Noncoupled respiration: Difference between revisions

Revision as of 09:22, 11 January 2018

high-resolution terminology - matching measurements at high-resolution

Noncoupled respiration

Noncoupled respiration is distinguished from general (pharmacological or mechanical) uncoupled respiration, to give a label to an effort to reach the state of maximum uncoupler-activated respiration without inhibiting respiration. Noncoupled respiration, therefore, yields an estimate of ET-capacity. Experimentally uncoupled respiration may fail to yield an estimate of ET-capacity, due to inhibition of respiration above optimum uncoupler concentrations or insufficient stimulation by sub-optimal uncoupler concentrations. Optimum uncoupler concentrations for evaluation of (noncoupled) ET-capacity require inhibitor titrations (Steinlechner-Maran 1996 Am J Physiol Cell Physiol; Huetter 2004 Biochem J; Gnaiger 2008 POS).

Noncoupled respiration is maximum electron flow in an open-transmembrane proton circuit mode of operation (see ET-capacity).

Abbreviation: E

Reference: Gnaiger 2014 MitoPathways, MitoPedia: Respiratory states

MitoPedia concepts: Respiratory state, Recommended

MitoPedia methods: Respirometry

MitoPedia topics: EAGLE

Contributed by Gnaiger E 2010-08-15, edited 2015-01-19.

» More details: Uncoupler

Revision as of 11:18, 10 January 2018 (view source) Gnaiger Erich (talk \| contribs) No edit summary ← Older edit		Revision as of 09:22, 11 January 2018 (view source) Beno Marija (talk \| contribs) No edit summary Newer edit →
Line 20:		Line 20:

	== Biochemical coupling efficiency: from 0 to <1 ==		== Biochemical coupling efficiency: from 0 to <1 ==
	::::» ''More details:'' [[OXPHOS coupling efficiency]] and [[ET-~~pathway~~ coupling efficiency]]		::::» ''More details:'' [[OXPHOS coupling efficiency]] and [[ET-coupling efficiency]]