Kuzelova 2008 Gen Physiol Biophys
| Kuzelova M, Adameova A, Sumbalova Z, Paulikova I, Harcarová A, Svec P, Kucharska J. (2008) The effect of simvastatin on coenzyme Q and antioxidant/oxidant balance in diabetic-hypercholesterolaemic rats. Gen Physiol Biophys. 27:291-8. |
Kuzelova M, Adameova A, Sumbalova Z, Paulikova I, Harcarova A, Svec P, Kucharska (2008) Gen Physiol Biophys
Abstract: The effect of simvastatin administered for 10 days on coenzyme Q and antioxidant/oxidant balance in a rat model of diabetes mellitus and hypercholesterolaemia was studied. In the diabetic-hypercholesterolaemic rats the signs of oxidative stress-decreased alpha-tocopherol/cholesterol in the plasma (p < 0.01) and alpha-tocopherol in liver (p < 0.001) together with increased lipid peroxidation in the liver (TBARS, p < 0.05) were found. Increased coenzyme Q9 concentrations in the plasma (p < 0.05) and liver (p < 0.01), coenzyme Q10 in the myocardium (p < 0.05) and in the liver (p < 0.01) may indicate adaptation to oxidative stress. Administration of simvastatin (10 mg/kg) to the diabetic-hypercholesterolaemic rats counteracted increased myocardial (coenzyme Q10, p < 0.05) and liver (total coenzyme Q9, p < 0.05) coenzyme Q concentrations but did not improve alpha-tocopherol depletion and increased formation of TBARS in the liver. Even though simvastatin treatment did not induce coenzyme Q deficiency in plasma, heart and liver of the diabetic-hypercholesterolaemic rats as compared to the control levels, it was not able to prevent completely the changes in antioxidant/oxidant balance induced by diabetes and hypercholesterolaemia. The results highlight the importance of studying the effect of statins on the coenzyme Q levels in the animal models of pathological conditions known to change the initial antioxidant defence system. • Keywords: Hypercholesterolaemia, Diabetes, Coenzyme Q, a-tocopherol, Simvastatin, Rat, Liver
• O2k-Network Lab: SK Bratislava Sumbalova Z
Labels:
Pathology: Diabetes
Stress:Oxidative stress;RONS, Mitochondrial disease
Organism: Rat
Tissue;cell: Heart, Liver
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