Mansfield 2005 Cell Metab: Difference between revisions
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Latest revision as of 17:58, 13 April 2022
Mansfield KD, Guzy RD, Pan Y, Young RM, Cash TP, Schumacker PT, Simon MC (2005) Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab 1:393-9. |
ยป Open Access
Mansfield KD, Guzy RD, Pan Y, Young RM, Cash TP, Schumacker PT, Simon MC (2005) Cell Metab
Abstract: While cellular responses to low oxygen (O2) or hypoxia have been studied extensively, the precise identity of mammalian cellular O2 sensors remains controversial. Using murine embryonic cells lacking cytochrome c, and therefore mitochondrial activity, we show that mitochondrial reactive oxygen species (mtROS) are essential for proper O2 sensing and subsequent HIF-1ฮฑ and HIF-2ฮฑ stabilization at 1.5% O2. In the absence of this signal, HIF-ฮฑ subunits continue to be degraded. Furthermore, exogenous treatment with H2O2 or severe O2 deprivation is sufficient to stabilize HIF-ฮฑ even in the absence of cytochrome c and functional mitochondria. These results provide genetic evidence indicating that mtROS act upstream of prolyl hydroxylases in regulating HIF-1ฮฑ and HIF-2ฮฑ in this O2 sensing pathway. โข Keywords: hypoxia, reactive oxygen species, HIF-1ฮฑ, HIF-2ฮฑ, anoxia โข Bioblast editor: Sobotka O
Cited by
- Komlรณdi T, Gnaiger E (2022) Discrepancy on oxygen dependence of mitochondrial ROS production - review. MitoFit Preprints 2022 (in prep).
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Stress:Oxidative stress;RONS, Hypoxia
MitoFit 2022 ROS review