Calcium retention capacity: Difference between revisions
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{{MitoPedia | {{MitoPedia | ||
|abbr= | |abbr=CaRC | ||
|description=Calcium retention capacity ( | |description=Calcium retention capacity (CaRC) is a measure of the capability of mitochondria to retain calcium (Ca<sup>2+</sup>), primarily in the form of calcium phosphates, in the mitochondrial matrix. By storing calcium in the form of osmotically inactive precipitates the mitochondria contribute to the buffering of cytosolic free Ca<sup>2+</sup> levels and thereby to the regulation of calcium-dependent cellular processes. Alterations of CaRC are believed to be important in stress phenomena associated with energy limitation and have also been linked to neurodegenerative diseases [[Starkov 2010 FEBS J |(Starkov 2013 FEBS J).]] | ||
Experimentally, | Experimentally, CaRC has been indirectly assessed by determination of respiratory rates of isolated mitochondria which were exposed to continuously increasing doses of Ca<sup>2+</sup> by use of the [[TIP2k-Module| Titration-Injection microPump TIP2k]]. The upper limit of CaRC was observed as a sudden decrease of respiration presumed to reflect opening of the permeability transition pore [[Hansson_2010_J_Biol_Chem |(Hansson 2010 J Biol Chem).]] | ||
|info=[[Hansson 2010 J Biol Chem]], [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725145 Starkov 2010 FEBS Lett] | |info=[[Hansson 2010 J Biol Chem]], [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725145 Starkov 2010 FEBS Lett] | ||
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Revision as of 08:34, 22 April 2022
Description
Calcium retention capacity (CaRC) is a measure of the capability of mitochondria to retain calcium (Ca2+), primarily in the form of calcium phosphates, in the mitochondrial matrix. By storing calcium in the form of osmotically inactive precipitates the mitochondria contribute to the buffering of cytosolic free Ca2+ levels and thereby to the regulation of calcium-dependent cellular processes. Alterations of CaRC are believed to be important in stress phenomena associated with energy limitation and have also been linked to neurodegenerative diseases (Starkov 2013 FEBS J). Experimentally, CaRC has been indirectly assessed by determination of respiratory rates of isolated mitochondria which were exposed to continuously increasing doses of Ca2+ by use of the Titration-Injection microPump TIP2k. The upper limit of CaRC was observed as a sudden decrease of respiration presumed to reflect opening of the permeability transition pore (Hansson 2010 J Biol Chem).
Abbreviation: CaRC
Reference: Hansson 2010 J Biol Chem, Starkov 2010 FEBS Lett