Etomoxir: Difference between revisions
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{{MitoPedia | {{MitoPedia | ||
|abbr=Eto | |abbr=Eto | ||
|description='''Etomoxir''' (Eto; 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate) is an irreversible inhibitor of carnitine palmitoyltransferase | |description='''Etomoxir''' (Eto; 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate) is an irreversible inhibitor of [[carnitine palmitoyltransferase I]] (CPT-I) on the outer face of the mitochondrial inner membrane. Eto inhibits [[fatty acid oxidation]] by blocking the formation of acyl carnitines from long-chain fatty acids which require the carnitine shuttle for transport into mitochondria. In contrast to long-chain fatty acids, the transport of short- and medium-chain fatty acids is carnitine-independent. | ||
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:::: <span style="color:#8B008B">'''Caution:''' Store tightly sealed, protected from exposure to light. Acute toxicity (oral, dermal, inhalation).ย Dust mask or eyeshields, faceshields and gloves are recommended by the preparation.</span> | :::: <span style="color:#8B008B">'''Caution:''' Store tightly sealed, protected from exposure to light. Acute toxicity (oral, dermal, inhalation).ย Dust mask or eyeshields, faceshields and gloves are recommended by the preparation.</span> | ||
::::'''Preparation of 10 mM stock solution''' (dissolved in H<sub>2</sub>O): | ::::'''Preparation of 10 mM stock solution''' (dissolved in H<sub>2</sub>O): The commercially available white compound is soluble in water. | ||
::::# Weigh 5 mg etomoxir. | ::::# Weigh 5 mg etomoxir. | ||
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{{MitoPedia topics | {{MitoPedia topics | ||
|mitopedia topic=Inhibitor | |mitopedia topic=Inhibitor | ||
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Latest revision as of 06:35, 20 April 2023
Description
Etomoxir (Eto; 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate) is an irreversible inhibitor of carnitine palmitoyltransferase I (CPT-I) on the outer face of the mitochondrial inner membrane. Eto inhibits fatty acid oxidation by blocking the formation of acyl carnitines from long-chain fatty acids which require the carnitine shuttle for transport into mitochondria. In contrast to long-chain fatty acids, the transport of short- and medium-chain fatty acids is carnitine-independent.
Abbreviation: Eto
Application in HRR
- Eto (Etomoxir): ((+)-Etomoxir sodium salt hydrate); Sigma Aldrich; E-1905; storage: 2-8 ยฐC; M = 338.76 gยทmol-1
- Caution: Store tightly sealed, protected from exposure to light. Acute toxicity (oral, dermal, inhalation). Dust mask or eyeshields, faceshields and gloves are recommended by the preparation.
- Preparation of 10 mM stock solution (dissolved in H2O): The commercially available white compound is soluble in water.
- Weigh 5 mg etomoxir.
- Add 1.476 mL dt H2O.
- Divide into 500 ยตL portions.
- Store frozen at -20 ยฐC.
MitoPedia topics: Inhibitor
Labels:
MitoPedia:FAT4BRAIN