Ma 2012 Exp Diabetes Res
Ma ZA, Zhao Z, Turk J (2012) Mitochondrial dysfunction and Ξ²-cell failure in type 2 diabetes mellitus. Exp Diabetes Res 2012:703538. https://doi.org/10.1155/2012/703538 |
Ma ZA, Zhao Z, Turk J (2012) Exp Diabetes Res
Abstract: Type 2 diabetes mellitus (T2DM) is the most common human endocrine disease and is characterized by peripheral insulin resistance and pancreatic islet Ξ²-cell failure. Accumulating evidence indicates that mitochondrial dysfunction is a central contributor to Ξ²-cell failure in the evolution of T2DM. As reviewed elsewhere, reactive oxygen species (ROS) produced by Ξ²-cell mitochondria as a result of metabolic stress activate several stress-response pathways. This paper focuses on mechanisms whereby ROS affect mitochondrial structure and function and lead to Ξ²-cell failure. ROS activate UCP2, which results in proton leak across the mitochondrial inner membrane, and this leads to reduced Ξ²-cell ATP synthesis and content, which is a critical parameter in regulating glucose-stimulated insulin secretion. In addition, ROS oxidize polyunsaturated fatty acids in mitochondrial cardiolipin and other phospholipids, and this impairs membrane integrity and leads to cytochrome c release into cytosol and apoptosis. Group VIA phospholipase Aβ (iPLAβΞ²) appears to be a component of a mechanism for repairing mitochondrial phospholipids that contain oxidized fatty acid substituents, and genetic or acquired iPLAβΞ²-deficiency increases Ξ²-cell mitochondrial susceptibility to injury from ROS and predisposes to developing T2DM. Interventions that attenuate ROS effects on Ξ²-cell mitochondrial phospholipids might prevent or retard development of T2DM.
β’ Bioblast editor: Gnaiger E
Correction: FADH2 and Complex II
- FADH2 is shown as the substrate feeding electrons into Complex II (CII). This is wrong and requires correction - for details see Gnaiger (2024).
- Gnaiger E (2024) Complex II ambiguities β FADH2 in the electron transfer system. J Biol Chem 300:105470. https://doi.org/10.1016/j.jbc.2023.105470 - Β»Bioblast linkΒ«
Labels: Pathology: Diabetes