Hatefi 1962 J Biol Chem-XLI

Has title::Hatefi Y, Haavik AG, Griffiths DE (1962) Studies on the electron transfer system XLI. Reduced coenzyme Q (QH2)-cytochrome c reductase. J Biol Chem 237: 1681-1685.

» [[Has info::PMID: 13905328 Open Access]]

Was written by::Hatefi Y, Was written by::Haavik AG, Was written by::Griffiths DE (Was published in year::1962) Was published in journal::J Biol Chem

Abstract: [[has abstract::The preparation from beef heart mitochondria and the properties, of a highly active and stable enzyme system, capable of catalyzing the reduction of cytochrome c by reduced coenzyme Q2 are described. The enzyme complex contains cytochrome b and cytochrome c1 in high concentration, and is free of cytochrome c oxidase, cytochrome c, flavoproteins, and the citric acid cycle dehydrogenases. The activity of the enzyme corresponds to a QO2, of about 320,000 at 38°. This activity is strongly inhibited by antimycin A, 2-nonyl-4-hydroxy-quinoline-N-oxide, and 2-alkyl-3-hydroxynaphthoquinone. Amytal, thenoyltrifluoroacetone, and a number of specific metal-chelating compounds are ineffective as inhibitors.]] • Keywords: has publicationkeywords::Coenzyme Q, has publicationkeywords::Reduced coenzyme Q (QH2), has publicationkeywords::Cytochrome c reductase, has publicationkeywords::Beef heart

Labels:

Organism: Organism::Bovines  Tissue;cell: tissue and cell::Heart  Preparation: Preparation::Isolated Mitochondria  Enzyme: Enzyme::Complex IV; Cytochrome c Oxidase  Regulation: Topic::Substrate  Coupling state: Coupling states::ETS