Difference between revisions of "Kosenko 2010 Biology Bull"

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Kosenko EA, Abramova MB, Venediktova NI, Popova II, Kaminskii YG (2010) The drug hypoxen: A new inhibitor of mitochondrial respiration and dehydrogenases. Biology Bull 37:346-50.

» PMID: 20799641

Kosenko EA, Abramova MB, Venediktova NI, Popova II, Kaminskii YG (2010) Biology Bull

Abstract: The effect of hypoxen on the oxygen consumption and activity of dehydrogenases in rat liver mitochondria has been studied. The addition of hypoxen to mitochondria caused a reduction of the rate of phosphorylating and uncoupling respiration. The minimal effective concentration of hypoxen was 15 μg/ml with succinate, 60 μg/ml with pyruvate or palmitoylcarnitine, and 120 μg/ml with glutamate as the substrates. The activities of malate, glutamate, and succinate dehydrogenases in mitochondria were significantly decreased by the effect of hypoxen. • Keywords: hypoxen (Oliphen, Moscow)

Labels:

Organism: Rat Tissue;cell: Liver Preparation: Isolated mitochondria

HRR: Oxygraph-2k

Pharmacology; Biotechnology

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 {{Publication
-|title=Kosenko EA, Abramova MB, Venediktova NI, Popova II, Kaminskii YG (2010) The drug hypoxen: A new inhibitor of mitochondrial respiration and dehydrogenases. Biology Bull 37: 346-350.
+|title=Kosenko EA, Abramova MB, Venediktova NI, Popova II, Kaminskii YG (2010) The drug hypoxen: A new inhibitor of mitochondrial respiration and dehydrogenases. Biology Bull 37:346-50.
 |info=[http://www.ncbi.nlm.nih.gov/pubmed?term=The%20drug%20hypoxen%3A%20A%20new%20inhibitor%20of%20mitochondrial%20respiration%20and%20dehydrogenases%20 PMID: 20799641]
 |authors=Kosenko EA, Abramova MB, Venediktova NI, Popova II, Kaminskii YG
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 }}
 {{Labeling
-|instruments=Oxygraph-2k
 |organism=Rat
 |tissues=Liver
-|preparations=Isolated Mitochondria
+|preparations=Isolated mitochondria
+|instruments=Oxygraph-2k
 |additional=Pharmacology; Biotechnology
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