Kinase perturbations redirect mitochondrial function
MitoFit Prep 2022.11. (2022) MitoFit Prep
Abstract: Torres-Quesada 2022 Abstract Bioblast: Protein kinases take the center stage in numerous signaling pathways by phosphorylating compartmentalized protein substrates for controlling cell proliferation, cell cycle and metabolism. Kinase dysfunctions have been linked to numerous human diseases such as cancer. This has led to the development of kinase inhibitors which aim to target oncogenic kinase activities. The specificity of the cancer blockers depends on the range of targeted kinases. Therefore, the question arises of how cell-type-specific off-target effects impair the specificities of cancer drugs. Blockade of kinase activities has been shown to converge on the energetic organelle, the mitochondria. In this review, we highlight examples of selected major kinases which impact mitochondrial signaling. Further, we discuss pharmacological strategies to target kinase activities which are linked to cancer progression and redirecting mitochondrial function. Finally, we propose that cell-based recordings of mitochondrial bioenergetic states might predict off-target or identify specific on-target effects of kinase inhibitors. β’ Keywords: Kinases, signaling, mitochondria, kinase inhibitors, cancer, drug off-target effects β’ Bioblast editor: Doerrier C β’ O2k-Network Lab: AT Innsbruck Oroboros
Labels: MiParea: Pharmacology;toxicology
Pathology: Cancer
Organism: Human
MitoKIN, Bioblast 2022
Torres-Quesada 2022 MitoFit Kinase