Huete-Ortega 2020 MitoFit Preprint Arch EA
| Huete-Ortega M, DiMarcello M, Iglesias-Gonzalez J, Gnaiger E (2020) High-resolution respirometry for chloroplast and mitochondrial bioenergetics in Chlamydomonas reinhardtii ― towards biotechnology exploitations doi:10.26124/mitofit:200005. |
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Huete-Ortega Maria, DiMarcello Marco, Iglesias-Gonzalez Javier, Gnaiger Erich (2020) MitoFit Preprint Arch
Abstract: Version 1 (v1) 2020-1-27 doi:10.26124/mitofit:200005
The COVID-19 virus emerged in 2019. Mortality rates as at 20th March 2020 are much higher in southern than northern Europe. The elderly, and those with pre-existing conditions, are at greatest risk. It is hypothesised, vitamin D deficiency may significantly compromise, respiratory immune response function, thus greatly increasing risk of COVID-19 hospitalisation, severity and mortality. Winter vitamin D levels: based on; limited data, including; historical measured regional vitamin D deficiency rates (<25 nmol/L), intakes, and plasma vitamin D levels; fortification and supplementation policies; and public vitamin D awareness: appear to be significantly lower in southern, than northern Europe. In respiratory system conditions, such as influenza, vitamin D has wide-ranging and fundamental roles, including through: gene transcription via COVID-19 relevant VDR (Vitamin D Receptor) pathways; ACE1 and ACE2 pathways; wider immune function; airway epithelial cell tight-junction function and integrity; and mitochondrial related, energetics, apoptosis and inflammation, management. Studies suggest vitamin D supplementation may be protective against respiratory conditions, in ‘D’ deficient persons. Would vitamin D supplementation of the deficient, mitigate the severity of the current COVID-19 outbreak; and reduce future, likely upcoming, seasonal amplification effects? • Keywords: NextGen, algae, PB-Module. • Bioblast editor: Iglesias-Gonzalez J
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Labels: MiParea: mt-Medicine
Pathology: Infectious, Obesity
Organism: Human
Virus
