Electron leak: Difference between revisions
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{{MitoPedia | {{MitoPedia | ||
|description=Electrons that escape the [[electron transfer | |description=Electrons that escape the [[electron transfer pathway]] without completing the reduction of oxygen to water at cytochrome ''c'' oxidase, causing the production of [[Reactive_oxygen_species |ROS]]. The rate of electron leak depends on the topology of the complex, the redox state of the moiety responsible of electron leakiness and usually on the protonmotive force ([[Protonmotive force|ฮ''p'']]). In some cases, the [[Protonmotive force|ฮ''p'']] dependance relies more on the โpH component than in the โ''ฮจ''. | ||
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::: '''Specific''' | ::: '''Specific''' | ||
::::ยป [[Reactive_oxygen_species]] | ::::ยป [[Reactive_oxygen_species]] | ||
::::ยป [[LEAK | ::::ยป [[LEAK respiration]] | ||
::::ยป [[LEAK state with ATP]] | ::::ยป [[LEAK state with ATP]] | ||
::::ยป [[LEAK state with Omy|LEAK state with oligomycin]] | ::::ยป [[LEAK state with Omy|LEAK state with oligomycin]] | ||
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== References == | |||
# Jastroch M, Divakaruni AS, MookerjeecS, Treberg JR, Brand MD (2010) Mitochondrial proton and electron leaks. Essays Biochemistry 47: 53โ67 pp. | |||
{{MitoPedia concepts | {{MitoPedia concepts | ||
Latest revision as of 10:35, 8 June 2020
- high-resolution terminology - matching measurements at high-resolution
Electron leak
Description
Electrons that escape the electron transfer pathway without completing the reduction of oxygen to water at cytochrome c oxidase, causing the production of ROS. The rate of electron leak depends on the topology of the complex, the redox state of the moiety responsible of electron leakiness and usually on the protonmotive force (ฮp). In some cases, the ฮp dependance relies more on the โpH component than in the โฮจ.
- ยป Keywords: electron leak
- Specific
References
- Jastroch M, Divakaruni AS, MookerjeecS, Treberg JR, Brand MD (2010) Mitochondrial proton and electron leaks. Essays Biochemistry 47: 53โ67 pp.
MitoPedia concepts:
MiP concept
MitoPedia methods:
Respirometry,
Fluorometry
MitoPedia topics: EAGLE
