Yusoff 2015 InTech
Yusoff AAM, Ahmad F, Idris Z, Jaafar H, Abdullah JM (2015) Understanding mitochondrial DNA in brain tumorigenesis. In: Lichtor T, ed. Molecular considerations and evolving surgical management issues in the treatment of patients with a brain tumor. InTech: http://dx.doi.org/10.5772/58965 |
Β» Open Access
Yusoff AAM, Ahmad F, Idris Z, Jaafar H, Abdullah JM (2015) InTech
Abstract: In developed countries, most studies reveal that the number of people who develop brain tumors and die from them has increased. Brain tumor, one of the most devastating central nervous system pathologies, is the leading cause of solid tumor death in children under the age of 15, and the second leading cause of cancer death in male adults ages 20-39. So far, researches on genesis and development of tumor are intensively focused and studied on alteration of the gene in nucleus and brain tumors is the one where most were reported arise as the result of progressive nuclear genetic alterations. Multiple genetic events have been identified in brain tumor cells involving some well-known susceptibility genes such as tumor suppressor and oncogenes that are encoded by the nuclear DNA (nDNA). For instance, the p53 tumor suppressor gene is frequently mutated and often detected altered or lost early in brain tumor mainly in astrocytic tumors formation [1-3]. Similarly, mutations or loss of PTEN (phosphatase and tensin homolog), p16, RB (retinoblastoma) and amplification of EGFR (epidermal growth factor receptor), MDM2, CDK4, CDK6 (cyclin-dependent kinase) are also involved in the pathogenesis of brain tumor [4,5].
β’ Bioblast editor: Gnaiger E
Labels:
Pathology: Cancer
Organism: Human Tissue;cell: Nervous system
Enzyme: Complex II;succinate dehydrogenase
Correction: FADH2 and Complex II
- FADH2 is shown as the substrate feeding electrons into Complex II (CII). This is wrong and requires correction - for details see Gnaiger (2024).
- Gnaiger E (2024) Complex II ambiguities β FADH2 in the electron transfer system. J Biol Chem 300:105470. https://doi.org/10.1016/j.jbc.2023.105470 - Β»Bioblast linkΒ«