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• Onukwufor 2022 Antioxidants (Basel)
  ...AP (2022) Iron dysregulation in mitochondrial dysfunction and Alzheimer's disease. Antioxidants (Basel) 11:692. https://doi.org/10.3390/antiox11040692 ...ly unsuccessful. Here, we review evidence linking iron dysregulation to AD and the potential for targeting ferroptosis as a therapeutic intervention for A
  2 KB (228 words) - 07:13, 24 April 2023
• Oliveira 2015 Biotechniques
  for energy production and lipid palmitate (C16:0) and the monounsat
  1 KB (188 words) - 12:04, 14 July 2016
• Bernardinelli 2017 PLoS One
  ...) Mis-targeting of the mitochondrial protein LIPT2 leads to apoptotic cell death. PLoS One 12(6):e0179591. ...(IClswell), mitochondrial membrane potential collapse, caspase-3 cleavage and nuclear DNA fragmentation. The findings presented here may help elucidate t
  2 KB (228 words) - 16:37, 23 January 2019
• Morato 2015 Cell Death Differ
  ...irtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy. Cell Death Differ 22:1742-53. |journal=Cell Death Differ
  2 KB (252 words) - 08:22, 21 February 2020
• Brodnanova 2021 Eur J Pharmacol
  ...mine on thapsigargin- and tunicamycin-induced endoplasmic reticulum stress and mitochondrial dysfunction in neuroblastoma SH-SY5Y cells. Eur J Pharmacol 9 .... Splicing of XBP1 mRNA was studied by RT-PCR. Finally, expression of Hrd1 and Hsp60 was determined by Western blot analysis.
  2 KB (333 words) - 16:01, 21 July 2021
• Eira da Costa 2013 Abstract MiP2013
  ...ainst mitochondrial dysfunction in a ''PINK1/parkin'' model of Parkinson’s disease. Mitochondr Physiol Network 18.08. ..., and that enhancing its function may ameliorate mitochondrial dysfunction and rescue neurodegeneration in PD.
  2 KB (319 words) - 11:11, 28 April 2017
• Grespi 2016 Abstract Mito Xmas Meeting Innsbruck
  |title=MicroRNAs as modulators of mitochondrial remodeling and apoptosis. ...ould provide new potential therapeutic targets for a currently untreatable disease.
  2 KB (283 words) - 12:58, 13 December 2016
• Benard 2011 Springer
  ...ial dynamics and bioenergetics. In: Lu Bingwei (ed) Mitochondrial dynamics and neurodegeneration. Springer ISBN 978-94-007-1290-4:47-68. ...mit to increase our basic knowledge on the regulation of energy metabolism and to decipher the pathophysiology of a group of rare neuronal diseases.
  2 KB (299 words) - 04:21, 10 November 2023
• Noelker 2015 J Neurol Sci
  ...rosidase deficiency and mitochondrial impairment in experimental Parkinson disease. J Neurol Sci 356:129-36. ...tion of GCase activity with conduritol-B-epoxide (CBE) enhances both α-Syn and MPP(+) induced toxicity ''in vitro''. However, only CBE-induced enhancement
  2 KB (293 words) - 10:04, 23 February 2016
• Reguis Yadao 2018 Thesis
  ...Smooth muscle cell mitochondrial respiration – effects of aerobic training and type I diabetes. Master's Thesis 71. ...osing diabetic models that carry an inherently high risk of cardiovascular disease to prolonged exercise.
  3 KB (338 words) - 16:39, 31 January 2019
• Mejia-Vergara 2020 Curr Neurol Neurosci Rep
  ...ophysiology of conversion to symptomatic leber hereditary optic neuropathy and therapeutic implications: a review. Curr Neurol Neurosci Rep 20:11. https:/ ...mitochondrial genetics are helping to elucidate the nuances of conversion and allow for new therapeutic options.
  2 KB (251 words) - 04:46, 5 November 2023
• Seitaj 2020 Cells
  ...tif containing protein 5 (TMBIM5) sustains mitochondrial structure, shape, and function by impacting the mitochondrial protein synthesis machinery. Cells ...conclude that TMBIM5 is important to maintain the mitochondrial structure and function possibly through the control of mitochondrial biogenesis.
  3 KB (353 words) - 20:58, 1 October 2020
• Bamberger 2018 MiP2018
  ...nt of elamipretide: targeting mitochondrial dysfunction in rare and common disease. ...th. Elamipretide is currently in clinical development for PMM, BTHS, LHON, and AMD.
  3 KB (336 words) - 04:40, 12 February 2020
• Viall 2013 J Autoimmun
  ...bodies internalised by human syncytiotrophoblast cause aberrant cell death and the release of necrotic trophoblast debris. J Autoimmun 47:45-57. ...ily members. Once internalised by the syncytiotrophoblast, aPL affects the death-regulating mitochondria, causing extrusion of necrotic trophoblast debris w
  2 KB (307 words) - 12:56, 25 February 2020
• MiPliterature
  ...ger.com/us/book/9781402067136 Mitochondrial Metablism, Diseases, Diagnosis and Therapy]. Springer Science: 409 pp. ...inger.com/us/book/9780230517578 The Living End. The future of death, aging and immortality]. Macmillan.
  3 KB (365 words) - 14:48, 4 May 2017
• Nakamura 2011 J Biol Chem
  ...Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein. J Biol Chem 286:20710-26. ...orphology of an organelle long implicated in the pathogenesis of Parkinson disease.
  2 KB (291 words) - 15:52, 19 March 2015
• Bobba 2015 Apoptosis
  ..., La Piana G, Calissano P, Atlante A (2015) Glycolytic enzyme upregulation and numbness of mitochondrial activity characterize the early phase of apoptosi |abstract=Alzheimer’s disease (AD) and cancer proceed
  2 KB (270 words) - 13:51, 27 March 2018
• Schaefer 2016 Abstract ADFLIM 2016
  |title=ADFLIM in AD research –imaging mitochondrial function in Alzheimer´s disease ...imbalance in the brain, being one trigger of neuronal death in Alzheimer´s disease.
  2 KB (300 words) - 15:38, 23 January 2019
• Torres 2016 Redox Biol
  ...replenishment as a potential therapeutic approach for Niemann Pick type C disease. Redox Biol 11:60-72. ...pecific replenishment of mGSH may be a potential promising therapy for NPC disease, worth exploring alone or in combination with other options.
  3 KB (447 words) - 16:18, 13 November 2017
• Luis-Garcia 2018 Am J Respir Crit Care Med
  ...nown etiology, characterized by the expansion of the fibroblast population and destruction of lung parenchyma. |injuries=Cell death
  954 bytes (119 words) - 16:25, 8 May 2018

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