Q-pools: Difference between revisions
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|abbr=Q | |abbr=Q | ||
|description= | |description=Different '''Q-pools''' are more or less clearly distinguished in the cell, related to a variety of models describing degress of Q-pool behavior. (''1'') [[CoQ]]-pools are distinguished according to their compartmentation in the cell: mitochondrial CoQ (mtCoQ) and CoQ in other organelles versus plasma-membrane CoQ. (''2'') The total mitochondrial CoQ-pool mtCoQ is partitioned into an [[ETS]]-reactive Q-pool, Q<sub>ra</sub>, and an inactive mtCoQ-pool, Q<sub>ia</sub>. (''2a'') The Q<sub>ra</sub>-pool is fully reduced in the form of quinol QH<sub>2</sub> under anoxia, fully oxidized in the form of quinone in aerobic [[mitochondrial preparations]] incubated without [[CHNO-fuel substrate]]s, and intermediate redox states of Q<sub>ra</sub> are sensitive to pathway control and coupling control of mitochondrial electron transfer and [[OXPHOS]]. (''2b'') The Q<sub>ia</sub>-pool remains partially reduced and oxidized in aerob-anoxic transitions and is insensitive to mitochondrial respiratory states. (''3'') The Q<sub>ra</sub>-pool is partitioned into Q with Q-pool behavior according to the fluid-state model (synonymous: random-collision model) and Q tightly bound to supercomplexes according to the solid-state model. The two models describe the extremes in a continuum of homogenous or heterogenous Q-pool behavior. The CII-Q-CIII segment of the [[S-pathway]] is frequently considered to follow homogenous Q-pool behavior participating in the Q<sub>hom</sub>-pool, whereas the CI-Q-CIII segment of the [[N-pathway]] indicates [[supercomplex]] organization with different degrees of Q-pool heterogeneity contributing to the Q<sub>het</sub>-pool with metabolic channeling. | ||
|info=[[Komlodi 2021 MitoFit Q]] | |info=[[Komlodi 2021 MitoFit Q]] | ||
}} | }} | ||
Communicated by [[Gnaiger Erich]] 2021-04-03 | |||
{| class="wikitable" | |||
|- | |||
! Q-pool !! Symbol !! Definition !! Balance | |||
|- | |||
| Coenzyme Q || CoQ || total CoQ in the cell || | |||
|- | |||
| mitochondrial CoQ || mtCoQ || total CoQ in mitochondria || mtCoQ = Q<sub>ra</sub> + Q<sub>ia</sub> | |||
|- | |||
| inactive mtCoQ || Q<sub>ia</sub> || inactive mitochondrial CoQ, paritally oxidized under anoxia and partially reduced in aerobic mt-preparations incubated without CHNO-fuel substrates || | |||
|- | |||
| ETS-reactive Q || Q<sub>ra</sub> = Q || Electron-transfer-system reactive mtCoQ, fully reduced under anoxia, fully oxidized in aerobic mt-preparations incubated without CHNO-fuel substrates || Q = Q<sub>hom</sub> + Q<sub>het</sub> | |||
|- | |||
| homogenous Q || Q<sub>hom</sub> || homogenous pool of ETS-reactive Q according to the fluid-state model (random collision model) || | |||
|- | |||
| heterogenous Q || Q<sub>het</sub> || heterogenous pool of ETS-reactive Q according to the solid-state model || | |||
|} | |||
== Keywords == | |||
{{Template:Keywords: Q}} | |||
== The [[Q-Module]] is part of the [[NextGen-O2k]] project == | |||
:::: {{Template:Q-Module}} | |||
{{NextGen-O2k H2020-support}} | |||
{{MitoPedia concepts | {{MitoPedia concepts | ||
|mitopedia concept=MiP concept | |mitopedia concept=MiP concept | ||
}} | }} | ||
{{MitoPedia topics | {{MitoPedia topics | ||
|mitopedia topic=Substrate and metabolite | |mitopedia topic=Substrate and metabolite | ||
}} | }} | ||
Revision as of 11:26, 3 April 2021
Description
Different Q-pools are more or less clearly distinguished in the cell, related to a variety of models describing degress of Q-pool behavior. (1) CoQ-pools are distinguished according to their compartmentation in the cell: mitochondrial CoQ (mtCoQ) and CoQ in other organelles versus plasma-membrane CoQ. (2) The total mitochondrial CoQ-pool mtCoQ is partitioned into an ETS-reactive Q-pool, Qra, and an inactive mtCoQ-pool, Qia. (2a) The Qra-pool is fully reduced in the form of quinol QH2 under anoxia, fully oxidized in the form of quinone in aerobic mitochondrial preparations incubated without CHNO-fuel substrates, and intermediate redox states of Qra are sensitive to pathway control and coupling control of mitochondrial electron transfer and OXPHOS. (2b) The Qia-pool remains partially reduced and oxidized in aerob-anoxic transitions and is insensitive to mitochondrial respiratory states. (3) The Qra-pool is partitioned into Q with Q-pool behavior according to the fluid-state model (synonymous: random-collision model) and Q tightly bound to supercomplexes according to the solid-state model. The two models describe the extremes in a continuum of homogenous or heterogenous Q-pool behavior. The CII-Q-CIII segment of the S-pathway is frequently considered to follow homogenous Q-pool behavior participating in the Qhom-pool, whereas the CI-Q-CIII segment of the N-pathway indicates supercomplex organization with different degrees of Q-pool heterogeneity contributing to the Qhet-pool with metabolic channeling.
Abbreviation: Q
Reference: Komlodi 2021 MitoFit Q
Communicated by Gnaiger Erich 2021-04-03
Q-pool | Symbol | Definition | Balance |
---|---|---|---|
Coenzyme Q | CoQ | total CoQ in the cell | |
mitochondrial CoQ | mtCoQ | total CoQ in mitochondria | mtCoQ = Qra + Qia |
inactive mtCoQ | Qia | inactive mitochondrial CoQ, paritally oxidized under anoxia and partially reduced in aerobic mt-preparations incubated without CHNO-fuel substrates | |
ETS-reactive Q | Qra = Q | Electron-transfer-system reactive mtCoQ, fully reduced under anoxia, fully oxidized in aerobic mt-preparations incubated without CHNO-fuel substrates | Q = Qhom + Qhet |
homogenous Q | Qhom | homogenous pool of ETS-reactive Q according to the fluid-state model (random collision model) | |
heterogenous Q | Qhet | heterogenous pool of ETS-reactive Q according to the solid-state model |
Keywords
- Bioblast links: Q - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
- Coenzyme Q
- ยป Coenzyme Q
- ยป Quinone, Ubiquinone Q; oxidized
- ยป Quinol, Ubiquinol QH2; reduced
- ยป Semiquinone
- ยป Coenzyme Q2
- ยป Q-redox state
- ยป Q-pools
- Coenzyme Q
- Mitochondrial pathways, respiratory Complexes, and Q
- ยป Q-cycle
- ยป Q-junction
- ยป Convergent electron flow
- ยป NS-pathway
- ยป FNS
- ยป FNSGp
- Mitochondrial pathways, respiratory Complexes, and Q
- ยป N-pathway
- ยป Reverse electron flow from CII to CI
- ยป CI
- ยป Rotenone
- ยป Amytal
- ยป Piericidin
- NextGen-O2k and Q-Module
- ยป NextGen-O2k
- ยป Q-Module
- ยป Q-Sensor
- ยป Cyclic voltammetry
- ยป Three-electrode system
- NextGen-O2k and Q-Module
- General
The Q-Module is part of the NextGen-O2k project
- The Q-Module allows for monitoring of the redox state of electron transfer-reactive coenzyme Q at the Q-junction using the specific Q-Stoppers with the integrated three-electrode system and the modified electronics of the NextGen-O2k. Cyclic voltammetry is used for quality control and for defining the polarization voltage applied during Q-redox measurements.
- Reference:
- Komlรณdi T, Cardoso LHD, Doerrier C, Moore AL, Rich PR, Gnaiger E (2021) Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria. Bioenerg Commun 2021.3. https://doi.org/10.26124/bec:2021-0003
- Reference:
MitoPedia concepts:
MiP concept
MitoPedia topics:
Substrate and metabolite