Template:SUIT PGM low ADP: Difference between revisions

Latest revision as of 12:06, 5 January 2024

The addition of fuel substrates may trigger a transient peak increase in mitochondrial respiration due to the presence of low ADP concentrations. Once ADP is phosphorylated to ATP the respiration decreases.

In the presence of ATPases in the sample, ATP is recycled to ADP, making it not possible to measure LEAK state.

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	The addition of fuel substrates may trigger a transient peak increase in mitochondrial respiration due to the presence of low [[ADP]] concentrations~~, and reduction of the [[NAD]] pool~~. Once [[ADP]] is phosphorylated to [[ATP]] the respiration decreases ~~and a further reduction of [[NAD]] can be observed~~.		The addition of fuel substrates may trigger a transient peak increase in mitochondrial respiration due to the presence of low [[ADP]] concentrations. Once [[ADP]] is phosphorylated to [[ATP]] the respiration decreases.
	*In the presence of [[ATPases]] in the sample, [[ATP]] is recycled to [[ADP]], making it not possible to measure [[LEAK]] state.		*In the presence of [[ATPases]] in the sample, [[ATP]] is recycled to [[ADP]], making it not possible to measure [[LEAK]] state.