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	Year	Reference	Coupling	Pathway	Preparation	Organism	Tissue;cell
Liu 2017 Physiol Rep	2017	Liu A, Philip J, Vinnakota KC, Van den Bergh F, Tabima DM, Hacker T, Beard DA, Chesler NC (2017) Estrogen maintains mitochondrial content and function in the right ventricle of rats with pulmonary hypertension. Physiol Rep 5:e13157.	OXPHOS LEAK	F N	Isolated mitochondria	Rat	Heart
Wolff 2017 Thesis	2017	Wolff C (2017) Impact of lipid metabolism on skeletal muscle mitochondrial function in type 2 diabetes mellitus patients. Dissertation p68.	LEAK OXPHOS ET	F N NS	Permeabilized tissue	Horse Human	Skeletal muscle
Napa 2017 Int J Dent	2017	Napa K, Baeder AC, Witt JE, Rayburn ST, Miller MG, Dallon BW, Gibbs JL, Wilcox SH, Winden DR, Smith JH, Reynolds PR, Bikman BT (2017) LPS from P. gingivalis negatively alters gingival cell mitochondrial bioenergetics. Int J Dent 2017:2697210.	LEAK OXPHOS ET	N NS ROX	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell
Cunha 2017 Int J Biol Macromol	2017	Cunha de Padua MM, Suter Correia Cadena SM, de Oliveira Petkowicz CL, Martinez GR, Rodrigues Noleto G (2017) Galactomannan from Schizolobium amazonicum seed and its sulfated derivatives impair metabolism in HepG2 cells. Int J Biol Macromol 101:64-473.	LEAK ROUTINE ET	ROX	Intact cells	Human	Liver
Joergensen 2017 Physiol Rep	2017	Jørgensen W, Rud KA, Mortensen OH, Frandsen L, Grunnet N, Quistorff B (2017) Your mitochondria are what you eat: a high-fat or a high-sucrose diet eliminates metabolic flexibility in isolated mitochondria from rat skeletal muscle. Physiol Rep 5. pii: e13207.	LEAK OXPHOS	F N NS	Isolated mitochondria	Rat	Skeletal muscle
Leo 2017 Front Zool	2017	Leo E, Kunz KL, Schmidt M, Storch D, Portner HO, Mark FC (2017) Mitochondrial acclimation potential to ocean acidification and warming of Polar cod (Boreogadus saida) and Atlantic cod (Gadus morhua). Front Zool 14:21.	LEAK OXPHOS ET	CIV NS ROX	Permeabilized tissue	Fishes	Heart
Chang 2017 J Biol Chem	2017	Chang JS, Ha K (2017) An unexpected role for the transcriptional coactivator isoform NT-PGC-1α in the regulation of mitochondrial respiration in brown adipocytes. J Biol Chem 292:9958-66.	LEAK ET ROUTINE	ROX	Intact cells	Mouse	Fat
Uzhachenko 2017 Aging (Albany NY)	2017	Uzhachenko R, Boyd K, Olivares-Villagomez D, Zhu Y, Goodwin JS, Rana T, Shanker A, Tan WJ, Bondar T, Medzhitov R, Ivanova AV (2017) Mitochondrial protein Fus1/Tusc2 in premature aging and age-related pathologies: critical roles of calcium and energy homeostasis. Aging (Albany NY) 9:627-49.	LEAK ET ROUTINE	ROX	Intact cells	Mouse	Kidney Endothelial;epithelial;mesothelial cell Fibroblast
Boutant 2017 EMBO J	2017	Boutant M, Kulkarni SS, Joffraud M, Ratajczak J, Valera-Alberni M, Combe R, Zorzano A, Cantó C (2017) Mfn2 is critical for brown adipose tissue thermogenic function. EMBO J 36:1543-58.	ROUTINE LEAK OXPHOS ET	ROX N S NS	Intact cells Homogenate Isolated mitochondria	Mouse	Fat Fibroblast
Schoenfeld 2017 Neurochem Int	2017	Schönfeld P, Reiser G (2017) Brain energy metabolism spurns fatty acids as fuel due to their inherent mitotoxicity and potential capacity to unleash neurodegeneration. Neurochem Int 109:68-77.	OXPHOS LEAK	F N	Isolated mitochondria	Rat	Nervous system Liver
Kane 2017 J Cell Mol Med	2017	Kane MS, Alban J, Desquiret-Dumas V, Gueguen N, Ishak L, Ferre M, Amati-Bonneau P, Procaccio V, Bonneau D, Lenaers G, Reynier P, Chevrollier A (2017) Autophagy controls the pathogenicity of OPA1 mutations in dominant optic atrophy. J Cell Mol Med 21:2284-97.	LEAK ET	Other combinations ROX	Intact cells	Human	Fibroblast
Lalia 2017 Aging (Albany NY)	2017	Lalia AZ, Dasari S, Robinson MM, Abid H, Morse DM, Klaus KA, Lanza IR (2017) Influence of omega-3 fatty acids on skeletal muscle protein metabolism and mitochondrial bioenergetics in older adults. Aging (Albany NY) 9:1096-1129.	OXPHOS LEAK ET	F N NS ROX S	Isolated mitochondria	Human	Skeletal muscle
Anderson 2017 Cell Metab	2017	Anderson KA, Huynh FK, Fisher-Wellman K, Stuart JD, Peterson BS, Douros JD, Wagner GR, Thompson JW, Madsen AS, Green MF, Sivley RM, Ilkayeva OR, Stevens RD, Backos DS, Capra JA, Olsen CA, Campbell JE, Muoio DM, Grimsrud PA, Hirschey MD (2017) SIRT4 is a lysine deacylase that controls leucine metabolism and insulin secretion. Cell Metab 25:838-55.	OXPHOS LEAK	F N NS Other combinations	Isolated mitochondria	Mouse	Heart Liver
Mitroshina 2017 Mod Technol Med	2017	Mitroshina ЕV, Abogessimengane BZ, Urazov МD, Hamraoui I, Mishchenko ТА, Astrakhanova ТА, Shchelchkova NА, Lapshin RD, Shishkina ТV, Belousova II, Mukhina IV, Vedunova МV (2017) Adaptive role of glial cell line-derived neurotrophic factor in cerebral ischemia. Mod Technol Med 9:68-76.	OXPHOS LEAK	N S	Isolated mitochondria	Mouse	Nervous system
Gerber 2017 Brain	2017	Gerber S, Charif M, Chevrollier A, Chaumette T, Angebault C, Kane MS, Paris A, Alban J, Quiles M, Delettre C, Bonneau D, Procaccio V, Amati-Bonneau P, Reynier P, Leruez S, Calmon R, Boddaert N, Funalot B, Rio M, Bouccara D, Meunier I, Sesaki H, Kaplan J, Hamel CP, Rozet JM, Lenaers G (2017) Mutations in DNM1L, as in OPA1, result indominant optic atrophy despite opposite effects on mitochondrial fusion and fission. Brain 140:2586-96.	LEAK OXPHOS ET	N S NS	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell Fibroblast
Scrima 2017 PLOS ONE	2017	Scrima R, Menga M, Pacelli C, Agriesti F, Cela O, Piccoli C, Cotoia A, De Gregorio A, Gefter JV, Cinnella G, Capitanio N (2017) Para-hydroxyphenylpyruvate inhibits the pro-inflammatory stimulation of macrophage preventing LPS-mediated nitro-oxidative unbalance and immunometabolic shift. PLOS ONE 12:e0188683.	LEAK ROUTINE ET	ROX	Intact cells	Human Mouse	Endothelial;epithelial;mesothelial cell Blood cells Fibroblast Macrophage-derived
Nogueira 2017 Free Radic Biol Med	2017	Nogueira NP, Saraiva FMS, Oliveira MP, Mendonca APM, Inacio JDF, Almeida-Amaral EE, Menna-Barreto RF, Laranja GAT, Lopes Torres EJ, Oliveira MF, Paes MC (2017) Heme modulates Trypanosoma cruzi bioenergetics inducing mitochondrial ROS production. Free Radic Biol Med 108:183-91.	LEAK ROUTINE OXPHOS ET	S	Intact organism Permeabilized cells	Protists
Boudoures 2017 Thesis	2017	Boudoures AL (2017) Mitochondrial damage accumulation in oocytes – a potential link between maternal obesity and increased cardiometabolic disease risk in offspring. PhD Thesis p179.	LEAK OXPHOS ET	F N NS	Permeabilized tissue	Mouse	Heart
Elmer 2017 US Patent	2017	Elmer E, Hansson MJ, Ehinger JK, Piel S, Moss S (2017) Succinate prodrugs for use in the treatment of lactic acidosis or drug-induced side-effects due to complex I-related impairment of mitochondrial oxidative phosphorylation. US Patent US20170100359 A1.	LEAK ROUTINE OXPHOS ET	S ROX	Intact cells	Human	Heart Blood cells Fibroblast Macrophage-derived Platelet
Darrell 2017 US Patent	2017	Neufer PD, Anderson EJ, Szeto HH (2017) Methods for preventing or treating insulin resistance. US Patent US20170100450 A1.	LEAK OXPHOS	F N S ROX	Permeabilized tissue	Human Rat	Skeletal muscle
Rouet 2017 US Patent	2017	Rouet P, Smih F (2017) ApoO for use in method for treating cancer and various pathophysiological situations. US Patent US20170035842 A1.	LEAK ET	ROX	Isolated mitochondria	Human Mouse	Heart Liver
Beresewicz 2017 PLoS One	2017	Beresewicz M, Boratynska-Jasinska A, Charzewski L, Kawalec M, Kabzinska D, Kochanski A, Krzysko KA, Zablocka B (2017) The effect of a novel c.820C>T (Arg274Trp) mutation in the mitofusin 2 gene on fibroblast metabolism and clinical manifestation in a patient. PLoS One 12:0169999.	LEAK ET ROUTINE		Intact cells	Human	Fibroblast Endothelial;epithelial;mesothelial cell
Dallon 2017 Biochem J	2017	Dallon BW, Parker BA, Hodson AE, Tippetts TS, Harrison ME, Appiah MMA, Witt JE, Gibbs JL, Gray HM, Sant TM, Bikman BT (2017) Insulin selectively reduces mitochondrial uncoupling in brown adipose tissue in mice. Biochem J 475:561-9.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle Fat
Galambo 2017 Thesis	2017	Galambo D (2017) The effect of cardiolipin on vascular smooth muscle cell dedifferentiation, function, and mitochondrial respiration. Master's Thesis p.90.	LEAK OXPHOS	F N CIV NS ROX	Permeabilized tissue	Mouse	Endothelial;epithelial;mesothelial cell
Lau 2017 Dissertation	2017	Lau G (2017) Adaptive variation of mitochondrial function in response to oxygen variability in intertidal sculpins (Cottidae, Actinopterygii). Dissertation p148.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Fishes	Nervous system
Cavalcanti-de-Albuquerque 2017 Mol Neurobiol	2017	Cavalcanti-de-Albuquerque JP, de Souza Ferreira E, de Carvalho DP, Galina A (2017) Mitochondria-bound hexokinase (mt-HK) activity differ in cortical and hypothalamic synaptosomes: differential role of mt-HK in H₂O₂ depuration. Mol Neurobiol 55:5889-5900.	LEAK OXPHOS	N S Gp ROX	Intact cells	Rat	Nervous system
Porplycia 2017 Am J Physiol Regul Integr Comp Physiol	2017	Porplycia D, Lau GY, McDonald J, Chen Z, Richards JG, Moyes CD (2017) Subfunctionalization of COX4 paralogs in fish. Am J Physiol Regul Integr Comp Physiol 312:R671-R680.	LEAK	CIV ROX	Isolated mitochondria	Fishes	Skeletal muscle
Victor 2017 Thesis	2017	Victor L (2017) Investigating the possible cytoprotective effects of melatonin isomer against simulated ischemic injury. Master's Thesis 76.	LEAK OXPHOS ET	N CIV NS ROX	Permeabilized cells	Rat	Fibroblast
Westerlund 2017 Pediatr Res	2017	Westerlund E, Marelsson SE, Ehinger JK, Sjövall F, Morota S, Åsander Frostner E, Oldfors A, Darin N, Lundgren J, Hansson MJ, Fellman V, Elmér E (2017) Oxygen consumption in platelets as an adjunct diagnostic method for pediatric mitochondrial disease. Pediatr Res 83:455-65.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Human	Platelet Blood cells
Bansal 2017 Environ Health Perspect	2017	Bansal A, Rashid C, Xin F, Li C, Polyak E, Duemler A, van der Meer T, Stefaniak M, Wajid S, Doliba N, Bartolomei MS, Simmons RA (2017) Sex- and dose-specific effects of maternal bisphenol A exposure on pancreatic islets of first- and second-generation adult mice offspring. Environ Health Perspect 125:097022.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Islet cell;pancreas;thymus
Sivertsson 2017 Am J Physiol Renal Physiol	2017	Sivertsson E, Friederich-Persson M, Öberg CM, Fasching A, Hansell P, Rippe B, Palm F (2017) Inhibition of mammalian target of rapamycin decreases intrarenal oxygen availability and alters glomerular permeability. Am J Physiol Renal Physiol 314:F864-F872.	LEAK OXPHOS	N	Isolated mitochondria	Rat	Kidney
Goedecke 2017 JMIR Res Protoc	2017	Goedecke JH, Mendham AE, Clamp L, Nono Nankam PA, Fortuin-de Smidt MC, Phiri L, Micklesfield LK, Keswell D, Woudberg NJ, Lecour S, Alhamud A, Kaba M, Lutomia FM, van Jaarsveld PJ, de Villiers A, Kahn SE, Chorell E, Hauksson J, Olsson T (2017) An exercise intervention to unravel the mechanisms underlying insulin resistance in a cohort of black South African women: Protocol for a randomized controlled trial. JMIR Res Protoc 03/10/2017:9098.	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle Fat
Lores-Arnaiz 2017 J Neurochem	2017	Lores-Arnaiz S, Karadayian AG, Gutnisky A, Rodríguez de Lores Arnaiz G (2017) The low affinity neurotensin receptor antagonist levocabastine impairs brain nitric oxide synthesis and mitochondrial function by independent mechanisms. J Neurochem 143:684-96.	LEAK OXPHOS ET	N NS		Rat	Nervous system
Cockova 2017 Thesis	2017	Čočková Z (2017) Modulation of RNA demethylase FTO function in SH-SY5Y cells: the effect on insulin signaling and mitochondrial respiration. Diploma Thesis p70.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells Isolated mitochondria	Human	Nervous system
Schreiber 2017 Cell Metab	2017	Schreiber R, Diwoky C, Schoiswohl G, Feiler U, Wongsiriroj N, Abdellatif M, Kolb D, Hoeks J, Kershaw EE, Sedej S, Schrauwen P, Haemmerle G, Zechner R (2017) Cold-induced thermogenesis depends on ATGL-mediated lipolysis in cardiac muscle, but not brown adipose tissue. Cell Metab 26:753-63.	LEAK	N Gp	Homogenate	Mouse	Fat
Fourcade 2017 Aging Cell	2017	Fourcade S, Morató L, Parameswaran J, Ruiz M, Ruiz-Cortés T, Jové M, Naudí A, Martínez-Redondo P, Dierssen M, Ferrer I, Villarroya F, Pamplona R, Vaquero A, Portero-Otín M, Pujol A (2017) Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance. Aging Cell 16:1404-13.	LEAK OXPHOS	N S NS ROX		Mouse
Huang 2017 Sci Rep	2017	Huang L, Zhang K, Guo Y, Huang F, Yang K, Chen L, Huang K, Zhang F, Long Q, Yang Q (2017) Honokiol protects against doxorubicin cardiotoxicity via improving mitochondrial function in mouse hearts. Sci Rep 7:11989.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse	Heart
Ho 2017 Thesis	2017	Ho DH (2017) The role of MLQ protein in structure and function of mammalian ATP synthase. Master's Thesis p84.	LEAK OXPHOS ET	N S CIV NS ROX	Intact cells Permeabilized cells	Human	Kidney
Hartmann 2017 Crit Care Med	2017	Hartmann C, Loconte M, Antonucci E, Holzhauser M, Hölle T, Katzsch D, Merz T, McCook O, Wachter U, Vogt JA, Hoffmann A, Wepler M, Gröger M, Matejovic M, Calzia E, Georgieff M, Asfar P, Radermacher P, Nussbaum BL (2017) Effects of hyperoxia during resuscitation from hemorrhagic shock in swine with preexisting coronary artery disease. Crit Care Med 45:e1270-9.	LEAK OXPHOS ET		Homogenate	Pig	Heart Liver Kidney
Dent 2017 Mol Metab	2017	Dent JR, Martins VF, Svensson K, LaBarge SA, Schlenk NC, Esparza MC, Buckner EH, Meyer GA, Hamilton DL, Schenk S, Philp A (2017) Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation. Mol Metab 6:1574-84.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Hals 2017 Physiol Rep	2017	Hals I, Ohki T, Singh R, Ma Z, Björklund A, Balasuriya C, Scholz H, Grill V (2017) Hyperoxia reduces insulin release and induces mitochondrial dysfunction with possible implications for hyperoxic treatment of neonates. Physiol Rep 5. pii: e13447.	LEAK OXPHOS ET	N	Permeabilized cells	Human Mouse	Islet cell;pancreas;thymus
Porter 2017 Adipocyte	2017	Porter C (2017) Quantification of UCP1 function in human brown adipose tissue. Adipocyte 6:167-74.	LEAK ROUTINE OXPHOS ET		Permeabilized tissue Isolated mitochondria Intact cells		Fat
Friederich 2017 Hum Mol Genet	2017	Friederich MW, Erdogan AJ, Coughlin CR 2nd, Elos MT, Jiang H, O'Rourke CP, Lovell MA, Wartchow E, Gowan K, Chatfield KC, Chick WS, Spector EB, Van Hove JLK, Riemer J (2017) Mutations in the accessory subunit NDUFB10 result in isolated complex I deficiency and illustrate the critical role of intermembrane space import for complex I holoenzyme assembly. Hum Mol Genet 26:702-16.	ROUTINE OXPHOS ET LEAK	N S CIV NS ROX	Permeabilized cells Intact cells	Human	Fibroblast
Fisar 2017 Indian J Biochem Biophys	2017	Fišar Z, Hroudová J, Namrata S, Macečková D, Kopřivová A (2017) Protocols for high-resolution respirometry experiments to test the activity of electron transfer system of pig brain mitochondria. Indian J Biochem Biophys 54:258-72.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Pig	Nervous system
Nemeth 2017 Thesis	2017	Németh B (2017) The effect of itaconic acid on mitochondrial substrate-level phosphorylation. PhD Thesis p84.	LEAK OXPHOS	S	Isolated mitochondria	Mouse	Liver
Martins 2017 Thesis	2017	Martins WC (2017) Estudo do efeito protetor da atorvastatina e dos eventos iniciais da neurotoxicidade induzida pelo peptídeo β-amilóide (Aβ1-40) em camundongos. Doctoral Thesis p85.	LEAK OXPHOS ET	N NS ROX	Homogenate	Mouse	Nervous system
Wen 2017 Antioxid Redox Signal	2017	Wen JJ, Porter C, Garg NJ. (2017) Inhibition of NFE2L2-Antioxidant Response Element Pathway by Mitochondrial Reactive Oxygen Species Contributes to Development of Cardiomyopathy and Left Ventricular Dysfunction in Chagas Disease. Antioxid Redox Signal. 27(9):550-566.	LEAK OXPHOS ET		Permeabilized tissue	Mouse	Heart
Phillips 2017 Cancer Res	2017	Phillips CM, Zatarain JR, Nicholls ME, Porter C, Widen SG, Thanki K, Johnson P, Jawad MU, Moyer MP, Randall JW, Hellmich JL, Maskey M, Qiu S, Wood TG, Druzhyna N, Szczesny B, Módis K1, Szabo C, Chao C, Hellmich MR. (2017) Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis.. Cancer Res. 77(21):5741-5754.	LEAK ROUTINE ET		Intact cells	Human	Endothelial;epithelial;mesothelial cell
Schaefer 2017 Thesis	2017	Schaefer P (2017) Metabolic imaging in Alzheimer´s disease using NADH autofluorescence. Dissertation p93.	LEAK ET ROUTINE	CIV ROX	Intact cells	Human	HEK Other cell lines
De Souza 2017 Thesis	2017	de Souza LF (2017) Modulação redox de peroxirredoxinas e a participação dos sistemas da GSH e da Trx na proteção/função celular. Tese (doutorado) p103.	LEAK ROUTINE ET		Intact cells	Human	Other cell lines
Da Silva 2017 Neurotox Res	2017	Da Silva JC, Amaral AU, Cecatto C, Wajner A, Dos Santos Godoy K, Ribeiro RT, de Mello Gonçalves A, Zanatta Â, da Rosa MS, Loureiro SO, Vargas CR, Leipnitz G, de Souza DOG, Wajner M (2017) α-Ketoadipic acid and α-aminoadipic acid cause disturbance of glutamatergic neurotransmission and induction of oxidative stress in vitro in brain of adolescent rats. Neurotox Res 32:276-90.	LEAK OXPHOS ET	N	Isolated mitochondria Homogenate	Rat	Nervous system
De Lourdes Jorge 2017 Transplant Proc	2017	de Lourdes Jorge G, Dos Reis Tártaro R, Fazzio Escanhoela CA, Boin IFSF (2017) Later evaluation of ischemia and reperfusion by the Pringle maneuver in Wistar rats, demonstrating that hepatic lesions can be reversible. Transplant Proc 49:898-901.	LEAK OXPHOS ET	N	Intact cells	Rat	Liver
Sansone 2017 Proc Natl Acad Sci U S A	2017	Sansone P, Savini C, Kurelac I, Chang Q, Amato LB, Strillacci A, Stepanova A, Iommarini L, Mastroleo C, Daly L, Galkin A, Thakur BK, Soplop N, Uryu K, Hoshino A, Norton L, Bonafé M, Cricca M, Gasparre G, Lyden D, Bromberg J (2017) Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer. Proc Natl Acad Sci U S A 114:E9066-75.	LEAK OXPHOS			Human
Cervoni 2017 J Exp Biol	2017	Cervoni MS, Cardoso-Júnior CAM, Craveiro G, Souza AO, Alberici LC, Hartfelder K (2017) Mitochondrial capacity, oxidative damage and hypoxia gene expression are associated with age-related division of labor in honey bee (Apis mellifera L.) workers. J Exp Biol 220:4035-46.	LEAK ROUTINE OXPHOS ET	N ROX	Intact cells
Warren 2017 Metabolism	2017	Warren JL, Bulur S, Ovalle F, Windham ST, Gower BA, Fisher G (2017) Effects of acute hyperinsulinemia on skeletal muscle mitochondrial function, reactive oxygen species production, and metabolism in premenopausal women. Metabolism 77:1-12.	LEAK OXPHOS	F N NS	Permeabilized tissue	Human	Skeletal muscle
Xu 2017 Diabetes	2017	Xu D, Xu S, Kyaw AMM, Lim YC, Chia SY, Chee Siang DT, Alvarez-Dominguez JR, Chen P, Leow MK, Sun L (2017) RNA binding protein Ybx2 regulates RNA stability during cold-induced brown fat activation. Diabetes 66:2987-3000.	LEAK OXPHOS ET	N ROX		Mouse	Skeletal muscle
Cunha-de 2017 Thesis	2017	Cunha-de Padua MM (2017) Mecanismos citotóxicos da galactomanana de sementes de Schizolobium amazonicum e seus complexos com oxovanádio em células de hepatocarcinoma humano (HepG2) e efeito do silenciamento da enzima glucose-6-fosfato isomerase (GPI) na sobrevivência de células de adenocarcinoma de cólon humano (LS174T). Doctoral Thesis p160.	LEAK ROUTINE OXPHOS ET	N NS ROX	Intact cells Permeabilized cells	Human	Liver Other cell lines
Chin 2017 US Patent	2017	Chin MT, Chien WM, Dinca A (2017) Methods for treating and preventing cardiomyopathy. US Patent WO2016094791A1.	LEAK OXPHOS ET	N CIV ROX	Homogenate	Mouse	Heart
Asseburg 2017 Thesis	2017	Asseburg H (2017) Untersuchungen zur nutritiven Prävention der Neurodegeneration – Wirkungen von Trauben- und Olivenpolyphenolen auf die mitochondriale und kognitive Dysfunktion bei der Gehirnalterung und Alzheimer-Erkrankung. Dissertation p296.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells Isolated mitochondria Intact cells	Mouse Rat	Nervous system Other cell lines
Nabeebaccus 2017 JCI Insight	2017	Nabeebaccus AA, Zoccarato A, Hafstad AD, Santos CX, Aasum E, Brewer AC, Zhang M, Beretta M, Yin X, West JA, Schröder K, Griffin JL, Eykyn TR, Abel ED, Mayr M, Shah AM (2017) Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation. JCI Insight 2:96184.	LEAK ET	F N	Isolated mitochondria	Mouse	Heart
Rontoyanni 2017 Shock	2017	Rontoyanni VG, Malagaris I, Herndon DN, Rivas E, Capek KD, Delgadillo AD, Bhattarai N, Elizondo A, Voigt CD, Finnerty CC, Suman OE, Porter C (2017) Skeletal muscle mitochondrial function is determined by burn severity, sex and sepsis, and is associated with glucose metabolism and functional capacity in burned children. Shock 50:141-48.	LEAK OXPHOS	F N NS	Permeabilized tissue	Human	Skeletal muscle
Pamenter 2017 J Exp Biol	2017	Pamenter ME, Lau GY, Richards JG, Milsom WK (2017) Naked mole rat brain mitochondria electron transport system flux and H⁺ leak are reduced during acute hypoxia. J Exp Biol 221.	LEAK OXPHOS ET	N S CIV	Permeabilized cells	Other mammals	Nervous system
Cardinale 2017 Front Physiol	2017	Cardinale DA, Lilja M, Mandić M, Gustafsson T, Larsen FJ, Lundberg TR (2017) Resistance training with co-ingestion of anti-inflammatory drugs attenuates mitochondrial function. Front Physiol 8:1074.	LEAK OXPHOS ET	F N NS	Permeabilized tissue	Human	Skeletal muscle
Selwood 2017 US Patent	2017	Selwood DL, Baker D, Szabadkai G, Duchen MR, Hill JM, Warne JND (2017) Quinolium conjugates of cyclosporin. US Patent US20170349632 A1.	LEAK OXPHOS ET	N ROX	Isolated mitochondria	Mouse	Liver
Ma 2017 Int J Cancer	2017	Ma L, Fu Q, Xu B, Zhou H, Gao J, Shao X, Xiong J, Gu Q, Wen S, Li F, Shen L, Chen G, Fang H, Lyu J (2017) Breast cancer-associated mitochondrial DNA haplogroup promotes neoplastic growth via ROS-mediated AKT activation. Int J Cancer 142:1786-96.	LEAK ROUTINE ET		Intact cells	Human
Comelli 2017 J Bioenerg Biomembr	2017	Comelli M, Pretis I, Buso A, Mavelli I (2017) Mitochondrial energy metabolism and signalling in human glioblastoma cell lines with different PTEN gene status. J Bioenerg Biomembr 50:33-52.	LEAK ROUTINE OXPHOS ET	N Gp CIV NS ROX	Intact cells Permeabilized cells	Human	Nervous system
Koning 2017 J Cereb Blood Flow Metab	2017	Koning G, Leverin AL, Nair S, Schwendimann L, Ek J, Carlsson Y, Gressens P, Thornton C, Wang X, Mallard C, Hagberg H (2017) Magnesium induces preconditioning of the neonatal brain via profound mitochondrial protection. J Cereb Blood Flow Metab 39:1038-55.	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Rat
Wetzel 2017 Thesis	2017	Wetzel MD (2017) Mechanism of metformin action in dermal fibroblasts. PhD Thesis 125.	LEAK OXPHOS	F N NS ROX	Intact cells	Human	Fibroblast
Thomsen 2017 Neurobiol Aging	2017	Thomsen K, Yokota T, Hasan-Olive MM, Sherazi N, Fakouri NB, Desler C, Regnell CE, Larsen S, Rasmussen LJ, Dela F, Bergersen LH, Lauritzen M (2017) Initial brain aging: heterogeneity of mitochondrial size is associated with decline in complex I-linked respiration in cortex and hippocampus. Neurobiol Aging 61:215-24.	LEAK OXPHOS	N NS ROX		Mouse	Nervous system
Sivitz 2017 Neuromethods	2017	Sivitz WI (2017) Techniques to investigate bioenergetics of mitochondria. In: Strack S, Usachev Y (eds) Techniques to investigate mitochondrial function in neurons. Neuromethods 123:67-94. Humana Press, New York. https://doi.org/10.1007/978-1-4939-6890-9_4	LEAK OXPHOS ET	F N S	Isolated mitochondria Intact cells
Scheede-Bergdahl 2017 Can J Physiol Pharmacol	2017	Scheede-Bergdahl C, Bergdahl A (2017) Adaptation of mitochondrial expression and ATP production in dedifferentiating vascular smooth muscle cells. Can J Physiol Pharmacol 95:1473-9.	LEAK OXPHOS	F N CIV NS ROX	Permeabilized tissue	Mouse	Endothelial;epithelial;mesothelial cell
Tueller 2017 Biochem Biophys Res Commun	2017	Tueller DJ, Harley JS, Hancock CR (2017) Effects of curcumin and ursolic acid on the mitochondrial coupling efficiency and hydrogen peroxide emission of intact skeletal myoblasts. Biochem Biophys Res Commun 492:368-72.	LEAK ROUTINE OXPHOS	F N NS ROX	Permeabilized cells Intact cells		Skeletal muscle
Stepanova 2017 J Cereb Blood Flow Metab	2017	Stepanova A, Kahl A, Konrad C, Ten V, Starkov AS, Galkin A (2017) Reverse electron transfer results in a loss of flavin from mitochondrial complex I: Potential mechanism for brain ischemia-reperfusion injury. J Cereb Blood Flow Metab 37:3649-58.	OXPHOS ET LEAK	N NS ROX	Isolated mitochondria	Mouse	Nervous system
Lou 2017 Physiol Rep	2017	Lou PH, Lucchinetti E, Scott KY, Huang Y, Gandhi M, Hersberger M, Clanachan AS, Lemieux H, Zaugg M (2017) Alterations in fatty acid metabolism and sirtuin signaling characterize early type-2 diabetic hearts of fructose-fed rats. Physiol Rep 5 pii: e13388.	LEAK OXPHOS	F N CIV NS		Rat	Heart
Park 2017 Metab Brain Dis	2017	Park HS, Cho HS, Kim TW (2017) Physical exercise promotes memory capability by enhancing hippocampal mitochondrial functions and inhibiting apoptosis in obesity-induced insulin resistance by high fat diet. Metab Brain Dis 33:283-92.	OXPHOS LEAK	N NS	Permeabilized tissue	Mouse	Nervous system
Shen 2017 Thesis	2017	Shen NY (2017) Characterizing protein arginine methyltransferase expression, localization, and function during myogenesis. Master's Thesis p106.	LEAK OXPHOS	N NS	Permeabilized cells	Mouse	Skeletal muscle
Perks 2017 Sci Adv	2017	Perks KL, Ferreira N, Richman TR, Ermer JA, Kuznetsova I, Shearwood AJ, Lee RG, Viola HM, Johnstone VPA, Matthews V, Hool LC, Rackham O, Filipovska A (2017) Adult-onset obesity is triggered by impaired mitochondrial gene expression. Sci Adv 3:e1700677.	LEAK OXPHOS ET	N NS	Isolated mitochondria	Mouse	Heart Liver
Zhou 2017 Oxid Med Cell Longev	2017	Zhou H, Nie K, Qiu R, Xiong J, Shao X, Wang B, Shen L, Lyu J, Fang H (2017) Generation and bioenergetic profiles of cybrids with east Asian mtDNA haplogroups. Oxid Med Cell Longev 2017:1062314.	LEAK ROUTINE		Intact cells	Human
De Velasco 2017 Br J Nutr	2017	de Velasco PC, Chicaybam G, Ramos-Filho DM, Dos Santos RMAR, Mairink C, Sardinha FLC, El-Bacha T, Galina A, Tavares-do-Carmo MDG (2017) Maternal intake of trans-unsaturated or interesterified fatty acids during pregnancy and lactation modifies mitochondrial bioenergetics in the liver of adult offspring in mice. Br J Nutr 118:41-52.	LEAK OXPHOS ET	N NS ROX	Isolated mitochondria	Mouse	Liver
Yeh 2017 Thesis	2017	Yeh A (2017) Modulation of mitochondrial function as an indicator for sublethal effects of contaminants of emerging concern. Dissertation p117.	LEAK OXPHOS ET	N CIV NS ROX	Permeabilized cells Permeabilized tissue	Human Fishes	Liver
Wu 2017 Sci Rep	2017	Wu LH, Chang SC, Fu TC, Huang CH, Wang JS (2017) High-intensity interval training improves mitochondrial function and suppresses thrombin generation in platelets undergoing hypoxic stress. Sci Rep 7:4191.	LEAK OXPHOS ET ROUTINE	N NS ROX CIV	Permeabilized cells Intact cells	Human	Blood cells Platelet
Yu 2017 Free Radic Biol Med	2017	Yu Y, Wang L, Delguste F, Durand A, Guilbaud A, Rousselin C, Schmidt AM, Tessier F, Boulanger E, Neviere R (2017) Advanced glycation end products receptor RAGE controls myocardial dysfunction and oxidative stress in high-fat fed mice by sustaining mitochondrial dynamics and autophagy-lysosome pathway. Free Radic Biol Med 112:397-410.	LEAK OXPHOS	F N CIV ROX	Permeabilized tissue	Mouse	Heart
Pfeiffer 2017 Free Radic Biol Med	2017	Pfeiffer A, Schneider J, Bueno D, Dolga A, Voss TD, Lewerenz J, Wüllner V, Methner A (2017) Bcl-xL knockout attenuates mitochondrial respiration and causes oxidative stress that is compensated by pentose phosphate pathway activity. Free Radic Biol Med 112:350-9.	LEAK ROUTINE OXPHOS ET	N NS ROX	Permeabilized cells	Mouse	Fibroblast
Permer 2017 Bachelor Thesis	2017	Permer M (2017) Respirometrische Charakterisierung kryopräservierter HEK 239T Zellen. Bachelor Thesis 1-56.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS ROX	Permeabilized cells Intact cells	Human	Other cell lines HEK
Bal 2017 J Biol Chem	2017	Bal NC, Singh S, Reis FCG, Maurya SK, Pani S, Rowland LA, Periasamy M (2017) Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice. J Biol Chem 292:16616-25.	LEAK OXPHOS	N NS	Permeabilized tissue	Mouse	Skeletal muscle Fat
Michalak 2017 Oxid Med Cell Longev	2017	Michalak S, Florczak-Wyspiańska J, Rybacka-Mossakowska J, Ambrosius W, Osztynowicz K, Baszczuk A, Kozubski W, Wysocka E (2017) Mitochondrial respiration in intact peripheral blood mononuclear cells and sirtuin 3 activity in patients with movement disorders. Oxid Med Cell Longev 2017:9703574.	LEAK ROUTINE ET	ROX	Intact cells		Blood cells
Trewin 2017 PLOS ONE	2017	Trewin AJ, Levinger I, Parker L, Shaw CS, Serpiello FR, Anderson MJ, McConell GK, Hare DL, Stepto NK (2017) Acute exercise alters skeletal muscle mitochondrial respiration and H₂O₂ emission in response to hyperinsulinemic-euglycemic clamp in middle-aged obese men. PLOS ONE 12:e0188421.	LEAK OXPHOS ET	F N NS ROX	Permeabilized tissue	Human	Skeletal muscle
Xiong 2017 J Am Heart Assoc	2017	Xiong S, Wang B, Lin S, Zhang H, Li Y, Wei X, Cui Y, Wei X, Lu Z, Gao P, Li L, Zhao Z, Liu D, Zhu Z (2017) Activation of transient receptor potential melastatin subtype 8 attenuates cold-induced hypertension through ameliorating vascular mitochondrial dysfunction. J Am Heart Assoc 6. pii: e005495.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Mouse	Endothelial;epithelial;mesothelial cell
Rohde 2017 Cell Death Differ	2017	Rohde K, Kleinesudeik L, Roesler S, Löwe O, Heidler J, Schröder K, Wittig I, Dröse S, Fulda S (2017) A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis. Cell Death Differ 24:83-97.	LEAK ROUTINE ET	CIV ROX	Intact cells	Mouse	Fibroblast
Han 2017 Invest Ophthalmol Vis Sci	2017	Han WH, Gotzmann J, Kuny S, Huang H, Chan CB, Lemieux H, Sauvé Y (2017) Modifications in retinal mitochondrial respiration precede type 2 diabetes and protracted microvascular retinopathy. Invest Ophthalmol Vis Sci 58:3826-39.	LEAK OXPHOS	N S CIV NS ROX	Homogenate	Rat	Nervous system
Carraro 2017 Mol Cell Endocrinol	2017	Carraro RS, Souza GF, Solon C, Razolli DS, Chausse B, Barbizan R, Victorio SC, Velloso LA (2017) Hypothalamic mitochondrial abnormalities occur downstream of inflammation in diet-induced obesity. Mol Cell Endocrinol 460:238-45.	LEAK OXPHOS	N ROX	Permeabilized tissue	Mouse	Nervous system
Schmidt 2017 J Vasc Surg	2017	Schmidt CA, Ryan TE, Lin CT, Inigo MM, Green TD, Brault JJ, Spangenburg EE, McClung JM (2017) Diminished force production and mitochondrial respiratory deficits are strain-dependent myopathies of subacute limb ischemia. J Vasc Surg 65:1504-1514.	OXPHOS ET LEAK	N S CIV NS	Permeabilized tissue Isolated mitochondria	Mouse	Skeletal muscle
Asping 2017 Eur J Clin Pharmacol	2017	Asping M, Stride N, Søgaard D, Dohlmann TL, Helge JW, Dela F, Larsen S (2017) The effects of 2 weeks of statin treatment on mitochondrial respiratory capacity in middle-aged males: the LIFESTAT study. Eur J Clin Pharmacol 73:679-87.	LEAK ET	F N S CIV NS ROX	Permeabilized tissue	Human
Zholobenko 2017 PLOS ONE	2017	Zholobenko AV, Mouithys-Mickalad A, Dostal Z, Serteyn D, Modriansky M (2017) On the causes and consequences of the uncoupler-like effects of quercetin and dehydrosilybin in H9c2 cells. PLOS ONE 12:e0185691.	LEAK OXPHOS ET ROUTINE	F N S NS ROX	Permeabilized cells Intact cells	Rat	Heart
Lang 2017 Aging (Albany NY)	2017	Lang A, Anand R, Altinoluk-Hambüchen S, Ezzahoini H, Stefanski A, Iram A, Bergmann L, Urbach J, Böhler P, Hänsel J, Franke M, Stühler K, Krutmann J, Scheller J, Stork B, Reichert AS, Piekorz RP (2017) SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy. Aging (Albany NY) 9:2163-89.	LEAK ET ROUTINE	ROX	Intact cells	Human	Kidney HEK
Warren 2017 J Nutr Metab	2017	Warren JL, Gower BA, Hunter GR, Windham ST, Moellering DR, Fisher G (2017) Associations of mitochondrial fatty acid oxidation with body fat in premenopausal women. J Nutr Metab 2017:7832057.	LEAK OXPHOS	F N	Permeabilized tissue	Human	Skeletal muscle
Ruiz 2017 Brain Pathol	2017	Ruiz M, Bégou M, Launay N, Ranea-Robles P, Bianchi P, López-Erauskin J, Morató L, Guilera C, Petit B, Vaurs-Barriere C, Guéret-Gonthier C, Bonnet-Dupeyron MN, Fourcade S, Auwerx J, Boespflug-Tanguy O, Pujol A (2017) Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease. Brain Pathol 28:611-30.	LEAK ROUTINE ET	ROX	Intact cells	Human Mouse	Nervous system Fibroblast
White 2017 Sci Rep	2017	White SH, Warren LK, Li C, Wohlgemuth SE (2017) Submaximal exercise training improves mitochondrial efficiency in the gluteus medius but not in the triceps brachii of young equine athletes. Sci Rep 7:14389.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Horse	Skeletal muscle
Favero 2017 Thesis	2017	Favero BC (2017) Efeitos da leucina sobre a via da mTOR e da miostatina em cultura celular de miotúbulos. Dissertation p55.	LEAK ROUTINE ET			Mouse	Skeletal muscle
Mueller 2017 Orphanet J Rare Dis	2017	Mueller SM, Gehrig SM, Petersen JA, Frese S, Mihaylova V, Ligon-Auer M, Khmara N, Nuoffer JM, Schaller A, Lundby C, Toigo M, Jung HH (2017) Effects of endurance training on skeletal muscle mitochondrial function in Huntington disease patients. Orphanet J Rare Dis 12:184.	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
JanssenDuijghuijsen 2017 Front Physiol	2017	JanssenDuijghuijsen LM, Grefte S, de Boer VCJ, Zeper L, van Dartel DAM, van der Stelt I, Bekkenkamp-Grovenstein M, van Norren K, Wichers HJ, Keijer J (2017) Mitochondrial ATP depletion disrupts Caco-2 monolayer integrity and internalizes Claudin 7. Front Physiol 8:794.	LEAK ROUTINE ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell Other cell lines
Dixit 2017 Free Radic Biol Med	2017	Dixit S, Fessel JP, Harrison FE (2017) Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer's disease and a novel protective role for ascorbate. Free Radic Biol Med 112:515-23.	LEAK OXPHOS	N	Isolated mitochondria	Mouse	Heart
Santos 2017 Sci Rep	2017	Santos GC, Zeidler JD, Pérez-Valencia JA, Sant'Anna-Silva ACB, Da Poian AT, El-Bacha T, Almeida FCL (2017) Metabolomic analysis reveals vitamin D-induced decrease in polyol pathway and subtle modulation of glycolysis in HEK293T cells. Sci Rep 7:9510.	LEAK ET	ROX		Human	Kidney HEK
Bowen 2017 J Am Heart Assoc	2017	Bowen TS, Brauer D, Rolim NPL, Bækkerud FH, Kricke A, Ormbostad Berre AM, Fischer T, Linke A, da Silva GJ, Wisloff U, Adams V (2017) Exercise training reveals inflexibility of the diaphragm in an animal model of patients with obesity-driven heart failure with a preserved ejection fraction. J Am Heart Assoc 6. pii: e006416.	LEAK OXPHOS	N NS	Permeabilized tissue	Rat	Skeletal muscle
Welker 2017 Thesis	2017	Welker L (2017) Metabolic and morphologic shifts in Neuro2a cells cultured in galactose medium. Master's Thesis p26.	LEAK ROUTINE ET		Intact cells	Mouse
Lopez 2017 Sci Rep	2017	Lopez Sanchez MIG, Waugh HS, Tsatsanis A, Wong BX, Crowston JG, Duce JA, Trounce IA (2017) Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta. Sci Rep 7:9835.	LEAK OXPHOS ET	N NS ROX	Permeabilized cells	Human
Xu 2017 J Hum Genet	2017	Xu B, Li X, Du M, Zhou C, Fang H, Lyu J, Yang Y (2017) Novel mutation of ND4 gene identified by targeted next-generation sequencing in patient with Leigh syndrome. J Hum Genet 62:291-7.	LEAK ROUTINE		Intact cells	Human	Blood cells Platelet
Dechandt 2017 J Bioenerg Biomembr	2017	Dechandt CRP, Zuccolotto-Dos-Reis FH, Teodoro BG, Fernandes AMAP, Eberlin MN, Kettelhut IC, Curti C, Alberici LC (2017) Triacsin C reduces lipid droplet formation and induces mitochondrial biogenesis in primary rat hepatocytes. J Bioenerg Biomembr 49:399-411.	LEAK ROUTINE ET	F N ROX	Permeabilized cells Intact cells	Rat	Liver
Kanaan 2017 Redox Biol	2017	Kanaan GN, Ichim B, Gharibeh L, Maharsy W, Patten DA, Xuan JY, Reunov A, Marshall P, Veinot J, Menzies K, Nemer M, Harper ME (2017) Glutaredoxin-2 controls cardiac mitochondrial dynamics and energetics in mice, and protects against human cardiac pathologies. Redox Biol 14:509-21.	LEAK OXPHOS	N CIV NS ROX	Permeabilized tissue	Mouse	Heart
Wollenman 2017 PLOS ONE	2017	Wollenman LC, Vander Ploeg MR, Miller ML, Zhang Y, Bazil JN (2017) The effect of respiration buffer composition on mitochondrial metabolism and function. PLOS ONE 12:e0187523.	LEAK OXPHOS ET	F N S NS	Isolated mitochondria	Guinea pig	Heart Liver
Min 2017 Skelet Muscle	2017	Min K, Lawan A, Bennett AM (2017) Loss of MKP-5 promotes myofiber survival by activating STAT3/Bcl-2 signaling during regenerative myogenesis. Skelet Muscle 7:21.	LEAK OXPHOS	N	Permeabilized tissue	Mouse	Skeletal muscle
MiPNet21.14 Reference sample HRR	2016-10-19	Development of a reference sample for HRR.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Intact cells Permeabilized cells	Human	HEK
MiPNet21.13 Comparison mt-preparations	2016-10-18	O2k-Protocols: Mitochondrial preparations for HRR.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells Homogenate Isolated mitochondria	Mouse	Heart
MiPNet21.12 Comparison mt respiration media	2016-10-18	O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Intact cells Permeabilized cells	Human	HEK
MiPNet08.09 CellRespiration	2016-08-11	High-resolution respirometry and coupling-control protocol with living cells: ROUTINE, LEAK, ET-pathway, ROX.	LEAK ROUTINE ET		Intact cells	Human	Blood cells Lymphocyte
MiPNet10.04 CellRespiration	2016-08-08	An experiment with high-resolution respirometry: coupling control in cell respiration.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Blood cells
MiPNet21.07 MitoFit DatLab PT	2016-07-20	MitoFit DatLab proficiency test.	LEAK OXPHOS ET	F N S Gp CIV Other combinations ROX	Permeabilized cells	Human
Assmann 2016 Cell Rep	2016	Assmann N, Dettmer K, Simbuerger JM, Broeker C, Nuernberger N, Renner K, Courtneidge H, Klootwijk ED, Duerkop A, Hall A, Kleta R, Oefner PJ, Reichold M, Reinders J (2016) Renal fanconi syndrome is caused by a mistargeting-based mitochondriopathy. Cell Rep 15:1423-9.	LEAK OXPHOS ET	F N S NS Other combinations ROX	Intact cells	Pig	Kidney Other cell lines
Wijermars 2016 Am J Transplant	2016	Wijermars LG, Schaapherder AF, Kostidis S, Wüst RC, Lindeman JH (2016) Succinate accumulation and ischemia reperfusion injury: of mice but not men - A study in renal ischemia reperfusion. Am J Transplant 16:2741-6.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human Pig Mouse Rat	Kidney
Heinonen 2016 Hum Exp Toxicol	2016	Heinonen JA, Schramko AA, Skrifvars MB, Litonius E, Backman JT, Mervaala E, Rosenberg PH (2016) The effects of intravenous lipid emulsion on hemodynamic recovery and myocardial cell mitochondrial function after bupivacaine toxicity in anesthetized pigs. Hum Exp Toxicol 36:365-75.	LEAK OXPHOS ET	F N S NS	Homogenate	Pig	Heart
Ryan 2016 J Mol Cell Cardiol	2016	Ryan TE, Schmidt CA, Alleman RJ, Tsang AM, Green TD, Neufer PD, Brown DA, McClung JM (2016) Mitochondrial therapy improves limb perfusion and myopathy following hindlimb ischemia. J Mol Cell Cardiol 97:191-6.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Skeletal muscle
Bai 2016 PLOS ONE	2016	Bai F, Fink BD, Yu L, Sivitz WI (2016) Voltage-dependent regulation of Complex II energized mitochondrial oxygen flux. PLOS ONE 11:e0154982.	LEAK OXPHOS ET	N S CIV NS	Isolated mitochondria	Mouse	Heart Skeletal muscle Nervous system Liver
Wuest 2016 Cardiovasc Res	2016	Wüst RC, de Vries HJ, Wintjes LT, Rodenburg RJ, Niessen HW, Stienen GJ (2016) Mitochondrial complex I dysfunction and altered NAD(P)H kinetics in rat myocardium in cardiac right ventricular hypertrophy and failure. Cardiovasc Res 111:362-72.	LEAK OXPHOS	N S	Intact cells Permeabilized tissue	Rat	Heart
Barison 2016 J Bioenerg Biomembr	2016	Barisón MJ, Damasceno FS, Mantilla BS, Silber AM (2016) The active transport of histidine and its role in ATP production in Trypanosoma cruzi. J Bioenerg Biomembr 48:437-49.	LEAK ROUTINE ET		Intact cells	Protists
Zhunussova 2016 PLOS ONE	2016	Zhunussova A, Vitol EA, Polyak B, Tuleukhanov S, Brooks AD, Sensenig R, Friedman G, Orynbayeva Z (2016) Mitochondria-mediated anticancer effects of non-thermal atmospheric plasma. PLOS ONE 11:e0156818.	LEAK ROUTINE ET		Intact cells	Human	Genital Other cell lines
Granata 2016 FASEB J	2016	Granata C, Oliveira RS, Little JP, Renner K, Bishop DJ (2016) Mitochondrial adaptations to high-volume exercise training are rapidly reversed after a reduction in training volume in human skeletal muscle. FASEB J 30:3413-23. https://doi.org/10.1096/fj.201500100R	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Morton 2016 Nat Med	2016	Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MT, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S (2016) Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. Nat Med 22:771-9.	LEAK OXPHOS	N S	Isolated mitochondria	Mouse	Liver
Milerova 2016 Mol Cell Biochem	2016	Milerová M, Drahota Z, Chytilová A, Tauchmannová K, Houštěk J, Ošťádal B (2016) Sex difference in the sensitivity of cardiac mitochondrial permeability transition pore to calcium load. Mol Cell Biochem 412:147-54.	LEAK OXPHOS	N NS	Isolated mitochondria	Rat	Heart
Herbst 2016 Appl Physiol Nutr Metab	2016	Herbst EA, Holloway GP (2016) Exercise increases mitochondrial glutamate oxidation in the mouse cerebral cortex. Appl Physiol Nutr Metab 41:799-801.	LEAK OXPHOS	N	Permeabilized tissue	Mouse	Nervous system
Cecatto 2016 Thesis	2016	Cecatto C (2016) Efeitos de acidos graxos hidroxilados de cadeia longa acumulados nas deficiencias da 3-hidroxiacil CoA desidrogenase de cadeia longa e da proteina trifunctional mitocondrial sobre a homeostase energetica mitochondrial nos musculos cardiaco e esqueletico de ratos jovens. Dissertation p103.	LEAK OXPHOS ET	N S	Permeabilized tissue Isolated mitochondria	Rat	Heart Skeletal muscle
Cecatto 2016 Toxicol In Vitro	2016	Cecatto C, Godoy KD, da Silva JC, Amaral AU, Wajner M (2016) Disturbance of mitochondrial functions provoked by the major long-chain 3-hydroxylated fatty acids accumulating in MTP and LCHAD deficiencies in skeletal muscle. Toxicol In Vitro 36:1-9.	LEAK OXPHOS ET	N	Permeabilized tissue Isolated mitochondria	Rat	Skeletal muscle
Sheremet 2016 Biochemistry (Moscow)	2016	Sheremet NL, Nevinitsyna TA, Zhorzholadze NV, Ronzina IA, Itkis YS, Krylova TD, Tsygankova PG, Malakhova VA, Zakharova EY, Tokarchuk AV, Panteleeva AA, Karger EM, Lyamzaev KG, Avetisov SE (2016) Previously unclassified mutation of mtDNA m.3472T>C: evidence of pathogenicity in Leber’s hereditary optic neuropathy. Biochemistry (Moscow) BM16-078.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell Fibroblast Platelet
Reis 2016 Aging (Albany NY)	2016	Reis FC, Branquinho JL, Brandão BB, Guerra BA, Silva ID, Frontini A, Thomou T, Sartini L, Cinti S, Kahn CR, Festuccia WT, Kowaltowski AJ, Mori MA (2016) Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice. Aging (Albany NY) 8:1201-22.	LEAK	N S ROX	Permeabilized cells	Mouse	Fat
Du 2016 Aquat Toxicol	2016	Du X, Crawford DL, Nacci DE, Oleksiak MF (2016) Heritable oxidative phosphorylation differences in a pollutant resistant Fundulus heteroclitus population. Aquat Toxicol 177:44-50.	LEAK OXPHOS ET	N S CIV Other combinations ROX	Permeabilized cells	Fishes	Liver
Kontro 2016 Thesis	2016	Kontro H (2016) Mitochondrial function and sirtuin expression in hippocampus of young and old high and low-capacity runner rats. Master's Thesis p35.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Nervous system
Iglesias-Gonzalez 2016 Mol Neurobiol	2016	Iglesias-González J, Sánchez-Iglesias S, Beiras-Iglesias A, Méndez-Álvarez E, Soto-Otero R (2016) Effects of aluminium on rat brain mitochondria bioenergetics: an in vitro and in vivo study. Mol Neurobiol 54:563-70.	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Rat	Nervous system
Bratic 2016 PLoS Genet	2016	Bratic A, Clemente P, Calvo-Garrido J, Maffezzini C, Felser A, Wibom R, Wedell A, Freyer C, Wredenberg A (2016) Mitochondrial polyadenylation is a one-step process required for mRNA integrity and tRNA maturation. PLoS Genet 12:e1006028.	LEAK OXPHOS ET	N CIV NS	Permeabilized tissue	Drosophila
Rohlenova 2016 Antioxid Redox Signal	2016	Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork-Geleta A, Blecha J, Endaya B, Werner L, Cerny J, Zobalova R, Goodwin J, Spacek T, Alisadeh E, Yan B, Nguyen M, Vondrusova M, Sobol M, Jezek P, Hozak P, Truksa J, Rohlena J, Dong L, Neuzil J (2016) Selective disruption of respiratory supercomplexes as a new strategy to suppress Her2^high breast cancer. Antioxid Redox Signal 26:84-103.	LEAK ROUTINE ET	N S Other combinations	Permeabilized cells Homogenate	Human Mouse	Liver Genital Other cell lines
Amaral 2016 Biochim Biophys Acta	2016	Amaral AU, Cecatto C, da Silva JC, Wajner A, Godoy KD, Ribeiro RT, Wajner M (2016) cis-4-Decenoic and decanoic acids impair mitochondrial energy, redox and Ca²⁺ homeostasis and induce mitochondrial permeability transition pore opening in rat brain and liver: Possible implications for the pathogenesis of MCAD deficiency. Biochim Biophys Acta 1857:1363-72.	LEAK OXPHOS ET	N	Isolated mitochondria	Rat	Nervous system Liver
Uecal 2016 J Neurotrauma	2016	Üçal M, Kraitsy K, Weidinger A, Paier-Pourani J, Patz S, Fink B, Molcanyi M, Schäfer U (2016) Comprehensive profiling of modulation of nitric oxide levels and mitochondrial activity in the injured brain: an experimental study based on the fluid percussion injury model in rats. J Neurotrauma 34:475-86.	LEAK OXPHOS	N S	Homogenate	Rat	Nervous system
Seiferling 2016 EMBO Rep	2016	Seiferling D, Szczepanowska K, Becker C, Senft K, Hermans S, Maiti P, König T, Kukat A, Trifunovic A (2016) Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt. EMBO Rep 17:953-64.	LEAK OXPHOS ET	N NS	Isolated mitochondria	Mouse	Heart
Radovic 2016 Diabetologia	2016	Radović B, Vujić N, Leopold C, Schlager S, Goeritzer M, Patankar JV, Korbelius M, Kolb D, Reindl J, Wegscheider M, Tomin T, Birner-Gruenberger R, Schittmayer M, Groschner L, Magnes C, Diwoky C, Frank S, Steyrer E, Du H, Graier WF, Madl T, Kratky D (2016) Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice. Diabetologia 59:1743-52.	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Mouse	Liver
Scrima 2016 Biochim Biophys Acta	2016	Scrima R, Cela O, Merla G, Augello B, Rubino R, Quarato G, Fugetto S, Menga M, Fuhr L, Relógio A, Piccoli C, Mazzoccoli G, Capitanio N (2016) Clock-genes and mitochondrial respiratory activity: Evidence of a reciprocal interplay. Biochim Biophys Acta 1857:1344-51.	LEAK ROUTINE ET	ROX	Intact cells	Human	Liver Endothelial;epithelial;mesothelial cell Other cell lines Fibroblast
Munro 2016 Free Radic Biol Med	2016	Munro D, Banh S, Sotiri E, Tamanna N, Treberg JR (2016) The thioredoxin and glutathione-dependent H₂O₂ consumption pathways in muscle mitochondria: Involvement in H₂O₂ metabolism and consequence to H₂O₂ efflux assays. Free Radic Biol Med 96:334-46.	LEAK OXPHOS	N S	Isolated mitochondria	Rat	Skeletal muscle
Holandino 2016 Bioelectrochemistry	2016	Holandino C, Teixeira CA, de Oliveira FA, Barbosa GM, Siqueira CM, Messeder DJ, de Aguiar FS, da Veiga VF, Girard-Dias W, Miranda K, Galina A, Capella MA, Morales MM (2016) Direct electric current treatment modifies mitochondrial function and lipid body content in the A549 cancer cell line. Bioelectrochemistry 111:83-92.	LEAK ROUTINE ET	ROX	Intact cells	Human	Lung;gill Other cell lines
Peyta 2016 Biochim Biophys Acta	2016	Peyta L, Jarnouen K, Pinault M, Guimaraes C, Pais de Barros JP, Chevalier S, Dumas JF, Maillot F, Hatch GM, Loyer P, Servais S (2016) Reduced cardiolipin content decreases respiratory chain capacities and increases ATP synthesis yield in the human HepaRG cells. Biochim Biophys Acta 1857:443-53.	LEAK OXPHOS ET	N CIV NS ROX	Permeabilized cells	Human	Liver Other cell lines
Davuluri 2016 Proc Natl Acad Sci U S A	2016	Davuluri G, Song P, Liu Z, Wald D, Sakaguchi TF, Green MR, Devireddy L (2016) Inactivation of 3-hydroxybutyrate dehydrogenase 2 delays zebrafish erythroid maturation by conferring premature mitophagy. Proc Natl Acad Sci U S A 113:E1460-9.	LEAK ROUTINE ET		Intact cells	Zebrafish	Blood cells
Moore 2016 Cryobiology	2016	Moore DS, Hand SC (2016) Cryopreservation of lipid bilayers by LEA proteins from Artemia franciscana and trehalose. Cryobiology 73:240-7.	LEAK OXPHOS ET	S	Isolated mitochondria	Rat	Liver
Silva 2016 Thesis	2016	Silva Luana Caroline Schüeler da (2016) Fucoxantina inibe a oxidação de LDL e ativação de macrófagos in vitro. PhD Thesis:93 pp.	LEAK ROUTINE ET	ROX	Intact cells	Human
Oliveira 2016 PLOS ONE	2016	Oliveira MP, Correa Soares JB, Oliveira MF (2016) Sexual preferences in nutrient utilization regulate oxygen consumption and reactive oxygen species generation in Schistosoma mansoni: potential implications for parasite redox biology. PLOS ONE 11:e0158429.	LEAK ROUTINE	F ROX	Intact organism	Other invertebrates
Hagl 2016 Neuromolecular Med	2016	Hagl S, Asseburg H, Heinrich M, Sus N, Blumrich EM, Dringen R, Frank J, Eckert GP (2016) Effects of long-term rice bran extract supplementation on survival, cognition and brain mitochondrial function in aged NMRI mice. Neuromolecular Med 18:347-63.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Miotto 2016 Biochem J	2016	Miotto PM, Holloway GP (2016) In the absence of phosphate shuttling, exercise reveals the in vivo importance of creatine-independent mitochondrial ADP transport. Biochem J 473:2831-43.	LEAK OXPHOS	N NS	Permeabilized tissue	Mouse	Skeletal muscle
Lashbrook 2016 Thesis	2016	Lashbrook M (2016) Functional responses of cardiac and skeletal muscle mitochondria to short-term obesity: are all obesities the same? Master's Thesis 63pp.	LEAK OXPHOS	F N NS	Permeabilized tissue Isolated mitochondria	Mouse Other mammals	Heart Skeletal muscle
Vevera 2016 Physiol Res	2016	Vevera J, Fišar Z, Nekovářová T, Vrablík M, Zlatohlávek L, Hroudová J, Singh N, Raboch J, Valeš K (2016) Statin-induced changes in mitochondrial respiration in blood platelets in rats and human with dyslipidemia. Physiol Res 65:777-88.	LEAK ROUTINE OXPHOS ET	N S NS Other combinations ROX	Intact cells Permeabilized cells	Human Rat	Blood cells Platelet
Moon 2016 J Biol Chem	2016	Moon SH, Mancuso DJ, Sims HF, Liu X, Nguyen AL, Yang K, Guan S, Dilthey BG, Jenkins CM, Weinheimer CJ, Kovacs A, Abendschein D, Gross RW (2016) Cardiac myocyte-specific knock-out of calcium-independent phospholipase A2γ (iPLA2γ) decreases oxidized fatty acids during ischemia/reperfusion and reduces infarct size. J Biol Chem 291:19687-700.	LEAK OXPHOS	F N S NS Other combinations ROX	Isolated mitochondria	Mouse	Heart
Gehrig 2016 Orphanet J Rare Dis	2016	Gehrig SM, Mihaylova V, Frese S, Mueller SM, Ligon-Auer M, Spengler CM, Petersen JA, Lundby C, Jung HH (2016) Altered skeletal muscle (mitochondrial) properties in patients with mitochondrial DNA single deletion myopath. Orphanet J Rare Dis 11:105.	LEAK OXPHOS	F N S CIV NS Other combinations ROX	Permeabilized tissue	Human	Skeletal muscle
Li 2016 Sci Rep	2016	Li N, Guenancia C, Rigal E, Hachet O, Chollet P, Desmoulins L, Leloup C, Rochette L, Vergely C (2016) Short-term moderate diet restriction in adulthood can reverse oxidative, cardiovascular and metabolic alterations induced by postnatal overfeeding in mice. Sci Rep 6:30817	LEAK OXPHOS	N NS ROX	Permeabilized tissue	Mouse	Heart
Boeck 2016 Mitochondrion	2016	Boeck C, Koenig AM, Schury K, Geiger ML, Karabatsiakis A, Wilker S, Waller C, Gündel H, Fegert JM, Calzia E, Kolassa IT (2016) Inflammation in adult women with a history of child maltreatment: The involvement of mitochondrial alterations and oxidative stress. Mitochondrion 30:197-207.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Lymphocyte
Christensen 2016 J Appl Physiol (1985)	2016	Christensen PM, Jacobs RA, Bonne T, Flück D, Bangsbo J, Lundby C (2016) A short period of high-intensity interval training improves skeletal muscle mitochondrial function and pulmonary oxygen uptake kinetics. J Appl Physiol (1985) 120:1319-27.	LEAK OXPHOS ET	F N S CIV NS Other combinations ROX	Permeabilized tissue	Human	Skeletal muscle
Karlsson 2016 Shock	2016	Karlsson M, Hara N, Morata S, Sjövall F, Kilbaugh T, Hansson MJ, Uchino H, Elmér E (2016) Diverse and tissue-specific mitochondrial respiratory response in a mouse model of sepsis-induced multiple organ failure. Shock 45:404-10.	LEAK OXPHOS ET	N S CIV NS	Homogenate	Mouse	Nervous system Liver
Sengupta 2016 Free Radic Biol Med	2016	Sengupta S, Yang G, O'Donnell JC, Hinson MD, McCormack SE, Falk MJ, La P, Robinson MB, Williams ML, Yohannes MT, Polyak E, Nakamaru-Ogiso E, Dennery PA (2016) The circadian gene Rev-erbα improves cellular bioenergetics and provides preconditioning for protection against oxidative stress. Free Radic Biol Med 93:177-89.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Lung;gill Fibroblast
Anand 2016 PLOS ONE	2016	Anand R, Strecker V, Urbach J, Wittig I, Reichert AS (2016) Mic13 is essential for formation of crista junctions in mammalian cells. PLOS ONE 11:e0160258.	LEAK ROUTINE OXPHOS ET	N CIV NS Other combinations ROX	Permeabilized cells Intact cells		HEK
Peruzzo 2016 Cell Cycle	2016	Peruzzo P, Comelli M, Di Giorgio E, Franforte E, Mavelli I, Brancolini C (2016) Transformation by different oncogenes relies on specific metabolic adaptations. Cell Cycle 15:2656-68.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Fibroblast
De Carvalho 2016 J Cell Biochem	2016	de Carvalho AK, da Silva S, Serafini E, de Souza DR, Farias HR, de Bem Silveira G, Silveira PC, de Souza CT, Portela LV, Muller AP (2016) Prior exercise training prevent hyperglycemia in STZ mice by increasing hepatic glycogen and mitochondrial function on skeletal muscle. J Cell Biochem 118:678-85.	LEAK OXPHOS	S	Homogenate	Mouse	Skeletal muscle Liver
Tsai 2016 Sci Rep	2016	Tsai HH, Chang SC, Chou CH, Weng TP, Hsu CC, Wang JS (2016) Exercise training alleviates hypoxia-induced mitochondrial dysfunction in the lymphocytes of sedentary males. Sci Rep 6:35170.	LEAK ROUTINE OXPHOS ET	F N S NS Other combinations ROX	Permeabilized cells Intact cells	Human	Lymphocyte Blood cells
Kilbaugh 2016 Mitochondrion	2016	Kilbaugh TJ, Karlsson M, Duhaime AC, Hansson MJ, Elmer E, Margulies SS (2016) Mitochondrial response in a toddler-aged swine model following diffuse non-impact traumatic brain injury. Mitochondrion 26:19-25.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Pig	Nervous system
McCourt 2016 PLOS ONE	2016	McCourt AC, Jakobsson L, Larsson S, Holm C, Piel S, Elmér E, Björkqvist M (2016) White adipose tissue browning in the R6/2 mouse model of Huntington's disease. PLOS ONE 11:e0159870.	LEAK OXPHOS ET	NS ROX	Permeabilized cells	Mouse	Fat
Kacso 2016 Biochem J	2016	Kacso G, Ravasz D, Doczi J, Németh B, Madgar O, Saada A, Ilin P, Miller C, Ostergaard E, Iordanov I, Adams D, Vargedo Z, Araki M, Araki K, Nakahara M, Ito H, Gál A, Molnár MJ, Nagy Z, Patocs A, Adam-Vizi V, Chinopoulos C (2016) Two transgenic mouse models for β-subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations. Biochem J 473:3463-85.	LEAK OXPHOS	F N Other combinations	Isolated mitochondria	Mouse	Heart Nervous system Liver
Rackham 2016 Cell Rep	2016	Rackham O, Busch JD, Matic S, Siira SJ, Kuznetsova I, Atanassov I, Ermer JA, Shearwood AM, Richman TR, Stewart JB, Mourier A, Milenkovic D, Larsson NG, Filipovska A (2016) Hierarchical RNA processing is required for mitochondrial ribosome assembly. Cell Rep 16:1874-90.	LEAK OXPHOS ET	N S CIV NS Other combinations	Isolated mitochondria	Mouse	Heart
Thomas 2016 Neurodegeneration Therapeutics	2016	Thomas RR, Keeney PM, Berr SB, Khan SM, Portell FR, Shakenov MZ, Antkowiak PF, Kundu B, Tustison N, Brohawn DG, Bennett JP (2016) Recombinant human TFAM stimulates rat brain, rat cervical spinal cord and human neural stem cell mitochondrial bioenergetics. Neurodegeneration Therapeutics p41.	LEAK OXPHOS	N S CIV	Isolated mitochondria	Rat	Nervous system
Franko 2016 Diabetes	2016	Franko A, Huypens P, Neschen S, Irmler M, Rozman J, Rathkolb B, Neff F, Prehn C, Dubois G, Baumann M, Massinger R, Gradinger D, Przemeck GK, Repp B, Aichler M, Feuchtinger A, Schommers P, Stöhr O, Sanchez-Lasheras C, Adamski J, Peter A, Prokisch H, Beckers J, Walch AK, Fuchs H, Wolf E, Schubert M, Wiesner RJ, Hrabě de Angelis M (2016) Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice. Diabetes 65:2540-52.	LEAK OXPHOS	N S CIV ROX	Permeabilized cells Permeabilized tissue	Human	Skeletal muscle Fibroblast
Ryan 2016 Diabetes	2016	Ryan TE, Schmidt CA, Green TD, Spangenburg EE, Neufer PD, McClung JM (2016) Targeted expression of catalase to mitochondria protects against ischemic myopathy in high fat fed mice. Diabetes 65:2553-68.	LEAK OXPHOS ET	N S CIV Other combinations ROX	Isolated mitochondria	Mouse	Skeletal muscle
Bal 2016 J Biol Chem	2016	Bal NC, Maurya SK, Singh S, Wehrens XH, Periasamy M (2016) Increased reliance on muscle based thermogenesis upon acute minimization of brown adipose tissue function. J Biol Chem 291:17247-57.	LEAK OXPHOS	N NS	Permeabilized tissue	Mouse	Skeletal muscle
Van Zutphen 2016 J Hepatol	2016	van Zutphen T, Ciapaite J, Bloks VW, Ackereley C, Gerding A, Jurdzinski A, Allgayer de Moraes R, Zhang L, Wolters JC, Bischoff R, Wanders RJA, Houten SM, Bronte-Tinkew D, Shatseva T, Lewis GF, Groen AK, Reijngoud DJ, Bakker BM, Jonker JW, Kim PK, Bandsma RH (2016) Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction. J Hepatol 65:1198-1208.	LEAK OXPHOS ET	F N NS Other combinations	Isolated mitochondria	Rat	Liver
Camacho-Pereira 2016 Cell Metab	2016	Camacho-Pereira J, Tarragó MG, Chini CC, Nin V, Escande C, Warner GM, Puranik AS, Schoon RA, Reid JM, Galina A, Chini EN (2016) CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism. Cell Metab 23:1127-39.	LEAK ROUTINE OXPHOS ET	S ROX	Isolated mitochondria Intact cells	Human Mouse	Liver Lung;gill Other cell lines
Saben 2016 Cell Rep	2016	Saben JL, Boudoures AL, Asghar Z, Thompson A, Drury A, Zhang W, Chi M, Cusumano A, Scheaffer S, Moley KH (2016) Maternal metabolic syndrome programs mitochondrial dysfunction via germline changes across three generations. Cell Rep 16:1-8.	LEAK OXPHOS ET	N NS	Permeabilized tissue	Mouse	Skeletal muscle
Most 2016 Am J Clin Nutr	2016	Most J, Timmers S, Warnke I, Jocken JW, van Boekschoten M, de Groot P, Bendik I, Schrauwen P, Goossens GH, Blaak EE (2016) Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial. Am J Clin Nutr 104:215-27.	LEAK OXPHOS ET	F N NS	Permeabilized tissue	Human	Skeletal muscle
Gregg 2016 Diabetes	2016	Gregg T, Poudel C, Schmidt BA, Dhillon RS, Sdao SM, Truchan NA, Baar EL, Fernandez LA, Denu JM, Eliceiri KW, Rogers JD, Kimple ME, Lamming DW, Merrins MJ (2016) Pancreatic β cells from mice offset age-associated mitochondrial deficiency with reduced K_ATP channel activity. Diabetes 65:2700-10.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human Mouse	Islet cell;pancreas;thymus Other cell lines
Richman 2016 Nat Commun	2016	Richman TR, Spåhr H, Ermer JA, Davies SM, Viola HM, Bates KA, Papadimitriou J, Hool LC, Rodger J, Larsson NG, Rackham O, Filipovska A (2016) Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice. Nat Commun 7:11884.	LEAK OXPHOS	N S CIV	Isolated mitochondria	Mouse	Heart Liver
Gomez 2016 Thesis	2016	Gomez CR (2016) Mitochondrial responses to anoxia exposure in red eared sliders (Trachemys scripta). Master's Thesis p102.	LEAK OXPHOS ET	S	Permeabilized cells Isolated mitochondria	Reptiles	Heart Nervous system
Jang 2016 J Intensive Care Med	2016	Jang DH, Greenwood JC, Spyres MB, Eckmann D (2016) Measurement of mitochondrial respiration and motility in acute care: sepsis, trauma, and poisoning. J Intensive Care Med 32:86-94.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Lymphocyte
Price 2016 J Thermal Biol	2016	Price ER, Sirsat TS, Sirsat SKG, Kang G, Keereetaweep J, Aziz M, Chapman KD, Dzialowski EM (2016) Thermal acclimation in American alligators: Effects of temperature regime on growth rate, mitochondrial function, and membrane composition. J Thermal Biol p11.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Reptiles	Heart Skeletal muscle
Jiroutkova 2016 JPEN J Parenter Enteral Nutr	2016	Jiroutková K, Krajčová A, Žiak J, Fric M, Gojda J, Džupa V, Kalous M, Tůmová J, Trnka J, Duška F (2016) Mitochondrial function in an in vitro model of skeletal muscle of patients with protracted critical illness and intensive care unit-acquired weakness. JPEN J Parenter Enteral Nutr 41:1213-21.	LEAK ET	F ROX		Human	Skeletal muscle Other cell lines
Kawalec 2016 Praca doktorska	2016	Kawalec MM (2016) Badanie komórkowych skutków mutacji w genie mitofuzyny 2. Próba zaproponowania testu patogenności mutacji. Praca doktorska p86.	LEAK ROUTINE ET		Intact cells	Mouse	Fibroblast
Pesta 2016 FASEB J	2016	Pesta DH, Tsirigotis DN, Befroy DE, Caballero D, Jurczak MJ, Rahimi Y, Cline GW, Dufour S, Birkenfeld AL, Rothman DL, Carpenter TO, Insogna K, Petersen KF, Bergwitz C, Shulman GI (2016) Hypophosphatemia promotes lower rates of muscle ATP synthesis. FASEB J 30:3378-87.	LEAK OXPHOS	N	Isolated mitochondria	Mouse	Skeletal muscle
Layec 2016 Am J Physiol Endocrinol Metab	2016	Layec G, Gifford JR, Trinity JD, Hart CR, Garten RS, Park SY, Le Fur Y, Jeong EK, Richardson RS (2016) Accuracy and precision of quantitative 31P-MRS measurements of human skeletal muscle mitochondrial function. Am J Physiol Endocrinol Metab 311:E358-66.	LEAK OXPHOS	N NS	Permeabilized tissue	Human	Skeletal muscle
Gilliam 2016 Am J Physiol Endocrinol Metab	2016	Gilliam LA, Lark DS, Reese LR, Torres MJ, Ryan TE, Lin CT, Cathey BL, Neufer PD (2016) Targeted overexpression of mitochondrial catalase protects against cancer chemotherapy-induced skeletal muscle dysfunction. Am J Physiol Endocrinol Metab 311:E293-301.	LEAK OXPHOS	F N NS Other combinations	Permeabilized tissue	Mouse	Skeletal muscle
Sobotka 2016 J Bioenerg Biomembr	2016	Sobotka O, Endlicher R, Drahota Z, Kučera O, Rychtrmoc D, Raad M, Hakeem K, Červinková Z (2016) Impaired mitochondrial functions contribute to 3-bromopyruvate toxicity in primary rat and mouse hepatocytes. J Bioenerg Biomembr 48:363-73.	LEAK OXPHOS	N S CIV	Intact cells Permeabilized cells Homogenate Isolated mitochondria	Mouse Rat	Liver
Ojuka 2016 Am J Physiol Endocrinol Metab	2016	Ojuka E, Andrew B, Bezuidenhout N, George S, Maarman G, Madlala HP, Mendham A, Osiki PO (2016) Measurement of β-oxidation capacity of biological samples by respirometry: a review of principles and substrates. Am J Physiol Endocrinol Metab 310:E715-23. https://doi.org/10.1152/ajpendo.00475.2015	LEAK OXPHOS ET	F	Permeabilized tissue Isolated mitochondria	Human Mouse Rat	Skeletal muscle Liver
Dias 2016 Neurobiol Aging	2016	Dias C, Lourenço CF, Ferreiro E, Barbosa RM, Laranjinha J, Ledo A (2016) Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation. Neurobiol Aging 46:84-95.	LEAK ET	N S ROX	Permeabilized tissue	Mouse	Nervous system
Barth 2016 Thesis	2016	Barth C (2016) Effekte einer intermittierenden Hyperoxie auf die mitochondriale Atmung in Alveolarmakrophagen. Dissertation p69.	LEAK ROUTINE OXPHOS	N S CIV NS ROX	Permeabilized cells Intact cells	Mouse	Lung;gill Macrophage-derived
Alleman 2016 Am J Physiol Heart Circ Physiol	2016	Alleman RJ, Tsang AM, Ryan TE, Patteson DJ, McClung JM, Spangenburg EE, Shaikh SR, Neufer PD, Brown DA (2016) Exercise-induced protection against reperfusion arrhythmia involves stabilization of mitochondrial energetics. Am J Physiol Heart Circ Physiol 310:H1360-70.	LEAK OXPHOS	N NS	Isolated mitochondria	Rat	Heart
Lores-Arnaiz 2016 Neurochem Res	2016	Lores-Arnaiz S, Lombardi P, Karadayian AG, Orgambide F, Cicerchia D, Bustamante J (2016) Brain cortex mitochondrial bioenergetics in synaptosomes and non-synaptic mitochondria during aging. Neurochem Res 41:353-63.	LEAK ROUTINE OXPHOS ET	N S	Isolated mitochondria Intact cells	Mouse	Nervous system
Chu 2016 World J Gastroenterol	2016	Chu MJ, Premkumar R, Hickey AJ, Jiang Y, Delahunt B, Phillips AR, Bartlett A (2016) Steatotic livers are susceptible to normothermic ischemia-reperfusion injury from mitochondrial Complex-I dysfunction. World J Gastroenterol 22:4673-84.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Liver
Liepinsh 2016 Biochem J	2016	Liepinsh E, Makrecka-Kuka M, Volska K, Kuka J, Makarova E, Antone U, Sevostjanovs E, Vilskersts R, Strods A, Tars K, Dambrova M (2016) Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria. Biochem J 473:1191-202.	LEAK OXPHOS	S NS	Isolated mitochondria	Rat	Heart
Chabi 2016 Exp Gerontol	2016	Chabi B, Pauly M, Carillon J, Carnac G, Favier FB, Fouret G, Bonafos B, Vanterpool F, Vernus B, Coudray C, Feillet-Coudray C, Bonnieu Z, Lacan D, Koechlin-Ramonatxo C (2016) Protective effect of myostatin gene deletion on aging-related muscle metabolic decline. Exp Gerontol 78:23-31.	LEAK OXPHOS	N NS	Isolated mitochondria	Mouse	Skeletal muscle
Sirsat 2016 Biol Open	2016	Sirsat SK, Sirsat TS, Price ER, Dzialowski EM (2016) Post-hatching development of mitochondrial function, organ mass and metabolic rate in two ectotherms, the American alligator (Alligator mississippiensis) and the common snapping turtle (Chelydra serpentina). Biol Open 5:443-51.	LEAK OXPHOS ET	N NS	Permeabilized tissue	Reptiles	Heart Skeletal muscle
Amaral 2016 J Neurochem	2016	Amaral AU, Cecatto C, Castilho RF, Wajner M (2016) 2-methylcitric acid impairs glutamate metabolism and induces permeability transition in brain mitochondria. J Neurochem 137:62-75.	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Rat	Nervous system
Castellano-Gonzalez 2016 Oncotarget	2016	Castellano-González G, Pichaud N, Ballard JW, Bessede A, Marcal H, Guillemin GJ (2016) Epigallocatechin-3-gallate induces oxidative phosphorylation by activating cytochrome c oxidase in human cultured neurons and astrocytes. Oncotarget 7:7426-40	LEAK ROUTINE ET	ROX	Intact cells	Human	Nervous system
Salin 2016 J Exp Biol	2016	Salin K, Auer SK, Anderson GJ, Selman C, Metcalfe NB (2016) Inadequate food intake at high temperatures is related to depressed mitochondrial respiratory capacity. J Exp Biol 219:1356-62.	LEAK OXPHOS	N S CIV NS Other combinations ROX	Permeabilized tissue	Fishes	Skeletal muscle Liver
Lesage 2016 Am J Hum Genet	2016	Lesage S, Drouet V, Majounie E, Deramecourt V, Jacoupy M, Nicolas A, Cormier-Dequaire F, Hassoun SM, Pujol C, Ciura S, Erpapazoglou Z, Usenko T, Maurage CA, Sahbatou M, Liebau S, Ding J, Bilgic B, Emre M, Erginel-Unaltuna N, Guven G, Tison F, Tranchant C, Vidailhet M, Corvol JC, Krack P, Leutenegger AL, Nalls MA, Hernandez DG, Heutink P, Gibbs JR, Hardy J, Wood NW, Gasser T, Durr A, Deleuze JF, Tazir M, Destée A, Lohmann E, Kabashi E, Singleton A, Corti O, Brice A (2016) Loss of VPS13C function in autosomal-recessive parkinsonism causes mitochondrial dysfunction and increases PINK1/Parkin-Dependent Mitophagy. Am J Hum Genet 98:500-13.	LEAK ROUTINE ET	ROX	Intact cells	Other mammals	Kidney Other cell lines
Schoepf 2016 FEBS J	2016	Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells. https://doi.org/10.1111/febs.13733	LEAK OXPHOS ET	F N S NS Other combinations ROX	Permeabilized cells Permeabilized tissue	Human	Endothelial;epithelial;mesothelial cell Genital Other cell lines Fibroblast
Sanchez-Calvo 2016 PLOS ONE	2016	Sánchez-Calvo B, Cassina A, Rios N, Peluffo G, Boggia J, Radi R, Rubbo H, Trostchansky A (2016) Nitro-arachidonic acid prevents Angiotensin II-induced mitochondrial dysfunction in a cell line of kidney proximal tubular cells. PLOS ONE 11:e0150459.	LEAK ROUTINE ET	ROX	Intact cells	Human	Kidney Other cell lines
Ruas 2016 PLOS ONE	2016	Ruas JS, Siqueira-Santos ES, Amigo I, Rodrigues-Silva E, Kowaltowski AJ, Castilho RF (2016) Underestimation of the maximal capacity of the mitochondrial electron transport system in oligomycin-treated cells. PLOS ONE 11:e0150967.	LEAK OXPHOS ET	N	Intact cells Permeabilized cells Isolated mitochondria	Human Rat	Nervous system Genital Other cell lines
Zabielski 2016 Diabetes	2016	Zabielski P, Lanza IR, Gopala S, Holtz Heppelmann CJ, Bergen HR 3rd, Dasari S, Nair KS (2016) Altered skeletal muscle mitochondrial proteome as the basis of disruption of mitochondrial function in diabetic mice. Diabetes 65:561-73.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized cells	Mouse	Skeletal muscle
Pamenter 2016 Biol Lett	2016	Pamenter ME, Gomez CR, Richards JG, Milsom WK (2016) Mitochondrial responses to prolonged anoxia in brain of red-eared slider turtles. Biol Lett 12. pii: 20150797.	LEAK OXPHOS ET	N S CIV ROX	Permeabilized tissue	Reptiles	Nervous system
Chang 2016 Transl Res	2016	Chang JC, Wu SL, Liu KH, Chen YH, Chuang CS, Cheng FC, Su HL, Wei YH, Kuo SJ, Liu CS (2016) Allogeneic/xenogeneic transplantation of peptide-labeled mitochondria in Parkinson's disease: restoration of mitochondria functions and attenuation of 6-hydroxydopamine-induced neurotoxicity. Transl Res 170:40-56.	LEAK OXPHOS ET	N	Isolated mitochondria	Rat	Nervous system Other cell lines
Osiki 2016 FASEB J	2016	Osiki PO, Ojuka E, Marmaan G (2016) An investigation of the suitability of using octanoylcarnitine together with malate as a substrate combination for assessing Beta-oxidation using High Resolution Respirometry. FASEB J 30: 1015.12 .	LEAK OXPHOS ET	F	Permeabilized tissue	Rat	Skeletal muscle
Siewiera 2016 Life Sci	2016	Siewiera K, Kassassir H, Talar M, Wieteska L, Watala C (2016) Higher mitochondrial potential and elevated mitochondrial respiration are associated with excessive activation of blood platelets in diabetic rats. Life Sci 148:293-304.	LEAK ROUTINE ET	ROX	Intact cells	Rat	Blood cells Platelet
Xiong 2016 Hypertension	2016	Xiong S, Wang P, Ma L, Gao P, Gong L, Li L, Li Q, Sun F, Zhou X, He H, Chen J, Yan Z, Liu D, Zhu Z (2016) Ameliorating endothelial mitochondrial dysfunction restores coronary function via transient receptor potential vanilloid 1-mediated protein kinase A/uncoupling protein 2 pathway. Hypertension 67:451-60.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Intact cells Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell Other cell lines
Farsijani 2016 J Clin Invest	2016	Farsijani NM, Liu Q, Kobayashi H, Davidoff O, Sha F, Fandrey J, Ikizler TA, O'Connor PM, Haase VH (2016) Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin. J Clin Invest 126:1425-37.	LEAK OXPHOS	N S CIV ROX	Permeabilized tissue	Mouse	Nervous system
Bynum 2016 Transfusion	2016	Bynum JA, Adam Meledeo M, Getz TM, Rodriguez AC, Aden JK, Cap AP, Pidcoke HF (2016) Bioenergetic profiling of platelet mitochondria during storage: 4°C storage extends platelet mitochondrial function and viability. Transfusion 56 Suppl 1:S76-84.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Platelet
Du 2016 J Exp Biol	2016	Du SN, Mahalingam S, Borowiec BG, Scott GR (2016) Mitochondrial physiology and reactive oxygen species production are altered by hypoxia acclimation in killifish (Fundulus heteroclitus). J Exp Biol 219:1130-8.	LEAK OXPHOS ET	N S CIV NS	Isolated mitochondria	Fishes	Liver
Reijne 2016 PLOS ONE	2016	Reijne AC, Ciapaite J, van Dijk TH, Havinga R, van der Zee EA, Groen AK, Reijngoud DJ, Bakker BM, van Dijk G (2016) Whole-body vibration partially reverses aging-induced increases in visceral adiposity and hepatic lipid storage in mice. PLOS ONE 11:e0149419.	LEAK OXPHOS	F N Other combinations	Isolated mitochondria	Mouse	Skeletal muscle Liver
Sirsat 2016 J Comp Physiol B	2016	Sirsat SK, Sirsat TS, Crossley JL, Sotherland PR, Dzialowski EM (2016) The 12-day thermoregulatory metamorphosis of Red-winged Blackbirds (Agelaius phoeniceus). J Comp Physiol B 186:651-663.	LEAK OXPHOS	N	Permeabilized tissue	Birds	Skeletal muscle
Hamilton 2016 Am J Physiol Heart Circ Physiol	2016	Hamilton DJ, Zhang A, Li S, Cao TN, Smith JA, Vedula I, Cordero-Reyes AM, Youker KA, Torre-Amione G, Gupte AA (2016) Combination of angiotensin II and l-NG-nitroarginine methyl ester exacerbates mitochondrial dysfunction and oxidative stress to cause heart failure. Am J Physiol Heart Circ Physiol 310:H667-80.	LEAK OXPHOS	F N S NS Other combinations ROX	Permeabilized tissue Isolated mitochondria	Mouse	Heart
Vinnakota 2016a Biophys J	2016	Vinnakota KC, Bazil JN, Van den Bergh F, Wiseman RW, Beard DA (2016) Feedback regulation and time hierarchy of oxidative phosphorylation in cardiac mitochondria. Biophys J 110:972-80.	LEAK OXPHOS	N	Isolated mitochondria	Rat	Heart
Leucci 2016 Nature	2016	Leucci E, Vendramin R, Spinazzi M, Laurette P, Fiers M, Wouters J, Radaelli E, Eyckerman S, Leonelli C, Vanderheyden K, Rogiers A, Hermans E, Baatsen P, Aerts S, Amant F, Van Aelst S, van den Oord J, de Strooper B, Davidson I, Lafontaine DL, Gevaert K, Vandesompele J, Mestdagh P, Marine JC (2016) Melanoma addiction to the long non-coding RNA SAMMSON. Nature 531:518-22.	LEAK OXPHOS ET	N CIV NS ROX	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell Other cell lines
Vinnakota 2016b Biophys J	2016	Vinnakota KC, Singhal A, Van den Bergh F, Bagher-Oskouei M, Wiseman RW, Beard DA (2016) Open-loop control of oxidative phosphorylation in skeletal and cardiac muscle mitochondria by Ca²⁺. Biophys J 110:954-61.	LEAK OXPHOS	N	Isolated mitochondria	Rat	Heart Skeletal muscle
Cannon 2016 Lung	2016	Cannon DT, Liu J, Sakurai R, Rossiter HB, Rehan VK (2016) Impaired lung mitochondrial respiration following perinatal nicotine exposure in rats. Lung 194:325-8.	LEAK OXPHOS ET	N S CIV NS	Permeabilized tissue	Rat	Lung;gill
Cheng 2016 Nat Immunol	2016	Cheng SC, Scicluna BP, Arts RJ, Gresnigt MS, Lachmandas E, Giamarellos-Bourboulis EJ, Kox M, Manjeri GR, Wagenaars JA, Cremer OL, Leentjens J, van der Meer AJ, van de Veerdonk FL, Bonten MJ, Schultz MJ, Willems PH, Pickkers P, Joosten LA, van der Poll T, Netea MG (2016) Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis. Nat Immunol 17:406-13.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Lymphocyte
LaBarge 2016 FASEB J	2016	LaBarge SA, Migdal CW, Buckner EH, Okuno H, Gertsman I, Stocks B, Barshop BA, Nalbandian SR, Philp A, McCurdy CE, Schenk S (2016) p300 is not required for skeletal muscle metabolic adaptation to endurance exercise training. FASEB J 30:1623-33.	LEAK OXPHOS ET	F N NS ROX S Other combinations	Permeabilized tissue	Mouse	Skeletal muscle
Sparks 2016 Diabetologia	2016	Sparks LM, Gemmink A, Phielix E, Bosma M, Schaart G, Moonen-Kornips E, Jörgensen JA, Nascimento EB, Hesselink MK, Schrauwen P, Hoeks J (2016) ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity. Diabetologia 59:1030-9.	LEAK OXPHOS ET	F N NS Other combinations	Permeabilized tissue Isolated mitochondria	Human Mouse Rat	Skeletal muscle Other cell lines
Ehinger 2016 Mov Disord	2016	Ehinger JK, Morota S, Hansson MJ, Gesine P, Elmér E (2016) Mitochondrial respiratory function in peripheral blood cells from Huntington’s disease patients. Mov Disord doi:10.1002/mdc3.12308.	LEAK ROUTINE OXPHOS ET	N S CIV NS Other combinations ROX	Permeabilized cells Intact cells	Human	Blood cells Lymphocyte Platelet
Baeder 2016 Int J Dent	2016	Baeder AC, Napa K, Richardson ST, Taylor OJ, Andersen SG, Wilcox SH, Winden DR, Reynolds PR, Bikman BT (2016) Oral gingival cell cigarette smoke exposure induces muscle cell metabolic disruption. Int J Dent 2016:2763160.	LEAK OXPHOS ET	N NS ROX	Permeabilized cells	Mouse	Skeletal muscle
Shama 2016 Evol Appl	2016	Shama LNS, Mark FC, Strobel A, Lokmer A, John U, Wegner KM (2016) Transgenerational effects persist down the maternal line in marine sticklebacks: gene expression matches physiology in a warming ocean. Evol Appl 10013/epic.47323.	LEAK OXPHOS ET	NS ROX	Permeabilized tissue	Fishes	Heart
Wang 2016 Toxicol Sci	2016	Wang L, Espinoza HM, MacDonald JW, Bammler TK, Williams CR, Yeh A, Louie KW, Marcinek DJ, Gallagher EP (2016) Olfactory Transcriptional Analysis of Salmon Exposed to Mixtures of Chlorpyrifos and Malathion Reveal Novel Molecular Pathways of Neurobehavioral Injury. Toxicol Sci 149:145-57.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Fishes	Endothelial;epithelial;mesothelial cell
Keller 2016 Oxid Med Cell Longev	2016	Keller AC, Knaub LA, McClatchey PM, Connon CA, Bouchard R, Miller MW, Geary KE, Walker LA, Klemm DJ, Reusch JE (2016) Differential mitochondrial adaptation in primary vascular smooth muscle cells from a diabetic rat model. Oxid Med Cell Longev 2016:8524267.	LEAK OXPHOS ET	N NS	Permeabilized cells	Rat	Endothelial;epithelial;mesothelial cell
Birkenmeier 2016 Int J Cancer	2016	Birkenmeier Katrin, Droese Stefan, Wittig Ilka, Winkelmann Ria, Kaefer Viktoria, Doering Claudia, Hartmann Sylvia, Wenz Tina, Reichert Andreas S, Brandt Ulrich, Hansmann Martin‐Leo (2016) Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation. Int J Cancer 138:2231-46.	LEAK ROUTINE ET	ROX	Intact cells	Human	Other cell lines HeLa Macrophage-derived
Tunholi 2016 J Invertebr Pathol	2016	Tunholi VM, Tunholi-Alves VM, Santos AT, Garcia Jda S, Maldonado A Jr, da-Silva WS, Rodrigues Mde L, Pinheiro J (2016) Evaluation of the mitochondrial system in the gonad-digestive gland complex of Biomphalaria glabrata (Mollusca, Gastropoda) after infection by Echinostoma paraensei (Trematoda, Echinostomatidae). J Invertebr Pathol 136:136-41.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Molluscs	Genital
Lund 2016 J Physiol	2016	Lund MT, Kristensen M, Hansen M, Tveskov L, Floyd AK, Støckel M, Vainer B, Poulsen SS, Helge JW, Prats C, Dela F (2016) Hepatic mitochondrial oxidative phosphorylation is normal in obese patients with and without type 2 diabetes. J Physiol 594:4351-8.	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Human	Liver
Santos 2016 Insect Biochem Mol Biol	2016	Santos DE, Alberici LC, Hartfelder K (2016) Mitochondrial structure and dynamics as critical factors in honey bee (Apis mellifera L.) caste development. Insect Biochem Mol Biol 73:1-11.	LEAK OXPHOS ET	S	Permeabilized tissue	Hexapods	Fat
Tam 2016 Eur J Appl Physiol	2016	Tam E, Bruseghini P, Calabria E, Sacco LD, Doria C, Grassi B, Pietrangelo T, Pogliaghi S, Reggiani C, Salvadego D, Schena F, Toniolo L, Verratti V, Vernillo G, Capelli C (2016) Gokyo Khumbu/Ama Dablam Trek 2012: effects of physical training and high-altitude exposure on oxidative metabolism, muscle composition, and metabolic cost of walking in women. Eur J Appl Physiol 116:129-44.	LEAK OXPHOS	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Jacobs 2016 J Physiol	2016	Jacobs RA, Lundby AM, Fenk S, Gehrig S, Siebenmann C, Flück D, Kirk N, Hilty MP, Lundby C (2016) Twenty-eight days of exposure to 3,454 m increases mitochondrial volume density in human skeletal muscle. J Physiol 594:1151-66.	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Li 2016 J Appl Physiol (1985)	2016	Li C, White SH, Warren LK, Wohlgemuth SE (2016) Effects of aging on mitochondrial function in skeletal muscle of quarter horses. J Appl Physiol (1985) 121:299-311.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Horse	Skeletal muscle
Sadhukhan 2016 Proc Natl Acad Sci U S A	2016	Sadhukhan S, Liu X, Ryu D, Nelson OD, Stupinski JA, Li Z, Chen W, Zhang S, Weiss RS, Locasale JW, Auwerx J, Lin H (2016) Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function. Proc Natl Acad Sci U S A 113:4320-5.	LEAK OXPHOS	F N	Permeabilized tissue	Mouse	Heart
Nemeth 2016 FASEB J	2016	Németh B, Doczi J, Csete D, Kacso G, Ravasz D, Adams D, Kiss G, Nagy AM, Horvath G, Tretter L, Mócsai A, Csépányi-Kömi R, Iordanov I, Adam-Vizi V, Chinopoulos C (2016) Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage. FASEB J 30:286-300.	LEAK OXPHOS	S	Isolated mitochondria	Mouse	Liver
Hagl 2016 Nutr Neurosci	2016	Hagl S, Berressem D, Grewal R, Grebenstein N, Frank J, Eckert GP (2016) Rice bran extract improves mitochondrial dysfunction in brains of aged NMRI mice. Nutr Neurosci 19:1-10.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Scialo 2016 Cell Metab	2016	Scialò F, Sriram A, Fernández-Ayala D, Gubina N, Lõhmus M, Nelson G, Logan A, Cooper HM, Navas P, Enríquez JA, Murphy MP, Sanz A (2016) Mitochondrial ROS produced via reverse electron transport extend animal lifespan. Cell Metab 23:725-34.	LEAK OXPHOS	N Gp CIV Other combinations ROX	Homogenate	Drosophila
Mizushima 2016 J Mol Cell Cardiol	2016	Mizushima W, Takahashi H, Watanabe M, Kinugawa S, Matsushima S, Takada S, Yokota T, Furihata T, Matsumoto J, Tsuda M, Chiba I, Nagashima S, Yanagi S, Matsumoto M, Nakayama KI, Tsutsui H, Hatakeyama S (2016) The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes. J Mol Cell Cardiol 100:43-53.	LEAK OXPHOS ET		Permeabilized cells	Rat	Heart
Bonifacio 2016 Arch Toxicol	2016	Bonifacio A, Mullen PJ, Mityko IS, Navegantes LC, Bouitbir J, Krähenbühl S (2016) Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo. Arch Toxicol 90:203-15. doi: 10.1007/s00204-014-1378-4	LEAK OXPHOS ET	N S DQ CIV NS	Permeabilized cells Permeabilized tissue Intact cells	Rat	Heart
Kimball 2016 Thesis	2016	Kimball RL (2016) The role of hypoxia on pyruvate kinase M2, mammalian target of rapamycin, mitochondrial function, and cell invasion in the trophoblast. Master Thesis p55.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Human	Genital Other cell lines
Power 2016 Am J Physiol Heart Circ Physiol	2016	Power AS, Pham T, Loiselle DS, Crossman DH, Ward ML, Hickey AJ (2016) Impaired ADP channeling to mitochondria and elevated reactive oxygen species in hypertensive hearts. https://doi.org/10.1152/ajpheart.00050.2016	LEAK OXPHOS ET	N CIV NS	Permeabilized tissue Homogenate	Rat	Heart
Snook 2016 Am J Physiol Regul Integr Comp Physiol	2016	Snook LA, MacPherson RE, Monaco CM, Frendo-Cumbo S, Castellani L, Peppler WT, Anderson ZG, Buzelle SL, LeBlanc PJ, Holloway GP, Wright DC (2016) Prior exercise training blunts short term highfat diet induced weight gain. Am J Physiol Regul Integr Comp Physiol 311:R315-24.	LEAK OXPHOS ET	N NS	Permeabilized tissue	Mouse	Fat
Piwonska 2016 Acta Neurobiol Exp (Wars)	2016	Piwońska M, Szewczyk A, Schröder UH, Reymann KG, Bednarczyk P (2016) Effectors of large-conductance calcium-activated potassium channel modulate glutamate excitotoxicity in organotypic hippocampal slice cultures. Acta Neurobiol Exp (Wars) 76:20-31.	LEAK OXPHOS	N	Isolated mitochondria	Rat	Nervous system
Reynolds 2016 Am J Physiol Endocrinol Metab	2016	Reynolds MS, Hancock CR, Ray JD, Kener KB, Draney C, Garland K, Hardman J, Bikman BT, Tessem JS (2016) β-cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion. Am J Physiol Endocrinol Metab 311:E186-201.	LEAK ROUTINE OXPHOS ET	N S ROX	Permeabilized cells Intact cells	Rat	Islet cell;pancreas;thymus
Distefano 2016 J Gerontol A Biol Sci Med Sci	2016	Distefano G, Standley RA, Dubé JJ, Carnero EA, Ritov VB, Stefanovic-Racic M, Toledo FG, Piva SR, Goodpaster BH, Coen PM (2016) Chronological age does not influence ex-vivo mitochondrial respiration and quality control in skeletal muscle. J Gerontol A Biol Sci Med Sci 72:535-42.	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Human	Skeletal muscle
Yavari 2016 Cell Metab	2016	Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martinez de Morentin PB, Cansell C, Lam BY, Chuster A, Petkevicius K, Nguyen-Tu MS, Martinez-Sanchez A, Pullen TJ, Oliver PL, Stockenhuber A, Nguyen C, Lazdam M, O'Dowd JF, Harikumar P, Toth M, Beall C, Kyriakou T, Parnis J, Sarma D, Katritsis G, Wortmann DD, Harper AR, Brown LA, Willows R, Gandra S, Poncio V, de Oliveira Figueiredo MJ, Qi NR, Peirson SN, McCrimmon RJ, Gereben B, Tretter L, Fekete C, Redwood C, Yeo GS, Heisler LK, Rutter GA, Smith MA, Withers DJ, Carling D, Sternick EB, Arch JR, Cawthorne MA, Watkins H, Ashrafian H (2016) Chronic activation of γ2 AMPK induces obesity and reduces β cell function. Cell Metab 23:821-36.	LEAK OXPHOS ET	N NS ROX	Homogenate	Mouse	Nervous system
Yamada 2016 J Physiol	2016	Yamada T, Takakura H, Jue T, Hashimoto T, Ishizawa R, Furuichi Y, Kato Y, Iwanaka N, Masuda K (2016) Myoglobin and the regulation of mitochondrial respiratory chain complex IV. J Physiol 594:483-95.	LEAK OXPHOS	N S CIV Other combinations ROX		Mouse	Skeletal muscle Other cell lines
Soendergaard 2016 Eur J Sport Sci	2016	Søndergård SD, Dela F, Helge JW, Larsen S (2016) Actovegin, a non-prohibited drug increases oxidative capacity in human skeletal muscle. Eur J Sport Sci 16:801-7.	LEAK OXPHOS ET	N NS	Permeabilized tissue	Human	Skeletal muscle
Wolff 2016 J Evol Biol	2016	Wolff JN, Pichaud N, Camus MF, Côté G, Blier PU, Dowling DK (2016) Evolutionary implications of mitochondrial genetic variation: mitochondrial genetic effects on OXPHOS respiration and mitochondrial quantity change with age and sex in fruit flies. J Evol Biol 29:736-47.	LEAK OXPHOS ET	N Gp CIV Other combinations ROX	Permeabilized tissue	Drosophila	Skeletal muscle
Strifler 2016 PLOS ONE	2016	Strifler G, Tuboly E, Szél E, Kaszonyi E, Cao C, Kaszaki J, Mészáros A, Boros M, Hartmann P (2016) Inhaled methane limits the mitochondrial electron transport chain dysfunction during experimental liver ischemia-reperfusion injury. PLOS ONE 11:e0146363.	LEAK OXPHOS	N S CIV NS ROX	Homogenate Isolated mitochondria	Rat	Liver
Puskarich 2016 J Crit Care	2016	Puskarich MA, Kline JA, Watts JA, Shirey K, Hosler J, Jones AE (2016) Early alterations in platelet mitochondrial function are associated with survival and organ failure in patients with septic shock. J Crit Care 31:63-7.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Platelet
Lalia 2016 J Clin Endocrinol Metab	2016	Lalia AZ, Dasari S, Johnson ML, Robinson MM, Konopka AR, Distelmaier K, Port JD, Glavin MT, Esponda RR, Nair KS, Lanza IR (2016) Predictors of whole-body insulin sensitivity across ages and adiposity in adult humans. J Clin Endocrinol Metab 101:626-34.	LEAK OXPHOS	NS	Isolated mitochondria	Human	Skeletal muscle
Li 2016 Neurochem Int	2016	Li H, Liu Y, Lin LT, Wang XR, Du SQ, Yan CQ, He T, Yang JW, Liu CZ (2016) Acupuncture reversed hippocampal mitochondrial dysfunction in vascular dementia rats. Neurochem Int 92:35-42.	LEAK OXPHOS	S	Isolated mitochondria	Rat	Nervous system
Krischek 2016 Mol Reprod Dev	2016	Krischek C, Janisch S, Naraballobh W, Brunner R, Wimmers K, Wicke M (2016) Altered incubation temperatures between embryonic Days 7 and 13 influence the weights and the mitochondrial respiratory and enzyme activities in breast and leg muscles of broiler embryos. Mol Reprod Dev 83:71-8.	LEAK OXPHOS	N S	Permeabilized tissue	Chicken	Skeletal muscle
Johnson 2016 Diabetes	2016	Johnson ML, Distelmaier K, Lanza IR, Irving BA, Robinson MM, Konopka AR, Shulman GI, Nair KS (2016) Mechanism by which caloric restriction improves insulin sensitivity in sedentary obese adults. Diabetes 65:74-84.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Human	Skeletal muscle
Jang 2016 Clin Toxicol (Phila)	2016	Jang DH, Shofer FS, Weiss SL, Becker LB (2016) Impairment of mitochondrial respiration following ex vivo cyanide exposure in peripheral blood mononuclear cells. Clin Toxicol (Phila) 54:303-7.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Lymphocyte
Morad 2016 J Lipid Res	2016	Morad SA, Ryan TE, Neufer PD, Zeczycki TN, Davis TS, MacDougall MR, Fox TE, Tan SF, Feith DJ, Loughran TP Jr, Kester M, Claxton DF, Barth BM, Deering TG, Cabot MC (2016) Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia. J Lipid Res 57:1231-42.	LEAK OXPHOS	N S NS	Permeabilized cells	Human	Blood cells Other cell lines
Cacabelos 2016 Acta Neuropathol Commun	2016	Cacabelos D, Ramírez-Núñez O, Granado-Serrano AB, Torres P, Ayala V, Moiseeva V, Povedano M, Ferrer I, Pamplona R, Portero-Otin M, Boada J (2016) Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS. Acta Neuropathol Commun 4:3.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized tissue Intact cells	Mouse	Nervous system Other cell lines
Cagnone 2016 Sci Rep	2016	Cagnone GL, Tsai TS, Makanji Y, Matthews P, Gould J, Bonkowski MS, Elgass KD, Wong AS, Wu LE, McKenzie M, Sinclair DA, John JC (2016) Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency. Sci Rep 6:23229.	LEAK OXPHOS ET	S ROX	Isolated mitochondria	Pig	Genital
Johnson 2016 Stem Cells Dev	2016	Johnson J, Lee W, Frazier AE, Vaghjiani V, Laskowski A, Rodriguez AL, Cagnone GL, McKenzie M, White SJ, Nisbet DR, Thorburn DR, St John JC (2016) Deletion of the complex I subunit NDUFS4 adversely modulates cellular differentiation. Stem Cells Dev 25:239-50.	LEAK OXPHOS	N	Isolated mitochondria	Mouse	Stem cells
Ejaz 2016 Diabetes	2016	Ejaz A, Martinez-Guino L, Goldfine AB, Ribas-Aulinas F, De Nigris V, Ribó S, Gonzalez-Franquesa A, Garcia-Roves PM, Li E, Dreyfuss JM, Gall W, Kim JK, Bottiglieri T, Villarroya F, Gerszten RE, Patti ME, Lerin C (2016) Dietary betaine supplementation increases Fgf21 levels to improve glucose homeostasis and reduce hepatic lipid accumulation in mice. Diabetes 65:902-12.	LEAK OXPHOS	NS Other combinations ROX	Homogenate	Mouse	Fat
Doerrier 2016 Mitochondrion	2016	Doerrier C, García JA, Volt H, Díaz-Casado ME, Luna-Sánchez M, Fernández-Gil B, Escames G, López LC, Acuña-Castroviejo D (2016) Permeabilized myocardial fibers as model to detect mitochondrial dysfunction during sepsis and melatonin effects without disruption of mitochondrial network. Mitochondrion 27:56-63.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Heart
Bernardo 2015 J Nutr Biochem	2016	Bernardo AF, Cortez E, Neves FA, Vieira AKG, Soares V, Rodrigues-Cunha AC, Andrade DC, Thole AA, Gabriel-Costa D, Brum PC, Moura AS, Garcia-Souza EP (2015) Overnutrition during lactation leads to impairment in insulin signaling, upregulation of GLUT1 and increased mitochondrial carbohydrate oxidation in heart of weaned mice. J Nutr Biochem 29:124-32.	LEAK OXPHOS	F N NS	Permeabilized tissue	Mouse	Heart
Takada 2016 Cardiovasc Res	2016	Takada S, Masaki Y, Kinugawa S, Matsumoto J, Furihata T, Mizushima W, Kadoguchi T, Fukushima A, Homma T, Takahashi M, Harashima S, Matsushima S, Yokota T, Tanaka S, Okita K, Tsutsui H (2016) Dipeptidyl peptidase-4 inhibitor improved exercise capacity and mitochondrial biogenesis in mice with heart failure via activation of glucagon-like peptide-1 receptor signalling. Cardiovasc Res 111:338-47.	LEAK OXPHOS		Permeabilized tissue	Mouse	Skeletal muscle
Bareth 2016 Mol Biol Cell	2016	Bareth B, Nikolov M, Lorenzi I, Hildenbeutel M, Mick DU, Helbig C, Urlaub Z, Ott M, Rehling P, Dennerlein S (2016) Oms1 associates with cytochrome c oxidase assembly intermediates to stabilize newly synthesized Cox1. Mol Biol Cell 27:1570-80.	LEAK OXPHOS		Isolated mitochondria	Saccharomyces cerevisiae
Casinelli 2016 Cell Death Discov	2016	Casinelli G, LaRosa J, Sharma M, Cherok E, Banerjee S, Branca M, Edmunds L, Wang Y, Sims-Lucas S, Churley L, Kelly S, Sun M, Stolz D, Graves JA (2016) N-Myc overexpression increases cisplatin resistance in neuroblastoma via deregulation of mitochondrial dynamics. Cell Death Discov 2:16082.	OXPHOS LEAK	N S	Permeabilized cells	Human	Nervous system Other cell lines
Gorbacheva 2016 International Symposium Mitochondrial Motility	2016	Gorbacheva OS, Strutynskyi RB, Khmil NV, Belosludtseva NV, Murzaeva SV, Korobeynikova MO, Alilova GA, Lezhnev EI, Mironova GD (2016) Study of the influence of flocalin on the energy and ion exchanges in rat liver mitochondria. International Symposium Mitochondrial Motility 73-7.	LEAK	F N S		Rat	Liver
Kancirova 2016 Physiol Res	2016	Kancirová I, Jašová M, Muráriková M, Sumbalová Z, Uličná O, Ravingerová T, Waczulíková I, Ziegelhöffer A, Ferko M (2016) Cardioprotection induced by remote ischemic preconditioning preserves the mitochondrial respiratory function in acute diabetic myocardium. Physiol Res 65:S611-19.	LEAK OXPHOS	F N	Isolated mitochondria	Rat	Heart
Grundmanova 2016 Physiol Res	2016	Grundmanová M, Jarkovská D, Süß A, Tůma Z, Marková M, Grundman Z, El-Kadi A, Čedíková M, Štengl M, Kuncová J (2016) Propofol-induced mitochondrial and contractile dysfunction of the rat ventricular myocardium. Physiol Res 65:S601-9.	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Rat	Heart
Scott 2016 Thesis	2016	Scott KY (2016) Evaluation of cardiac mitochondrial function in the fructose-fed rat. Master's Thesis p98.	LEAK OXPHOS ET	F N S CIV ROX	Isolated mitochondria	Rat	Heart
Schaefer 2016 PLOS ONE	2016	Schaefer PM, von Einem B, Walther P, Calzia E, von Arnim CA (2016) Metabolic characterization of intact cells reveals intracellular amyloid beta but not its precursor protein to reduce mitochondrial respiration. PLOS ONE 11:e0168157.	LEAK ROUTINE ET	CIV ROX	Intact cells	Human Mouse	Nervous system HEK
Van Hoose 2016 J Nutr Biochem	2016	Van Hoose PM, Kelm NQ, Piell KM, Cole MP (2016) Conjugated linoleic acid and nitrite attenuate mitochondrial dysfunction during myocardial ischemia. J Nutr Biochem 34:8-16.	LEAK OXPHOS ET	N ROX	Isolated mitochondria	Mouse	Heart
Bastow 2016 J Cell Sci	2016	Bastow EL, Peswani AR, Tarrant DS, Pentland DR, Chen X, Morgan A, Staniforth GL, Tullet JM, Rowe ML, Howard MJ, Tuite MF, Gourlay CW (2016) New links between SOD1 and metabolic dysfunction from a yeast model of amyotrophic lateral sclerosis. J Cell Sci 129:4118-29.	LEAK ROUTINE ET	ROX	Intact cells	Saccharomyces cerevisiae
Queliconi 2016 PLOS ONE	2016	Queliconi BB, Kowaltowski AJ, Gottlieb RA (2016) Bicarbonate increases ischemia-reperfusion damage by inhibiting mitophagy. PLOS ONE 11:e0167678.	LEAK OXPHOS ET	S ROX	Isolated mitochondria	Rat	Heart
MacPherson 2016 Am J Physiol Cell Physiol	2016	MacPherson RE, Dragos SM, Ramos S, Sutton C, Frendo-Cumbo S, Castellani L, Watt MJ, Perry CG, Mutch DM, Wright DC (2016) Reduced ATGL-mediated lipolysis attenuates β-adrenergic-induced AMPK signaling, but not the induction of PKA-targeted genes, in adipocytes and adipose tissue. Am J Physiol Cell Physiol 311:C269-76.	OXPHOS LEAK	N	Permeabilized tissue	Mouse	Fat
Moll 2016 bioRxiv	2016	Moll CWI, Lindtner RA, Vogel GF, Brunner M, Gutleben K, Blauth M, Krumschnabel G, Ebner HL (2016) Bone marrow mesenchymal stem cells from osteoporotic patients do not show altered mitochondrial energetics or ultrastructure. bioRxiv doi.org/10.1101/046300.	LEAK ROUTINE OXPHOS ET	N S ROX	Intact cells Permeabilized cells	Human	Stem cells
Baris 2016 Am J Physiol Regul Integr Comp Physiol	2016	Baris TZ, Blier PU, Pichaud N, Crawford DL, Oleksiak MF (2016) Gene by environmental interactions affecting oxidative phosphorylation and thermal sensitivity. Am J Physiol Regul Integr Comp Physiol 311:R157-65.	LEAK OXPHOS ET	CIV NS ROX S	Permeabilized tissue	Fishes	Heart
Ferguson 2016 J Bioenerg Biomembr	2016	Ferguson MA, Sutton RM, Karlsson M, Sjövall F, Becker LB, Berg RA, Margulies SS, Kilbaugh TJ (2016) Increased platelet mitochondrial respiration after cardiac arrest and resuscitation as a potential peripheral biosignature of cerebral bioenergetic dysfunction. J Bioenerg Biomembr 48:269-79.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Homogenate Intact cells	Pig	Nervous system Platelet
Lark 2016 Am J Physiol Cell Physiol	2016	Lark DS, Torres MJ, Lin CT, Ryan TE, Anderson EJ, Neufer PD (2016) Direct real-time quantification of mitochondrial oxidative phosphorylation efficiency in permeabilized skeletal muscle myofibers. Am J Physiol Cell Physiol 311:C239-45.	LEAK OXPHOS ET	N Gp NS	Permeabilized tissue Isolated mitochondria	Mouse	Skeletal muscle
Valek 2016 Redox Biol	2016	Valek L, Häussler A, Dröse S, Eaton P, Schröder K, Tegeder I (2016) Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain. Redox Biol 11:176-91.	OXPHOS LEAK	N S CIV ROX	Homogenate	Mouse	Nervous system
Berressem 2016 PLOS ONE	2016	Berressem D, Koch K, Franke N, Klein J, Eckert GP (2016) Intravenous treatment with a long-chain omega-3 lipid emulsion provides neuroprotection in a murine model of ischemic stroke - a pilot study. PLOS ONE 11:e0167329.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Pambianco 2016 Cell Rep	2016	Pambianco S, Giovarelli M, Perrotta C, Zecchini S, Cervia D3, Di Renzo I, Moscheni C, Ripolone M, Violano R, Moggio M, Bassi MT, Puri PL, Latella L, Clementi E, De Palma C (2016) Reversal of defective mitochondrial biogenesis in limb-girdle muscular dystrophy 2D by independent modulation of histone and PGC-1α acetylation. Cell Rep 17:3010-23.	LEAK OXPHOS	F N S NS ROX	Permeabilized cells Isolated mitochondria Permeabilized tissue	Mouse	Skeletal muscle
Witt 2016 Metab Brain Dis	2016	Witt AM, Larsen FS, Bjerring PN (2016) Accumulation of lactate in the rat brain during hyperammonaemia is not associated with impaired mitochondrial respiratory capacity. Metab Brain Dis 32:461-70.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Nervous system
Diana 2016 Surg Endosc	2016	Diana M, Noll E, Charles AL, Diemunsch P, Geny B, Liu YY, Marchegiani F, Schiraldi L, Agnus V, Lindner V, Swanström L, Dallemagne B, Marescaux J (2016) Precision real-time evaluation of bowel perfusion: accuracy of confocal endomicroscopy assessment of stoma in a controlled hemorrhagic shock model. Surg Endosc 31:680-91.	OXPHOS LEAK	S	Permeabilized tissue	Pig	Endothelial;epithelial;mesothelial cell
Timpani 2016 Neurotherapeutics	2016	Timpani CA, Trewin AJ, Stojanovska V, Robinson A, Goodman CA, Nurgali K, Betik AC, Stepto N, Hayes A, McConell GK, Rybalka E (2016) Attempting to compensate for reduced neuronal nitric oxide synthase protein with nitrate supplementation cannot overcome metabolic dysfunction but rather has detrimental effects in Dystrophin-deficient mdx muscle. Neurotherapeutics 14:429-46.	LEAK OXPHOS ET	N CIV NS Other combinations ROX S	Permeabilized tissue	Mouse	Skeletal muscle
Briston 2016 Sci Rep	2016	Briston T, Lewis S, Koglin M, Mistry K, Shen Y, Hartopp N, Katsumata R, Fukumoto H, Duchen MR, Szabadkai G, Staddon JM, Roberts M, Powney B (2016) Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria. Sci Rep 6:37798.	LEAK OXPHOS ET	N S ROX	Isolated mitochondria	Rat	Liver
Williams 2016 Diabetes	2016	Williams AS, Trefts E, Lantier L, Grueter C, Bracy DP, James FD, Pozzi A, Zent R, Wasserman DH (2016) Integrin-linked kinase is necessary for the development of diet-induced hepatic insulin resistance. Diabetes 66:325-34.	OXPHOS LEAK	F N	Isolated mitochondria	Mouse	Liver
Torres 2016 Redox Biol	2016	Torres S, Matías N, Baulies A, Nuñez S, Alarcon-Vila C, Martinez L, Nuño N, Fernandez A, Caballeria J, Levade T, Gonzalez-Franquesa A, Garcia-Rovés P, Balboa E, Zanlungo S, Fabrías G, Casas J, Enrich C, Garcia-Ruiz C, Fernández-Checa JC (2016) Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease. Redox Biol 11:60-72.	LEAK ROUTINE OXPHOS ET	N S ROX	Homogenate Intact cells	Human Mouse	Nervous system Liver Endothelial;epithelial;mesothelial cell Fibroblast
Hals 2016 Islets	2016	Hals IK, Singh R, Ma Z, Scholz H, Björklund A, Grill V (2016) Culture at low glucose up-regulates mitochondrial function in pancreatic β cells with accompanying effects on viability. Islets 8:165-76.	LEAK ET	ROX	Intact cells	Rat	Islet cell;pancreas;thymus
Mickevicius 2016 Thesis	2016	Mickevicius L (2016) Effect of short time ischemia/reperfusion in vivo on rat kidney mitochondria oxidative phosphorylation. Diploma Thesis p38.	OXPHOS LEAK	N NS	Isolated mitochondria	Rat	Kidney
Chorner 2016 Am J Physiol Regul Integr Comp Physiol	2016	Chorner Z, Barbeau PA, Castellani L, Wright DC, Chabowski A, Holloway GP (2016) Dietary α-linolenic acid supplementation alters skeletal muscle plasma membrane lipid composition, sarcolemmal FAT/CD36 abundance, and palmitate transport rates. Am J Physiol Regul Integr Comp Physiol 311:R1234-42.	LEAK OXPHOS	F N NS	Isolated mitochondria	Rat	Skeletal muscle
Frey 2016 Biochim Biophys Acta	2016	Frey S, Geffroy G, Desquiret-Dumas V, Gueguen N, Bris C, Belal S, Amati-Bonneau P, Chevrollier A, Barth M, Henrion D, Lenaers G, Bonneau D, Reynier P, Procaccio V (2016) The addition of ketone bodies alleviates mitochondrial dysfunction by restoring complex I assembly in a MELAS cellular model. Biochim Biophys Acta 1863:284-91.	ROUTINE LEAK ET	N S NS	Permeabilized cells Intact cells	Human	Nervous system
Heimer 2016 Am J Hum Genet	2016	Heimer G, Kerätär JM, Riley LG, Balasubramaniam S, Eyal E, Pietikäinen LP, Hiltunen JK, Marek-Yagel D, Hamada J, Gregory A, Rogers C, Hogarth P, Nance MA, Shalva N, Veber A, Tzadok M, Nissenkorn A, Tonduti D, Renaldo F, Kraoua I, Panteghini C, Valletta L, Garavaglia B, Cowley MJ, Gayevskiy V, Roscioli T, Silberstein JM, Hoffmann C, Raas-Rothschild A, Tiranti V, Anikster Y, Christodoulou J, Kastaniotis AJ, Ben-Zeev B, Hayflick SJ (2016) MECR mutations cause childhood-onset dystonia and optic atrophy, a mitochondrial fatty acid synthesis disorder. Am J Hum Genet 99:1229-44.	LEAK ROUTINE ET	ROX	Intact cells	Human	Fibroblast
Mezera 2016 Oxid Med Cell Longev	2016	Mezera V, Endlicher R, Kucera O, Sobotka O, Drahota Z, Cervinkova Z (2016) Effects of epigallocatechin gallate on tert-butyl hydroperoxide-induced mitochondrial dysfunction in rat liver mitochondria and hepatocytes. Oxid Med Cell Longev 7573131:8pp.	LEAK OXPHOS	N S	Permeabilized cells Isolated mitochondria	Rat	Liver
Chondronikola 2016 Cell Metab	2016	Chondronikola M, Volpi E, Børsheim E, Porter C, Saraf MK, Annamalai P, Yfanti C, Chao T, Wong D, Shinoda K, Labbė SM, Hurren NM, Cesani F, Kajimura S, Sidossis LS. (2016) Brown adipose tissue activation is linked to distinct systemic effects on lipid metabolism in humans. Cell Metab 23:1200-6.	LEAK OXPHOS			Human
Fisar 2016a Folia Biol (Praha)	2016	Fisar Z, Hroudova J (2016) Pig brain mitochondria as a biological model for study of mitochondrial respiration. Folia Biol (Praha) 62:15-25.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Pig	Nervous system
Fisar 2016 Curr Alzheimer Res	2016	Fišar Z, Hroudová J, Hansíková H, Spáčilová J, Lelková P, Wenchich L, Jirák R, Zvěřová M, Zeman J, Martásek P, Raboch J (2016) Mitochondrial respiration in the platelets of patients with Alzheimer's disease. Curr Alzheimer Res 13:930-41.	LEAK OXPHOS ET	N S NS ROX	Intact cells Permeabilized cells	Human	Blood cells Platelet
Liang 2016 J Biol Chem	2016	Liang X, Liu L, Fu T, Zhou Q, Zhou D, Xiao L, Liu L, Kong Y, Xie H, Yi F, Lai L, Vega RB, Kelly DP, Smith SR, Gan Z (2016) Exercise inducible lactate dehydrogenase B regulates mitochondrial function in skeletal muscle. J Biol Chem 291:25306-18.	LEAK OXPHOS ET	N	Permeabilized tissue	Mouse	Skeletal muscle
Grimm 2016 Methods Mol Biol	2016	Grimm A, Schmitt K, Eckert A (2016) Advanced mitochondrial respiration assay for evaluation of mitochondrial dysfunction in Alzheimer's disease. Methods Mol Biol 1303:171-83.	LEAK OXPHOS ET	N CIV ROX	Isolated mitochondria	Mouse	Nervous system
Renner 2016 Mycotoxin Res	2016	Renner L, Kahlert S, Tesch T, Bannert E, Frahm J, Barta-Böszörményi A, Kluess J, Kersten S, Schönfeld P, Rothkötter HJ, Dänicke S (2016) Chronic DON exposure and acute LPS challenge: effects on porcine liver morphology and function. Mycotoxin Res 33:207-18.	LEAK OXPHOS	N	Isolated mitochondria	Pig	Liver
Kucera 2016 Drug Chem Toxicol	2016	Kučera O, Endlicher R, Rychtrmoc D, Lotková H, Sobotka O, Červinková Z (2016) Acetaminophen toxicity in rat and mouse hepatocytes in vitro. Drug Chem Toxicol 40:448-56.	LEAK OXPHOS	N NS	Permeabilized cells	Mouse Rat	Liver
Docherty 2016 Stem Cell Res Ther	2016	Docherty CK, Salt IP, Mercer JR (2016) Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells. Stem Cell Res Ther 7:78.	LEAK ET	ROX	Intact cells	Human	Kidney HEK
Salvadego 2016 J Appl Physiol (1985)	2016	Salvadego D, Keramidas ME, Brocca L, Domenis R, Mavelli I, Rittweger J, Eiken O, Mekjavic IB, Grassi B (2016) Separate and combined effects of a 10-d exposure to hypoxia and inactivity on oxidative function in vivo and mitochondrial respiration ex vivo in humans. J Appl Physiol (1985) 121:154-63.	LEAK OXPHOS ET	N ROX	Permeabilized tissue	Human	Skeletal muscle
Perna 2016 Amino Acids	2016	Perna MK, Kokenge AN, Miles KN, Udobi KC, Clark JF, Pyne-Geithman GJ, Khuchua Z, Skelton MR (2016) Creatine transporter deficiency leads to increased whole body and cellular metabolism. Amino Acids 48:2057-65.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Schiffer 2016 Am J Physiol Cell Physiol	2016	Schiffer TA, Peleli M, Sundqvist ML, Ekblom B, Lundberg JO, Weitzberg E, Larsen FJ (2016) Control of human energy expenditure by cytochrome c oxidase subunit IV-2. Am J Physiol Cell Physiol 311:C452-61.	LEAK OXPHOS ET ROUTINE	N NS	Permeabilized cells Isolated mitochondria Intact cells	Human	Skeletal muscle HEK
Singh 2016 Mol Neurobiol	2016	Singh N, Hroudová J, Fišar Z (2016) In vitro effects of cognitives and nootropics on mitochondrial respiration and monoamine oxidase activity. Mol Neurobiol 54:5894-904.	LEAK	N S ROX	Isolated mitochondria	Pig	Nervous system
Spendiff 2016 J Physiol	2016	Spendiff S, Vuda M, Gouspillou G, Aare S, Perez A, Morais JA, Jagoe RT, Filion ME, Glicksman R, Kapchinsky S, MacMillan NJ, Pion CH, Aubertin-Leheudre M, Hettwer S, Correa JA, Taivassalo T, Hepple RT (2016) Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians. J Physiol 594:7361-79.	OXPHOS LEAK	N CIV NS ROX	Permeabilized tissue	Human Mouse	Skeletal muscle
Raturi 2016 J Cell Biol	2016	Raturi A, Gutiérrez T, Ortiz-Sandoval C, Ruangkittisakul A, Herrera-Cruz MS, Rockley JP, Gesson K, Ourdev D, Lou PH, Lucchinetti E, Tahbaz N, Zaugg M, Baksh S, Ballanyi K, Simmen T (2016) TMX1 determines cancer cell metabolism as a thiol-based modulator of ER-mitochondria Ca²⁺ flux. J Cell Biol 214:433-44.	LEAK ET ROUTINE		Permeabilized cells Intact cells	Mouse Human	HeLa Other cell lines
Gerber 2016 J Med Genet	2016	Gerber S, Ding MG, Gérard X, Zwicker K, Zanlonghi X, Rio M, Serre V, Hanein S, Munnich A, Rotig A, Bianchi L, Amati-Bonneau P, Elpeleg O, Kaplan J, Brandt U, Rozet JM (2016) Compound heterozygosity for severe and hypomorphic NDUFS2 mutations cause non-syndromic LHON-like optic neuropathy. J Med Genet 54:346-56.	LEAK ROUTINE ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell Fibroblast
Strifler 2016b PLOS ONE	2016	Strifler G, Tuboly E, Görbe A, Boros M, Pécz D, Hartmann P (2016) Targeting mitochondrial dysfunction with L-alpha glycerylphosphorylcholine. PLOS ONE 11:e0166682.	LEAK OXPHOS ET	N S NS Other combinations ROX	Homogenate	Rat	Liver
Liu 2016 EMBO Mol Med	2016	Liu J, Liang X, Zhou D, Lai L, Xiao L, Liu L, Fu T, Kong Y, Zhou Q, Vega RB, Zhu MS, Kelly DP, Gao X, Gan Z (2016) Coupling of mitochondrial function and skeletal muscle fiber type by a miR-499/Fnip1/AMPK circuit. EMBO Mol Med 8:1212-1228.	LEAK OXPHOS ET	N ROX	Permeabilized cells Permeabilized tissue	Mouse	Skeletal muscle
Wilson 2016 US Patent	2016	Wilson TD (2016) Peptide therapeutics and methods for using same. US Patent US20160151446 A1.	LEAK		Permeabilized tissue	Rat	Skeletal muscle
Berger 2016 Nat Commun	2016	Berger E, Rath E, Yuan D, Waldschmitt N, Khaloian S, Allgäuer M, Staszewski O, Lobner EM, Schöttl T, Giesbertz P, Coleman OI, Prinz M, Weber A, Gerhard M, Klingenspor M, Janssen KP, Heikenwalder M, Haller D (2016) Mitochondrial function controls intestinal epithelial stemness and proliferation. Nat Commun 7:13171.	LEAK OXPHOS	S ROX		Mouse	Endothelial;epithelial;mesothelial cell
Eisenberg 2016 Nat Med	2016	Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F (2016) Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med 22:1428-38.	LEAK ET OXPHOS	N ROX	Isolated mitochondria	Mouse	Heart
Safiedeen 2016 Antioxid Redox Signal	2016	Safiedeen Z, Rodríguez-Gómez I, Vergori L, Soleti R, Vaithilingam D, Douma I, Agouni A, Leiber D, Dubois S, Simard G, Zibara K, Andriantsitohaina R, Martínez MC (2016) Temporal cross talk between endoplasmic reticulum and mitochondria regulates oxidative stress and mediates microparticle-induced endothelial dysfunction. Antioxid Redox Signal 26:15-27.	LEAK ET ROUTINE	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell
Porter 2016 J Burn Care Res	2016	Porter C, Herndon DN, Børsheim E, Bhattarai N, Chao T, Reidy PT, Rasmussen BB, Andersen CR, Suman OE, Sidossis LS. (2016) Long-Term Skeletal Muscle Mitochondrial Dysfunction is Associated with Hypermetabolism in Severely Burned Children.. J Burn Care Res 37(1):53-63.	LEAK OXPHOS		Permeabilized tissue		Skeletal muscle
Giraldos Jimenez 2016 Thesis	2016	Giraldos Jiménez D (2016) Oxidative phosphorylation system’s role in adipogenic differentiation. Thesis p25.	LEAK ROUTINE	ROX
Coelho 2016 Oncol Rep	2016	Coelho RG, Cazarin JM, Cavalcanti de Albuquerque JP, de Andrade BM, Carvalho DP (2016) Differential glycolytic profile and Warburg effect in papillary thyroid carcinoma cell lines. Oncol Rep 36:3673-81.	LEAK	CIV	Intact cells	Human	Other cell lines
Chakraborty 2016 Pancreatology	2016	Chakraborty M, Hickey AJ, Petrov MS, Macdonald JR, Thompson N, Newby L, Sim D, Windsor JA, Phillips AR (2016) Mitochondrial dysfunction in peripheral blood mononuclear cells in early experimental and clinical acute pancreatitis. Pancreatology 16:739-47.	LEAK OXPHOS ROUTINE ET	N Gp CIV NS ROX S	Permeabilized cells	Human Rat	Blood cells
Holzem 2016 FASEB J	2016	Holzem KM, Vinnakota KC, Ravikumar VK, Madden EJ, Ewald GA, Dikranian K, Beard DA, Efimov IR (2016) Mitochondrial structure and function are not different between nonfailing donor and end-stage failing human hearts. FASEB J 30:2698-707.	OXPHOS LEAK	F N	Permeabilized tissue Isolated mitochondria	Human	Heart
Nauta 2016 Thesis	2016	Nauta TD (2016) HIF-2α regulates in vitro neovascularization during hypoxia. Doctoral Dissertation p206.	LEAK ROUTINE ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell
Bueno 2016 Thesis	2016	Bueno e Silva MM (2016) Alterações mitocondriais e reprogramação metabólica em células de glioblastoma após tratamento com temozolomida. Dissertation p71.	LEAK ROUTINE ET		Intact cells	Human	Nervous system Other cell lines
Shirey 2016 Biochemistry	2016	Shirey K, Stover KR, Cleary J, Hoang N, Hosler J (2016) Membrane-anchored cyclic peptides as effectors of mitochondrial oxidative phosphorylation. Biochemistry 55:2100-11.	LEAK OXPHOS ET	CIV NS N S	Isolated mitochondria SMP	Rat	Heart Liver
Hamilton 2016 Physiol Rep	2016	Hamilton DJ, Minze LJ, Kumar T, Cao TN, Lyon CJ, Geiger PC, Hsueh WA, Gupte AA (2016) Estrogen receptor alpha activation enhances mitochondrial function and systemic metabolism in high-fat-fed ovariectomized mice. Physiol Rep 4. pii: e12913.	LEAK OXPHOS	F N NS	Isolated mitochondria	Mouse	Heart
Salin 2016 Physiol Biochem Zool	2016	Salin K, Auer SK, Rudolf AM, Anderson GJ, Selman C, Metcalfe NB (2016) Variation in metabolic rate among individuals is related to tissue-specific differences in mitochondrial LEAK respiration. Physiol Biochem Zool 89:511-23.	LEAK OXPHOS	N CIV NS ROX	Homogenate	Fishes	Skeletal muscle Liver
Nissinen 2016 Sci Rep	2016	Nissinen TA, Degerman J, Räsänen M, Poikonen AR, Koskinen S, Mervaala E, Pasternack A, Ritvos O, Kivelä R, Hulmi JJ (2016) Systemic blockade of ACVR2B ligands prevents chemotherapy-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative capacity or atrogenes. Sci Rep 6:32695.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Mouse	Skeletal muscle
Abdel-Rahman 2016 Oxid Med Cell Longev	2016	Abdel-Rahman EA, Mokhtar A, Aaliya A, Radwan Y, Yasseen B, Al-Okda A, Atwa A, Elhanafy E, Habashy M, Ali SS (2016) Resolving contributions of oxygen-consuming and ROS-generating enzymes at the synapse. Oxid Med Cell Longev p19.	LEAK OXPHOS	N NS ROX	Permeabilized cells	Mouse	Nervous system
Roempler 2016 J Biol Chem	2016	Römpler K, Müller T, Juris L, Wissel M, Vukotic M, Hofmann K, Deckers M (2016) Overlapping role of respiratory supercomplex factor Rcf2 and its N-terminal homolog Rcf3 in Saccharomyces cerevisiae. J Biol Chem 291:23769-78.	LEAK OXPHOS	N CIV NS ROX	Isolated mitochondria	Saccharomyces cerevisiae
Ivarsson 2016 Physiol Behav	2016	Ivarsson N, Schiffer TA, Hernández A, Lanner JT, Weitzberg E, Lundberg JO, Westerblad H (2016) Dietary nitrate markedly improves voluntary running in mice. Physiol Behav 168:55-61.	OXPHOS LEAK		Isolated mitochondria	Mouse	Skeletal muscle
Du 2016 Thesis	2016	Du X (2016) Anthropogenic pollution effects on mitochondrial energy metabolism, gene expression, and genotypes of natural Fundulus heteroclitus populations. Dissertation p175.	LEAK OXPHOS ET	S CIV ROX N NS	Permeabilized cells	Fishes	Liver
Chen 2016 Nat Chem Biol	2016	Chen YJ, Mahieu NG, Huang X, Singh M, Crawford PA, Johnson SL, Gross RW, Schaefer J, Patti GJ (2016) Lactate metabolism is associated with mammalian mitochondria. Nat Chem Biol 12:937-43.	LEAK OXPHOS ET	N NS ROX	Isolated mitochondria	Human	HeLa
Fink 2016 Am J Physiol Regul Integr Comp Physiol	2016	Fink BD, Bai F, Yu L, Sivitz WI (2016) Impaired utilization of membrane potential by complex II-energized mitochondria of obese, diabetic mice assessed using ADP recycling methodology. Am J Physiol Regul Integr Comp Physiol 311:756-63.	OXPHOS LEAK	S	Isolated mitochondria	Mouse	Skeletal muscle
Raesaenen 2016 Proc Natl Acad Sci U S A	2016	Räsänen M, Degerman J, Nissinen TA, Miinalainen I, Kerkelä R, Siltanen A, Backman JT, Mervaala E, Hulmi JJ, Kivelä R, Alitalo K (2016) VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection. Proc Natl Acad Sci U S A 113:13144-49.	LEAK OXPHOS ET	N S NS	Homogenate	Mouse	Heart
Reich 2016 Thesis	2016	Reich V (2016) Pathophysiologie und Verfahrensentwicklung: Mechanismen der Metabolisierung von Schwefelwasserstoff im mitochondrialen Atmungskreislauf von Lungenalveolarmakrophagen. Dissertation p91.	LEAK OXPHOS ET	N S CIV NS ROX	Intact cells Permeabilized cells	Mouse	Macrophage-derived
Timmers 2016 Diabetes Care	2016	Timmers S, de Ligt M, Phielix E, van de Weijer T, Hansen J, Moonen-Kornips E, Schaart G, Kunz I, Hesselink MK, Schrauwen-Hinderling VB, Schrauwen P (2016) Resveratrol as add-on therapy in subjects with well-controlled type 2 diabetes: a randomized controlled trial. Diabetes Care 39:2211-17.	LEAK ET OXPHOS	F N NS	Permeabilized tissue	Human	Skeletal muscle
Maarman 2016 J Appl Physiol (1985)	2016	Maarman GJ, Andrew BM, Blackhurst DM, Ojuka EO (2016) Melatonin protects against uric acid-induced mitochondrial dysfunction, oxidative stress, and triglyceride accumulation in C₂C₁₂ myotubes. J Appl Physiol (1985) 122:1003-10.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Mouse	Skeletal muscle
Hartmannova 2016 Hum Mol Genet	2016	Hartmannová H, Piherová L, Tauchmannová K, Kidd K, Acott PD, Crocker JF, Oussedik Y, Mallet M, Hodaňová K, Stránecký V, Přistoupilová A, Barešová V, Jedličková I, Živná M, Sovová J, Hůlková H, Robins V, Vrbacký M, Pecina P, Kaplanová V, Houštěk J, Mráček T, Thibeault Y, Bleyer AJ, Kmoch S (2016) Acadian variant of Fanconi syndrome is caused by mitochondrial respiratory chain complex I deficiency due to a non-coding mutation in complex I assembly factor NDUFAF6. Hum Mol Genet 25:4062-79.	LEAK OXPHOS ET	N S Gp CIV NS ROX	Permeabilized cells	Human	Fibroblast
Amigo 2016 Aging Cell	2016	Amigo I, Menezes-Filho SL, Luévano-Martínez LA, Chausse B, Kowaltowski AJ (2016) Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity. Aging Cell 16:73-81.	LEAK OXPHOS ET	N S	Isolated mitochondria	Mouse	Nervous system
Tyrrell 2016 Redox Biol	2016	Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Molina AJ (2016) Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health. Redox Biol 10:65-77. https://doi.org/10.1016/j.redox.2016.09.009	OXPHOS LEAK ET	N NS ROX	Permeabilized tissue Isolated mitochondria Intact cells	Other mammals Human	Skeletal muscle Blood cells Platelet
Heim 2016 Thesis	2016	Heim A (2016) Tissue-specific seasonal changes in mitochondrial respiratory function and membrane composition in the golden-matled ground squirrel. Master's Thesis p77.	LEAK OXPHOS	F N NS Other combinations	Isolated mitochondria	Other mammals	Heart Skeletal muscle Liver Fat
Drehmer 2016 Stem Cell Res	2016	Drehmer DL, de Aguiar AM, Brandt AP, Petiz L, Cadena SM, Rebelatto CK, Brofman PR, Filipak Neto F, Dallagiovanna B, Abud AP (2016) Metabolic switches during the first steps of adipogenic stem cells differentiation. Stem Cell Res 17:413-421.	LEAK ROUTINE ET	ROX	Intact cells	Human	Fat Stem cells
Dechandt 2016 Anal Biochem	2016	Dechandt CRP, Couto-Lima CA, Alberici LC (2016) Triglyceride depletion of brown adipose tissue enables analysis of mitochondrial respiratory function in permeabilized biopsies. Anal Biochem 515:55-60.	LEAK OXPHOS ET	N S ROX	Permeabilized tissue	Rat	Fat
Smith 2016 Diabetes	2016	Smith BK, Ford RJ, Desjardins EM, Green AE, Hughes MC, Houde VP, Day EA, Marcinko K, Crane JD, Mottillo EP, Perry CG, Kemp BE, Tarnopolsky MA, Steinberg GR (2016) Salsalate (Salicylate) uncouples mitochondria, improves glucose homeostasis, and reduces liver lipids independent of AMPK β1. Diabetes 65:3352-61.	LEAK OXPHOS ET	F N NS Other combinations ROX	Permeabilized cells Isolated mitochondria Permeabilized tissue	Mouse	Skeletal muscle Liver Fat
Scialo 2016 PLOS ONE	2016	Scialo F, Sriram A, Stefanatos R, Sanz A (2016) Practical recommendations for the use of the GeneSwitch Gal4 system to knock-Down genes in Drosophila melanogaster. PLOS ONE 11:e0161817.	LEAK OXPHOS	N CIV Other combinations ROX Gp	Homogenate	Drosophila
Davuluri 2016 J Physiol	2016	Davuluri G, Allawy A, Thapaliya S, Rennison JH, Singh D, Kumar A, Sandlers Y, Van Wagoner DR, Flask CA, Hoppel C, Kasumov T, Dasarathy S (2016) Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress. J Physiol 594:7341-60.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Skeletal muscle Other cell lines
Salin 2016 Physiol Rep	2016	Salin K, Villasevil EM, Auer SK, Anderson GJ, Selman C, Metcalfe NB, Chinopoulos C (2016) Simultaneous measurement of mitochondrial respiration and ATP production in tissue homogenates and calculation of effective P/O ratios. Physiol Rep 10.14814/phy2.13007.	LEAK OXPHOS	N NS ROX	Homogenate	Fishes	Liver
Galli 2016 Am J Physiol Regul Integr Comp Physiol	2016	Galli GL, Crossley J, Elsey RM, Dzialowski EM, Shiels HA, Crossley DA 2nd (2016) Developmental plasticity of mitochondrial function in American alligators, Alligator mississippiensis. Am J Physiol Regul Integr Comp Physiol 311:R1164-72.	LEAK OXPHOS ET	N S CIV Other combinations ROX	Isolated mitochondria	Reptiles	Heart
Berschneider 2016 Thesis	2016	Berschneider K (2016) Connecting the functions of the proteasome and mitochondria in the lung. Dissertation p161.	LEAK ROUTINE ET	ROX	Permeabilized cells	Mouse	Lung;gill
McFarlane 2016 Thesis	2016	McFarlane SV (2016) Temperature-dependent alterations of brown adipose tissue metabolism during hibernation in the thirteen-lined ground squirrel, Ictidomys tridecemlineatus. Dissertation p74.	LEAK ROUTINE OXPHOS ET	F N	Isolated mitochondria Intact cells	Other mammals	Fat
Watala 2016 Int J Pharm	2016	Watala C, Karolczak K, Kassassir H, Siewiera K, Maczynska K, Pieniazek A, Labieniec-Watala M (2016) How do the full-generation poly(amido)amine (PAMAM) dendrimers activate blood platelets? Platelet membrane zeta potential and other membrane-associated phenomena. Int J Pharm 500:379-89.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Platelet
Porter 2016 Cell Metab	2016	Porter C, Herndon DN, Chondronikola M, Chao T, Annamalai P, Bhattarai N, Saraf MK, Capek KD, Reidy PT, Daquinag AC, Kolonin MG, Rasmussen BB, Borsheim E, Toliver-Kinsky T, Sidossis LS (2016) Human and mouse brown adipose tissue mitochondria have comparable UCP1 function. Cell Metab 24:246-55.	LEAK OXPHOS ET	F N NS Other combinations	Permeabilized tissue	Human Mouse	Skeletal muscle Fat
Brandt 2016 Chem Biol Interact	2016	Brandt AP, Gozzi GJ, Pires Ado R, Martinez GR, Dos Santos Canuto AV, Echevarria A, Di Pietro A, Cadena SM (2016) Impairment of oxidative phosphorylation increases the toxicity of SYD-1 on hepatocarcinoma cells (HepG2). Chem Biol Interact 256:154-60.	LEAK ROUTINE ET	ROX	Intact cells	Human	Liver Other cell lines
Bagur 2016 Biochim Biophys Acta	2016	Bagur R, Tanguy S, Foriel S, Grichine A, Sanchez C, Pernet-Gallay K, Kaambre T, Kuznetsov AV, Usson Y, Boucher F, Guzun R (2016) The impact of cardiac ischemia/reperfusion on the mitochondria-cytoskeleton interactions. Biochim Biophys Acta 1862:1159-71.	OXPHOS LEAK	N S	Permeabilized tissue	Rat	Heart
Tretter 2016 Biochim Biophys Acta	2016	Tretter L, Patocs A, Chinopoulos C (2016) Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis. https://doi.org/10.1016/j.bbabio.2016.03.012	LEAK OXPHOS	N S NS
Hancock 2016 Amino Acids	2016	Hancock CN, Liu W, Alvord WG, Phang JM (2016) Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate. Amino Acids 48:859-72.	LEAK ROUTINE ET	S Other combinations ROX	Isolated mitochondria Oxidase;biochemical oxidation Intact cells	Mouse	Liver
Wang 2016 J Biol Chem	2016	Wang H, Lu J, Edmunds LR, Kulkarni S, Dolezal J, Tao J, Ranganathan S, Jackson L, Fromherz M, Stolz DB, Uppala R, Bharathi S, Monga SP, Goetzman ES, Prochownik EV (2016) Coordinated activities of multiple Myc-dependent and Myc-independent biosynthetic pathways in Hepatoblastoma. J Biol Chem 291:26241-51.	OXPHOS LEAK	N S NS	Homogenate	Mouse	Liver
McCurdy 2016 JCI Insight	2016	McCurdy CE, Schenk S, Hetrick B, Houck J, Drew BG, Kaye S, Lashbrook M, Bergman BC, Takahashi DL, Dean TA, Nemkov T, Gertsman I, Hansen KC, Philp A, Hevener AL, Chicco AJ, Aagaard KM, Grove KL, Friedman JE (2016) Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques. JCI Insight 1:e86612.	LEAK OXPHOS ET	F N S NS	Permeabilized tissue	Other mammals	Skeletal muscle
Chowdhury 2015 Biosci Rep	2016	Chowdhury SK, Djordjevic J, Albensi B, Fernyhough P (2015) Simultaneous evaluation of substrate-dependent oxygen consumption rates and mitochondrial membrane potential by TMRM and safranin in cortical mitochondria. Biosci Rep 36:e00286.	LEAK OXPHOS ET	N S NS ROX	Homogenate Isolated mitochondria	Mouse	Nervous system
Macheiner 2016 Sci Rep	2016	Macheiner T, Fengler VH, Agreiter M, Eisenberg T, Madeo F, Kolb D, Huppertz B, Ackbar R, Sargsyan K (2016) Magnetomitotransfer: An efficient way for direct mitochondria transfer into cultured human cells. Sci Rep 6:35571.	LEAK ROUTINE ET	ROX		Human	Fibroblast Lung;gill
Van Schaardenburgh 2016 PLOS ONE	2016	van Schaardenburgh M, Wohlwend M, Rognmo Ø, Mattsson EJ (2016) Mitochondrial respiration after one session of calf raise exercise in patients with peripheral vascular disease and healthy older adults. PLOS ONE 11:e0165038.	LEAK OXPHOS ET	F N S NS	Permeabilized tissue	Human	Skeletal muscle
Szczepanowska 2016 EMBO J	2016	Szczepanowska K, Maiti P, Kukat A, Hofsetz E, Nolte H, Senft K, Becker C, Ruzzenente B, Hornig-Do HT, Wibom R, Wiesner RJ, Krüger M, Trifunovic A (2016) CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels. EMBO J 35:2566-83.	LEAK OXPHOS ET	N NS	Isolated mitochondria	Mouse	Heart
Silva Ramos 2016 Biochim Biophys Acta	2016	Silva Ramos E, Larsson NG, Mourier A (2016) Bioenergetic roles of mitochondrial fusion. Biochim Biophys Acta 1857:1277-83.	LEAK OXPHOS ET	S Gp	Permeabilized cells	Mouse	Fibroblast
Talati 2016 Am J Respir Crit Care Med	2016	Talati MH, Brittain EL, Fessel JP, Penner N, Atkinson J, Funke M, Grueter C, Jerome WG, Freeman M, Newman JH, West J, Hemnes AR (2016) Mechanisms of lipid accumulation in the bone morphogenetic protein receptor type 2 mutant right ventricle. Am J Respir Crit Care Med 194:719-28.	LEAK	F N	Permeabilized tissue	Mouse	Heart
Loureiro 2016 Oxid Med Cell Longev	2016	Loureiro AC, do Rêgo-Monteiro IC, Louzada RA, Ortenzi VH, de Aguiar AP, de Abreu ES, Cavalcanti-de-Albuquerque JP, Hecht F, de Oliveira AC, Ceccatto VM, Fortunato RS, Carvalho DP (2016) Differential expression of NADPH oxidases depends on skeletal muscle fiber type in rats. Oxid Med Cell Longev 2016:6738701.	LEAK OXPHOS	N CIV NS ROX	Permeabilized tissue	Rat	Skeletal muscle
Strifler 2016 Magyar Sebeszet	2016	Strifler G, Meszaros A, Pecz D, Ficzere A, Barath B, Mihaly B, Hartmann P (2016) A májfunkció vizsgálata respirometriával - Examination of liver mitochondria with respirometry. Magyar Sebészet 69:194–8.	OXPHOS LEAK	N S CIV NS ROX Other combinations	Homogenate	Rat	Liver
Stier 2016 Methods Ecol Evol	2016	Stier A, Romestaing C, Schull Q, Lefol E, Robin JP, Roussel D, Bize P (2016) How to measure mitochondrial function in birds using red blood cells: a case study in the king penguin and perspectives in ecology and evolution. Methods Ecol Evol doi:10.1111/2041-210X.12724.	LEAK ROUTINE OXPHOS ET	N S ROX	Permeabilized tissue Intact cells	Birds	Skeletal muscle Blood cells
Khattar 2016 J Neurosci Methods	2016	Khattar NK, Yablonska S, Baranov SV, Baranova OV, Kretz ES, Larkin TM, Carlisle DL, Richardson RM, Friedlander RM (2016) Isolation of functionally active and highly purified neuronal mitochondria from human cortex. J Neurosci Methods 263:1-6.	LEAK OXPHOS ET	N	Isolated mitochondria	Human Mouse	Nervous system
Brecht 2016 Toxicol In Vitro	2016	Brecht K, Riebel V, Couttet P, Paech F, Wolf A, Chibout SD, Pognan F, Krähenbühl S, Uteng M (2016) Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin. Toxicol In Vitro 40:55-65.	LEAK OXPHOS ET	N S CIV Other combinations ROX DQ	Permeabilized cells	Human	Islet cell;pancreas;thymus
Pohland 2016 Neurochem Res	2016	Pohland M, Hagl S, Pellowska M, Wurglics M, Schubert-Zsilavecz M, Eckert GP (2016) MH84: a novel γ-secretase modulator/PPARγ agonist-improves mitochondrial dysfunction in a cellular model of Alzheimer's disease. Neurochem Res 41:231-42.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Kidney HEK
Mills 2016 Cell Metab	2016	Mills KF, Yoshida S, Stein LR, Uchida K, Yoshino J, Imai SI (2016) Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metab 24:1–12.	OXPHOS LEAK ET	N S NS	Permeabilized tissue	Mouse	Skeletal muscle
Larsen 2016 FASEB J	2016	Larsen FJ, Schiffer TA, Ørtenblad N, Zinner C, Morales-Alamo D, Willis SJ, Calbet JA, Holmberg HC, Boushel R (2016) High-intensity sprint training inhibits mitochondrial respiration through aconitase inactivation. FASEB J 30:417-27.	LEAK ROUTINE OXPHOS	N NS	Permeabilized cells Isolated mitochondria Intact cells	Human	Skeletal muscle
Wos 2016 Arch Biochem Biophys	2016	Woś M, Szczepanowska J, Pikuła S, Tylki-Szymańska A, Zabłocki K, Bandorowicz-Pikuła J (2016) Mitochondrial dysfunction in fibroblasts derived from patients with Niemann-Pick type C disease. Arch Biochem Biophys 593:50-9.	LEAK ROUTINE ET		Intact cells	Human	Endothelial;epithelial;mesothelial cell Fibroblast
Asseburg 2016 Neuromolecular Med	2016	Asseburg H, Schäfer C, Müller M, Hagl S, Pohland M, Berressem D, Borchiellini M, Plank C, Eckert GP (2016) Effects of grape skin extract on age-related mitochondrial dysfunction, memory and life span in C57BL/6J mice. Neuromolecular Med 18:378-95.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
MiPNet17.03 Shredder vs Fibers	2015-06-18	Mitochondrial respiration in permeabilized fibers versus homogenate from fish liver and heart. An application study with the PBI-Shredder.	LEAK OXPHOS ET	N S NS	Homogenate	Fishes	Heart Liver
Wahrheit 2015 Eng Life Sci	2015	Wahrheit J, Nonnenmacher Y, Sperber S, Heinzle E (2015) High-throughput respiration screening of single mitochondrial substrates using permeabilized CHO cells highlights control of mitochondria metabolism. Eng Life Sci 15:184-94.	LEAK OXPHOS	N S ROX	Permeabilized cells	Other mammals	Genital
Zelenka 2015 Oxid Med Cell Longev	2015	Zelenka J, Dvořák A, Alán L (2015) L-lactate protects skin fibroblasts against aging-associated mitochondrial dysfunction via mitohormesis. Oxid Med Cell Longev 2015:351698.	LEAK ROUTINE ET	N S	Isolated mitochondria Intact cells	Rat	Liver Endothelial;epithelial;mesothelial cell Fibroblast
Konopka 2015 Diabetes	2015	Konopka AR, Asante A, Lanza IR, Robinson MM, Johnson ML, Dalla Man C, Cobelli C, Amols MH, Irving BA, Nair KS (2015) Defects in mitochondrial efficiency and H₂O₂ emissions in obese women are restored to a lean phenotype with aerobic exercise training. Diabetes 64:2104-15.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Human	Skeletal muscle
Katunga 2015 Mol Metab	2015	Katunga LA, Gudimella P, Efird JT, Abernathy S, Mattox TA, Beatty C, Darden TM, Thayne KA, Alwair H, Kypson AP, Virag JA, Anderson EJ (2015) Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy. Mol Metab 4:493-506.	LEAK OXPHOS	F	Permeabilized tissue	Mouse	Heart
Johnson 2015 Aging Cell	2015	Johnson ML, Lalia AZ, Dasari S, Pallauf M, Fitch M, Hellerstein MK, Lanza IR (2015) Eicosapentaenoic acid but not docosahexaenoic acid restores skeletal muscle mitochondrial oxidative capacity in old mice. Aging Cell 14:734-43.	LEAK OXPHOS	F N S NS ROX	Isolated mitochondria	Mouse	Skeletal muscle
Schwarzkopf 2015 Neuroscience	2015	Schwarzkopf TM, Koch K, Klein J (2015) Reduced severity of ischemic stroke and improvement of mitochondrial function after dietary treatment with the anaplerotic substance triheptanoin. Neuroscience 300:201-9.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Li 2015 Sci Rep	2015	Li P, Wang B, Sun F, Li Y, Li Q, Lang H, Zhao Z, Gao P, Zhao Y, Shang Q, Liu D, Zhu Z (2015) Mitochondrial respiratory dysfunctions of blood mononuclear cells link with cardiac disturbance in patients with early-stage heart failure. Sci Rep 5:10229.	LEAK ROUTINE OXPHOS ET	N S NS	Intact cells	Human	Blood cells Lymphocyte
Ramos-Filho 2015 PLoS One	2015	Ramos-Filho D, Chicaybam G, de-Souza-Ferreira E, Guerra Martinez C, Kurtenbach E, Casimiro-Lopes G, Galina A (2015) High intensity interval training (HIIT) induces specific changes in respiration and electron leakage in the mitochondria of different rat skeletal muscles. PLoS One 10:e0131766.	LEAK OXPHOS ET	F N S Gp NS ROX	Permeabilized tissue	Rat	Skeletal muscle
Youcef 2015 Biochem Pharmacol	2015	Youcef G, Belaidi E, Waeckel L, Fazal L, Clemessy M, Vincent MP, Zadigue G, Richer C, Alhenc-Gelas F, Ovize M, Pizard A (2015) Tissue kallikrein is required for the cardioprotective effect of cyclosporin A in myocardial ischemia in the mouse. Biochem Pharmacol 94:22-9.	LEAK OXPHOS	N S CIV	Isolated mitochondria	Mouse	Heart
Acosta 2015 Obesity (Silver Spring)	2015	Acosta A, Camilleri M, Shin A, Vazquez-Roque MI, Iturrino J, Lanza IR, Nair KS, Burton D, O'Neill J, Eckert D, Carlson P, Vella A, Zinsmeister AR (2015) Association of UCP-3 rs1626521 with obesity and stomach functions in humans. Obesity (Silver Spring) 23:898-906.	LEAK OXPHOS	N S NS	Isolated mitochondria	Human	Skeletal muscle
Smolkova 2015 Int J Biochem Cell Biol	2015	Smolková K, Dvořák A, Zelenka J, Vítek L, Ježek P (2015) Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells. Int J Biochem Cell Biol 65:125-33.	LEAK ROUTINE ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell Other cell lines
Labieniec-Watala 2015 Int J Pharm Sci Res	2015	Labieniec-Watala M, Przygodzki T, Siewiera K, Podsedek A, Watala C (2015) Facts and artifacts in the evaluation of the anti-diabetic activity of spent hop extract in rat hearts in the “experimental model of diabetes. Int J Pharm Sci Res 1:106.	LEAK OXPHOS ET	S ROX	Isolated mitochondria	Rat	Heart
Pasdar 2015 PLoS One	2015	Pasdar EA, Smits M, Stapelberg M, Bajzikova M, Stantic M, Goodwin J, Yan B, Stursa J, Kovarova J, Sachaphibulkij K, Bezawork-Geleta A, Sobol M, Filimonenko A, Tomasetti M, Zobalova R, Hozak P, Dong LF, Neuzil J (2015) Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents. PLoS One 10:e0119549.	LEAK ROUTINE OXPHOS ET	N S NS	Permeabilized cells Intact cells	Human Mouse	Endothelial;epithelial;mesothelial cell Other cell lines
De Andrade 2015 Exp Cell Res	2015	de Andrade DC, de Carvalho SN, Pinheiro D, Thole AA, Moura AS, de Carvalho L, Cortez EA (2015) Bone marrow mononuclear cell transplantation improves mitochondrial bioenergetics in the liver of cholestatic rats. Exp Cell Res 336:15-22.	LEAK OXPHOS	F NS	Permeabilized tissue	Rat	Liver
Canto 2015 Curr Protoc Mouse Biol	2015	Cantó C, Garcia-Roves PM (2015) High-resolution respirometry for mitochondrial characterization of ex vivo mouse tissues. Curr Protoc Mouse Biol 5:135-53.	LEAK OXPHOS ET	N S NS	Permeabilized tissue Homogenate	Mouse	Heart Skeletal muscle Nervous system Liver Fat
Mikulecky 2015 World Heart J	2015	Mikulecký M Sr, Gvozdjáková A, Kucharská J, Mojto V, Mikulecký M Jr, Singh RB, Cornélissen G (2015) Are mitochondrial energetics in the rat under control of the solar (24 hours) and/or lunar (24.8 hours) day?. World Heart J 7.	LEAK OXPHOS		Isolated mitochondria	Rat	Heart Nervous system Liver
Yan 2015 BMC Cancer	2015	Yan B, Stantic M, Zobalova R, Bezawork-Geleta A, Stapelberg M, Stursa J, Prokopova K, Dong L, Neuzil J (2015) Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner. BMC Cancer 15:401.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human Mouse	Genital Other cell lines
Cagnone 2015 Methods Mol Biol	2015	Cagnone G, Vaghjiani V, Lee W, Sun C, Johnson J, Yeung KY, St John JC (2015) Analysis of the mitochondrial DNA and its replicative capacity in induced pluripotent stem cells. Methods Mol Biol 1357:231-67.	LEAK ROUTINE ET	ROX	Intact cells	Human	Stem cells
Porter 2015 Shock	2015	Porter C, Herndon DN, Bhattarai N, Ogunbileje JO, Szczesny B, Szabo C, Toliver-Kinsky T, Sidossis LS (2015) Severe burn injury induces thermogenically functional mitochondria in murine white adipose tissue. Shock 44:258-64.	LEAK	F N S NS Other combinations	Permeabilized tissue	Mouse	Fat
Lantier 2015 Diabetes	2015	Lantier L, Williams AS, Williams IM, Yang KK, Bracy DP, Goelzer M, James FD, Gius D, Wasserman DH (2015) SIRT3 is crucial for maintaining skeletal muscle insulin action and protects against severe insulin resistance in high fat fed mice. Diabetes 64:3081-92.	LEAK OXPHOS	F N	Permeabilized tissue	Mouse	Skeletal muscle
Hagve 2015 Am J Physiol Endocrinol Metab	2015	Hagve M, Gjessing PF, Fuskevåg OM, Larsen TS, Irtun Ø (2015) Skeletal muscle mitochondria exhibit decreased pyruvate oxidation capacity and increased ROS emission during surgery-induced acute insulin resistance. Am J Physiol Endocrinol Metab 308:E613-20.	LEAK OXPHOS	F N	Isolated mitochondria	Pig	Skeletal muscle Liver
Conner 2015 FASEB J	2015	Conner B, Hetrik B, Chicco A, McCurdy C (2015) Maternal obesity alters offspring muscle mitochondrial function in nonhuman primates. FASEB J 29:1036.7.	LEAK OXPHOS	F	Permeabilized tissue	Other mammals	Skeletal muscle
Koliaki 2015 Cell Metab	2015	Koliaki C, Szendroedi J, Kaul K, Jelenik T, Nowotny P, Jankowiak F, Herder C, Carstensen M, Krausch M, Knoefel WT, Schlensak M, Roden M (2015) Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis. Cell Metab 21:739-46.	LEAK OXPHOS ET	F N NS Other combinations ROX	Homogenate Isolated mitochondria	Human	Liver
Six 2015 Cell Death Dis	2015	Six E, Lagresle-Peyrou C, Susini S, De Chappedelaine C, Sigrist N, Sadek H, Chouteau M, Cagnard N, Fontenay M, Hermine O, Chomienne C, Reynier P, Fischer A, André-Schmutz I, Gueguen N, Cavazzana M (2015) AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages. Cell Death Dis 6:e1856.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Other cell lines
Kawalec 2015 PLoS One	2015	Kawalec M, Boratyńska-Jasińska A, Beręsewicz M, Dymkowska D, Zabłocki K, Zabłocka B (2015) Mitofusin 2 deficiency affects energy metabolism and mitochondrial biogenesis in MEF cells. PLoS One 10:e0134162.	LEAK ROUTINE ET		Permeabilized cells	Mouse	Fibroblast
Sidossis 2015 Cell Metab	2015	Sidossis LS, Porter C, Saraf MK, Børsheim E, Radhakrishnan RS, Chao T, Ali A, Chondronikola M, Mlcak R, Finnerty CC, Hawkins HK, Toliver-Kinsky T, Herndon DN (2015) Browning of subcutaneous white adipose tissue in humans after severe adrenergic stress. Cell Metab 22:219-27.	LEAK	F N NS Other combinations	Permeabilized cells	Human Mouse	Fat
Hwang 2015 EMBO Mol Med	2015	Hwang S, Disatnik MH, Mochly-Rosen D (2015) Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease. EMBO Mol Med 7:1307-26.	LEAK OXPHOS ET	ROX	Intact cells	Rat	Nervous system Other cell lines
Imran 2015 J Neurochem	2015	Imran I, Hillert MH, Klein J (2015) Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain. J Neurochem 135:1007-18.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Rat	Nervous system
Cahill 2015 J Biol Chem	2015	Cahill TJ, Leo V, Kelly M, Stockenhuber A, Kennedy NW, Bao L, Cereghetti G, Harper AR, Czibik G, Lao C, Bellahcene M, Steeples V, Ghaffari S, Yavari A, Mayer A, Poulton J, Ferguson D, Scorrano L, Hettiarachchi NT, Peers C, Boyle J, Hill RB, Simmons A, Watkins H, Dear TN, Ashrafian H (2015) Resistance of dynamin-related protein 1 oligomers to disassembly impairs mitophagy resulting in myocardial inflammation and heart failure. J Biol Chem 290:25907-19.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Heart
Ikaga 2015 Biochem Biophys Rep	2015	Ikaga R, Namekatac I, Kotiadisd VN, Ogawab H, Duchend MR, Tanakac H, Iida-Tanakab N (2015) Knockdown of aquaporin-8 induces mitochondrial dysfunction in 3T3-L1 cells. Biochem Biophys Rep 4:187–95.	LEAK ROUTINE ET	CIV ROX	Intact cells	Mouse	Fat Other cell lines
Chweih 2015 Exp Physiol	2015	Chweih H, Castilho RF, Figueira TR (2015) Tissue and sex specificities in Ca(2+) handling by isolated mitochondria in conditions avoiding the permeability transition. Exp Physiol 100(9):1073-92.	LEAK OXPHOS	N	Isolated mitochondria	Rat	Heart Skeletal muscle Nervous system Liver
Errea 2015 J Neuroinflammation	2015	Errea O, Moreno B, Gonzalez-Franquesa A, Garcia-Roves PM, Villoslada P (2015) The disruption of mitochondrial axonal transport is an early event in neuroinflammation. J Neuroinflammation 12:152.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Mouse	Nervous system
Garama 2015 Mol Cell Biol	2015	Garama DJ, Harris TJ, White CL, Rossello FJ, Abdul-Hay M, Gough DJ, Levy DE (2015) A synthetic lethal interaction between glutathione synthesis and mitochondrial reactive oxygen species provides a tumor-specific vulnerability dependent on STAT3. Mol Cell Biol 35:3646-56.	LEAK ROUTINE ET		Intact cells	Mouse	Endothelial;epithelial;mesothelial cell Fibroblast
Karadayian 2015 Neuroscience	2015	Karadayian AG, Bustamante J, Czerniczyniec A, Lombardi P, Cutrera RA, Lores-Arnaiz S (2015) Alcohol hangover induces mitochondrial dysfunction and free radical production in mouse cerebellum. Neuroscience 304:47-59.	LEAK OXPHOS	N S Other combinations	Isolated mitochondria	Mouse	Nervous system
Hagl 2015 Molecules	2015	Hagl S, Berressem D, Bruns B, Sus N, Frank J, Eckert GP (2015) Beneficial Effects of Ethanolic and Hexanic Rice Bran Extract on Mitochondrial Function in PC12 Cells and the Search for Bioactive Components. Molecules 20(9):16524-39.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Rat	Nervous system Other cell lines
Hagl 2015 Neurochem Int	2015	Hagl S, Kocher A, Schiborr C, Kolesova N, Frank J, Eckert GP (2015) Curcumin micelles improve mitochondrial function in neuronal PC12 cells and brains of NMRI mice - Impact on bioavailability. Neurochem Int 89:234-42.	LEAK OXPHOS ET	N S CIV	Isolated mitochondria	Mouse	Nervous system
Li 2015 Oxid Med Cell Longev	2015	Li H, Miao W, Ma J, Xv Z, Bo H, Li J, Zhang Y and Ji LL (2015) Acute Exercise-Induced Mitochondrial Stress Triggers an Inflammatory Response in the Myocardium via NLRP3 Inflammasome Activation with Mitophagy. Oxid Med Cell Longev: 357150.	LEAK OXPHOS	N	Isolated mitochondria	Rat	Heart
Kilbaugh 2015 J Am Heart Assoc	2015	Kilbaugh TJ, Sutton RM, Karlsson M, Hansson MJ, Naim MY, Morgan RW, Bratinov G, Lampe JW, Nadkarni VM, Becker LB, Margulies SS, Berg RA (2015) Persistently altered brain mitochondrial bioenergetics after apparently successful resuscitation from cardiac arrest. J Am Heart Assoc 4(9) pii: e002232.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Pig	Nervous system
Cassina 2015 Biol Reprod	2015	Cassina AM, Silveira P, Cantu L, Montes JM, Radi R, Sapiro R (2015) Defective human sperm cells are associated with mitochondrial dysfunction and oxidant production. Biol Reprod 93:119.	LEAK ROUTINE ET	ROX		Human	Genital
Lehtola 2015 Master's Thesis	2015	Lehtola A (2015) Main protein component of high density lipoprotein, apolipoprotein A1, modulates leukocyte cell respiration. Master's Thesis 1-44.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Intact cells Permeabilized cells	Human	Blood cells Other cell lines Lymphocyte
Wessels 2015 Am J Physiol	2015	Wessels B, van den Broek NM, Ciapaite J, Houten SM, Wanders RJA, Nicolay K, Prompers JJ (2015) Carnitine supplementation in high-fat diet-fed rats does not ameliorate lipid-induced skeletal muscle mitochondrial dysfunction in vivo. Am J Physiol 309(7):E670-8.	LEAK OXPHOS ET	F N	Isolated mitochondria	Rat	Skeletal muscle
Rodrigues 2015 J Cell Biochem	2015	Rodrigues MF, Carvalho É, Pezzuto P, Rumjanek FD, Amoêdo ND (2015) Reciprocal modulation of histone deacetylase inhibitors sodium butyrate and trichostatin a on the energy metabolism of breast cancer cells. Int J Biochem Cell Biol 116:797-808.	LEAK ROUTINE OXPHOS ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell Other cell lines
Khera 2015 Placenta	2015	Khera A, Dong LF, Holland OJ, Vanderlelie J, Pasdar EA, Neuzil J, Perkins AV (2015) Selenium supplementation induces mitochondrial biogenesis in trophoblasts. Placenta 36:863-9.	LEAK ROUTINE OXPHOS ET	N S CIV	Permeabilized cells Intact cells	Human	Genital Other cell lines
Skemiene 2015 FEBS J	2015	Skemiene K, Liobikas J, Borutaite V (2015) Anthocyanins as substrates for mitochondrial complex I - protective effect against heart ischemic injury. FEBS J 282:963-71.	LEAK OXPHOS	N S	Isolated mitochondria	Rat	Heart
Hezel 2015 Redox Biol	2015	Hezel MP, Liu M, Schiffer TA, Larsen FJ, Checa A, Wheelock CE, Carlström M, Lundberg JO, Weitzberg E (2015) Effects of long-term dietary nitrate supplementation in mice. Redox Biol 5:234-42.	LEAK OXPHOS ET	N	Isolated mitochondria	Mouse	Skeletal muscle
Kelly 2015 Biotechnol J	2015	Kelly PS, Breen L, Gallagher C, Kelly S, Henry M, Lao NT, Meleady P, O'Gorman D, Clynes M, Barron N (2015) Re-programming CHO cell metabolism using miR-23 tips the balance towards a highly productive phenotype. Biotechnol J 10:1029-40.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Intact cells Permeabilized cells		CHO
Gainutdinov 2015 Arch Biochem Biophys	2015	Gainutdinov T, Molkentin JD, Siemen D, Ziemer M, Debska-Vielhaber G, Vielhaber S, Gizatullina Z, Orynbayeva Z, Gellerich FN (2015) Knockout of cyclophilin D in Ppif(-/-) mice increases stability of brain mitochondria against Ca(2+) stress. Arch Biochem Biophys 579:40-6.	LEAK OXPHOS	N S ROX	Isolated mitochondria	Mouse	Nervous system
Silachev 2015 Chem Biol Interact	2015	Silachev DN, Gulyaev MV, Zorova LD, Khailova LS, Gubsky LV, Pirogov YA, Plotnikov EY, Sukhikh GT, Zorov DB (2015) Magnetic resonance spectroscopy of the ischemic brain under lithium treatment. Link to mitochondrial disorders under stroke. Chem Biol Interact 237:175-82.	LEAK OXPHOS	S	Isolated mitochondria	Rat	Nervous system
Du 2015 Aquat Toxicol	2015	Du X, Crawford DL, Oleksiak MF (2015) Effects of anthropogenic pollution on the oxidative phosphorylation pathway of hepatocytes from natural populations of Fundulus heteroclitus. Aquat Toxicol 165:231-40.	LEAK OXPHOS ET	N S CIV ROX	Permeabilized cells	Fishes	Liver
Jardim-Messeder 2015 New Phytol	2015	Jardim-Messeder D, Caverzan A, Rauber R, de Souza Ferreira E, Margis-Pinheiro M, Galina A (2015) Succinate dehydrogenase (mitochondrial Complex II) is a source of reactive oxygen species in plants and regulates development and stress responses. New Phytol 208:776-89.	LEAK OXPHOS	S	Isolated mitochondria	Plants
Kilbaugh 2015 Exp Neurol	2015	Kilbaugh TJ, Karlsson M, Byro M, Bebee A, Ralston J, Sullivan S, Duhaime AC, Hansson MJ, Elmér E, Margulies SS (2015) Mitochondrial bioenergetic alterations after focal traumatic brain injury in the immature brain. Exp Neurol 271:136-144.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized tissue Homogenate	Pig	Nervous system
Kilbaugh 2015 PLoS One	2015	Kilbaugh TJ, Lvova M, Karlsson M, Zhang Z, Leipzig J, Wallace DC, Margulies SS (2015) Peripheral blood mitochondrial DNA as a biomarker of cerebral mitochondrial dysfunction following traumatic brain injury in a porcine model. PLoS One 10:e0130927.	LEAK OXPHOS	N S NS	Homogenate	Pig	Nervous system
Orynbayeva 2015 Nanomedicine (Lond)	2015	Orynbayeva Z, Sensenig R, Polyak B (2015) Metabolic and structural integrity of magnetic nanoparticle-loaded primary endothelial cells for targeted cell therapy. Nanomedicine (Lond) 10:1555-68.	LEAK ROUTINE ET	ROX	Intact cells	Rat	Endothelial;epithelial;mesothelial cell
Grevengoed 2015 J Lipid Res	2015	Grevengoed TJ, Martin SA, Katunga L, Cooper DE, Anderson EJ, Murphy RC, Coleman RA (2015) Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function. J Lipid Res 56:1572-82.	LEAK OXPHOS	F N NS ROX	Permeabilized tissue	Mouse	Heart Other cell lines HEK
Dueregger 2015 PLoS One	2015	Dueregger A, Schöpf B, Eder T, Höfer J, Gnaiger E, Aufinger A, Kenner L, Perktold B, Ramoner R, Klocker H, Eder IE (2015) Differential utilization of dietary fatty acids in benign and malignant cells of the prostate. PLoS One 10(8):e0135704.	LEAK ROUTINE OXPHOS ET	F N NS ROX	Permeabilized cells Permeabilized tissue	Human	Genital Other cell lines
Correa 2015 Critical Care Horizon	2015	Corrêa TD, Jakob SM, Takala J (2015) Mitochondrial function in sepsis. Critical Care Horizon 1:31-41 .	LEAK OXPHOS	N S CIV ROX	Isolated mitochondria	Pig	Liver
Tyrrell 2015 Exp Gerontol	2015	Tyrrell DJ, Bharadwaj MS, Van Horn CG, Marsh AP, Nicklas BJ, Molina AJ (2015) Blood-cell bioenergetics are associated with physical function and inflammation in overweight/obese older adults. Exp Gerontol 70:84-91.	LEAK ET		Intact cells	Human	Blood cells Lymphocyte
Hanssen 2015 Nat Med	2015	Hanssen MJ, Hoeks J, Brans B, van der Lans AA, Schaart G, van den Driessche JJ, Jörgensen JA, Boekschoten MV, Hesselink MK, Havekes B, Kersten S, Mottaghy FM, van Marken Lichtenbelt WD, Schrauwen P (2015) Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. Nat Med 21:863-5.	LEAK OXPHOS ET	F N NS Other combinations	Permeabilized tissue	Human	Skeletal muscle
Ortiz 2015 J Pineal Res	2015	Ortiz F, Acuña-Castroviejo D, Doerrier C, Dayoub JC, López LC, Venegas C, García JA, López A, Volt H, Luna-Sánchez M, Escames G (2015) Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis. J Pineal Res 58:34-49.	LEAK OXPHOS ET	N S	Homogenate Isolated mitochondria
Schoettl 2015 Mol Metab	2015	Schöttl T, Kappler L, Fromme T, Klingenspor M (2015) Limited OXPHOS capacity in white adipocytes is a hallmark of obesity in laboratory mice irrespective of the glucose tolerance status. Mol Metab 4:631-42.	LEAK ROUTINE OXPHOS ET	F N S ROX	Isolated mitochondria Intact cells	Mouse	Fat Other cell lines
Larsen 2015 Physiol Rep	2015	Larsen S, Scheede-Bergdahl C, Whitesell T, Boushel R, Bergdahl A (2015) Increased intrinsic mitochondrial respiratory capacity in skeletal muscle from rats with streptozotocin-induced hyperglycemia. Physiol Rep 3 pii:e12467.	LEAK OXPHOS	F N CIV NS Other combinations ROX	Permeabilized tissue	Rat	Skeletal muscle
Vincent 2015 Front Physiol	2015	Vincent G, Lamon S, Gant N, Vincent PJ, MacDonald JR, Markworth JF, Edge JA, Hickey AJ (2015) Changes in mitochondrial function and mitochondria associated protein expression in response to 2-weeks of high intensity interval training. Front Physiol 6:51.	LEAK OXPHOS ET	N S ROX	Permeabilized tissue	Human	Skeletal muscle
Ruiz-Perez 2015 J Biol Chem	2015	Ruiz-Pérez MV, Medina MÁ, Urdiales JL, Keinänen TA, Sánchez-Jiménez F (2015) Polyamine metabolism is sensitive to glycolysis inhibition in human neuroblastoma cells. J Biol Chem 290:6106-19.	LEAK ROUTINE ET	ROX	Intact cells	Human	Nervous system Other cell lines Neuroblastoma
Williams 2015 J Biol Chem	2015	Williams AS, Kang L, Zheng J, Grueter CA, Bracy DP, James FD, Pozzi A, Wasserman DH (2015) Integrin α1-null mice exhibit improved fatty liver when fed a high fat diet despite severe hepatic insulin resistance. J Biol Chem 290:6546-57.	LEAK OXPHOS	F N	Permeabilized tissue	Mouse	Liver Other cell lines
Irving 2015 J Clin Endocrinol Metab	2015	Irving BA, Lanza IR, Henderson GC, Rao RR, Spiegelman BM, Nair KS (2015) Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age. J Clin Endocrinol Metab 100:1654-63.	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Human	Skeletal muscle
Kluckova 2015 Methods Mol Biol	2015	Kluckova K, Dong L, Bajzikova M, Rohlena J, Neuzil J (2015) Evaluation of respiration of mitochondria in cancer cells exposed to mitochondria-targeted agents. Methods Mol Biol 1265:181-94.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells Homogenate Intact cells	Mouse	Endothelial;epithelial;mesothelial cell Genital Other cell lines
Hecker 2015 Methods Mol Biol	2015	Hecker M, Sommer N, Mayer K (2015) Assessment of short- and medium-chain fatty acids on mitochondrial function in severe Inflammation. Methods Mol Biol 1265:389-96.	LEAK ROUTINE ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell
Laursen 2015 Proc Natl Acad Sci USA	2015	Laursen WJ, Mastrotto M, Pesta D, Funk OH, Goodman JB, Merriman DK, Ingolia N, Shulman GI, Bagriantsev SN, Gracheva EO (2015) Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation. Proc Natl Acad Sci USA 112:1607-12.	LEAK OXPHOS	N	Isolated mitochondria	Other mammals	Nervous system HEK
Aroor 2015 Diabetes	2015	Aroor AR, Habibi J, Ford DA, Nistala R, Lastra G, Manrique C, Dunham MM, Ford KD, Thyfault JP, Parks EJ, Sowers JR, Rector RS (2015) Dipeptidyl peptidase-4 inhibition ameliorates western diet-induced hepatic steatosis and insulin resistance through hepatic lipid remodeling and modulation of hepatic mitochondrial function. Diabetes 64:1988-2001.	LEAK ROUTINE OXPHOS ET	F N S NS	Isolated mitochondria	Mouse	Liver
Diana 2015 Br J Surg	2015	Diana M, Agnus V, Halvax P, Liu YY, Dallemagne B, Schlagowski AI, Geny B, Diemunsch P, Lindner V, Marescaux J (2015) Intraoperative fluorescence-based enhanced reality laparoscopic real-time imaging to assess bowel perfusion at the anastomotic site in an experimental model. Br J Surg 102:e169-76.	LEAK OXPHOS		Permeabilized tissue	Pig	Endothelial;epithelial;mesothelial cell
Sheldon 2015 Am J Physiol Gastrointest Liver Physiol	2015	Sheldon RD, Padilla J, Jenkins NT, Laughlin MH, Rector RS (2015) Chronic NOS inhibition accelerates NAFLD progression in an obese rat model. Am J Physiol Gastrointest Liver Physiol 308:G540-9.	LEAK OXPHOS ET	N NS	Isolated mitochondria	Rat	Liver
Bowen 2015 Eur J Heart Fail	2015	Bowen TS, Rolim NP, Fischer T, Baekkerud FH, Medeiros A, Werner S, Brønstad E, Rognmo O, Mangner N, Linke A, Schuler G, Silva GJ, Wisløff U, Adams V (2015) Heart failure with preserved ejection fraction induces molecular, mitochondrial, histological, and functional alterations in rat respiratory and limb skeletal muscle. Eur J Heart Fail 17:263-72.	LEAK OXPHOS ET	N NS	Permeabilized tissue	Rat	Skeletal muscle
Hendricks 2015 Thesis	2015	Hendricks EW (2015) The impact of aging and estrogen therapy on synaptic mitochondrial bioenergetics in an Alzheimer's mouse model. Master Thesis 1-67.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Isolated mitochondria Intact cells	Mouse	Nervous system
Wuest 2015 J Physiol	2015	Wüst RC, Helmes M, Stienen GJ (2015) Rapid changes in NADH and flavin autofluorescence in rat cardiac trabeculae reveal large mitochondrial complex II reserve capacity. J Physiol 593:1829-40.	LEAK OXPHOS	N S NS ROX	Permeabilized tissue	Rat	Heart
Mourier 2015 J Cell Biol	2015	Mourier A, Motori E, Brandt T, Lagouge M, Atanassov I, Galinier A, Rappl G, Brodesser S, Hultenby K, Dieterich C, Larsson NG (2015) Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels. J Cell Biol 208:429-42.	LEAK OXPHOS ET	N S Gp Other combinations	Permeabilized cells Isolated mitochondria	Mouse	Heart Fibroblast
Iftikar 2015 Comp Biochem Physiol A Mol Integr Physiol	2015	Iftikar FI, Morash AJ, Cook DG, Herbert NA, Hickey AJ (2015) Temperature acclimation of mitochondria function from the hearts of a temperate wrasse (Notolabrus celidotus). Comp Biochem Physiol A Mol Integr Physiol 184:46-55.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Fishes	Heart
Christiansen 2015 J Vet Med Sci	2015	Christiansen LB, Dela F, Koch J, Yokota T (2015) Tissue-specific and substrate-specific mitochondrial bioenergetics in feline cardiac and skeletal muscles. J Vet Med Sci 77:669-75.	LEAK OXPHOS ET	F N S CIV NS Other combinations ROX	Permeabilized tissue	Cat	Heart Skeletal muscle
Papazova 2015 Am J Physiol Renal Physiol	2015	Papazova DA, Friederich-Persson M, Joles JA, Verhaar MC (2015) Renal transplantation induces mitochondrial uncoupling, increased kidney oxygen consumption, and decreased kidney oxygen tension. Am J Physiol Renal Physiol 308:F22-8.	LEAK OXPHOS	N	Isolated mitochondria	Rat	Kidney
Nordquist 2015 J Am Soc Nephrol	2015	Nordquist L, Friederich-Persson M, Fasching A, Liss P, Shoji K, Nangaku M, Hansell P, Palm F (2015) Activation of hypoxia-inducible factors prevents diabetic nephropathy. J Am Soc Nephrol 26:328-38.	LEAK OXPHOS	N	Isolated mitochondria	Rat	Kidney
Jeger 2015 BioMed Res Internat	2015	Jeger V, Brandt S, Porta F, Jakob SM, Takala J, Djafarzadeh S (2015) Dose response of Endotoxin on hepatocyte and muscle mitochondrial respiration in vitro. BioMed Res Internat Article ID 353074:1-13.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Isolated mitochondria Intact cells	Human	Skeletal muscle Liver Other cell lines
Beier 2015 FASEB J	2015	Beier UH, Angelin A, Akimova T, Wang L, Liu Y, Xiao H, Koike MA, Hancock SA, Bhatti TR, Han R, Jiao J, Veasey SC, Sims CA, Baur JA, Wallace DC, Hancock WW (2015) Essential role of mitochondrial energy metabolism in Foxp3⁺ T-regulatory cell function and allograft survival. FASEB J 29:2315-26. https://doi.org/10.1096/fj.14-268409	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Lark 2015 Front Physiol	2015	Lark DS, Reese LR, Ryan TE, Torres MJ, Smith CD, Lin CT, Neufer PD (2015) Protein kinase A governs oxidative phosphorylation kinetics and oxidant emitting potential at complex I. https://doi.org/10.3389/fphys.2015.00332	LEAK ET OXPHOS	N S	Permeabilized tissue Isolated mitochondria	Mouse	Skeletal muscle Liver
Dahl 2015 Acta Physiol (Oxf)	2015	Dahl R, Larsen S, Dohlmann TL, Qvortrup K, Helge JW, Dela F, Prats C (2015) Three dimensional reconstruction of the human skeletal muscle mitochondrial network as a tool to assess mitochondrial content and structural organization. Acta Physiol (Oxf) 213:145-55.	LEAK OXPHOS ET	N CIV NS	Permeabilized tissue	Human	Skeletal muscle
Hasli 2015 Master Thesis	2015	Hasli PR (2015) Characterization of mitochondrial respiration and quality differences in diploid and triploid Atlantic salmon (Salmo salar L.) at 5 °C, 10 °C and 15 °C. Master Thesis:1-147.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Homogenate	Fishes	Heart Skeletal muscle
Cell ergometry	2015	Gnaiger E (2015) Cell ergometry and OXPHOS. Mitochondr Physiol Network 2015-01-18.	LEAK OXPHOS ET	N S NS ROX
Krumschnabel 2015 Methods Mol Biol	2015	Krumschnabel G, Fontana-Ayoub M, Sumbalova Z, Heidler J, Gauper K, Fasching M, Gnaiger E (2015) Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production. Methods Mol Biol 1264:245-61.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse	Nervous system
Hagl 2015 J Alzheimers Dis	2015	Hagl S, Grewal R, Ciobanu I, Helal A, Khayyal MT, Muller WE, Eckert GP (2015) Rice bran extract compensates mitochondrial dysfunction in a cellular model of early Alzheimer’s disease. J Alzheimers Dis 43:927-38.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Rat	Nervous system Kidney Other cell lines
Wessels 2015 Diabetes Obes Metab	2015	Wessels B, Ciapaite J, van den Broek NM, Houten SM, Nicolay K, Prompers JJ (2015) Pioglitazone treatment restores in vivo muscle oxidative capacity in a rat model of diabetes. Diabetes Obes Metab 17:52-60.	LEAK OXPHOS ET	F N S	Isolated mitochondria	Rat	Skeletal muscle
Venter 2015 J Clin Cell Immunol	2015	Venter G, Wijers M, Oerlemans FTJJ, Manjeri G, Fransen JAM, Wieringa B (2015) Glycolytic metabolism is differentially coupled to proliferative potential and morphodynamic capacity in RAW 264.7 and Mafb/C-Maf deficient macrophage lineages. J Clin Cell Immunol 6:1-11.	LEAK ROUTINE ET	ROX		Mouse	Blood cells Macrophage-derived
Herbst 2015 J Physiol	2015	Herbst EA, Holloway GP (2015) Permeabilization of brain tissue in situ enables multi-region analysis of mitochondrial function in a single mouse brain. J Physiol 593:787-801.	LEAK OXPHOS	N S NS	Permeabilized tissue Isolated mitochondria	Mouse	Nervous system
Hanssen 2015 Diabetologia	2015	Hanssen MJ, Wierts R, Hoeks J, Gemmink A, Brans B, Mottaghy FM, Schrauwen P, van Marken Lichtenbelt WD (2015) Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance. Diabetologia 58:586-95.	LEAK ET	F	Isolated mitochondria	Human	Skeletal muscle
Tan 2015 Cell Metab	2015	Tan AS, Baty JW, Dong L, Bezawork-Geleta A, Endaya B, Goodwin J, Bajzikova M, Kovarova J, Peterka M, Yan B, Pesdar EA, Sobol M, Filimonenko A, Stuart S, Vondrusova M, Kluckova K, Sachaphibulkij K, Rohlena J, Hozak P, Truksa J, Eccles D, Haupt LM, Griffiths LR, Neuzil J, Berridge MV (2015) Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA. Cell Metab 21:81-94.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Isolated mitochondria Intact cells	Human Mouse	Endothelial;epithelial;mesothelial cell Genital Other cell lines
Porter 2015 Med Sci Sports Exerc	2015	Porter C, Reidy PT, Bhattarai N, Sidossis LS, Rasmussen BB (2015) Resistance exercise training alters mitochondrial function in human skeletal muscle. Med Sci Sports Exerc 47:1922-31.	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Human	Skeletal muscle
Ziak 2015 Mitochondrion	2015	Ziak J, Krajcova A, Jiroutkova K, Nemcova V, Dzupa V, Duska F (2015) Assessing the function of mitochondria in cytosolic context in human skeletal muscle: Adopting high-resolution respirometry to homogenate of needle biopsy tissue samples. Mitochondrion 21:106-12.	LEAK OXPHOS ET	N S NS ROX	Homogenate Isolated mitochondria	Human	Skeletal muscle
Schoettl 2015 Endocrinology	2015	Schöttl T, Kappler L, Braun K, Fromme T, Klingenspor M (2015) Limited mitochondrial capacity of visceral versus subcutaneous white adipocytes in male C57BL/6N mice. Endocrinology 156:923-33.	LEAK ROUTINE OXPHOS ET	N S ROX	Permeabilized cells Isolated mitochondria Intact cells	Mouse	Fat
Torelli 2015 Free Radic Biol Med	2015	Torelli NQ, Ferreira-Júnior JR, Kowaltowski AJ, da Cunha FM (2015) RTG1- and RTG2-dependent retrograde signaling controls mitochondrial activity and stress resistance in Saccharomyces cerevisiae. Free Radic Biol Med 81C:30-7.	LEAK ROUTINE OXPHOS ET	CIV ROX	Isolated mitochondria Intact cells	Saccharomyces cerevisiae
Kake-Guena 2015 J Exp Zool A Ecol Genet Physiol	2015	Kake-Guena SA, Touisse K, Vergilino R, Dufresne F, Blier PU, Lemieux H1 (2015) Assessment of mitochondrial functions in Daphnia pulex clones using high-resolution respirometry. J Exp Zool A Ecol Genet Physiol 323:292-300.	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Crustaceans
Lemoine 2015 Transplantation	2015	Lemoine S, Pillot B, Rognant N, Augeul L, Rayberin M, Varennes A, Laville M, Ovize M, Juillard L (2015) Postconditioning with cyclosporine a reduces early renal dysfunction by inhibiting mitochondrial permeability transition. Transplantation. 99:717-23	LEAK OXPHOS	N	Isolated mitochondria	Mouse	Kidney
Richman 2015 PLoS Genet	2015	Richman TR, Ermer JA, Davies SM, Perks KL, Viola HM, Shearwood AM, Hool LC, Rackham O, Filipovska A (2015) Mutation in MRPS34 compromises protein synthesis and causes mitochondrial dysfunction. PLoS Genet 11:e1005089.	LEAK OXPHOS	N S CIV	Isolated mitochondria	Mouse	Heart Liver
Grabez 2015 J Anim Sci	2015	Grabež V, Kathri M, Phung V, Moe KM, Slinde E, Skaugen M, Saarem K, Egelandsdal B (2015) Protein expression and oxygen consumption rate of early postmortem mitochondria relate to meat tenderness. J Anim Sci 93:1967-79.	LEAK OXPHOS ET	F N S NS Other combinations ROX	Permeabilized tissue	Bovines	Skeletal muscle
Makrecka-Kuka 2015 Biomolecules	2015	Makrecka-Kuka M, Krumschnabel G, Gnaiger E (2015) High-resolution respirometry for simultaneous measurement of oxygen and hydrogen peroxide fluxes in permeabilized cells, tissue homogenate and isolated mitochondria. https://doi.org/10.3390/biom5031319	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Homogenate Isolated mitochondria Intact cells	Human Mouse	Heart Nervous system HEK
Nelson 2015 Master Thesis	2015	Nelson MB (2015) The role of receptors for advanced glycation end-products (RAGE) and ceramide in cardiovascular disease. Master Thesis 1-53.	LEAK OXPHOS ET	N S NS	Permeabilized cells Permeabilized tissue	Mouse Rat	Heart Other cell lines
Drechsler 2015 Intensive Care Medicine Experimental	2015	Drechsler S, Weixelbaumer KM, Weidinger A, Raeven P, Khadem A, Redl H, van Griensven M, Bahrami S, Remick D, Kozlov A, Osuchowski MF (2015) Why do they die? Comparison of selected aspects of organ injury and dysfunction in mice surviving and dying in acute abdominal sepsis. Intensive Care Medicine Experimental 3:12.	LEAK OXPHOS ET	N S	Homogenate	Mouse	Liver Kidney
Ludzki 2015 Diabetes	2015	Ludzki A, Paglialunga S, Smith BK, Herbst EA, Allison MK, Heigenhauser GJ, Neufer PD, Holloway GP (2015) Rapid repression of ADP transport by palmitoyl-CoA is attenuated by exercise training in humans; a potential mechanism to decrease oxidative stress and improve skeletal muscle insulin signaling. Diabetes 64:2769-79.	LEAK OXPHOS	F N NS	Permeabilized tissue	Human Mouse	Skeletal muscle
Bonsignore 2015 Mech Ageing Dev	2015	Bonsignore LA, Tooley JG, Van Hoose PM, Wang E, Cheng A, Cole MP, Schaner Tooley CE (2015) NRMT1 knockout mice exhibit phenotypes associated with impaired DNA repair and premature aging. Mech Ageing Dev 146-148:42-52.	LEAK OXPHOS ET	N ROX	Isolated mitochondria	Mouse	Liver
Seillier 2015 EMBO Mol Med	2015	Seillier M, Pouyet L, N'Guessan P, Nollet M, Capo F, Guillaumond F, Peyta L, Dumas JF, Varrault A, Bertrand G, Bonnafous S, Tran A, Meur G, Marchetti P, Ravier MA, Dalle S, Gual P, Muller D, Rutter GA, Servais S, Iovanna JL, Carrier A (2015) Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1. EMBO Mol Med 7:802-18.	LEAK ROUTINE OXPHOS ET	F CIV NS ROX	Permeabilized cells Intact cells	Human Mouse	Fibroblast
Chu 2015 Liver Transpl	2015	Chu MJ, Hickey AJ, Jiang Y, Petzer A, Bartlett AS, Phillips AR (2015) Mitochondrial dysfunction in steatotic rat livers occurs because a defect in complex I makes the liver susceptible to prolonged cold ischemia. Liver Transpl 21:396-407.	LEAK OXPHOS ET	N S ROX	Homogenate	Rat	Liver
Beauchamp 2015 Biosci Rep	2015	Beauchamp B, Thrush AB, Quizi J, Antoun G, McIntosh N, Al-Dirbashi OY, Patti ME, Harper ME (2015) Undernutrition during pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring. Biosci Rep 35. pii:e00200.	LEAK OXPHOS	F NS Other combinations ROX	Homogenate	Mouse	Heart Liver
Hansson 2015 Eur J Pharmacol	2015	Hansson MJ, Llwyd O, Morin D, de Paulis D, Arnoux T, Gouarné C, Koul S, Engblom H, Bordet T, Tissier R, Arheden H, Erlinge D, Halestrap AP, Berdeaux A, Pruss RM, Schaller S (2015) Differences in the profile of protection afforded by TRO40303 and mild hypothermia in models of cardiac ischemia/reperfusion injury. Eur J Pharmacol 760:7-19.	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Pig	Heart
Ehinger 2015 J Neurol	2015	Ehinger JK, Morota S, Hansson MJ, Paul G, Elmér E (2015) Mitochondrial dysfunction in blood cells from amyotrophic lateral sclerosis patients. J Neurol 262:1493-503.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Human	Blood cells Lymphocyte Platelet
Tapia 2015 Crit Care	2015	Tapia P, Soto D, Bruhn A, Alegría L, Jarufe N, Luengo C, Kattan E, Regueira T, Meissner A, Menchaca R, Vives MI, Echeverría N, Ospina-Tascón G, Bakker J, Hernández G (2015) Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion. Crit Care 19:188.	LEAK OXPHOS	N NS	Isolated mitochondria	Other mammals	Liver
Agil 2015 J Pineal Res	2015	Agil A, El-Hammadi M, Jiménez-Aranda A, Tassi M, Abdo W, Fernández-Vázquez G, Reiter RJ (2015) Melatonin reduces hepatic mitochondrial dysfunction in diabetic obese rats. J Pineal Res 59:70-9.	LEAK OXPHOS	S	Isolated mitochondria	Rat	Liver
Margulies 2015 Brain Pathol	2015	Margulies SS, Kilbaugh T, Sullivan S, Smith C, Propert K, Byro M, Saliga K, Costine BA, Duhaime AC (2015) Establishing a clinically relevant large animal model platform for TBI therapy development: using Cyclosporin A as a case study. Brain Pathol 25:289-303.	LEAK OXPHOS	NS	Isolated mitochondria	Pig	Nervous system
Singh 2015 Biochim Biophys Acta	2015	Singh F, Charles AL, Schlagowski AI, Bouitbir J, Bonifacio A, Piquard F, Krähenbühl S, Geny B, Zoll J (2015) Reductive stress impairs myoblasts mitochondrial function and triggers mitochondrial hormesis. Biochim Biophys Acta 1853:1574-85.	LEAK OXPHOS	N S NS	Permeabilized tissue	Mouse	Skeletal muscle
Kruska 2015 Biochim Biophys Acta	2015	Kruska N, Schönfeld P, Pujol A, Reiser G (2015) Astrocytes and mitochondria from adrenoleukodystrophy protein (ABCD1)-deficient mice reveal that the adrenoleukodystrophy-associated very long-chain fatty acids target several cellular energy-dependent functions. Biochim Biophys Acta 1852:925-36.	LEAK OXPHOS ET	N NS	Isolated mitochondria	Mouse	Nervous system
Diana 2015 Obes Surg	2015	Diana M, Pop R, Beaujeux R, Dallemagne B, Halvax P, Schlagowski I, Liu YY, Diemunsch P, Geny B, Lindner V, Marescaux J (2015) Embolization of arterial gastric supply in obesity (EMBARGO): an endovascular approach in the management of morbid obesity. proof of the concept in the porcine model.. Obes Surg 25:550-8.	LEAK OXPHOS		Permeabilized tissue	Pig	Endothelial;epithelial;mesothelial cell
Czerniczyniec 2015 Brain Res	2015	Czerniczyniec A, La Padula P, Bustamante J, Karadayian AG, Lores-Arnaiz S, Costa LE (2015) Mitochondrial function in rat cerebral cortex and hippocampus after short- and long-term hypobaric hypoxia. Brain Res 1598:66-75.	LEAK OXPHOS	N	Isolated mitochondria	Rat	Nervous system
Den Besten 2015 Diabetes	2015	den Besten G, Bleeker A, Gerding A, van Eunen K, Havinga R, van Dijk TH, Oosterveer MH, Jonker JW, Groen AK, Reijngoud DJ, Bakker BM (2015) Short-chain fatty acids protect against high-fat diet-induced obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation. Diabetes 64:2398-408.	LEAK OXPHOS	F	Isolated mitochondria	Mouse	Liver
Hejzlarova 2015 Biochem J	2015	Hejzlarová K, Kaplanová V, Nůsková H, Kovářová N, Ješina P, Drahota Z, Mráček T, Seneca S, Houštěk J (2015) Alteration of structure and function of ATP synthase and cytochrome c oxidase by lack of Fo-a and Cox3 subunits caused by mitochondrial DNA 9205delTA mutation. Biochem J 466:601-11.	LEAK OXPHOS ET	S CIV	Permeabilized cells Isolated mitochondria	Human	Other cell lines
Chausse 2015 PLoS One	2015	Chausse B, Vieira-Lara MA, Sanchez AB, Medeiros MH, Kowaltowski AJ (2015) Intermittent fasting results in tissue-specific changes in bioenergetics and redox state. PLoS One 10:e0120413.	LEAK OXPHOS	N S CIV	Isolated mitochondria	Rat	Heart Skeletal muscle Nervous system Liver
Wang 2015 Nat Commun	2015	Wang Y, Oxer D, Hekimi S (2015) Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis. Nat Commun 6:6393.	LEAK OXPHOS	N S	Isolated mitochondria	Mouse	Heart Skeletal muscle Kidney
Joergensen 2015 J Cereb Blood Flow Metab	2015	Jørgensen T, Grunnet N, Quistorff B (2015) One-year high fat diet affects muscle-but not brain mitochondria. J Cereb Blood Flow Metab 35:943-50.	LEAK OXPHOS	F N S Other combinations	Isolated mitochondria	Rat	Skeletal muscle Nervous system
Park 2015 Proc Natl Acad Sci USA	2015	Park JH, Kang HJ, Lee YK, Kang H, Kim J, Chung JH, Chang JS, McPherron AC, Lee SB (2015) Inactivation of EWS reduces PGC-1α protein stability and mitochondrial homeostasis. Proc Natl Acad Sci USA 112:6074-9.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Fat
Paglialunga 2015 Diabetologia	2015	Paglialunga S, Ludzki A, Root-McCaig J, Holloway GP (2015) In adipose tissue, increased mitochondrial emission of reactive oxygen species is important for short-term high-fat diet-induced insulin resistance in mice. Diabetologia 58:1071-80.	LEAK OXPHOS	F N	Permeabilized tissue	Mouse	Fat

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