Hagl 2014 J Alzheimers Dis b
| Hagl S, Heinrich M, Kocher A, Schiborr C, Frank J, Eckert GP (2014) Curcumin micelles improve mitochondrial function in a mouse model of Alzheimerβs disease. J Alzheimers Dis 1:80-3. |
Β» article 39
Hagl S, Heinrich M, Kocher A, Schiborr C, Frank J, Eckert GP (2014) J Prevention Alzheimers Dis
Abstract: Preventive strategies for late-onset Alzheimerβs disease (AD) should start early at a prodromal stage. Mitochondrial dysfunction has been found to play an important role in the initiation of both aging and the pathogenesis of Alzheimerβs disease. Curcumin, a widely used spice and food-coloring agent, is a polyphenol derived from the rhizome of Curcuma longa. It is known to have anti-oxidant, anti-inflammatory, and anti-protein-aggregate activities which are usually considered beneficial for mitochondrial function. We assessed brain mitochondrial function and concentrations of soluble AΞ²40 in a mouse model of AD (Thy1-APP751SL transgenic mice) after 3- week administration of curcumin micelles. Curcumin micelles are a newly developed formulation that account for increased curcumin bioavailability. Curcumin treatment had positive effects on mitochondrial membrane potential and respiratory control ratio. Additionally, it decreased levels of soluble AΞ²40 in brains of Thy1-APPSL transgenic mice. Hence, curcumin micelles are a promising neutraceutical for the prevention of AD. β’ Keywords: Curcumin, Bioavailability, Mitochondria, Prevention, Alzheimer
β’ O2k-Network Lab: DE Giessen Eckert GP
Labels: MiParea: Respiration, Pharmacology;toxicology
Pathology: Alzheimer's
Organism: Mouse Tissue;cell: Nervous system Preparation: Isolated mitochondria
Coupling state: LEAK, OXPHOS, ET
Pathway: N, S, CIV, NS, ROX
HRR: Oxygraph-2k
Curcumin
