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	Year	Reference	Coupling	Pathways	Preparations	Species;model	Tissue;cell
Dechandt 2019 Front Neurol	2019	Dechandt CRP, Ferrari GD, Dos Santos JR, de Oliveira JAC, da Silva-Jr RMP, Cunha AOS, Garcia-Cairasco N, Alberici LC (2019) Energy metabolism and redox state in brains of wistar audiogenic rats, a genetic model of epilepsy. Front Neurol 10:1007.	LEAK OXPHOS ET	N ROX	Permeabilized tissue	Rat	Nervous system
Dejmek 2018 Physiol Res	2018	Dejmek J, Kohoutová M, Kripnerová M, Čedíková M, Tůma Z, Babuška V, Bolek L, Kuncová J (2018) Repeated exposure to hyperbaric hyperoxia affects mitochondrial functions of the lung fibroblasts. Physiol Res 67(Suppl 4):S633-S643.	LEAK ROUTINE OXPHOS ET	F N S CIV NS ROX	Permeabilized cells Intact cells	Human	Lung;gill Fibroblast
Dela 2018 Acta Physiol (Oxf)	2018	Dela F, Ingersen A, Andersen NB, Nielsen MB, Petersen HHH, Hansen CN, Larsen S, Wojtaszewski J, Helge JW (2018) Effects of one-legged high-intensity interval training on insulin-mediated skeletal muscle glucose homeostasis in patients with type 2 diabetes. Acta Physiol (Oxf) 226:e13245.	OXPHOS LEAK	N NS ROX	Permeabilized tissue	Human	Skeletal muscle
Deleye 2020 J Biol Chem	2020	Deleye Y, Cotte AK, Hannou SA, Hennuyer N, Bernard L, Derudas B, Caron S, Legry V, Vallez E, Dorchies E, Martin N, Lancel S, Annicotte JS, Bantubungi K, Pourtier A, Raverdy V, Pattou F, Lefebvre P, Abbadie C, Staels B, Haas JT, Paumelle R (2020) CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway. J Biol Chem 295:17310-22.	LEAK OXPHOS	F N	Homogenate	Mouse	Liver
Delfinis 2022 JCI Insight	2022	Delfinis LJ, Bellissimo CA, Gandhi S, DiBenedetto SN, Garibotti MC, Thuhan AK, Tsitkanou S, Rosa-Caldwell ME, Rahman FA, Cheng AJ, Wiggs MP, Schlattner U, Quadrilatero J, Greene NP, Perry CG (2022) Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress. https://doi.org/10.1172/jci.insight.155147	LEAK OXPHOS	N	Permeabilized tissue	Mouse	Skeletal muscle
Deline 2021 Biochim Biophys Acta Bioenerg	2021	Deline ML, Grashei M, van Heijster FHA, Schilling F, Straub J, Fromme T (2021) Adenylate kinase derived ATP shapes respiration and calcium storage of isolated mitochondria. Biochim Biophys Acta Bioenerg 1862:148409.	OXPHOS LEAK	S	Isolated mitochondria	Mouse	Liver
Della Noce 2022 J Biol Chem	2022	Della Noce B, Martins da Silva R, de Carvalho Uhl MV, Konnai S, Ohashi K, Calixto C, Arcanjo A, de Abreu LA, de Carvalho SS, da Silva Vaz I Jr, Logullo C (2022) Redox imbalance induces remodeling of glucose metabolism in Rhipicephalus microplus embryonic cell line. https://doi.org/10.1016/j.jbc.2022.101599	LEAK ROUTINE ET	ROX	Intact cells	Chelicerates	Other cell lines
Den Besten 2015 Diabetes	2015	den Besten G, Bleeker A, Gerding A, van Eunen K, Havinga R, van Dijk TH, Oosterveer MH, Jonker JW, Groen AK, Reijngoud DJ, Bakker BM (2015) Short-chain fatty acids protect against high-fat diet-induced obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation. Diabetes 64:2398-408.	LEAK OXPHOS	F	Isolated mitochondria	Mouse	Liver
Den Hollander 2014 Toxicol Sci	2014	den Hollander B, Sundström M, Pelander A, Ojanperä I, Mervaala E, Korpi ER, Kankuri E (2014) Keto amphetamine toxicity - focus on the redox reactivity of the cathinone designer drug mephedrone. Toxicol Sci 141:120-31.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Deng 2022 Cell Mol Life Sci	2022	Deng H, Gao Y, Trappetti V, Hertig D, Karatkevich D, Losmanova T, Urzi C, Ge H, Geest GA, Bruggmann R, Djonov V, Nuoffer JM, Vermathen P, Zamboni N, Riether C, Ochsenbein A, Peng RW, Kocher GJ, Schmid RA, Dorn P, Marti TM (2022) Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage. https://doi.org/10.1007/s00018-022-04453-5	LEAK	ROX N S CIV	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell
Dent 2017 Mol Metab	2017	Dent JR, Martins VF, Svensson K, LaBarge SA, Schlenk NC, Esparza MC, Buckner EH, Meyer GA, Hamilton DL, Schenk S, Philp A (2017) Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation. Mol Metab 6:1574-84.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Dent 2019 J Appl Physiol (1985)	2019	Dent JR, Hetrick B, Tahvilian S, Sathe A, Greyslak K, LaBarge SA, Svensson K, McCurdy CE, Schenk S (2019) Skeletal muscle mitochondrial function and exercise capacity is not impaired in mice with knockout of STAT3. J Appl Physiol (1985) 127:1117-27.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Derungs 2017 Mol Psychiatry	2017	Derungs R, Camici GG, Spescha RD, Welt T, Tackenberg C, Späni C, Wirth F, Grimm A, Eckert A, Nitsch RM, Kulic L (2017) Genetic ablation of the p66^Shc adaptor protein reverses cognitive deficits and improves mitochondrial function in an APP transgenic mouse model of Alzheimer's disease. Mol Psychiatry 22:605-14.	LEAK OXPHOS ET	N	Isolated mitochondria	Mouse	Nervous system
Deschaseaux 2018 US Patent	2018	Deschaseaux F, Guilloton F, Muller S, Sensebe L, Casteilla L, Carriere-Pazat A (2018) Method for obtaining human brown/beige adipocytes . US Patent US20180216070A1.	LEAK ROUTINE ET	ROX	Intact cells	Human	Fat
Deschauer 2006 Mol Genet Metab	2006	Deschauer M, Gizatullina Z, Schulze A, Pritsch M, Knöppel C, Knape M, Zierz S, Gellerich FN (2006) Molecular and biochemical investigations in fumarase deficiency. Mol Genet Metab 88:146-52.	LEAK OXPHOS ET	N S ROX	Permeabilized cells Intact cells	Human	Fibroblast
Deschemin 2023 Sci Rep	2023	Deschemin JC, Ransy C, Bouillaud F, Chung S, Galy B, Peyssonnaux C, Vaulont S (2023) Hepcidin deficiency in mice impairs white adipose tissue browning possibly due to a defect in de novo adipogenesis. https://doi.org/10.1038/s41598-023-39305-0	LEAK OXPHOS ET	S	Homogenate	Mouse	Fat
Desjardins 2022 Proc Natl Acad Sci U S A	2022	Desjardins EM, Smith BK, Day EA, Ducommun S, Sanders MJ, Nederveen JP, Ford RJ, Pinkosky SL, Townsend LK, Gutgesell RM, Lu R, Sakamoto K, Steinberg GR (2022) The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids. https://doi.org/10.1073/pnas.2119824119	LEAK OXPHOS ET	N NS	Isolated mitochondria	Mouse	Liver
Desmoulins 2019 Mol Metab	2019	Desmoulins L, Chrétien C, Paccoud R, Collins S, Cruciani-Guglielmacci C, Galinier A, Liénard F, Quinault A, Grall S, Allard C, Fenech C, Carneiro L, Mouillot T, Fournel A, Knauf C, Magnan C, Fioramonti X, Pénicaud L, Leloup C (2019) Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing. Mol Metab 20:166-77.	OXPHOS ET LEAK	N NS	Homogenate	Rat	Nervous system
Desprat 2015 Thesis	2015	Desprat JL, Teulier L, Puijalon S, Romestaing C, Dumet A, Lengagne T, Mondy N (2015) Caloric restriction and testosterone affect mitochondrial functioning and contractile properties of calling muscles in Hyla arborea.. Doctoral Thesis p153.	LEAK OXPHOS	F NS	Permeabilized tissue	Amphibians	Skeletal muscle
Desprat 2017 Comp Biochem Physiol A Mol Integr Physiol	2017	Desprat JL, Teulier L, Puijalon S, Dumet A, Romestaing C, Tattersall GJ, Lengagne T, Mondy N (2017) Doping for sex: Bad for mitochondrial performances? Case of testosterone supplemented Hyla arborea during the courtship period. Comp Biochem Physiol A Mol Integr Physiol 209:74-83.	OXPHOS ET LEAK	F NS	Permeabilized tissue	Amphibians	Skeletal muscle
Desquiret-Dumas 2019 Biochim Biophys Acta Mol Basis Dis	2019	Desquiret-Dumas V, Leman G, Wetterwald C, Chupin S, Lebert A, Khiati S, Le Mao M, Geffroy G, Kane MS, Chevrollier A, Goudenege D, Gadras C, Tessier L, Barth M, Leruez S, Amati-Bonneau P, Henrion D, Bonneau D, Procaccio V, Reynier P, Lenaers G, Gueguen N (2019) Warburg-like effect is a hallmark of complex I assembly defects. Biochim Biophys Acta Mol Basis Dis 1865:2475-89.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Fibroblast
Detaille 2019 PLoS One	2019	Detaille D, Pasdois P, Sémont A, Dos Santos P, Diolez P (2019) An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals. PLoS One 14:e0216385.	LEAK OXPHOS	N S NS ROX	Isolated mitochondria	Rat	Heart
Deutschman 2019 J Cell Sci	2019	Deutschman E, Ward JR, Kumar A, Ray G, Welch N, Lemieux ME, Dasarathy S, Longworth MS (2019) Condensin II protein dysfunction impacts mitochondrial respiration and mitochondrial oxidative stress responses. J Cell Sci 132:jcs233783.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell
Devaux 2015 Abstract MiP2015		Mitochondrial complexes I and II behave differently in two anoxia-tolerant species: adaptive mitochondrial plasticity may be related to the ability to undergo metabolic depression.	LEAK OXPHOS ET	N S	Homogenate	Fishes	Nervous system
Devaux 2019 Front Physiol	2019	Devaux JBL, Hedges CP, Birch N, Herbert N, Renshaw GMC, Hickey AJR (2019) Acidosis maintains the function of brain mitochondria in hypoxia-tolerant triplefin fish: a strategy to survive acute hypoxic exposure? Front Physiol 9:1941.	LEAK OXPHOS ET	Other combinations N NS	Permeabilized tissue Isolated mitochondria	Fishes	Nervous system
Devaux 2019 J Exp Biol	2019	Devaux JBL, Hickey AJR, Renshaw GMC (2019) Mitochondrial plasticity in the cerebellum of two anoxia-tolerant sharks: contrasting responses to anoxia/reoxygenation. J Exp Biol 222:jeb191353.	LEAK ROUTINE OXPHOS ET	N S NS	Homogenate	Fishes	Nervous system
Devaux 2023 J Comp Physiol B	2023	Devaux JBL, Hedges CP, Birch N, Herbert N, Renshaw GMC, Hickey AJR (2023) Electron transfer and ROS production in brain mitochondria of intertidal and subtidal triplefin fish (Tripterygiidae). https://doi.org/10.1007/s00360-023-01495-4	LEAK OXPHOS ET	N S NS CIV	Permeabilized cells	Fishes	Nervous system
Dewidar 2023 EBioMedicine	2023	Dewidar B, Mastrototaro L, Englisch C, Ress C, Granata C, Rohbeck E, Pesta D, Heilmann G, Wolkersdorfer M, Esposito I, Reina Do Fundo M, Zivehe F, Yavas A, Roden M (2023) Alterations of hepatic energy metabolism in murine models of obesity, diabetes and fatty liver diseases. https://doi.org/10.1016/j.ebiom.2023.104714	LEAK OXPHOS ET	F N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle Liver
Diana 2015 Br J Surg	2015	Diana M, Agnus V, Halvax P, Liu YY, Dallemagne B, Schlagowski AI, Geny B, Diemunsch P, Lindner V, Marescaux J (2015) Intraoperative fluorescence-based enhanced reality laparoscopic real-time imaging to assess bowel perfusion at the anastomotic site in an experimental model. Br J Surg 102:e169-76.	LEAK OXPHOS		Permeabilized tissue	Pig	Endothelial;epithelial;mesothelial cell
Diana 2015 Obes Surg	2015	Diana M, Pop R, Beaujeux R, Dallemagne B, Halvax P, Schlagowski I, Liu YY, Diemunsch P, Geny B, Lindner V, Marescaux J (2015) Embolization of arterial gastric supply in obesity (EMBARGO): an endovascular approach in the management of morbid obesity. proof of the concept in the porcine model.. Obes Surg 25:550-8.	LEAK OXPHOS		Permeabilized tissue	Pig	Endothelial;epithelial;mesothelial cell
Diana 2015 Surg Innov	2015	Diana M, Noll E, Diemunsch P, Moussallieh FM, Namer IJ, Charles AL, Lindner V, Agnus V, Geny B, Marescaux J (2015) Metabolism-guided bowel resection: potential role and accuracy of instant capillary lactates to identify the optimal resection site. Surg Innov 22:453-61.	LEAK OXPHOS	N S CIV		Pig	Endothelial;epithelial;mesothelial cell
Diana 2016 Surg Endosc	2016	Diana M, Noll E, Charles AL, Diemunsch P, Geny B, Liu YY, Marchegiani F, Schiraldi L, Agnus V, Lindner V, Swanström L, Dallemagne B, Marescaux J (2016) Precision real-time evaluation of bowel perfusion: accuracy of confocal endomicroscopy assessment of stoma in a controlled hemorrhagic shock model. Surg Endosc 31:680-91.	OXPHOS LEAK	S	Permeabilized tissue	Pig	Endothelial;epithelial;mesothelial cell
Diao 2019 Brain Res	2019	Diao X, Zhou Z, Xiang W, Jiang Y, Tian N, Tang X, Chen S, Wen J, Chen M, Liu K, Li Q, Liao R (2019) Glutathione alleviates acute intracerebral hemorrhage injury via reversing mitochondrial dysfunction. Brain Res 1727:146514.	LEAK OXPHOS ET	N	Isolated mitochondria	Mouse	Nervous system
Dias 2016 Neurobiol Aging	2016	Dias C, Lourenço CF, Ferreiro E, Barbosa RM, Laranjinha J, Ledo A (2016) Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation. Neurobiol Aging 46:84-95.	LEAK ET	N S ROX	Permeabilized tissue	Mouse	Nervous system
Dias 2018 Anal Biochem	2018	Dias C, Lourenco CF, Barbosa RM, Laranjinha J, Ledo A (2018) Analysis of respiratory capacity in brain tissue preparations: high-resolution respirometry for intact hippocampal slices. Anal Biochem 551:43-50.	LEAK ROUTINE ET	ROX	Intact cells	Mouse Rat	Nervous system
Diaz 2023 Front Mol Biosci	2023	Diaz EC, Adams SH, Weber JL, Cotter M, Børsheim E (2023) Elevated LDL-C, high blood pressure, and low peak V˙O2 associate with platelet mitochondria function in children-The Arkansas Active Kids Study. Front Mol Biosci 10:1136975. https://doi.org/10.3389/fmolb.2023.1136975	LEAK ROUTINE ET	N S	Permeabilized cells	Human	Blood cells Platelet
Dickinson 2013 Cell Death Differ	2013	Dickinson A, Yeung KY, Donoghue J, Baker MJ, Kelly RDW, McKenzie M, Johns TG, St. John JC (2013) The regulation of mitochondrial DNA copy number in glioblastoma cells. Cell Death Differ 20:1644–53.	LEAK ROUTINE ET	ROX		Human	Nervous system Other cell lines
Dickinson 2013 Thesis University of Warwick - Great Britain	2013	Dickinson A (2013) The role of mitochondrial DNA in tumorigenesis. Thesis University of Warwick - Great Britain 292pp.	LEAK ROUTINE ET	ROX	Intact cells	Human	Other cell lines
Dieter 2022 Int J Mol Sci	2022	Dieter F, Esselun C, Eckert GP (2022) Redox active α-lipoic acid differentially improves mitochondrial dysfunction in a cellular model of Alzheimer and its control cells. https://doi.org/10.3390/ijms23169186	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Neuroblastoma
Dikov 2010 Exp Gerontol	2010	Dikov D, Aulbach A, Muster B, Dröse S, Jendrach M, Bereiter-Hahn J (2010) Do UCP2 and mild uncoupling improve longevity? Exp Gerontol 45:586-95.	LEAK ROUTINE ET		Intact cells		HeLa Fibroblast HUVEC
Dilberger 2019 Nutrients	2019	Dilberger B, Passon M, Asseburg H, Silaidos CV, Schmitt F, Schmiedl T, Schieber A, Eckert GP (2019) Polyphenols and metabolites enhance survival in rodents and nematodes-impact of mitochondria. Nutrients 11:E1886.	LEAK OXPHOS ET	N S CIV NS	Isolated mitochondria	Caenorhabditis elegans
Dilberger 2019 Oxid Med Cell Longev	2019	Dilberger B, Baumanns S, Schmitt F, Schmiedl T, Hardt M, Wenzel U, Eckert GP (2019) Mitochondrial oxidative stress impairs energy metabolism and reduces stress resistance and longevity of C. elegans. Oxid Med Cell Longev 2019:6840540.	LEAK ROUTINE ET	N S CIV NS	Isolated mitochondria	Caenorhabditis elegans
Dirks 2020 J Physiol	2020	Dirks ML, Miotto PM, Goossens GH, Senden JM, Petrick HL, van Kranenburg J, van Loon LJC, Holloway GP (2020) Short-term bed rest-induced insulin resistance cannot be explained by increased mitochondrial H₂O₂ emission. J Physiol 598:123-37.	LEAK OXPHOS	N NS	Permeabilized tissue	Human	Skeletal muscle
Distefano 2016 J Gerontol A Biol Sci Med Sci	2016	Distefano G, Standley RA, Dubé JJ, Carnero EA, Ritov VB, Stefanovic-Racic M, Toledo FG, Piva SR, Goodpaster BH, Coen PM (2016) Chronological age does not influence ex-vivo mitochondrial respiration and quality control in skeletal muscle. J Gerontol A Biol Sci Med Sci 72:535-42.	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Human	Skeletal muscle
Distefano 2017 MiPschool Obergurgl		Effects of calorie restriction-induced weight loss and exercise on skeletal muscle mitochondrial energetics of older obese subjects.	LEAK OXPHOS ET	F NS	Permeabilized tissue	Human	Skeletal muscle
Distefano 2018 J Cachexia Sarcopenia Muscle	2018	Distefano G, Standley RA, Zhang X, Carnero EA, Yi F, Cornnell HH, Coen PM (2018) Physical activity unveils the relationship between mitochondrial energetics, muscle quality, and physical function in older adults. J Cachexia Sarcopenia Muscle 9:279-94.	LEAK OXPHOS ET	F N NS	Permeabilized tissue	Human	Skeletal muscle
Dixit 2017 Free Radic Biol Med	2017	Dixit S, Fessel JP, Harrison FE (2017) Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer's disease and a novel protective role for ascorbate. Free Radic Biol Med 112:515-23.	LEAK OXPHOS	N	Isolated mitochondria	Mouse	Heart
Djafarzadeh 2011 Mitochondrion	2011	Djafarzadeh S, Vuda M, Takala J, Ochs M, Jakob SM (2011) Toll-like receptor-3-induced mitochondrial dysfunction in cultured human hepatocytes. Mitochondrion 11:83-8.	LEAK OXPHOS	N S CIV ROX	Permeabilized cells	Human	Liver
Djafarzadeh 2012 PLoS One	2012	Djafarzadeh S, Vuda M, Takala J, Jakob SM (2012) Effect of remifentanil on mitochondrial oxygen consumption of cultured human hepatocytes. PLoS One 7:e45195.	LEAK OXPHOS ET	N S CIV	Isolated mitochondria	Human	Liver
Djafarzadeh 2017b J Vis Exp	2017	Djafarzadeh S, Jakob SM (2017) Isolation of intact mitochondria from skeletal muscle by differential centrifugation for High-Resolution Respirometry measurements. J Vis Exp doi: 10.3791/55251.	LEAK OXPHOS	N S CIV NS	Isolated mitochondria		Skeletal muscle

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