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From Bioblast
 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
Gerber 2016 J Med Genet2016Gerber S, Ding MG, GĂ©rard X, Zwicker K, Zanlonghi X, Rio M, Serre V, Hanein S, Munnich A, Rotig A, Bianchi L, Amati-Bonneau P, Elpeleg O, Kaplan J, Brandt U, Rozet JM (2016) Compound heterozygosity for severe and hypomorphic NDUFS2 mutations cause non-syndromic LHON-like optic neuropathy. J Med Genet 54:346-56.LEAK
ROUTINE
ET
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
Fibroblast
Vevera 2016 Physiol Res2016Vevera J, Fiơar Z, Nekováƙová T, Vrablík M, Zlatohlávek L, Hroudová J, Singh N, Raboch J, Valeơ K (2016) Statin-induced changes in mitochondrial respiration in blood platelets in rats and human with dyslipidemia. Physiol Res 65:777-88.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Other combinations
ROX
Intact cells
Permeabilized cells
Human
Rat
Blood cells
Platelet
Frey 2016 Biochim Biophys Acta2016Frey S, Geffroy G, Desquiret-Dumas V, Gueguen N, Bris C, Belal S, Amati-Bonneau P, Chevrollier A, Barth M, Henrion D, Lenaers G, Bonneau D, Reynier P, Procaccio V (2016) The addition of ketone bodies alleviates mitochondrial dysfunction by restoring complex I assembly in a MELAS cellular model. Biochim Biophys Acta 1863:284-91.ROUTINE
LEAK
ET
N
S
NS
Permeabilized cells
Intact cells
HumanNervous system
Giraldos Jimenez 2016 Thesis2016Giraldos JimĂ©nez D (2016) Oxidative phosphorylation system’s role in adipogenic differentiation. Thesis p25.LEAK
ROUTINE
ROX
Schiffer 2016 Am J Physiol Cell Physiol2016Schiffer TA, Peleli M, Sundqvist ML, Ekblom B, Lundberg JO, Weitzberg E, Larsen FJ (2016) Control of human energy expenditure by cytochrome c oxidase subunit IV-2. Am J Physiol Cell Physiol 311:C452-61.LEAK
OXPHOS
ET
ROUTINE
N
NS
Permeabilized cells
Isolated mitochondria
Intact cells
HumanSkeletal muscle
HEK
Gdynia 2016 Nat Commun2016Gdynia G, Sauer SW, Kopitz J, Fuchs D, Duglova K, Ruppert T, Miller M, Pahl J, Cerwenka A, Enders M, MairbĂ€url H, KamiƄski MM, Penzel R, Zhang C, Fuller JC, Wade RC, Benner A, Chang-Claude J, Brenner H, Hoffmeister M, Zentgraf H, Schirmacher P, Roth W (2016) The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration. Nat Commun 7:10764.ROUTINEROXPermeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Other cell lines
Zelenka 2016 Oxid Med Cell Longev2016Zelenka J, Dvoƙák A, Alán L, Zadinová M, Haluzík M, Vítek L (2016) Hyperbilirubinemia protects against aging-associated inflammation and metabolic deterioration. Oxid Med Cell Longev ID 6190609:10p.ROUTINEIntact cells
Isolated mitochondria
RatLiver
Kidney
Fibroblast
Drehmer 2016 Stem Cell Res2016Drehmer DL, de Aguiar AM, Brandt AP, Petiz L, Cadena SM, Rebelatto CK, Brofman PR, Filipak Neto F, Dallagiovanna B, Abud AP (2016) Metabolic switches during the first steps of adipogenic stem cells differentiation. Stem Cell Res 17:413-421.LEAK
ROUTINE
ET
ROXIntact cellsHumanFat
Stem cells
Cacabelos 2016 Acta Neuropathol Commun2016Cacabelos D, RamĂ­rez-NĂșñez O, Granado-Serrano AB, Torres P, Ayala V, Moiseeva V, Povedano M, Ferrer I, Pamplona R, Portero-Otin M, Boada J (2016) Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS. Acta Neuropathol Commun 4:3.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissue
Intact cells
MouseNervous system
Other cell lines
Salvi 2016 Oxid Med Cell Longev2016Salvi A, Patki G, Khan E, Asghar M, Salim S (2016) Protective effect of tempol on buthionine sulfoximine (BSO)-induced mitochondrial impairment in hippocampal derived HT22 cells. Oxid Med Cell Longev 2016:5059043.ROUTINEIntact cellsMouseNervous system
Other cell lines
Dutra 2016 Acta Trop2016Dutra FL, Oliveira MM, Santos RS, Silva WS, Alviano DS, Vieira DP, Lopes AH (2016) Effects of linalool and eugenol on the survival of Leishmania (L.) infantum chagasi within macrophages. Acta Trop 164:69-76.ROUTINEROXIntact organism
Intact cells
Protists
Sheremet 2016 Biochemistry (Moscow)2016Sheremet NL, Nevinitsyna TA, Zhorzholadze NV, Ronzina IA, Itkis YS, Krylova TD, Tsygankova PG, Malakhova VA, Zakharova EY, Tokarchuk AV, Panteleeva AA, Karger EM, Lyamzaev KG, Avetisov SE (2016) Previously unclassified mutation of mtDNA m.3472T>C: evidence of pathogenicity in Leber’s hereditary optic neuropathy. Biochemistry (Moscow) BM16-078.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Fibroblast
Platelet
Tsai 2016 Sci Rep2016Tsai HH, Chang SC, Chou CH, Weng TP, Hsu CC, Wang JS (2016) Exercise training alleviates hypoxia-induced mitochondrial dysfunction in the lymphocytes of sedentary males. Sci Rep 6:35170.LEAK
ROUTINE
OXPHOS
ET
F
N
S
NS
Other combinations
ROX
Permeabilized cells
Intact cells
HumanLymphocyte
Blood cells
Schaefer 2016 PLOS ONE2016Schaefer PM, von Einem B, Walther P, Calzia E, von Arnim CA (2016) Metabolic characterization of intact cells reveals intracellular amyloid beta but not its precursor protein to reduce mitochondrial respiration. PLOS ONE 11:e0168157.LEAK
ROUTINE
ET
CIV
ROX
Intact cellsHuman
Mouse
Nervous system
HEK
Castellano-Gonzalez 2016 Oncotarget2016Castellano-GonzĂĄlez G, Pichaud N, Ballard JW, Bessede A, Marcal H, Guillemin GJ (2016) Epigallocatechin-3-gallate induces oxidative phosphorylation by activating cytochrome c oxidase in human cultured neurons and astrocytes. Oncotarget 7:7426-40LEAK
ROUTINE
ET
ROXIntact cellsHumanNervous system
Strecker 2016 Biochim Biophys Acta2016Strecker V, Kadeer Z, Heidler J, Cruciat CM, Angerer H, Giese H, Pfeiffer K, Stuart RA, Wittig I (2016) Supercomplex-associated Cox26 protein binds to cytochrome c oxidase. Biochim Biophys Acta 1863:1643-52.ROUTINE
ET
ROXIntact cellsSaccharomyces cerevisiae
Boeck 2016 Mitochondrion2016Boeck C, Koenig AM, Schury K, Geiger ML, Karabatsiakis A, Wilker S, Waller C, GĂŒndel H, Fegert JM, Calzia E, Kolassa IT (2016) Inflammation in adult women with a history of child maltreatment: The involvement of mitochondrial alterations and oxidative stress. Mitochondrion 30:197-207.LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Lymphocyte
Kang 2016 Elife2016Kang Y, Baker MJ, Liem M, Louber J, McKenzie M, Atukorala I, Ang CS, Keerthikumar S, Mathivanan S, Stojanovski D (2016) Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability. Elife 5:e17463.ROUTINE
ET
ROXIntact cellsHuman
Torres 2016 Redox Biol2016Torres S, Matías N, Baulies A, Nuñez S, Alarcon-Vila C, Martinez L, Nuño N, Fernandez A, Caballeria J, Levade T, Gonzalez-Franquesa A, Garcia-Rovés P, Balboa E, Zanlungo S, Fabrías G, Casas J, Enrich C, Garcia-Ruiz C, Fernåndez-Checa JC (2016) Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease. Redox Biol 11:60-72.LEAK
ROUTINE
OXPHOS
ET
N
S
ROX
Homogenate
Intact cells
Human
Mouse
Nervous system
Liver
Endothelial;epithelial;mesothelial cell
Fibroblast
Xiong 2016 Hypertension2016Xiong S, Wang P, Ma L, Gao P, Gong L, Li L, Li Q, Sun F, Zhou X, He H, Chen J, Yan Z, Liu D, Zhu Z (2016) Ameliorating endothelial mitochondrial dysfunction restores coronary function via transient receptor potential vanilloid 1-mediated protein kinase A/uncoupling protein 2 pathway. Hypertension 67:451-60.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Intact cells
Permeabilized cells
HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Camacho-Pereira 2016 Cell Metab2016Camacho-Pereira J, TarragĂł MG, Chini CC, Nin V, Escande C, Warner GM, Puranik AS, Schoon RA, Reid JM, Galina A, Chini EN (2016) CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism. Cell Metab 23:1127-39.LEAK
ROUTINE
OXPHOS
ET
S
ROX
Isolated mitochondria
Intact cells
Human
Mouse
Liver
Lung;gill
Other cell lines
Larsen 2016 FASEB J2016Larsen FJ, Schiffer TA, Ørtenblad N, Zinner C, Morales-Alamo D, Willis SJ, Calbet JA, Holmberg HC, Boushel R (2016) High-intensity sprint training inhibits mitochondrial respiration through aconitase inactivation. FASEB J 30:417-27.LEAK
ROUTINE
OXPHOS
N
NS
Permeabilized cells
Isolated mitochondria
Intact cells
HumanSkeletal muscle
Hancock 2016 Amino Acids2016Hancock CN, Liu W, Alvord WG, Phang JM (2016) Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate. Amino Acids 48:859-72.LEAK
ROUTINE
ET
S
Other combinations
ROX
Isolated mitochondria
Oxidase;biochemical oxidation
Intact cells
MouseLiver
Schinagl 2016 PLoS One2016Schinagl CW, Vrabl P, Burgstaller W (2016) Adapting high-resolution respirometry to glucose-limited steady state mycelium of the filamentous fungus Penicillium ochrochloron: method development and standardisation. PLoS One 11:e0146878.ROUTINE
ET
Intact cellsFungi
Yao 2016 Biochem Biophys Res Commun2016Yao K, Zhang WW, Yao L, Yang S, Nie W, Huang F (2016) Carvedilol promotes mitochondrial biogenesis by regulating the PGC-1/TFAM pathway in human umbilical vein endothelial cells (HUVECs). Biochem Biophys Res Commun 470:961-6.ROUTINEIntact cellsHumanEndothelial;epithelial;mesothelial cell
HUVEC
Rohlenova 2016 Antioxid Redox Signal2016Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork-Geleta A, Blecha J, Endaya B, Werner L, Cerny J, Zobalova R, Goodwin J, Spacek T, Alisadeh E, Yan B, Nguyen M, Vondrusova M, Sobol M, Jezek P, Hozak P, Truksa J, Rohlena J, Dong L, Neuzil J (2016) Selective disruption of respiratory supercomplexes as a new strategy to suppress Her2high breast cancer. Antioxid Redox Signal 26:84-103.LEAK
ROUTINE
ET
N
S
Other combinations
Permeabilized cells
Homogenate
Human
Mouse
Liver
Genital
Other cell lines
Ferguson 2016 J Bioenerg Biomembr2016Ferguson MA, Sutton RM, Karlsson M, Sjövall F, Becker LB, Berg RA, Margulies SS, Kilbaugh TJ (2016) Increased platelet mitochondrial respiration after cardiac arrest and resuscitation as a potential peripheral biosignature of cerebral bioenergetic dysfunction. J Bioenerg Biomembr 48:269-79.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Homogenate
Intact cells
PigNervous system
Platelet
Brandt 2016 Chem Biol Interact2016Brandt AP, Gozzi GJ, Pires Ado R, Martinez GR, Dos Santos Canuto AV, Echevarria A, Di Pietro A, Cadena SM (2016) Impairment of oxidative phosphorylation increases the toxicity of SYD-1 on hepatocarcinoma cells (HepG2). Chem Biol Interact 256:154-60.LEAK
ROUTINE
ET
ROXIntact cellsHumanLiver
Other cell lines
Lukasiak 2016 Eur J Pharmacol2016Ɓukasiak A, Skup A, Chlopicki S, Ɓomnicka M, Kaczara P, Proniewski B, Szewczyk A, Wrzosek A (2016) SERCA, complex I of the respiratory chain and ATP-synthase inhibition are involved in pleiotropic effects of NS1619 on endothelial cells. Eur J Pharmacol 786:137-47.ROUTINE
ET
Other combinationsIntact cellsHumanOther cell lines
Endothelial;epithelial;mesothelial cell
Silva 2016 Thesis2016Silva Luana Caroline SchĂŒeler da (2016) Fucoxantina inibe a oxidação de LDL e ativação de macrĂłfagos in vitro. PhD Thesis:93 pp.LEAK
ROUTINE
ET
ROXIntact cellsHuman
Bueno 2016 Thesis2016Bueno e Silva MM (2016) AlteraçÔes mitocondriais e reprogramação metabólica em células de glioblastoma após tratamento com temozolomida. Dissertation p71.LEAK
ROUTINE
ET
Intact cellsHumanNervous system
Other cell lines
Chakraborty 2016 Pancreatology2016Chakraborty M, Hickey AJ, Petrov MS, Macdonald JR, Thompson N, Newby L, Sim D, Windsor JA, Phillips AR (2016) Mitochondrial dysfunction in peripheral blood mononuclear cells in early experimental and clinical acute pancreatitis. Pancreatology 16:739-47.LEAK
OXPHOS
ROUTINE
ET
N
Gp
CIV
NS
ROX
S
Permeabilized cellsHuman
Rat
Blood cells
Davuluri 2016 Proc Natl Acad Sci U S A2016Davuluri G, Song P, Liu Z, Wald D, Sakaguchi TF, Green MR, Devireddy L (2016) Inactivation of 3-hydroxybutyrate dehydrogenase 2 delays zebrafish erythroid maturation by conferring premature mitophagy. Proc Natl Acad Sci U S A 113:E1460-9.LEAK
ROUTINE
ET
Intact cellsZebrafishBlood cells
Cheng 2016 Nat Immunol2016Cheng SC, Scicluna BP, Arts RJ, Gresnigt MS, Lachmandas E, Giamarellos-Bourboulis EJ, Kox M, Manjeri GR, Wagenaars JA, Cremer OL, Leentjens J, van der Meer AJ, van de Veerdonk FL, Bonten MJ, Schultz MJ, Willems PH, Pickkers P, Joosten LA, van der Poll T, Netea MG (2016) Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis. Nat Immunol 17:406-13.LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Lymphocyte
Fonseca-Berzal 2016 Parasitology2016Fonseca-Berzal C, DA Silva CF, Menna-Barreto RF, Batista MM, Escario JA, ArĂĄn VJ, GĂłmez-Barrio A, Soeiro Mde N (2016) Biological approaches to characterize the mode of action of two 5-nitroindazolinone prototypes on Trypanosoma cruzi bloodstream trypomastigotes. Parasitology 143:1469-78.ROUTINEROXIntact organismProtists
Kawalec 2016 Praca doktorska2016Kawalec MM (2016) Badanie komórkowych skutków mutacji w genie mitofuzyny 2. Próba zaproponowania testu patogennoƛci mutacji. Praca doktorska p86.LEAK
ROUTINE
ET
Intact cellsMouseFibroblast
Macheiner 2016 Sci Rep2016Macheiner T, Fengler VH, Agreiter M, Eisenberg T, Madeo F, Kolb D, Huppertz B, Ackbar R, Sargsyan K (2016) Magnetomitotransfer: An efficient way for direct mitochondria transfer into cultured human cells. Sci Rep 6:35571.LEAK
ROUTINE
ET
ROXHumanFibroblast
Lung;gill
Cacabelos 2016 Neurobiol Dis2016Cacabelos D, Ayala V, Granado-Serrano AB, JovĂ© M, Torres P, Boada J, CabrĂ© R, RamĂ­rez-NĂșñez O, Gonzalo H, Soler-Cantero A, Serrano JC, Bellmunt MJ, Romero MP, Motilva MJ, Nonaka T, Hasegawa M, Ferrer I, Pamplona R, Portero-OtĂ­n M (2016) Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis. Neurobiol Dis 88:148-60.ROUTINEIntact cellsRatNervous system
Chabot 2016 J Fish Biol2016Chabot D, McKenzie DJ, Craig JF (2016) Metabolic rate in fishes: definitions, methods and significance for conservation physiology. https://doi.org/10.1111/jfb.12873.ROUTINEFishes
Bynum 2016 Transfusion2016Bynum JA, Adam Meledeo M, Getz TM, Rodriguez AC, Aden JK, Cap AP, Pidcoke HF (2016) Bioenergetic profiling of platelet mitochondria during storage: 4°C storage extends platelet mitochondrial function and viability. Transfusion 56 Suppl 1:S76-84.LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Platelet
Barison 2016 J Bioenerg Biomembr2016BarisĂłn MJ, Damasceno FS, Mantilla BS, Silber AM (2016) The active transport of histidine and its role in ATP production in Trypanosoma cruzi. J Bioenerg Biomembr 48:437-49.LEAK
ROUTINE
ET
Intact cellsProtists
Birkenmeier 2016 Int J Cancer2016Birkenmeier Katrin, Droese Stefan, Wittig Ilka, Winkelmann Ria, Kaefer Viktoria, Doering Claudia, Hartmann Sylvia, Wenz Tina, Reichert Andreas S, Brandt Ulrich, Hansmann Martin‐Leo (2016) Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation. Int J Cancer 138:2231-46.LEAK
ROUTINE
ET
ROXIntact cellsHumanOther cell lines
HeLa
Macrophage-derived
Alvarez-Mora 2016 Mol Neurobiol2016Alvarez-Mora MI, Rodriguez-Revenga L, Madrigal I, Guitart-Mampel M, Garrabou G, MilĂ  M (2016) Impaired mitochondrial function and dynamics in the pathogenesis of FXTAS. Mol Neurobiol 54:6896-902.ROUTINEN
S
NS
Intact cellsHumanFibroblast
Watala 2016 Int J Pharm2016Watala C, Karolczak K, Kassassir H, Siewiera K, Maczynska K, Pieniazek A, Labieniec-Watala M (2016) How do the full-generation poly(amido)amine (PAMAM) dendrimers activate blood platelets? Platelet membrane zeta potential and other membrane-associated phenomena. Int J Pharm 500:379-89.LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Platelet
Liu 2016 Apoptosis2016Liu X, Gao RW, Li M, Si CF, He YP, Wang M, Yang Y, Zheng QY, Wang CY (2016) The ROS derived mitochondrial respiration not from NADPH oxidase plays key role in Celastrol against angiotensin II-mediated HepG2 cell proliferation. Apoptosis 21:1315-26.ROUTINEIntact cellsHumanLiver
Other cell lines
Lores-Arnaiz 2016 Neurochem Res2016Lores-Arnaiz S, Lombardi P, Karadayian AG, Orgambide F, Cicerchia D, Bustamante J (2016) Brain cortex mitochondrial bioenergetics in synaptosomes and non-synaptic mitochondria during aging. Neurochem Res 41:353-63.LEAK
ROUTINE
OXPHOS
ET
N
S
Isolated mitochondria
Intact cells
MouseNervous system
Berschneider 2016 Thesis2016Berschneider K (2016) Connecting the functions of the proteasome and mitochondria in the lung. Dissertation p161.LEAK
ROUTINE
ET
ROXPermeabilized cellsMouseLung;gill
Sengupta 2016 Free Radic Biol Med2016Sengupta S, Yang G, O'Donnell JC, Hinson MD, McCormack SE, Falk MJ, La P, Robinson MB, Williams ML, Yohannes MT, Polyak E, Nakamaru-Ogiso E, Dennery PA (2016) The circadian gene Rev-erbα improves cellular bioenergetics and provides preconditioning for protection against oxidative stress. Free Radic Biol Med 93:177-89.LEAK
ROUTINE
ET
ROXIntact cellsMouseLung;gill
Fibroblast
Moll 2016 bioRxiv2016Moll CWI, Lindtner RA, Vogel GF, Brunner M, Gutleben K, Blauth M, Krumschnabel G, Ebner HL (2016) Bone marrow mesenchymal stem cells from osteoporotic patients do not show altered mitochondrial energetics or ultrastructure. bioRxiv doi.org/10.1101/046300.LEAK
ROUTINE
OXPHOS
ET
N
S
ROX
Intact cells
Permeabilized cells
HumanStem cells
Reynolds 2016 Am J Physiol Endocrinol Metab2016Reynolds MS, Hancock CR, Ray JD, Kener KB, Draney C, Garland K, Hardman J, Bikman BT, Tessem JS (2016) ÎČ-cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion. Am J Physiol Endocrinol Metab 311:E186-201.LEAK
ROUTINE
OXPHOS
ET
N
S
ROX
Permeabilized cells
Intact cells
RatIslet cell;pancreas;thymus
Raturi 2016 J Cell Biol2016Raturi A, Gutiérrez T, Ortiz-Sandoval C, Ruangkittisakul A, Herrera-Cruz MS, Rockley JP, Gesson K, Ourdev D, Lou PH, Lucchinetti E, Tahbaz N, Zaugg M, Baksh S, Ballanyi K, Simmen T (2016) TMX1 determines cancer cell metabolism as a thiol-based modulator of ER-mitochondria Ca2+ flux. J Cell Biol 214:433-44.LEAK
ET
ROUTINE
Permeabilized cells
Intact cells
Mouse
Human
HeLa
Other cell lines
Barth 2016 Thesis2016Barth C (2016) Effekte einer intermittierenden Hyperoxie auf die mitochondriale Atmung in Alveolarmakrophagen. Dissertation p69.LEAK
ROUTINE
OXPHOS
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
MouseLung;gill
Macrophage-derived
Stier 2016 Methods Ecol Evol2016Stier A, Romestaing C, Schull Q, Lefol E, Robin JP, Roussel D, Bize P (2016) How to measure mitochondrial function in birds using red blood cells: a case study in the king penguin and perspectives in ecology and evolution. Methods Ecol Evol doi:10.1111/2041-210X.12724.LEAK
ROUTINE
OXPHOS
ET
N
S
ROX
Permeabilized tissue
Intact cells
BirdsSkeletal muscle
Blood cells
Lesage 2016 Am J Hum Genet2016Lesage S, Drouet V, Majounie E, Deramecourt V, Jacoupy M, Nicolas A, Cormier-Dequaire F, Hassoun SM, Pujol C, Ciura S, Erpapazoglou Z, Usenko T, Maurage CA, Sahbatou M, Liebau S, Ding J, Bilgic B, Emre M, Erginel-Unaltuna N, Guven G, Tison F, Tranchant C, Vidailhet M, Corvol JC, Krack P, Leutenegger AL, Nalls MA, Hernandez DG, Heutink P, Gibbs JR, Hardy J, Wood NW, Gasser T, Durr A, Deleuze JF, Tazir M, Destée A, Lohmann E, Kabashi E, Singleton A, Corti O, Brice A (2016) Loss of VPS13C function in autosomal-recessive parkinsonism causes mitochondrial dysfunction and increases PINK1/Parkin-Dependent Mitophagy. Am J Hum Genet 98:500-13.LEAK
ROUTINE
ET
ROXIntact cellsOther mammalsKidney
Other cell lines
Svenkrtova 2016 Biogerontology2016Svenkrtova A, Belicova L, Volejnikova A, Sigler K, Jazwinski SM, Pichova A (2016) Stratification of yeast cells during chronological aging by size points to the role of trehalose in cell vitality. Biogerontology 17:395-408.ROUTINECIV
ROX
Intact cellsSaccharomyces cerevisiae
Zhunussova 2016 PLOS ONE2016Zhunussova A, Vitol EA, Polyak B, Tuleukhanov S, Brooks AD, Sensenig R, Friedman G, Orynbayeva Z (2016) Mitochondria-mediated anticancer effects of non-thermal atmospheric plasma. PLOS ONE 11:e0156818.LEAK
ROUTINE
ET
Intact cellsHumanGenital
Other cell lines
Nauta 2016 Thesis2016Nauta TD (2016) HIF-2α regulates in vitro neovascularization during hypoxia. Doctoral Dissertation p206.LEAK
ROUTINE
ET
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
Davuluri 2016 J Physiol2016Davuluri G, Allawy A, Thapaliya S, Rennison JH, Singh D, Kumar A, Sandlers Y, Van Wagoner DR, Flask CA, Hoppel C, Kasumov T, Dasarathy S (2016) Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress. J Physiol 594:7341-60.LEAK
ROUTINE
ET
ROXIntact cellsMouseSkeletal muscle
Other cell lines
Anand 2016 PLOS ONE2016Anand R, Strecker V, Urbach J, Wittig I, Reichert AS (2016) Mic13 is essential for formation of crista junctions in mammalian cells. PLOS ONE 11:e0160258.LEAK
ROUTINE
OXPHOS
ET
N
CIV
NS
Other combinations
ROX
Permeabilized cells
Intact cells
HEK
Bastow 2016 J Cell Sci2016Bastow EL, Peswani AR, Tarrant DS, Pentland DR, Chen X, Morgan A, Staniforth GL, Tullet JM, Rowe ML, Howard MJ, Tuite MF, Gourlay CW (2016) New links between SOD1 and metabolic dysfunction from a yeast model of amyotrophic lateral sclerosis. J Cell Sci 129:4118-29.LEAK
ROUTINE
ET
ROXIntact cellsSaccharomyces cerevisiae
Mesquita 2016 Thesis2016Mesquita Rodrigues C (2016) Efeito da depleção de ferro sobre Leishmania (Viannia) braziliensisuma anålise ultraestrutural, proteÎmica e interação com matrizes de colågeno sintéticas. Doctoral Dissertation p210.ROUTINEROXIntact cellsProtists
Puskarich 2016 J Crit Care2016Puskarich MA, Kline JA, Watts JA, Shirey K, Hosler J, Jones AE (2016) Early alterations in platelet mitochondrial function are associated with survival and organ failure in patients with septic shock. J Crit Care 31:63-7.LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Platelet
Holandino 2016 Bioelectrochemistry2016Holandino C, Teixeira CA, de Oliveira FA, Barbosa GM, Siqueira CM, Messeder DJ, de Aguiar FS, da Veiga VF, Girard-Dias W, Miranda K, Galina A, Capella MA, Morales MM (2016) Direct electric current treatment modifies mitochondrial function and lipid body content in the A549 cancer cell line. Bioelectrochemistry 111:83-92.LEAK
ROUTINE
ET
ROXIntact cellsHumanLung;gill
Other cell lines
Oliveira 2016 PLOS ONE2016Oliveira MP, Correa Soares JB, Oliveira MF (2016) Sexual preferences in nutrient utilization regulate oxygen consumption and reactive oxygen species generation in Schistosoma mansoni: potential implications for parasite redox biology. PLOS ONE 11:e0158429.LEAK
ROUTINE
F
ROX
Intact organismOther invertebrates
Heimer 2016 Am J Hum Genet2016Heimer G, KerÀtÀr JM, Riley LG, Balasubramaniam S, Eyal E, PietikÀinen LP, Hiltunen JK, Marek-Yagel D, Hamada J, Gregory A, Rogers C, Hogarth P, Nance MA, Shalva N, Veber A, Tzadok M, Nissenkorn A, Tonduti D, Renaldo F, Kraoua I, Panteghini C, Valletta L, Garavaglia B, Cowley MJ, Gayevskiy V, Roscioli T, Silberstein JM, Hoffmann C, Raas-Rothschild A, Tiranti V, Anikster Y, Christodoulou J, Kastaniotis AJ, Ben-Zeev B, Hayflick SJ (2016) MECR mutations cause childhood-onset dystonia and optic atrophy, a mitochondrial fatty acid synthesis disorder. Am J Hum Genet 99:1229-44.LEAK
ROUTINE
ET
ROXIntact cellsHumanFibroblast
Jang 2016 Clin Toxicol (Phila)2016Jang DH, Shofer FS, Weiss SL, Becker LB (2016) Impairment of mitochondrial respiration following ex vivo cyanide exposure in peripheral blood mononuclear cells. Clin Toxicol (Phila) 54:303-7.LEAK
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ET
ROXIntact cellsHumanBlood cells
Lymphocyte
Sanchez-Calvo 2016 PLOS ONE2016SĂĄnchez-Calvo B, Cassina A, Rios N, Peluffo G, Boggia J, Radi R, Rubbo H, Trostchansky A (2016) Nitro-arachidonic acid prevents Angiotensin II-induced mitochondrial dysfunction in a cell line of kidney proximal tubular cells. PLOS ONE 11:e0150459.LEAK
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ET
ROXIntact cellsHumanKidney
Other cell lines
Wos 2016 Arch Biochem Biophys2016Woƛ M, Szczepanowska J, PikuƂa S, Tylki-SzymaƄska A, ZabƂocki K, Bandorowicz-PikuƂa J (2016) Mitochondrial dysfunction in fibroblasts derived from patients with Niemann-Pick type C disease. Arch Biochem Biophys 593:50-9.LEAK
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ET
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Fibroblast
Jang 2016 J Intensive Care Med2016Jang DH, Greenwood JC, Spyres MB, Eckmann D (2016) Measurement of mitochondrial respiration and motility in acute care: sepsis, trauma, and poisoning. J Intensive Care Med 32:86-94.LEAK
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ET
ROXIntact cellsHumanBlood cells
Lymphocyte
McFarlane 2016 Thesis2016McFarlane SV (2016) Temperature-dependent alterations of brown adipose tissue metabolism during hibernation in the thirteen-lined ground squirrel, Ictidomys tridecemlineatus. Dissertation p74.LEAK
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OXPHOS
ET
F
N
Isolated mitochondria
Intact cells
Other mammalsFat
Shao 2016 Cell Res2016Shao LW, Niu R, Liu Y (2016) Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response. Cell Res 26:1182-96.ROUTINEIntact organismCaenorhabditis elegans
Ehinger 2016 Mov Disord2016Ehinger JK, Morota S, Hansson MJ, Gesine P, ElmĂ©r E (2016) Mitochondrial respiratory function in peripheral blood cells from Huntington’s disease patients. Mov Disord doi:10.1002/mdc3.12308.LEAK
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OXPHOS
ET
N
S
CIV
NS
Other combinations
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Lymphocyte
Platelet
Kuznetsov 2015 Biochim Biophys Acta2015Kuznetsov AV, Javadov S, Sickinger S, Frotschnig S, Grimm M (2014) H9c2 and HL-1 cells demonstrate distinct features of energy metabolism, mitochondrial function and sensitivity to hypoxia-reoxygenation. Biochim Biophys Acta 1853:276-84.ROUTINE
ET
Intact cellsRatHeart
Other cell lines
Assmann 2014 PhD Thesis2015Assmann N (2015) Impact of Fanconi-associated protein on the mitochonrial proteome. PhD Thesis 1-111.LEAK
ROUTINE
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
PigKidney
Other cell lines
Coupling-control protocol2015Gnaiger E (2015) From PCP to CCP. Mitochondr Physiol Network 2015-01-11.LEAK
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OXPHOS
ET
Martos 2015 Plant Physiol Biochem2015Martos GG, TerĂĄn Mdel M, DĂ­az Ricci JC (2015) The defence elicitor AsES causes a rapid and transient membrane depolarization, a triphasic oxidative burst and the accumulation of nitric oxide. Plant Physiol Biochem 97:443-50.ROUTINEIntact cellsPlants
Cagnone 2015 Methods Mol Biol2015Cagnone G, Vaghjiani V, Lee W, Sun C, Johnson J, Yeung KY, St John JC (2015) Analysis of the mitochondrial DNA and its replicative capacity in induced pluripotent stem cells. Methods Mol Biol 1357:231-67.LEAK
ROUTINE
ET
ROXIntact cellsHumanStem cells
Kilbaugh 2015 Exp Neurol2015Kilbaugh TJ, Karlsson M, Byro M, Bebee A, Ralston J, Sullivan S, Duhaime AC, Hansson MJ, Elmér E, Margulies SS (2015) Mitochondrial bioenergetic alterations after focal traumatic brain injury in the immature brain. Exp Neurol 271:136-144.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissue
Homogenate
PigNervous system
Hagl 2015 Molecules2015Hagl S, Berressem D, Bruns B, Sus N, Frank J, Eckert GP (2015) Beneficial Effects of Ethanolic and Hexanic Rice Bran Extract on Mitochondrial Function in PC12 Cells and the Search for Bioactive Components. Molecules 20(9):16524-39.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsRatNervous system
Other cell lines
Grimm 2015 Exp Gerontol2015Grimm C, Osiewacz HD (2015) Manganese rescues adverse effects on lifespan and development in Podospora anserina challenged by excess hydrogen peroxide. Exp Gerontol 63:8-17.ROUTINECIV
ROX
Isolated mitochondria
Intact cells
Fungi
Lisak 2015 Cell Death Differ2015Lisak D, Schacht T, Gawlitza A, Albrecht P, Aktas O, Koop B, Gliem M, Hofstetter HH, Zanger K, Bultynck G, Parys JB, De Smedt H, Kindler T, Adams-Quack P, Hahn M, Waisman A, Reed JC, Hövelmeyer N, Methner A (2015) BAX inhibitor-1 is a Ca2+ channel critically important for immune cell function and survival. Cell Death Differ 23:358-68.LEAK
ROUTINE
ET
ROXIntact cellsMouseBlood cells
Lymphocyte
Makrecka-Kuka 2015 Biomolecules2015Makrecka-Kuka M, Krumschnabel G, Gnaiger E (2015) High-resolution respirometry for simultaneous measurement of oxygen and hydrogen peroxide fluxes in permeabilized cells, tissue homogenate and isolated mitochondria. https://doi.org/10.3390/biom5031319LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Homogenate
Isolated mitochondria
Intact cells
Human
Mouse
Heart
Nervous system
HEK
Sundaram 2015 Mol Microbiol2015Sundaram V, Petkova MI, Pujol-Carrion N, Boada J, de la Torre-Ruiz MA (2015) Tor1, Sch9 and PKA downregulation in quiescence rely on Mtl1 to preserve mitochondrial integrity and cell survival. Mol Microbiol 97:93-109.LEAK
ROUTINE
ET
ROXIntact cellsSaccharomyces cerevisiae
Orynbayeva 2015 Nanomedicine (Lond)2015Orynbayeva Z, Sensenig R, Polyak B (2015) Metabolic and structural integrity of magnetic nanoparticle-loaded primary endothelial cells for targeted cell therapy. Nanomedicine (Lond) 10:1555-68.LEAK
ROUTINE
ET
ROXIntact cellsRatEndothelial;epithelial;mesothelial cell
Kawalec 2015 PLoS One2015Kawalec M, BoratyƄska-JasiƄska A, Beręsewicz M, Dymkowska D, ZabƂocki K, ZabƂocka B (2015) Mitofusin 2 deficiency affects energy metabolism and mitochondrial biogenesis in MEF cells. PLoS One 10:e0134162.LEAK
ROUTINE
ET
Permeabilized cellsMouseFibroblast
Ruiz-Perez 2015 J Biol Chem2015Ruiz-Pérez MV, Medina MÁ, Urdiales JL, KeinÀnen TA, Sånchez-Jiménez F (2015) Polyamine metabolism is sensitive to glycolysis inhibition in human neuroblastoma cells. J Biol Chem 290:6106-19.LEAK
ROUTINE
ET
ROXIntact cellsHumanNervous system
Other cell lines
Neuroblastoma
Farrar 2015 US Patent2015Farrar GJ, Millington-Ward S, Chadderton N (2015) Variants of yeast ndi1 gene, and uses thereof in the treatment of disease associated with mitochondrial dysfunction. US Patent WO 2013093029 A3.ROUTINEROXHumanHeLa
Van Rahden 2015 Am J Hum Genet2015van Rahden VA, Fernandez-Vizarra E, Alawi M, Brand K, Fellmann F, Horn D, Zeviani M, Kutsche K (2015) Mutations in NDUFB11, encoding a complex I component of the mitochondrial respiratory chain, cause microphthalmia with linear skin defects syndrome. Am J Hum Genet 96:640-50.LEAK
ROUTINE
ET
Intact cellsHumanHeLa
Yan 2015 BMC Cancer2015Yan B, Stantic M, Zobalova R, Bezawork-Geleta A, Stapelberg M, Stursa J, Prokopova K, Dong L, Neuzil J (2015) Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner. BMC Cancer 15:401.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
Human
Mouse
Genital
Other cell lines
Llobet 2015 Dis Model Mech2015Llobet L, Toivonen JM, Montoya J, Ruiz-Pesini E, LĂłpez-Gallardo E (2015) OXPHOS xenobiotics alter adipogenic differentiation at concentrations found in human blood. Dis Model Mech 8:1441-55.LEAK
ROUTINE
ET
Intact cellsHumanFat
Stem cells
Keane 2015 Clin Sci (Lond)2015Keane KN, Calton EK, Cruzat VF, Soares MJ, Newsholme P (2015) The impact of cryopreservation on human peripheral blood leukocyte bioenergetics. Clin Sci (Lond) 128:723–33.ROUTINE
ET
Intact cellsHumanBlood cells
Alonso-Vale 2015 FASEB J2015Alonso-Vale MI, Cruz M, Bolsoni-Lopes A, de SĂĄ R, Bresciani Martins de Andrade P (2015) Palmitoleic acid (C16:1n7) treatment enhances fatty acid oxidation and oxygen consumption in white adipocytes. FASEB J 29:884.25.ROUTINEIntact cellsMouseFat
Khera 2015 Placenta2015Khera A, Dong LF, Holland OJ, Vanderlelie J, Pasdar EA, Neuzil J, Perkins AV (2015) Selenium supplementation induces mitochondrial biogenesis in trophoblasts. Placenta 36:863-9.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
Permeabilized cells
Intact cells
HumanGenital
Other cell lines
Cassina 2015 Biol Reprod2015Cassina AM, Silveira P, Cantu L, Montes JM, Radi R, Sapiro R (2015) Defective human sperm cells are associated with mitochondrial dysfunction and oxidant production. Biol Reprod 93:119.LEAK
ROUTINE
ET
ROXHumanGenital
Aroor 2015 Diabetes2015Aroor AR, Habibi J, Ford DA, Nistala R, Lastra G, Manrique C, Dunham MM, Ford KD, Thyfault JP, Parks EJ, Sowers JR, Rector RS (2015) Dipeptidyl peptidase-4 inhibition ameliorates western diet-induced hepatic steatosis and insulin resistance through hepatic lipid remodeling and modulation of hepatic mitochondrial function. Diabetes 64:1988-2001.LEAK
ROUTINE
OXPHOS
ET
F
N
S
NS
Isolated mitochondriaMouseLiver
Schoeckel 2015 Cancer Metab2015Schöckel L, Glasauer A, Basit F, Bitschar K, Truong H, Erdmann G, Algire C, HÀgebarth A, Willems PH, Kopitz C, Koopman WJ, Héroult M (2015) Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth. Cancer Metab 3:11.ROUTINEROXIntact cellsHuman
Mouse
Endothelial;epithelial;mesothelial cell
Other cell lines
Kasvandik 2015 J Proteome Res2015Kasvandik S, Samuel K, Peters M, Eimre M, Peet N, Roost AM, Padrik L, Paju K, Peil L, Salumets A (2015) Deep quantitative proteomics reveals extensive metabolic reprogramming and cancer-like changes of ectopic endometriotic stromal cells. J Proteome Res 15:572-84.LEAK
ROUTINE
ET
ROXHumanGenital
Other cell lines
Ma 2015 Int J Biol Sci2015Ma W, Jing L, Valladares A, Mehta SL, Wang Z, Li PA, Bang JJ (2015) Silver nanoparticle exposure induced mitochondrial stress, caspase-3 activation and cell death: amelioration by sodium selenite. Int J Biol Sci 11:860-7.ROUTINEIntact cellsMouseNervous system
Other cell lines
Ikaga 2015 Biochem Biophys Rep2015Ikaga R, Namekatac I, Kotiadisd VN, Ogawab H, Duchend MR, Tanakac H, Iida-Tanakab N (2015) Knockdown of aquaporin-8 induces mitochondrial dysfunction in 3T3-L1 cells. Biochem Biophys Rep 4:187–95.LEAK
ROUTINE
ET
CIV
ROX
Intact cellsMouseFat
Other cell lines
Truksa 2015 Antioxid Redox Signal2015Truksa J, Dong L, Rohlena J, Stursa J, Vondrusova M, Goodwin J, Nguyen M, Kluckova K, Rychtarcikova Z, Lettlova S, Spacilova J, Stapelberg M, Zoratti M, Neuzil J (2015) Mitochondrially targeted vitamin E succinate modulates expression of mitochondrial DNA transcripts and mitochondrial biogenesis. Antioxid Redox Signal 22:883-900.ROUTINESIntact cellsHuman
Mouse
Genital
Other cell lines