R/E control ratio

high-resolution terminology - matching measurements at high-resolution

R/E control ratio

Description

The ROUTINE control ratio (R/E coupling control ratio) is the ratio of (partially coupled) ROUTINE respiration and (noncoupled) ETS capacity. The R/E control ratio is an expression of how close ROUTINE respiration operates to ETS capacity.

Abbreviation: R/E

Reference: Gnaiger 2014 MitoPathways

MitoPedia concepts: Respiratory control ratio 

Boundaries of the ROUTINE control ratio

R/E increases due to (i) high ATP demand and ADP-stimulated ROUTINE respiration, (ii) partial uncoupling, and (iii) limitation of oxidative capacity by defects of substrate oxidation and complexes of the ETS. The corresponding inverse ratio is the uncoupling control ratio, UCR, which can be seen as an index of apparent ETS excess capacity. The lower boundary of R/E is the L/E flux control ratio, whereas the upper boundary is set by the P/E flux control ratio (OXPHOS/ETS capacity).

Biochemical coupling efficiency: from 0 to <1

• More details: »Biochemical coupling efficiency

Compare:

• Excess E-R capacity factor, j_ExR = (E-R)/E = 1-R/E
• ROUTINE coupling efficiency, j_≈R = ≈R/R = (R-L)/R = 1-L/R
• NetROUTINE control ratio, ≈R/E = (R-L)/E