Difference between revisions of "Talk:Bioblast alert 2015"
From Bioblast
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*O2k-Publication: '''Heart failure and mitochondrial dysfunction'''. Increased OXPHOS capacity after cold preservation of the human heart – a paradox resolved by a dyscoupling mechanism. | *O2k-Publication: '''Heart failure and mitochondrial dysfunction'''. Increased OXPHOS capacity after cold preservation of the human heart – a paradox resolved by a dyscoupling mechanism. | ||
::[[Lemieux 2011 | ::[[Lemieux 2011 Int. J. Biochem. Cell Biol.|Lemieux H, Semsroth S, Antretter H, Hoefer D, Gnaiger E (2011) Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart. Int. J. Biochem. Cell Biol. 43: 1729–1738]]. -- [[Talk:Lemieux 2011 Int. J. Biochem. Cell Biol.|Discussion: Complementary results on the PGC-1a pathway]]. | ||
*'''[[Scientific service]]''': '''[[Tissue storage]]''' on ice is possible for limited periods of time (several hours) with preservation of mitochondrial respiratory function, as evaluated with [[SUIT protocol]]s. | *'''[[Scientific service]]''': '''[[Tissue storage]]''' on ice is possible for limited periods of time (several hours) with preservation of mitochondrial respiratory function, as evaluated with [[SUIT protocol]]s. | ||
Revision as of 13:47, 15 November 2011
Bioblast alert - in preparation
Bioblast alert #02
- O2k-Publication: Heart failure and mitochondrial dysfunction. Increased OXPHOS capacity after cold preservation of the human heart – a paradox resolved by a dyscoupling mechanism.
- Scientific service: Tissue storage on ice is possible for limited periods of time (several hours) with preservation of mitochondrial respiratory function, as evaluated with SUIT protocols.
- Term of the week: Uncoupled, non-coupled, dyscoupled - a hallmark of high-resolution respirometry is a matching high-resolution terminology.
- Evaluate an example of low-resolution terminology: Uncoupling was studied in stressed cells by measurement of coupled respiration, evaluation of uncoupled respiration after inhibition with oligomycin, and FCCP titration to quantify uncoupled respiration.
Bioblast alert ## to select
- O2k-Publication: Protocols for HRR: from intact cells to permeabilized muscle fibres
Bioblast alert ## to select
- O2k-Publication: Fluorescence in the O2k
- Hickey AJ, Renshaw GM, Speers-Roesch B, Richards JG, Wang Y, Farrell AP, Brauner CJ (2011) A radical approach to beating hypoxia: depressed free radical release from heart fibres of the hypoxia-tolerant epaulette shark (Hemiscyllum ocellatum). J. Comp. Physiol. B.[Epub ahead of print]
- Anderson EJ, Rodriguez E, Anderson CA, Thayne K, Chitwood WR, Kypson AP (2011) Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways. Am. J. Physiol. Heart Circ. Physiol. 300: H118-124.
- MiPNet Reference Laboratory: NZ Auckland Hickey AJ - 6 O2k, guest lecturer at IOC66, joint project (Marsden), guest tutor at IOC59.
Bioblast alert ## to select
- O2k-Publication: Efficiency, basal respiration, and oxygen kinetics in human muscle or Mitochondrial efficiency and P/O flux ratios: new perspectives in mitochondrial physiology (see Journal club);
- Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, Weitzberg E (2011) Dietary inorganic nitrate improves mitochondrial efficiency in humans. Cell Metab. 13: 149-159.
- Larsen FJ, Schiffer TA, Sahlin K, Ekblom B, Weitzberg E, Lundberg JO (2011) Mitochondrial oxygen affinity predicts basal metabolic rate in humans. FASEB J. 25: 2843-2852.
- Before alert, ask to join as MiPNet Reference Lab, and present new MiPNet Reference Lab
- Term: efficiency versus P/O ratio
