Fischer 2012 Abstract Bioblast: Difference between revisions
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|abstract=[[File:Michael.jpg.JPG|right|200px|Michael Fischer]] | |abstract=[[File:Michael.jpg.JPG|right|200px|Michael Fischer]] | ||
A recent study in the European Union found that musculoskeletal disorders account for 49% of all absences from work and 60% of permanent disability at an estimated cost of β¬240 billion [1]. However, treatment of chronic musculoskeletal pain is limited in its efficacy in part because the neurobiological mechanisms responsible for pain have not been fully elucidated. Myofacial pain syndrome is characterized by the presence of myofascial trigger points (MTrPs), which are defined as hyperirritable nodules located within a taut band of skeletal muscle [2]. While active MTrPs generate local and referred spontaneous pain, latent MTrPs can only elicit such pain when palpated; nevertheless, both types appear to be responsible for motor dysfunction associated with range of motion and stiffness issues. Recent cytokine findings in MTrPs in the context of ischemia and local pH changes suggest that mitochondria may be dysfunctional and play a key role in the pathogenesis [3]. Looking at mitochondrial function in MTrPs may help to determine what pharmacological and/or other manual therapy strategies might be useful to treat myofascial pain. It will be important to identify key biochemical entities to target future research. | A recent study in the European Union found that musculoskeletal disorders account for 49% of all absences from work and 60% of permanent disability at an estimated cost of β¬240 billion [1]. However, treatment of chronic musculoskeletal pain is limited in its efficacy in part because the neurobiological mechanisms responsible for pain have not been fully elucidated. Myofacial pain syndrome is characterized by the presence of myofascial trigger points (MTrPs), which are defined as hyperirritable nodules located within a taut band of skeletal muscle [2]. While active MTrPs generate local and referred spontaneous pain, latent MTrPs can only elicit such pain when palpated; nevertheless, both types appear to be responsible for motor dysfunction associated with range of motion and stiffness issues. Recent cytokine findings in MTrPs in the context of ischemia and local pH changes suggest that mitochondria may be dysfunctional and play a key role in the pathogenesis [3]. Looking at mitochondrial function in MTrPs may help to determine what pharmacological and/or other manual therapy strategies might be useful to treat myofascial pain. It will be important to identify key biochemical entities to target future research. | ||
Β | # [http://www.theworkfoundation.com/ Bevan S, Quadrello T, McGee R, Mahdon M, Vavrovsky A, Barham L - Fit for work? Musculoskeletal disorders in the European workforce] | ||
#Β [http://pubget.com/paper/pgtmp_54f5a0c0114c05dddb1a7e92a734c209/Central_Nervous_Sequelae_of_Local_Muscle_Pain Mense S, Hoheisel U (2005) Central nervous sequelae of local muscle pain. J Musculoskelet Pain 12: 101β109.] | |||
Β | # [http://www.ncbi.nlm.nih.gov/pubmed?term=Uncovering%20the%20biochemical%20milieu%20of%20myofascial%20trigger%20points%20using%20in%20vivo%20microdialysis%3A%20an%20application%20of%20muscle%20pain%20concepts%20to%20myofascial%20pain%20syndrome Shah JP, Gilliams EA (2008) Uncovering the biochemical milieu of myofascial trigger points using in vivo microdialysis: an application of muscle pain concepts to myofascial pain syndrome. J Bodyw Mov Ther 12: 371β384.] | ||
Β | |||
|keywords=Myofacial pain syndrome, Myofascial trigger points | |keywords=Myofacial pain syndrome, Myofascial trigger points | ||
|mipnetlab=AT Innsbruck Fischer M | |mipnetlab=AT Innsbruck Fischer M |
Revision as of 00:13, 28 November 2012
Fischer M (2012) Myofacial pain syndrome and myofascial trigger points. Mitochondr Physiol Network 17.12. |
Link: MiPNet17.12 Bioblast 2012 - Open Access
Fischer M (2012)
Event: Bioblast 2012
A recent study in the European Union found that musculoskeletal disorders account for 49% of all absences from work and 60% of permanent disability at an estimated cost of β¬240 billion [1]. However, treatment of chronic musculoskeletal pain is limited in its efficacy in part because the neurobiological mechanisms responsible for pain have not been fully elucidated. Myofacial pain syndrome is characterized by the presence of myofascial trigger points (MTrPs), which are defined as hyperirritable nodules located within a taut band of skeletal muscle [2]. While active MTrPs generate local and referred spontaneous pain, latent MTrPs can only elicit such pain when palpated; nevertheless, both types appear to be responsible for motor dysfunction associated with range of motion and stiffness issues. Recent cytokine findings in MTrPs in the context of ischemia and local pH changes suggest that mitochondria may be dysfunctional and play a key role in the pathogenesis [3]. Looking at mitochondrial function in MTrPs may help to determine what pharmacological and/or other manual therapy strategies might be useful to treat myofascial pain. It will be important to identify key biochemical entities to target future research.
- Bevan S, Quadrello T, McGee R, Mahdon M, Vavrovsky A, Barham L - Fit for work? Musculoskeletal disorders in the European workforce
- Mense S, Hoheisel U (2005) Central nervous sequelae of local muscle pain. J Musculoskelet Pain 12: 101β109.
- Shah JP, Gilliams EA (2008) Uncovering the biochemical milieu of myofascial trigger points using in vivo microdialysis: an application of muscle pain concepts to myofascial pain syndrome. J Bodyw Mov Ther 12: 371β384.
β’ Keywords: Myofacial pain syndrome, Myofascial trigger points
β’ O2k-Network Lab: AT Innsbruck Fischer M
Labels:
Stress:Mitochondrial Disease; Degenerative Disease and Defect"Mitochondrial Disease; Degenerative Disease and Defect" is not in the list (Cell death, Cryopreservation, Ischemia-reperfusion, Permeability transition, Oxidative stress;RONS, Temperature, Hypoxia, Mitochondrial disease) of allowed values for the "Stress" property. Organism: Human Tissue;cell: Neurons; Brain"Neurons; Brain" is not in the list (Heart, Skeletal muscle, Nervous system, Liver, Kidney, Lung;gill, Islet cell;pancreas;thymus, Endothelial;epithelial;mesothelial cell, Blood cells, Fat, ...) of allowed values for the "Tissue and cell" property.
Affiliations and author contributions
Klinik fΓΌr OrthopΓ€die, Innsbruck, Austria; Email: [email protected]