Difference between revisions of "R/E control ratio"
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|description=[[Image:R over E.jpg|50 px|ROUTINE control ratio]] The '''ROUTINE control ratio''' (''R/E'' coupling control ratio) is the ratio of (partially coupled) [[ROUTINE respiration]] and (noncoupled) [[ETS capacity]]. The ''R/E'' control ratio is an expression of how close ROUTINE respiration operates to ETS capacity. | |description=[[Image:R over E.jpg|50 px|ROUTINE control ratio]] The '''ROUTINE control ratio''' (''R/E'' coupling control ratio) is the ratio of (partially coupled) [[ROUTINE respiration]] and (noncoupled) [[ETS capacity]]. The ''R/E'' control ratio is an expression of how close ROUTINE respiration operates to ETS capacity. | ||
|info=[[Gnaiger 2014 MitoPathways]] | |info=[[Gnaiger 2014 MitoPathways]] | ||
}} | }} | ||
{{MitoPedia concepts | {{MitoPedia concepts | ||
|mitopedia concept=Respiratory control ratio | |mitopedia concept=Respiratory control ratio | ||
}} | }} | ||
== Boundaries of the ROUTINE control ratio == | == Boundaries of the ROUTINE control ratio == | ||
''R/E'' increases due to (i) high ATP demand and ADP-stimulated ROUTINE respiration, (ii) partial uncoupling, and (iii) limitation of oxidative capacity by defects of substrate oxidation and complexes of the ETS. The corresponding inverse ratio is the uncoupling control ratio, UCR, which can be seen as an index of apparent ETS excess capacity. The lower boundary of ''R/E'' is the ''[[L/E]]'' flux control ratio, whereas the upper boundary is set by the ''[[P/E]]'' flux control ratio (OXPHOS/ETS capacity). | :::: ''R/E'' increases due to (i) high ATP demand and ADP-stimulated ROUTINE respiration, (ii) partial uncoupling, and (iii) limitation of oxidative capacity by defects of substrate oxidation and complexes of the ETS. The corresponding inverse ratio is the uncoupling control ratio, UCR, which can be seen as an index of apparent ETS excess capacity. The lower boundary of ''R/E'' is the ''[[L/E]]'' flux control ratio, whereas the upper boundary is set by the ''[[P/E]]'' flux control ratio (OXPHOS/ETS capacity). | ||
== Biochemical coupling efficiency: from 0 to <1 == | == Biochemical coupling efficiency: from 0 to <1 == | ||
* ''More details:'' »[[Biochemical coupling efficiency]] | :::* ''More details:'' »[[Biochemical coupling efficiency]] | ||
Compare: | :::: Compare: | ||
* [[Excess E-R capacity factor]], ''j<sub>ExR</sub>'' = (''E-R'')/''E'' = 1-''R/E'' | ::::* [[Excess E-R capacity factor]], ''j<sub>ExR</sub>'' = (''E-R'')/''E'' = 1-''R/E'' | ||
* [[ROUTINE coupling efficiency]], ''j<sub>≈R</sub>'' = ''≈R/R'' = (''R-L'')/''R'' = 1-''L/R'' | ::::* [[ROUTINE coupling efficiency]], ''j<sub>≈R</sub>'' = ''≈R/R'' = (''R-L'')/''R'' = 1-''L/R'' | ||
* [[NetROUTINE control ratio]], ''≈R/E'' = (''R-L'')/''E'' | ::::* [[NetROUTINE control ratio]], ''≈R/E'' = (''R-L'')/''E'' | ||
Revision as of 14:17, 8 October 2016
- high-resolution terminology - matching measurements at high-resolution
R/E control ratio
Description
The ROUTINE control ratio (R/E coupling control ratio) is the ratio of (partially coupled) ROUTINE respiration and (noncoupled) ETS capacity. The R/E control ratio is an expression of how close ROUTINE respiration operates to ETS capacity.
Abbreviation: R/E
Reference: Gnaiger 2014 MitoPathways
MitoPedia concepts:
Respiratory control ratio
Boundaries of the ROUTINE control ratio
- R/E increases due to (i) high ATP demand and ADP-stimulated ROUTINE respiration, (ii) partial uncoupling, and (iii) limitation of oxidative capacity by defects of substrate oxidation and complexes of the ETS. The corresponding inverse ratio is the uncoupling control ratio, UCR, which can be seen as an index of apparent ETS excess capacity. The lower boundary of R/E is the L/E flux control ratio, whereas the upper boundary is set by the P/E flux control ratio (OXPHOS/ETS capacity).
Biochemical coupling efficiency: from 0 to <1
- More details: »Biochemical coupling efficiency
- Compare:
- Excess E-R capacity factor, jExR = (E-R)/E = 1-R/E
- ROUTINE coupling efficiency, j≈R = ≈R/R = (R-L)/R = 1-L/R
- NetROUTINE control ratio, ≈R/E = (R-L)/E
