- high-resolution terminology - matching measurements at high-resolution
Convergent electron flow
Description
[[Description::
Convergent electron flow is built into the metabolic design of the electron transfer system. The glycolytic pathways are characterized by important divergent branchpoints: phosphoenolpyruvate (PEPCK) branchpoint to pyruvate or oxaloactetate; pyruvate branchpoint to (aerobic) acetyl-CoA or (anaerobic) lactate or alanine. The mitochondrial electron transfer system, in contrast, is characterized by convergent junctions: (1) the N-junction and F-junction in the mitochondrial matrix at ETS level 4, with dehydrogenases (including the TCA cycle) and ß-oxidation generating NADH and FADH2 as substrates for Complex I and electron-transferring flavoprotein complex, respectively, and (2) the Q-junction with inner mt-membrane respiratory complexes at ETS level 3, reducing the oxidized ubiquinone and partially reduced semiquinone to the fully reduced ubiquinol, feeding electrons into Complex III.]]
Abbreviation: n.a.
Reference: [[Info::Gnaiger 2014 MitoPathways, Gnaiger_2009_Int J Biochem Cell Biol]]
MitoPedia methods:
Respirometry
MitoPedia topics:
Substrate and metabolite
