Difference between revisions of "Hroudova 2013 Mitochondrion"
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|organism=Human | |organism=Human | ||
|tissues=Blood Cell; Suspension Culture | |tissues=Blood Cell; Suspension Culture | ||
|preparations=Intact | |preparations=Intact cells, Permeabilized cells | ||
|injuries=Mitochondrial Disease; Degenerative Disease and Defect | |||
|couplingstates=ROUTINE, ETS | |couplingstates=ROUTINE, ETS | ||
|instruments=Oxygraph-2k | |||
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Revision as of 08:15, 8 August 2013
| Hroudová J, Fišar Z, Kitzlerová E, Zvěřová M, Raboch J (2013) Mitochondrial respiration in blood platelets of depressive patients. Mitochondrion doi: 10.1016/j.mito.2013.05.005 [Epub ahead of print] |
Hroudova J, Fisar Z, Kitzlerova E, Zverova M, Raboch J (2013) Mitochondrion
Abstract: Recent evidences include mitochondrial dysfunctions in pathophysiology of mood disorders. We examined association between depressive disorders and mitochondrial respiration using both intact and permeabilized blood platelets. In intact platelets, physiological respiration, maximal capacity of electron transport system and respiratory rate after Complex I inhibition were decreased in depressive patients, who reached partial remission, compared to healthy controls. Respiratory rates were unchanged in several respiratory states in permeabilized platelets. Results indicate that changes in respiratory rate in intact platelets can be used as biological marker of depressive disorder. Hypothesis was supported that decreased mitochondrial respiratory rate participate in pathophysiology of depression.
• O2k-Network Lab: CZ Prague Fisar Z
Labels:
Stress:Mitochondrial Disease; Degenerative Disease and Defect"Mitochondrial Disease; Degenerative Disease and Defect" is not in the list (Cell death, Cryopreservation, Ischemia-reperfusion, Permeability transition, Oxidative stress;RONS, Temperature, Hypoxia, Mitochondrial disease) of allowed values for the "Stress" property. Organism: Human Tissue;cell: Blood Cell; Suspension Culture"Blood Cell; Suspension Culture" is not in the list (Heart, Skeletal muscle, Nervous system, Liver, Kidney, Lung;gill, Islet cell;pancreas;thymus, Endothelial;epithelial;mesothelial cell, Blood cells, Fat, ...) of allowed values for the "Tissue and cell" property. Preparation: Intact cells, Permeabilized cells
Coupling state: ROUTINE, ETS"ETS" is not in the list (LEAK, ROUTINE, OXPHOS, ET) of allowed values for the "Coupling states" property.
HRR: Oxygraph-2k
