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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping

MitoEAGLE

COST Action MITOEAGLE approved

* Top news

We are happy to inform you that proposal OC-2015-2-19984 Mitochondrial mapping: Evolution - Age - Gender - Lifestyle - Environment was approved by the COST Committee of Senior Officials. - More details: » COST Action MITOEAGLE

* Evaluation highlights

The proposal addresses the considerable lack of uniformity and consensus on standard operating procedures in the design and implementation of research protocols involving mitochondrial physiology. This is a very real problem that can only be solved through networks on a scale such as this Action, that will work to harmonise experimental protocols across research groups. - More details »MITOEAGLE evaluation highlights

Summary

Every study of mitochondrial (mt) function and disease in human tissues is faced with EAGLE as the essential background conditions characterizing the individual patient, subject, study group, species, tissue or even cell line. A general data base on mitochondrial function is required to set results into the multidimensional context of EAGLE. The EAGLE database on mitochondrial physiology and pathology may be compared to, and should eventually be linked to, established genomic and proteomic data bases on human evolution, mouse models, and mitochondrial medicine on one hand, and anthropometric, ergonomic and physiological data bases on the other hand. An EAGLE data base does not exist, is necessary to interrelate results of different studies, to interpret the pathological phenotype, and must be operated on a global scale. The following steps should be taken towards establishing the EAGLE database.

COST Action MITOEAGLE

The objective of the MITOEAGLE network is to improve our knowledge on mitochondrial function in health and disease related to Evolution, Age, Gender, Lifestyle and Environment. Every study of mitochondrial (mt) function and disease is faced with EAGLE as the essential background conditions characterizing the individual patient, subject, study group, species, tissue or even cell line. To address the complex interrelationships of EAGLE with an initial focus on humans and rodent models, the network will enhance the value of each individual study by starting to analyse and catalog data beyond the published record. Highlighting the topic of mitochondrial function in relation to age, gender, lifstyle and environmental factors, unique new information will emerge on human biology from the development of a European reference database. Protocols, technologies and standard procedures will be compared and strategies defined for improvement of quality control. An interlaboratory proficiency ring test will be established as a world-wide innovation in the field of mitochondrial respiratory physiology. The expertise gained and new standards developed will be integrated into a strategic dissemination and education programme for mitochondrial phenotyping, aiming at an expanding European and MitoGlobal EAGLE network where researchers collaborate on mapping mitochondrial fitness in physiology and medicine, complementary to established mtDNA databases.

Further details » MitoGlobal EAGLE

• Keywords

mitochondrial physiology, gender, aging, oxidative stress, life style, nutrition, sports, degenerative diseases, neurodegeneration, obesity, diabetes, cardiovascular diseases, cancer, latent mitochondrial dysfunction, stress resistance, respirometry, membrane potential, ROS production, redox regulation, isolated mitochondria, homogenate, cells, permeabilized cells, muscle fibres, tissues, model organisms

• MITOEAGLE aims at meeting current demands of the global research community to improve the data base on mitochondrial function/dysfunction in various tissues of humans and animal models, and to diagnose the mitochondrial implications in various pathologies, for development and evaluation of mitochondria-targeted therapies.
• MITOEAGLE opens the feedback loop between the primary problems of attack (gender-specific mitochondrial roles in fitness, aging, pathologies) and the consequential models and methods employed.
• MITOEAGLE will generate the critical mass of partners required to address the complex conceptual and methodological problems that may have prevented so far the major break-though required for addressing the preventable diseases in westernized ageing societies.
• MITOEAGLE is an initiative towards a broad but focussed project, to ‘contribute substantially to the coordination and defragmentation of research efforts across Europe’.

General

Human tissues and blood cells

Initiate a consortium of research groups involved in studies of mitochondrial function in human tissues, with a focus on human

1. Muscle biopsies,
2. Blood cells,
3. Fat tissue.

The research groups involved include specialists on sports science, nutrition and life style, ageing and human diseases.

Animal models and cultured cells

Extend the consortium by research groups working on mitochondrial function in rodent models, with particular emphasis on a comparison of mt-function from mouse to man, using

1. Skeletal and cardiac muscle,
2. Brain,
3. Liver,
4. Cell models.

Satellite meetings

Organize a series of meetings of members of the consortium with a minimum of added costs, by integrating EAGLE sessions in regular meetings of established mitochondrial societies. Keep a track record for information flow to attending participants.

Workshops

Satellite workshops will extend the activities of the consortium, which may lead to continuing inter-laboratory studies, development of standards for quality control and teaching initiatives to disseminate and certify such standards for quality control.

Intergration with established and developing databases

Contact organizations and research groups operating comparable genomic and physiological databases, to share their expertise. Interdisciplinary expertise is required on the design of the EAGLE data base, considering the complexities of the logistic, legal and financial aspects.

Links

• National Exercise Clinical Trials Network (contact Lai Nicola)

http://www.uab.edu/medicine/exercise/nextnet

To share exercise data among the different national labs we are using redcap: http://www.project-redcap.org/

• NINDS Mitochondrial Diseases Common Data Element Project - Public Review Period: November 20, 2014 - January 16, 2015

http://www.commondataelements.ninds.nih.gov/MITO.aspx#tab=Data_Standards

• Work in progress: MiPMap

MitoFit