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• EMBO-FEBS Lecture Course Mitochondria in life, death and disease 2017 Brindisi IT
  ...2017 Oct 9 - 13. EMBO-FEBS Lecture Course 'Mitochondria in life, death and disease' |authors=Mitochondria in life, death and disease
  2 KB (245 words) - 08:55, 4 May 2017

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• Cell Death Dis
  |Title=[http://www.nature.com/cddis/index.html Cell Death and Disease]
  83 bytes (13 words) - 18:01, 22 March 2017
• EMBO-FEBS Lecture Course 2022 Budva ME
  ...27 - October 01. EMBO-FEBS Lecture Course 'Mitochondria in life, death and disease'. |authors=Mitochondria in life, death and disease
  1 KB (174 words) - 11:46, 2 February 2022
• EMBO-FEBS Lecture Course 2019 Herceg Novi ME
  ...2019 Sep 24-28. EMBO-FEBS Lecture Course 'Mitochondria in life, death and disease'. |authors=Mitochondria in life, death and disease
  2 KB (176 words) - 11:18, 1 April 2019
• Dhingra 2015 Cell Death Dis
  ...al reserve respiratory capacity to cell survival in cardiac myocytes. Cell Death Dis 6:e1956. https://doi.org/10.1038/cddis.2015.310 |journal=Cell Death Dis
  1 KB (147 words) - 09:21, 22 October 2023
• EMBO-FEBS Lecture Course Mitochondria in life, death and disease 2017 Brindisi IT
  ...2017 Oct 9 - 13. EMBO-FEBS Lecture Course 'Mitochondria in life, death and disease' |authors=Mitochondria in life, death and disease
  2 KB (245 words) - 08:55, 4 May 2017
• Lin 2006 Nature
  |title=Lin MT, Beal MF (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443:787-95. ...energy metabolism or free-radical generation, or specific interactions of disease-related proteins with mitochondria, hold great promise.
  1 KB (140 words) - 09:33, 12 April 2022
• Keane 2011 Parkinsons Dis
  ...awa M, Blain PG, Morris CM (2011) Mitochondrial dysfunction in Parkinson's disease. Parkinsons Dis 2011:716871. https://doi.org/10.4061/2011/716871 ...nal cell death in the substantia nigra pars compacta (SNpc) of PD patients and to highlight the important need for further research in this area.
  2 KB (214 words) - 23:28, 23 April 2023
• Forbes 2018 Nat Rev Nephrol
  ...Forbes JM, Thorburn DR (2018) Mitochondrial dysfunction in diabetic kidney disease. Nat Rev Nephrol 14:291-312. https://doi.org/10.1038/nrneph.2018.9 ...ormalities in mitochondrial function synergistically drive the development and progression of DKD.
  2 KB (247 words) - 20:08, 14 September 2023
• White 2007 Platelets
  ...latelets integrates the entire field of platelet biology, pathophysiology, and clinical medicine. ...logists, and researchers in thrombosis and hemostasis, as well as students and fellows in these fields.
  1 KB (166 words) - 10:44, 11 January 2018
• Garcia-Souza 2014 Int J Biochem Cell Biol
  ..., Oliveira MF (2014) Mitochondria: Biological roles in platelet physiology and pathology. Int J Biochem Cell Biol 50:156-60. ...cellular ATP production, redox balance, as well as in platelet activation and apoptosis. Here, we review aspects of platelet physiology in which mitochon
  1 KB (202 words) - 17:10, 27 March 2018
• Mann 2020 Sci Rep
  ...sensitizes breast cancer cells to docetaxel with increased mitotic arrest and necroptosis. https://doi.org/10.1038/s41598-019-57282-1 ...ome in response to taxane chemotherapy by enhancing necroptotic cell death and inhibiting the production of potentially chemoresistant polyploid cells.
  2 KB (308 words) - 15:31, 10 October 2023
• Polajnar 2014 Biochim Biophys Acta
  ...mutants aggregates: correlation between cell death, aggregate number/size and oxidative stress. Biochim Biophys Acta 1843:2089-99. ...nd in this way contribute to loss of stefin B functions. Relevance to EPM1 disease by gain in toxic function is discussed.
  2 KB (338 words) - 15:52, 27 July 2016
• Ganguly 2022 BEC
  ...of mitochondrial Complex I inhibitor rotenone: a complex interplay of cell death pathways. Bioenerg Commun 2022.14. https://doi.org/10.26124/bec:2022-0014 ...tosis in SH-SY5Y cells which presented morphological features of apoptosis and necrosis.
  3 KB (418 words) - 07:00, 8 January 2023
• Hwang 2015 EMBO Mol Med
  ...aired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease. EMBO Mol Med 7:1307-26. ...ive GAPDH rescues this blunted process and enhances mitochondrial function and cell survival, indicating a role for GAPDH-driven mitophagy in the patholog
  2 KB (250 words) - 14:41, 13 November 2017
• Moisoi 2009 Cell Death Differ
  ...n the activation of a brain-specific transcriptional stress response. Cell Death Differ 16:449-64. |journal=Cell Death Differ
  2 KB (307 words) - 12:23, 3 May 2022
• Caito 2015 Antioxid Redox Signal
  |title=Caito SW, Aschner M (2015) Mitochondrial redox dysfunction and environmental exposures. Antioxid Redox Signal 23:578-95. ...is emerging not only into the roles of mitochondria in disease development and progression but also as a target for environmental toxicants.
  2 KB (288 words) - 17:45, 8 November 2016
• Yano 2014 Nature Neurosci
  ...e evidence for a direct link between mutant Htt, mitochondrial dysfunction and neuronal pathology, with implications for mitochondrial protein import-base
  2 KB (244 words) - 15:40, 7 November 2016
• Costa 2013 Cell Death Dis
  ...chondrial dysfunction in a PINK1/parkin model of Parkinson's disease. Cell Death Dis 4:e467. |journal=Cell Death Dis
  3 KB (340 words) - 12:14, 27 March 2018
• D'Orsi 2017 Neurochem Int
  ...f mitochondrial physiology and cell death by the Bcl-2 family proteins Bax and Bok. Neurochem Int 109:162-70. ...pecifically, we discuss how the 'pro-apoptotic' Bcl-2 family proteins, Bax and Bok, physiologically expressed in the nervous system, regulate such 'non-ap
  2 KB (321 words) - 08:16, 28 March 2018
• Pimenta 2012 Cell Death Differ
  ...s of mitochondrial protein misfolding in ''Drosophila melanogaster''. Cell Death Differ doi:10.1038/cdd.2012.5. |journal=Cell Death Differ
  2 KB (312 words) - 13:37, 27 March 2018
• Onukwufor 2022 Antioxidants (Basel)
  ...AP (2022) Iron dysregulation in mitochondrial dysfunction and Alzheimer's disease. Antioxidants (Basel) 11:692. https://doi.org/10.3390/antiox11040692 ...ly unsuccessful. Here, we review evidence linking iron dysregulation to AD and the potential for targeting ferroptosis as a therapeutic intervention for A
  2 KB (228 words) - 07:13, 24 April 2023
• Oliveira 2015 Biotechniques
  for energy production and lipid palmitate (C16:0) and the monounsat
  1 KB (188 words) - 12:04, 14 July 2016
• Bernardinelli 2017 PLoS One
  ...) Mis-targeting of the mitochondrial protein LIPT2 leads to apoptotic cell death. PLoS One 12(6):e0179591. ...(IClswell), mitochondrial membrane potential collapse, caspase-3 cleavage and nuclear DNA fragmentation. The findings presented here may help elucidate t
  2 KB (228 words) - 16:37, 23 January 2019
• Morato 2015 Cell Death Differ
  ...irtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy. Cell Death Differ 22:1742-53. |journal=Cell Death Differ
  2 KB (252 words) - 08:22, 21 February 2020
• Brodnanova 2021 Eur J Pharmacol
  ...mine on thapsigargin- and tunicamycin-induced endoplasmic reticulum stress and mitochondrial dysfunction in neuroblastoma SH-SY5Y cells. Eur J Pharmacol 9 .... Splicing of XBP1 mRNA was studied by RT-PCR. Finally, expression of Hrd1 and Hsp60 was determined by Western blot analysis.
  2 KB (333 words) - 16:01, 21 July 2021
• Eira da Costa 2013 Abstract MiP2013
  ...ainst mitochondrial dysfunction in a ''PINK1/parkin'' model of Parkinson’s disease. Mitochondr Physiol Network 18.08. ..., and that enhancing its function may ameliorate mitochondrial dysfunction and rescue neurodegeneration in PD.
  2 KB (319 words) - 11:11, 28 April 2017
• Grespi 2016 Abstract Mito Xmas Meeting Innsbruck
  |title=MicroRNAs as modulators of mitochondrial remodeling and apoptosis. ...ould provide new potential therapeutic targets for a currently untreatable disease.
  2 KB (283 words) - 12:58, 13 December 2016
• Benard 2011 Springer
  ...ial dynamics and bioenergetics. In: Lu Bingwei (ed) Mitochondrial dynamics and neurodegeneration. Springer ISBN 978-94-007-1290-4:47-68. ...mit to increase our basic knowledge on the regulation of energy metabolism and to decipher the pathophysiology of a group of rare neuronal diseases.
  2 KB (299 words) - 04:21, 10 November 2023
• Noelker 2015 J Neurol Sci
  ...rosidase deficiency and mitochondrial impairment in experimental Parkinson disease. J Neurol Sci 356:129-36. ...tion of GCase activity with conduritol-B-epoxide (CBE) enhances both α-Syn and MPP(+) induced toxicity ''in vitro''. However, only CBE-induced enhancement
  2 KB (293 words) - 10:04, 23 February 2016
• Reguis Yadao 2018 Thesis
  ...Smooth muscle cell mitochondrial respiration – effects of aerobic training and type I diabetes. Master's Thesis 71. ...osing diabetic models that carry an inherently high risk of cardiovascular disease to prolonged exercise.
  3 KB (338 words) - 16:39, 31 January 2019
• Mejia-Vergara 2020 Curr Neurol Neurosci Rep
  ...ophysiology of conversion to symptomatic leber hereditary optic neuropathy and therapeutic implications: a review. Curr Neurol Neurosci Rep 20:11. https:/ ...mitochondrial genetics are helping to elucidate the nuances of conversion and allow for new therapeutic options.
  2 KB (251 words) - 04:46, 5 November 2023
• Seitaj 2020 Cells
  ...tif containing protein 5 (TMBIM5) sustains mitochondrial structure, shape, and function by impacting the mitochondrial protein synthesis machinery. Cells ...conclude that TMBIM5 is important to maintain the mitochondrial structure and function possibly through the control of mitochondrial biogenesis.
  3 KB (353 words) - 20:58, 1 October 2020
• Bamberger 2018 MiP2018
  ...nt of elamipretide: targeting mitochondrial dysfunction in rare and common disease. ...th. Elamipretide is currently in clinical development for PMM, BTHS, LHON, and AMD.
  3 KB (336 words) - 04:40, 12 February 2020
• Viall 2013 J Autoimmun
  ...bodies internalised by human syncytiotrophoblast cause aberrant cell death and the release of necrotic trophoblast debris. J Autoimmun 47:45-57. ...ily members. Once internalised by the syncytiotrophoblast, aPL affects the death-regulating mitochondria, causing extrusion of necrotic trophoblast debris w
  2 KB (307 words) - 12:56, 25 February 2020
• MiPliterature
  ...ger.com/us/book/9781402067136 Mitochondrial Metablism, Diseases, Diagnosis and Therapy]. Springer Science: 409 pp. ...inger.com/us/book/9780230517578 The Living End. The future of death, aging and immortality]. Macmillan.
  3 KB (365 words) - 14:48, 4 May 2017
• Nakamura 2011 J Biol Chem
  ...Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein. J Biol Chem 286:20710-26. ...orphology of an organelle long implicated in the pathogenesis of Parkinson disease.
  2 KB (291 words) - 15:52, 19 March 2015
• Bobba 2015 Apoptosis
  ..., La Piana G, Calissano P, Atlante A (2015) Glycolytic enzyme upregulation and numbness of mitochondrial activity characterize the early phase of apoptosi |abstract=Alzheimer’s disease (AD) and cancer proceed
  2 KB (270 words) - 13:51, 27 March 2018
• Schaefer 2016 Abstract ADFLIM 2016
  |title=ADFLIM in AD research –imaging mitochondrial function in Alzheimer´s disease ...imbalance in the brain, being one trigger of neuronal death in Alzheimer´s disease.
  2 KB (300 words) - 15:38, 23 January 2019
• Torres 2016 Redox Biol
  ...replenishment as a potential therapeutic approach for Niemann Pick type C disease. Redox Biol 11:60-72. ...pecific replenishment of mGSH may be a potential promising therapy for NPC disease, worth exploring alone or in combination with other options.
  3 KB (447 words) - 16:18, 13 November 2017
• Luis-Garcia 2018 Am J Respir Crit Care Med
  ...nown etiology, characterized by the expansion of the fibroblast population and destruction of lung parenchyma. |injuries=Cell death
  954 bytes (119 words) - 16:25, 8 May 2018
• Wilson 2018 Virginia Tech
  ...ow DA (2018) High-resolution respirometry of heart mitochondria in healthy and stressed states. Virginia Tech. ...would be the first step in determining if incorporation of NAC into heart disease treatment plans could begin to better treat the number of one cause of morb
  3 KB (361 words) - 15:49, 22 August 2018
• Ben-Shachar 2009 J Neural Transm (Vienna)
  ...n-Shachar D (2009) The interplay between mitochondrial complex I, dopamine and Sp1 in schizophrenia. J Neural Transm (Vienna) 116:1383-96. https://doi.org ...discusses the question of disease specificity of mitochondrial pathologies and suggests that mitochondria dysfunction could cause or arise from anomalitie
  2 KB (317 words) - 12:47, 19 December 2023
• Lang 2022 Cell Mol Life Sci
  ...ground: exploring the impact of mitochondrial DNA integrity on Parkinson's disease by highlighting the use of cybrid models. https://doi.org/10.1007/s00018-02 ...of cybrids in this PD research field and summarize various aspects of how and to what extent mtDNA variants may contribute to the etiology of PD.
  2 KB (300 words) - 14:41, 22 June 2022
• Liu 2009 J Biomed Sci
  ...is to examine the specificity of the interaction between the antioxidants and ROS production in stressed cells. ...respiration induced by oligomycin, and tumor necrosis factor-induced cell death.
  2 KB (260 words) - 23:33, 23 April 2023
• Blindheim 2018 IOC134
  |title=Bioactive lipophilic substances and their effect on neuronal cells. ...echanisms. Affecting millions of people worldwide every year, the need for disease-modifying therapies is pressing.
  3 KB (449 words) - 14:03, 25 September 2018
• Hein 2008 Hum Mol Genet
  ...drenoleukodystrophy-associated, very long chain fatty acids on glial cells and neurons from rat hippocampus in culture. Hum Mol Genet 17:1750-61. ...ell death mechanisms in neurodegenerative disease with peroxisomal defects and subsequent VLCFA accumulation.
  2 KB (292 words) - 11:04, 27 March 2018
• Hansson 2007 Thesis
  ...y transition following calcium overload. - Its role in neuronal cell death and potential as a pharmacological target. Doctoral Thesis 78p. to limit the evolving cell death following e.g. stroke or traumatic brain injury.
  3 KB (450 words) - 17:20, 7 November 2016
• Garrido-Maraver 2019 Cell Death Dis
  ...suppresses defects associated with loss of ''Drosophila'' mitofusin. Cell Death Dis 10:288. |journal=Cell Death Dis
  2 KB (255 words) - 10:25, 1 April 2019
• Schaefer 2017 Thesis
  |title=Schaefer P (2017) Metabolic imaging in Alzheimer´s disease using NADH autofluorescence. Dissertation p93. ...is will allow to clarify mitochondrial dysfunction not only in Alzheimer´s disease but it will provide a ubiquitous tool for multiple metabolic diseases.
  3 KB (361 words) - 12:50, 26 June 2019
• Bir 2013 Abstract MiP2013
  ...ve phosphorylation system: Implications in the pathogenesis of Parkinson’s disease. Mitochondr Physiol Network 18.08. ...dopaminergic neurons in PD causes mitochondrial injury and subsequent cell death. Our earlier study has shown that α-synuclein causes functional impairment
  4 KB (464 words) - 17:30, 19 February 2018
• Pfleger 2023 Methods Mol Biol
  ...rements of mitochondrial respiration in intact cells, permeabilized cells, and isolated tissue mitochondria using the Seahorse XF Analyzer. Methods Mol Bi ...ng oxygen consumption rates and their coupling to ATP production in intact and permeabilized cells, as well as in mitochondria isolated from tissue using
  1 KB (178 words) - 12:49, 27 April 2023
• Gellerich 2004 Mol Cell Biochem
  ...mitochondrial membranes, decreased rates of mitochondrial linked pathways and decreased activities of respiratory chain enzymes contribute to depression |injuries=Cell death, Mitochondrial disease
  2 KB (277 words) - 15:16, 24 March 2015
• MiPNet15.06 MiP2010
  ...dings, new methodological developments in measuring mitochondrial function and dysfunction are presented. ...istribution, and reproduction in any medium, provided the original authors and source are credited.
  2 KB (291 words) - 13:27, 17 October 2017
• Radi 2018 Proc Natl Acad Sci U S A
  |title=Radi R (2018) Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine. Proc Natl Acad Sci U S ...trite represents both a pathophysiologically relevant endogenous cytotoxin and a cytotoxic effector against invading pathogens.
  2 KB (318 words) - 14:34, 5 May 2022
• Kallijarvi 2013 Abstract IOC75
  ...liver, heart, and kidney of symptomatic mutants is decreased to 20%, 40%, and 40% of controls, respectively. In high-resolution respirometry analysis of ...involving fetal growth retardation, lactic acidosis, liver haemosiderosis, and aminoaciduria. Lancet 351: 490-493.
  4 KB (510 words) - 15:37, 9 November 2016
• Han 2019 Am J Respir Cell Mol Biol
  ...III, and V; increased mitochondrial ROS; and decreased membrane potential and ATP production (1). {{Template:Correction FADH2 and S-pathway}}
  1 KB (188 words) - 23:25, 23 April 2023
• Brown 2010 Abstract MiP2010
  ...dentified three mechanisms by which inflamed glia kill neurons: iNOS, PHOX and phagocytosis. ...ic damage. NO from nNOS can also synergise with hypoxia to induce neuronal death via inhibition of mitochondrial respiration (if glycolysis is blocked).
  3 KB (491 words) - 09:03, 5 May 2017
• Ehinger 2015 J Neurol
  ...udy of mitochondrial function in blood cells as a future biomarker for the disease.
  3 KB (385 words) - 18:28, 16 January 2021
• Camara 2011 Front Physiol
  ...owe DF (2011) Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury. Front Physiol 2:13. https://doi.org/10.3389/fphys.2011. ...sfunction will contribute to mitigating the severity or progression of the disease. To this end, this review will provide an overview of our current understan
  3 KB (366 words) - 01:20, 31 October 2023
• De Castro IP 2013 Cell Death Dis
  ...diated suppression of mitochondrial dysfunction in ''pink1'' mutants. Cell Death Dis 24:e873. |journal=Cell Death Dis
  2 KB (290 words) - 17:30, 9 November 2017
• Goudie 2017 Abstract IOC122
  ...stemic vs. local effects of the P110. We conclude that inhibition of DRP1 and Fis1 interaction provides a novel approach to mitigating IBD.
  2 KB (341 words) - 16:46, 27 March 2018
• Connolly 2018 Cell Death Differ
  ...ondrial dysfunction in cellular models of neurodegenerative diseases. Cell Death Differ 25:542-72. https://doi.org/10.1038/s41418-017-0020-4 |journal=Cell Death Differ
  3 KB (485 words) - 18:07, 13 September 2023
• Tian 2021 Front Physiol
  ...n, a novel therapeutic molecule, regulates oxidative stress, inflammation, and apoptosis. Front Physiol 12:2281. https://doi.org/10.3389/fphys.2021.789507 ...poptotic effects and its underlying mechanism, particularly in coronavirus disease-2019 (COVID-19), providing strategies for the medical application of H_{2 KB (324 words) - 14:59, 24 December 2021
• Leggio 2022 Adv Healthc Mater
  ...cytes rescue cell death and preserve mitochondrial function in Parkinson's disease. https://doi.org/10.1002/adhm.202201203 ...ghlight a regional diversity in the nigrostriatal system for the secretion and activities of astrocyte-EVs, with neuroprotective implications for PD.
  3 KB (399 words) - 15:59, 19 December 2023
• Yang 2023 Cell Death Discov
  ...2023) MEK1 drives oncogenic signaling and interacts with PARP1 for genomic and metabolic homeostasis in malignant pleural mesothelioma. https://doi.org/10 |info=Cell Death Discov 9:55. [https://pubmed.ncbi.nlm.nih.gov/36765038 PMID: 36765038 Open
  2 KB (350 words) - 17:13, 21 February 2023
• Sumner 2023 Transl Psychiatry
  ...Psychological and biological mechanisms linking trauma with cardiovascular disease risk. https://doi.org/10.1038/s41398-023-02330-8 ...stress, mitochondrial dysfunction, renin-angiotensin system dysregulation, and accelerated biological aging may all contribute to subsequent cardiovascula
  2 KB (319 words) - 16:31, 8 February 2023
• Read 2021 Redox Biol
  ...m-Snary KJ (2021) Mitochondrial iron-sulfur clusters: Structure, function, and an emerging role in vascular biology. Redox Biol 47:102164. doi:10.1016/j.r ...otential new therapeutic targets for diseases including malaria, diabetes, and cancer.
  2 KB (271 words) - 17:59, 2 April 2023
• Silva 2012 PLOS ONE
  ...nfected with Sindbis virus: implications to viral replication and neuronal death. PLoS One 7:e33871. ...ism of Neuro 2a cells may form the molecular basis of neuronal dysfunction and Sindbis virus-induced encephalitis.
  3 KB (407 words) - 14:53, 23 February 2020
• Herbst 2015 Neuroscience
  ...respiratory capacity within the striatum of the R6/1 model of Huntington's disease. Neuroscience 303:515-23. ...ice, and that exercise partially prevents changes in mitochondrial content and function that occur late in HD.
  2 KB (347 words) - 17:24, 7 November 2016
• Alegre 2019 Am J Transplant
  ...(Figure 1) is necessary for the ability of Tregs to maintain homeostasis, and find that tampering with Treg–mitochondrial complex III triggers fatal au {{Template:Correction FADH2 and S-pathway}}
  1 KB (195 words) - 21:37, 22 October 2023
• Brown G 2014 Abstract MiP2014
  |title=Complex I inhibition in microglia and inflammatory neuronal loss. ...y inhibit their mitochondrial Complex I, resulting in sustained activation and phagocytosis of live neurons.
  3 KB (429 words) - 14:17, 20 February 2015
• Marinho 2018 Evid Based Complement Alternat Med
  ...steatosis, and inflammation in a murine model of nonalcoholic fatty liver disease. Evid Based Complement Alternat Med 2018:4956079. ...NAFLD improving mitochondrial dysfunction, steatosis, acute inflammation, and oxidative stress.
  2 KB (335 words) - 11:33, 13 July 2018
• Schoepp 2017 MiPschool Obergurgl
  .../www.mitoglobal.org/index.php/MITOEAGLE|COST Action MitoEAGLE]] Generation and characterization of human cardiomyocytes obtained from iPSCs derived from p option for disease modelling and regenerative medicine. Directed differentiation of human
  3 KB (464 words) - 16:14, 12 January 2018
• Kalpage 2020 Int J Biochem Cell Biol
  ...c phosphorylation: Control of mitochondrial electron transport chain flux and apoptosis. Int J Biochem Cell Biol 121:105704. ...be dysfunctional in disease conditions such as ischemia-reperfusion injury and neurodegenerative disorders through increased ROS, or cancer, where post-tr
  3 KB (383 words) - 10:22, 10 March 2020
• Miquel 2014 Free Radic Biol Med
  ...ochondrial nitroxidative damage and dysfunction in the pathogenesis of ALS and suggest that mitochondria-targeted antioxidants may be of pharmacological u
  3 KB (390 words) - 11:31, 18 March 2018
• Poddar 2016 Abstract IOC116
  ...Effects of glucose hypometabolism on mitochondrial functions in rat brain and in SHSY5Y cells in culture. Mitochondr Physiol Network 21.11 ...The effects of 2-DG on brain mitochondrial functions, amyloid homeostasis and possible neurodegeneration will now be analyzed after intracerebroventricul
  2 KB (344 words) - 20:02, 20 November 2016
• Martin 2010 Proc Natl Acad Sci U S A
  ...are among the many biological processes affected by dietary energy intake and exercise. Although overfed sedentary rodents may be reasonable models for t |injuries=Mitochondrial disease
  1 KB (180 words) - 15:25, 16 February 2015
• Luna-Sánchez 2014 Abstract SECF
  ...le=Mitochondrial encephalopathy due to coenzyme q deficiency: pathogenesis and treatment. ...neurological symptoms (encephalopathy, cerebellar ataxia or multisystemic disease). To better understand the
  3 KB (443 words) - 16:58, 29 November 2016
• Kupsch 2014 J Neural Transm
  ...tion in the rat model of Parkinson's disease: respirometric, histological, and behavioral analyses. J Neural Transm 121:1245-57. ...tive phosphorylation. Mitochondrial dysfunction, motor behavior asymmetry, and dopaminergic neuronal cell loss correlated with dosage (1.25-5 μg/2 μl).
  2 KB (337 words) - 18:00, 7 November 2016
• Risiglione 2020 Int J Mol Sci
  ...</sup> mitochondrial toxicity mechanism in a cellular model of parkinson's disease. Int J Mol Sci 21:E7809. https://doi.org/10.3390/ijms21217809 ...levant for the standardization of studies that employ this neurotoxin as a disease model.
  3 KB (367 words) - 17:36, 5 October 2023
• Acuña-Castroviejo 2011 Curr Top Med Chem
  ...García JA; Reiter RJ (2011) Melatonin-mitochondria interplay in health and disease. Curr Top Med Chem 11:221-240. ...that involving mitochondrial dysfunction. This review summarizes the data and mechanisms of action of melatonin in relation to mitochondrial pathologies.
  3 KB (434 words) - 08:05, 21 February 2020
• Moreno-Ortega 2015 Aging Cell
  ...l Ca²⁺ homeostasis, mitogen-activated protein kinase signaling, and cell vulnerability upon exposure to amyloid β. Aging Cell 14:1094-102. ...e presence of Aβ, P86L-CALHM1 shifts the balance between neurodegeneration and neuronal survival toward the stimulation of pro-cytotoxic pathways, thus po
  2 KB (363 words) - 16:00, 9 November 2016
• Gatza 2011 Sci Transl Med
  ...ive T cells causes their selective apoptosis and arrests graft-versus-host disease. Sci Transl Med 3: 67ra8. ...through aerobic glycolysis, and identify the possibility that bioenergetic and redox characteristics can be selectively exploited as a therapeutic strateg
  2 KB (304 words) - 16:03, 9 November 2016
• Weissig 2015 Methods Mol Biol II
  ...ep, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. ...nelle that seems so clearly to control the life and death of a single cell and whole organisms alike.
  2 KB (280 words) - 14:58, 8 March 2016
• Angelin 2007 Proc Natl Acad Sci U S A
  ...l dysfunction in the pathogenesis of Ullrich congenital muscular dystrophy and prospective therapy with cyclosporins. Proc Natl Acad Sci U S A 104: 991-99 ...ogical therapy of Ullrich congenital muscular dystrophy with cyclosporin A and methylAla(3)ethylVal(4) cyclosporin.
  2 KB (321 words) - 11:28, 14 March 2013
• Foriel 2015 Abstract MiP2015
  ...eutic potential, toxicity and pharmacokinetics. Due to the extreme genetic and phenotypic heterogeneity of OxPhos disorders one cannot rely on a single in ...in patients and selecting phenotypes-readouts suitable for drug screening (death at critical stages of development, survival curves, ROS level).
  2 KB (343 words) - 16:17, 4 September 2015
• Menna-Barreto 2009 Free Radic Biol Med
  ...tion, leading to increased reactive oxygen species generation and parasite death. |keywords=''Trypanosoma cruzi''; Chagas disease; Chemotherapy; Naphthoquinones; Reactive oxygen species; Superoxide; Metabo
  3 KB (320 words) - 15:18, 13 November 2017
• Anderson 2011 Am J Physiol Heart Circ Physiol
  ...CA, Thayne K, Chitwood WR, Kypson AP (2011) Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways. Am ...viable target for future therapies directed at ameliorating heart failure and other co-morbidities that come with diabetes.
  3 KB (448 words) - 16:40, 14 October 2019
• Gopalakrishnan 2020 Sci Rep
  ...M, Eells JT (2020) Photobiomodulation preserves mitochondrial redox state and is retinoprotective in a rodent model of retinitis pigmentosa. Sci Rep 10:2 ...lism have considerable potential for the treatment of retinal degenerative disease.
  3 KB (395 words) - 04:44, 4 November 2023
• Bansal 2019 Academic Press
  ...to obesity and type 2 diabetes. Academic Press In: Mitochondria in obesity and type 2 diabetes. Morio B, Pénicaud L, Rigoulet M (eds) Academic Press. htt ...eld of research now popularly known as developmental origins of health and disease (DOHaD) emerged. It now is clear that perturbations during early life have
  2 KB (273 words) - 10:23, 9 May 2023
• Liu 2020 Cell Death Dis
  ...drial DNA in vascular smooth muscle cells impairs cell contractility. Cell Death Dis 11:35. |journal=Cell Death Dis
  2 KB (323 words) - 16:35, 29 February 2020
• Azzolini 2016 Abstract Mito Xmas Meeting Innsbruck
  ...hese results open the possibility to a new therapeutical approach for this disease by directly targeting the mitochondrial channel. |injuries=Cell death
  3 KB (398 words) - 18:28, 31 January 2020
• Corona 2014 Exp Neurol
  ...γ activation rescues mitochondrial function from inhibition of 2 complex I and loss of PINK1. Exp Neurol 253:16-27. ...different models of mitochondrial dysfunction associated with Parkinson's disease through a direct impact on mitochondrial function.
  3 KB (362 words) - 17:25, 9 November 2017
• Mercer 2013 Abstract IOC75
  == '''Mitochondrial bioenergetics and therapeutic intervention in vascular disease''' == ...to identify and translate therapies to reduce the effects of this disease and its associated co-morbidities.
  3 KB (495 words) - 15:30, 18 November 2014
• Sabogal-Guaqueta 2019 Biomed Pharmacother
  ...uates oxidative stress and mitochondrial dysfunction mediated by glutamate and NMDA toxicity. Biomed Pharmacother 118:109295. ...brain diseases where oxidative stress contributes to the pathology of the disease.
  3 KB (337 words) - 12:55, 4 November 2019
• Holland 2018 Cell Death Dis
  ...tations in preeclampsia associated with progression to term delivery. Cell Death Dis 9:1150. |journal=Cell Death Dis
  3 KB (384 words) - 13:30, 7 March 2020
• Brown 2012 Abstract Bioblast
  ...on our mitochondrial genome may explain its rapid evolution, poor adaption and our aging. Mitochondr Physiol Network 17.12. ..., there would have been selection pressure to delay ageing and age-related disease. But that selection pressure would have had relatively little effect on th
  2 KB (253 words) - 17:15, 3 February 2016
• Cherubini 2014 Abstract MiP2014
  ...triatal deregulation of Cdk5 alters mitochondrial dynamics in Huntington’s disease. ...gests that mitochondrial dysfunction occurs during the pathogenesis of the disease [3]. We previously described that deregulation of cyclin-dependent kinase 5
  4 KB (498 words) - 16:12, 15 February 2016
• Mahalaxmi 2022 Toxicol In Vitro
  ...d in the presence of albumin due to the molecular interaction between CCCP and albumin.
  2 KB (268 words) - 13:18, 5 December 2022
• Korre 2016 Am J Cardiol
  ...will improve CVD risk profiles and decrease on-duty CVD and sudden cardiac death events in the fire service. Our results may also support targeted noninvasi
  2 KB (351 words) - 00:17, 14 February 2020
• Muguiz 2017 J Cachexia Sarcopenia Muscle
  |event=10th International Conference on Cachexia, Sarcopenia and Muscle Wasting such as cancer, cardiovascular disease and Chronic Obstructive
  3 KB (408 words) - 10:24, 2 January 2018
• Lauritzen 2015 Am J Physiol Heart Circ Physiol
  ...LJ, Attramadal H, Storm-Mathisen J, Bergersen LH (2015) Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure. A ...ced cardiac-restricted mtDNA damage for investigation of mtDNA-based heart disease.
  3 KB (337 words) - 12:09, 8 November 2016
• Modesti 2021 Cells
  ...Giorgi C, Pinton P (2021) Mitochondrial Ca2+ Signaling in Health, Disease and Therapy. Cells 10(6):1317. ...e related mechanisms and the significance of this regulation in physiology and human diseases. We also highlight strategies aimed at remedying mCa2+ dysre
  2 KB (265 words) - 10:47, 9 February 2022
• Wang 2023 Cancer Cell Int
  ...L, Cao J, Liu M, Li H, Gu H (2023) PRRG4 regulates mitochondrial function and promotes migratory behaviors of breast cancer cells through the Src-STAT3-P ...st cancer. However, it is not clear whether PRRG4 can affect the migration and invasion of breast cancer cells through regulating mitochondria function.
  3 KB (440 words) - 17:10, 19 December 2023
• Kwak 2012 Free Radic Biol Med
  ...Bamman MM, Neufer PD (2012) Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes ...aximal mitochondrial respiratory capacity, mitochondrial oxidative stress, and apoptosis in primary human skeletal myotubes, suggesting that mitochondrial
  3 KB (381 words) - 17:27, 25 February 2020
• Musicco 2023 Int J Mol Sci
  ...ed. Thus, mitochondria-targeted drugs may open new frontiers to a tailored and personalized cancer therapy. {{Template:Correction FADH2 and S-pathway}}
  2 KB (297 words) - 22:08, 22 October 2023
• Pretorius 2015 Abstract MiPschool Cape Town 2015
  |title=Metallothioneins are involved in mitochondrial function and disease. ...icant differences at protein level could be detected, the metabolism of WT and MT1+2KO mice differed markedly during normal mitochondrial function as well
  3 KB (504 words) - 11:46, 25 February 2015
• Jacome-Sosa 2021 Commun Biol
  ...ad NA (2021) CD36 maintains the gastric mucosa and associates with gastric disease. Commun Biol 4:1247. https://doi.org/10.1038/s42003-021-02765-z ...he UK Biobank. The findings support role of CD36 in gastric tissue repair, and its deletion associated with chronic diseases that can predispose to malign
  3 KB (391 words) - 14:00, 30 April 2024
• Wei 1999 JAMA
  ...low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men. JAMA 282:1547-53. ...endations for risk stratification by disease conditions and cardiovascular disease (CVD) risk factors, but the role of physical inactivity is not prominent in
  3 KB (479 words) - 11:20, 11 December 2019
• Miquel 2012 PLoS One
  ...of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis. PLoS One 7:e3 ...icate that improvement of the mitochondrial redox status by DCA leads to a disease-modifying effect, further supporting the therapeutic potential of mitochond
  3 KB (416 words) - 11:33, 18 March 2018
• Kumari 2012 PLoS One
  ..., Mehta SL, Li PA (2012) Glutamate induces mitochondrial dynamic imbalance and autophagy activation: preventive effects of selenium. PLoS One 7:e39382. ...to define the therapeutic potentials of selenium in animal disease models and in human.
  2 KB (291 words) - 15:02, 13 November 2017
• Basso 2015 Abstract MiPschool London 2015
  ...pids and calcium exchange and for the regulation of calcium dependent cell death. ...nsory and motor axons, revealed that ubiquitination is impaired in all the disease-mutated MFN. Although the mechanism by which mutations in MFN lead to neuro
  3 KB (496 words) - 16:42, 13 April 2015
• Calabria 2019 Front Neurosci
  ...erico, Mariotti Raffaella (2019) ASCs-exosomes recover coupling efficiency and mitochondrial membrane potential in an ''in vitro'' model of ALS. Front Neu ...ial bioenergetic defects directly associated with the SOD1(G93A) mutation, and prove the efficacy of adipose-derived stem cells exosomes to rescue the fun
  3 KB (398 words) - 09:36, 19 June 2020
• Xiong 2016 Hypertension
  ...sent a promising intervention for the primary prevention of coronary heart disease. |keywords=TRPV1 protein, Mouse, Atherosclerosis, Coronary disease, Endothelium, Mitochondria, Reactive oxygen species, Uncoupling protein 2,
  3 KB (432 words) - 19:28, 29 February 2020
• Van Hoose 2015 Thesis
  ...itochondrial respiration and electron transport chain activity ''in vivo'' and attenuates mitochondrial dysfunction during cardiac injury. Dissertations p ...complications, such as myocardial infarction (MI), is the leading cause of death within the United States.
  3 KB (456 words) - 16:23, 13 November 2017
• Lee 2022 Hum Mol Genet
  ...pin deficiency and cause an autosomal recessive multi-system mitochondrial disease. https://doi.org/10.1093/hmg/ddac040 ...stemic involvement. Furthermore, we identify key signatures in cardiolipin and proteome profiles across various degrees of cardiolipin loss, facilitating
  3 KB (441 words) - 11:39, 5 December 2022
• Keeney 2009 Hum Gene Ther
  ...ochondrial gene therapy augments mitochondrial physiology in a Parkinson's disease cell model. Hum Gene Ther 20:897-907. ...PD neurons and needs additional development to define its pharmacodynamics and delineate its molecular mechanisms. It also is unclear whether single-donor
  3 KB (405 words) - 14:52, 13 November 2017
• Nollet 2018 IOC130
  ...to identify and design novel therapeutic strategies tailored to different disease stages. ...erfusion and ischemia, which further exacerbates mitochondrial dysfunction and oxidative stress, ultimately leading to cardiac remodeling[1].
  4 KB (513 words) - 12:02, 22 May 2018
• Rajendran 2019 EMBO Mol Med
  ...n. These findings demonstrate the value of AOX, both as a mechanistic tool and a potential therapeutic strategy, for cIII deficiencies. |injuries=Mitochondrial disease
  2 KB (347 words) - 10:12, 8 June 2020
• Borutaite MiP2010
  ...Budvytyte R (2010) Effect of beta amyloid oligomers on neuronal viability and mitochondrial functions. ...-5 nm) did not cause detectable neuronal death. Aβ1-42 oligomers, monomers and fibrils were non-toxic to glial cells in CGC cultures or macrophage J774 ce
  3 KB (468 words) - 16:04, 15 February 2016
• Donnarumma 2022 Nat Commun
  ...T (2022) Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure. https://doi.org/10.1038/s41467-022-34316-3 ...MTFP1 in the control of bioenergetic efficiency and cell death sensitivity and define its importance in preventing pathogenic cardiac remodeling.
  2 KB (257 words) - 18:59, 9 November 2022
• Guerra-Alvarez 2015 J Neurochem
  ...ositive allosteric modulation of alpha-7 nicotinic receptors promotes cell death by inducing Ca²⁺ release from the endoplasmic reticulum. J Neuro ...sup>]ER ) by a Ca²⁺ -induced Ca²⁺ release mechanism; and (iv) reduces cell viability. These findings were corroborated in rat hippoc
  3 KB (468 words) - 15:12, 10 October 2016
• Souza da Silva 2020 Mol Neurobiol
  ...nous purine presented a neuroprotective effect on presynaptic mitochondria and should be considered for further studies in AD models. |keywords=Alzheimer’s disease, Amyloid-β oligomers, Guanosine, Neuroprotection, Presynaptic mitochondria
  3 KB (347 words) - 10:38, 16 April 2021
• Kodama 2009 JAMA
  ...predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. JAMA 301:2024-35. ...rse association between cardiorespiratory fitness (CRF) and coronary heart disease (CHD) or all-cause mortality in healthy participants.
  4 KB (521 words) - 10:42, 23 December 2019
• Cornelissen 2020 Hum Mol Genet
  ...Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2. Hum Mol Genet 29:1096-106. ...nduced increased mitochondrial production of reactive oxygen species (ROS) and apoptosis, which was prevented by treatment with anti-oxidants. Retention o
  2 KB (358 words) - 17:53, 30 June 2020
• Gnaiger 2013 Abstract ASMRM
  ...r E(2013) Loss of mitochondrial competence and degenerative disease: cause and effect. Abstract ASMRM-Seoul. ...ondrial fever’), putting the cell at risk of further degeneration and cell death, with all sequelae of age-related diseases [4].
  3 KB (380 words) - 18:26, 10 January 2022
• Schaefer 2016 Abstract MitoFit Science Camp 2016
  ...ent role of amyloid beta and its intracellular localization in Alzheimer´s disease associated mitochondrial dysfunction. ...d consequently are discussed to be one underlying feature of neuronal cell death. The amyloid precursor protein (APP) as well as amyloid beta (Aβ), one of
  3 KB (494 words) - 15:19, 23 January 2019
• Uribe-Alvarez 2018 Microbiologyopen
  ...is'' grows in ''Saccharomyces cerevisiae'' evoking early death of the host and deregulation of mitochondrial metabolism. Microbiologyopen 8:e00675. host fertility, protein expression, lifespan, and metabolism. Understanding and engineering
  2 KB (249 words) - 13:06, 17 April 2019
• Lauritzen 2010 Mol Cell Biol
  ...ial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior. Mol Cell Biol 30:1357-67. ...ution and deletions previously have been shown to correlate with premature and natural aging, respectively, we show that a high level of apyrimidinic site
  2 KB (278 words) - 15:07, 13 November 2017
• Fisher-Wellman 2023 Cancers (Basel)
  ...rgizes to corrupt mitochondrial respiration and signal caspase driven cell death in drug-resistant acute myeloid leukemia. https://doi.org/10.3390/cancers15 ...utic avenue. The inhibitor regimen showed efficacy in an ''in vivo'' model and in primary AML cells from patients. These results support the implementatio
  3 KB (455 words) - 13:58, 19 July 2023
• Verebne Tar 2016 Abstract MitoFit Science Camp 2016
  ...or PA200 in mitochondrial homeostasis in a cellular model for Huntington’s disease. ...forming inclusion bodies, moreover, polyQ length correlates disease onset and severity.
  5 KB (660 words) - 13:48, 27 March 2018
• MacCannell 2021 Int J Obes (Lond)
  ...berts LD (2021) Sexual dimorphism in adipose tissue mitochondrial function and metabolic flexibility in obesity. Int J Obes (Lond) 45:1773-81. ...s metabolic disease risk. The link between sexual dimorphisms of adiposity and metabolism is poorly defined. We hypothesise that depot-specific adipose ti
  3 KB (397 words) - 15:21, 16 August 2021
• Barksdale 2010 FASEB J
  ...ndez-Ferro M, Roberts RC, Bijur GN (2010) Mitochondrial viability in mouse and human postmortem brain. FASEB J 24:3590-9. ...t source of viable mitochondria to study metabolic processes in health and disease. It is also possible to archive these mitochondria for future studies.
  2 KB (276 words) - 15:50, 15 June 2015
• CSH Asia 2017 Suzhou CN
  ::::1. mtDNA transmission and diseases ::::2. Mitochondria in cell death
  2 KB (277 words) - 17:24, 17 October 2017
• Ruiz 2017 Brain Pathol
  ...and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease. Brain Pathol 28:611-30. ...tasis in myelin diseases, provide insight into the pathophysiology of PMD, and may bear implications for tailored pharmacological intervention.
  3 KB (433 words) - 14:59, 2 January 2019
• Logan 2014 Nat Genet
  ...oni F, Sheridan E (2014) Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium sign ...was severely fragmented. Whereas the pathophysiology of muscular dystrophy and the core myopathies involves abnormal mitochondrial Ca2+ handling, the phen
  3 KB (384 words) - 15:12, 13 November 2017
• Hagenbuchner 2013 Oncogene
  ...exer P, Ausserlechner MJ (2013) BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/fission m ...olysis inhibitors target an 'archilles heel' of Survivin-overexpressing NB and may be highly useful as chemosensitizers in the treatment of high-stage NB.
  2 KB (271 words) - 14:27, 13 November 2017
• Rhein 2010 PloS One
  ...0) Ginkgo biloba extract ameliorates oxidative phosphorylation performance and rescues abeta-induced failure. PloS One 5:e12359. ...ATP levels which may finally instigate loss of synapses and neuronal cell death in AD. Therefore, the aim of the present study was to investigate whether s
  3 KB (447 words) - 16:14, 9 November 2016
• Iglesias-Gonzalez 2012 Neurochem Res
  ...euroblastoma cells and rat brain mitochondria: protective role of catalase and superoxide dismutase. Neurochem Res 37:2150-60. ...ts cytotoxicity. The here reported data suggest that both superoxide anion and hydroperoxyl radical could account for 6-OHDA toxicity. Furthermore, factor
  5 KB (720 words) - 11:38, 23 January 2019
• Shi 2020 Diabetes
  ...ish a critical role of liver ChREBP in coping with hepatic fructose stress and protecting from hepatotoxicity by regulating LPK. |keywords=Fructose metabolism, ChREBP, Glycogen storage disease, Liver injury, Transcriptional regulation, Transcription factor
  3 KB (360 words) - 17:11, 29 February 2020
• Santidrian 2013 J Clin Invest
  ...ay LJ, Yagi T, Felding-Habermann B (2013) Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression. J Clin Invest 123:106 ...normalization of the NAD+/NADH balance can inhibit metastasis and prevent disease progression.
  2 KB (285 words) - 16:24, 5 March 2015
• Pokkunuri 2020 Am J Physiol Renal Physiol
  ...omerase inhibition impairs Keap1/Nrf2 signaling and mitochondrial function and induces apoptosis in renal proximal tubular cells. Am J Physiol Renal Physi ...s suggest an important role for PDI in renal cell apoptosis involving Nrf2 and mitochondrial dysfunction.
  2 KB (325 words) - 18:16, 6 November 2020
• Bombaca 2018 Free Radic Biol Med
  ...OF, Da Silva Júnior EN, Menna-Barreto RFS (2018) Mitochondrial disfunction and ROS production are essential for anti-Trypanosoma cruzi activity of β-lapa ...oxidative misbalance, which exacerbated ROS generation and led to parasite death. Although other mechanisms cannot be discounted, mainly in N1-treated paras
  3 KB (460 words) - 13:49, 14 August 2019
• Chang 2016 Transl Res
  ...mitochondria in Parkinson's disease: restoration of mitochondria functions and attenuation of 6-hydroxydopamine-induced neurotoxicity. Transl Res 170:40-5 ...opaminergic neuron in the treated PD rats, mitochondrial complex I protein and mitochondrial dynamics were restored, thus ameliorating the oxidative DNA d
  3 KB (405 words) - 17:19, 9 November 2017
• Alfatni 2020 J Clin Med
  ...nonuclear cells and platelets mitochondrial dysfunction, oxidative stress, and circulating mtDNA in cardiovascular diseases. J Clin Med 9 pii:E311. ...on, oxidative stress, and circulating mtDNA as biomarkers of CVD diagnosis and prognosis. This new approach might also allow further interesting therapeut
  2 KB (328 words) - 20:19, 7 March 2020
• Hoel 2017 MiPschool Obergurgl
  ...ress conditions, and have also been linked to diseases such as Parkinson’s disease. ...to investigate proteins that are involved in the dynamics, quality control and biogenesis of mitochondria.
  2 KB (324 words) - 14:40, 27 March 2018
• Sun 2012 Front Mol Neurosci
  ...ibited caspase activation, while treatment with the inhibitor of calpains- and papain-like cathepsins (2S,3S)-trans-epoxysuccinyl-leucylamido-3-methyl-but |keywords=EPM1, Cathepsin, Cell death, Cystatin, Histone
  2 KB (278 words) - 13:52, 29 July 2016
• Andersen 2013 Int J Circumpolar Health
  ...I starting point was in the overweight range. This is not conceivable in a disease-free, physically active, pre-western hunter population. ...ture of Greenland Inuit and Caucasian Danes will influence this difference and hamper a clear distinction with time.
  2 KB (311 words) - 12:40, 21 December 2019
• Da Silva 2017 Thesis
  ...entration of autophagy markers (LC3, ATG3 e ATG16 ), in the levels of PINK and PARKIN – mitophagy marker, as well as in the NRF1 of mitochondrial biogen
  3 KB (449 words) - 11:51, 3 May 2019
• Nedel 2021 Intensive Care Med Exp
  ...olic signatures in mitochondria whose association with disease progression and clinical outcomes remain elusive. ...Our primary outcome was 6-month mortality, and secondary outcomes were ICU and hospital ward mortality.
  3 KB (452 words) - 14:29, 2 August 2021
• Gellerich 2008 J Biol Chem
  ...of brain mitochondria by extramitochondrial Ca2+ in transgenic huntington disease rats. J Biol Chem 283:30715-24. ...e mitochondrial dysregulation leading to energetic depression, cell death, and tissue atrophy in HD.
  3 KB (427 words) - 14:58, 8 June 2015
• Gumeni 2017 Abstract MITOEAGLE Barcelona
  Impact of mitochondrial dynamics on the proteostasis network and longevity in ''Drosophila melanogaster'' ...existence of extensive cross-talk and functional wiring between mitostatic and proteostatic modules; this cross talk is likely operating through a circuit
  3 KB (447 words) - 14:37, 12 January 2018
• Latina 2021 Acta Neuropathol Commun
  ...d tau peptide reduces retinal degeneration in a mouse model of Alzheimer's Disease. Acta Neuropathol Commun 9:38. ...diagnostic and therapeutic avenues for the clinical management of cerebral and extracerebral AD signs in human beings.
  4 KB (480 words) - 11:20, 8 July 2021
• Dhandapani 2014 Abstract IOC 2014-04 Schroecken
  ...ative oxidases (AOX) that branch the mitochondrial electron transportation and maintain electron flow under conditions where the cytochrome pathway of the ...mitochondrial respiratory chain complexes III or IV are the cause for the disease, AOX expression should rescue or alleviate the symptoms. We will challenge
  3 KB (464 words) - 09:19, 14 June 2017
• Lages 2015 PeerJ
  ...a A, Castilho LR, Rehen SK (2015) Low oxygen alters mitochondrial function and response to oxidative stress in human neural progenitor cells. PeerJ 3:e148 ...evels should be considered for ''in vitro'' models of neuronal development and drug screening.
  2 KB (285 words) - 15:04, 13 November 2017
• Jones 2010 Biochim Biophys Acta
  ...0) Age-related deficiencies in Complex I endogenous substrate availability and reserve capacity of Complex IV in cortical neuron electron transport. Bioch ...d to an age-related catastrophic decline in energy production and neuronal death.
  2 KB (304 words) - 14:38, 20 March 2015
• Sulfite oxidase
  ...SO result in severe neurological problems, stunted brain growth, and early death [2]. ...o acids with the formation of a sulfate, electrons pass to cytochrom ''c'' and are further utilized in the respiratory system.
  2 KB (311 words) - 10:34, 3 July 2017
• Davoudi 2014 PhD Thesis
  ...ffect of experimental complex III deficiency on respiratory chain assembly and function. PhD Thesis 1-65. aminoaciduria, cholestasis, iron accumulation, lactic acidosis, and early death,
  2 KB (333 words) - 17:29, 9 November 2017
• Doerrier 2015 Thesis
  ...unction associated with sepsis. In this regard, the inflammatory response and the ROS/RNS increase during sepsis trigger mitochondrial dysfunction. Mitoc other processes in physiological and pathological conditions. Therefore, the analysis of mitochondrial function
  2 KB (326 words) - 15:11, 23 January 2019
• Rohlenova 2016 Antioxid Redox Signal
  ...tron transport chain is a viable strategy to eliminate Her2^high disease. ...in vivo'', leading to elevated reactive oxygen species production and cell death. Intriguingly, higher sensitivity of Her2^high cells to MitoTam i
  3 KB (443 words) - 07:01, 20 April 2020
• Koopman 2012 Abstract Bioblast
  ...esponses, production of reactive oxygen species (ROS), and programmed cell death (apoptosis). ...(dys)function. Here it will be summarized how these insights were obtained and how they can contribute to the rational design of intervention strategies f
  5 KB (661 words) - 11:23, 23 February 2015
• Lee 2018 Reprod Sci
  ...n of pyruvate dehydrogenase kinase 1 by hypoxia alters cellular metabolism and inhibits apoptosis in endometriotic stromal cells. Reprod Sci 26:734-44. ...etriotic cells may adapt to hypoxic microenvironment via upregulating PDK1 and reprogramming metabolism, which provides a survival advantage in the hostil
  2 KB (312 words) - 04:39, 21 November 2023
• Jang 2018 J Med Toxicol
  ...methods have potential application to guide therapy and gauge severity of disease in poisoning related to cellular inhibitors of public health concern.
  2 KB (302 words) - 14:37, 5 July 2023
• Rodriguez-Nuevo 2018 EMBO J
  ...J, Villarroya F, Sandri M, Shirihai O, Zorzano A (2018) Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency. EMBO J 37. ...tivation, and inflammation, which contributes to enhanced Fgf21 expression and to growth impairment.
  2 KB (354 words) - 13:40, 28 May 2018
• Mittal 2011 HPB (Oxford)
  ...illips AR (2011) Early organ-specific mitochondrial dysfunction of jejunum and lung found in rats with experimental acute pancreatitis. HPB (Oxford) 13:33 ...Primary mitochondrial dysfunction plays a central role in the development and progression of organ failure in critical illness. The present study investi
  2 KB (332 words) - 11:30, 23 January 2019
• Ciminale 2016 Abstract Mito Xmas Meeting Innsbruck
  ...membrane potential and partial localization of the protein to the cytosol and nucleus. Current studies are aimed identifying possible posttranslational m ::::# Dept Surgery, Oncology and Gastroenterology, Univ Padova, Italy
  2 KB (329 words) - 10:39, 13 December 2016
• Eisenberg 2016 Nat Med
  ..., Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F (2016) Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med 22:1428-38. ...suggest a new and feasible strategy for protection against cardiovascular disease.
  3 KB (516 words) - 10:05, 14 October 2021
• Percival 2013 Hum Mol Genet
  ...el MP, Knowels G, Marcinek DJ (2013) Defects in mitochondrial localization and ATP synthesis in the mdx mouse model of Duchenne muscular dystrophy are not ...understanding of how mitochondrial bioenergetic dysfunction contributes to disease pathogenesis in dystrophin-deficient skeletal muscle ''in vivo''.
  3 KB (338 words) - 16:20, 25 November 2015
• Fonseca-Berzal 2016 Parasitology
  ...al machinery as part of the mode of action of both 5-nitroindazolinones 22 and 24 on ''T. cruzi trypomastigotes''. |keywords=Chagas disease, Autophagy, Flow cytometry, High-resolution respirometry, Mitochondrion, Tr
  2 KB (308 words) - 11:39, 26 June 2019
• Parvez 2010 Biochim Biophys Acta
  ...nd a Hill coefficient of 1.3. In both systems (i.e. energized mitochondria and mitoplasts) the inhibitory effect on permeability transition was attenuated |keywords=Parkinson's disease, Permeability transition, Apoptosis, Mitochondria, Ropinirole, Neuroprotec
  3 KB (397 words) - 10:43, 23 January 2019
• Juellig 2008 Proteomics
  ...y assays often also showed mismatches between increased protein expression and activities suggesting elevated protein expression may be compensatory in th |injuries=Mitochondrial disease
  2 KB (327 words) - 14:10, 27 March 2015
• Ohta 2021 Curr Pharm Des
  |title=Ohta S (2021) Direct targets and subsequent pathways for molecular hydrogen to exert multiple functions: foc ...ub>2} action on lipopolysaccharide signaling, MAPK and NF-κB pathways and the Nrf2 paradox. Finally, as a novel idea for the direct targeting of H<su
  3 KB (395 words) - 18:28, 24 December 2021
• Hansson 2008 Free Radic Biol Med
  ...is a significant cause of pathological ROS generation in excitotoxic cell death. |injuries=Ischemia-reperfusion, Oxidative stress;RONS, Mitochondrial disease
  2 KB (332 words) - 17:34, 25 February 2020
• Larche 2006 J Am Coll Cardiol
  ...ial permeability transition prevents sepsis-induced myocardial dysfunction and mortality. J Am Coll Cardiol 48:377-85. ...ial permeability transition was achieved by means of pharmacological drugs and overexpression of the antiapoptotic protein B-cell leukemia (Bcl)-2.
  3 KB (360 words) - 11:50, 22 December 2020
• Ghanim 2017 Abstract IOC122
  ...ing more invasive therapies could greatly increase the comfort of patients and ideally increase the survival rate. ...he first identified protein that has a defined function in its native site and acquires a new beneficial function after partial unfolding. Other similar p
  3 KB (382 words) - 14:28, 7 June 2017
• Baxter 2020 Elife
  ...ith low 5'UTR GC content. BUD23 emerges as essential to mouse development, and to postnatal cardiac function.
  2 KB (309 words) - 13:19, 7 March 2020
• Repp 2019 Thesis
  ...p BM (2019) Identification and verification of novel disease-causing genes and therapy options for patients with mitochondrial disorders – Focus on ACAD ...gy metabolism. In addition to the mitochondrial β-oxidation of fatty acids and the citrate cycle the re-oxidation by the aerobic hydrogen transmitting coe
  6 KB (868 words) - 22:12, 9 July 2020
• Hepple 2014 Abstract MiP2014
  ...l activity levels, examining the impact of aging on mitochondrial function and the role played by denervation across this continuum. ...=Cell death, Permeability transition, Oxidative stress;RONS, Mitochondrial disease
  3 KB (339 words) - 12:10, 28 March 2018
• Zhao 2022 J Cell Sci
  ...c insight into how mitochondrial dysfunction causes pathological molecular and cellular alterations during cardiogenesis. |injuries=Mitochondrial disease
  2 KB (315 words) - 13:47, 5 December 2022
• Lancel 2009 J Pharmacol Exp Ther
  ...s mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis. J Pharmacol 329:641-48. ...optotic effects. The role of CO in regulation of mitochondrial dysfunction and biogenesis associated
  3 KB (359 words) - 11:49, 22 December 2020
• Nozickova 2017 MiPschool Obergurgl
  ...SO result in severe neurological problems, stunted brain growth, and early death [2]. ...AMINO ACIDS with the formation of a sulfate, electrons pass to cytochrom c and are further utilized in respiratory chain.
  2 KB (349 words) - 16:12, 12 January 2018
• Kolonics 2022 Abstract Bioblast
  ...ubescens'' extract on Paraquat induced parkinsonism model in SH-SY5Y cells and mitochondrial dysfunction. '''Bioblast 2022: BEC Inaugural Conference.''' I ...fatty acids and antioxidant pigments like astaxanthin, β-carotene, lutein and other vitamins. These pigments are naturally occurring polyphenolic compoun
  5 KB (779 words) - 08:51, 28 July 2022
• Valenti 2015 Abstract MiPschool London 2015
  ...ction by epigallocatechin-3 gallate in human disease: a matter of life and death. ...es and to correct clinical phenotypes linked to increased oxidative stress and energy deficit.
  4 KB (571 words) - 14:05, 13 April 2015
• Mancini 2017 Thesis
  ...n impairment in BBB altering components as aquaporin-4 (AQP-4) in NTg mice and tomato lectin in 3xTg-DA mice. Together, the results of the present study r
  4 KB (569 words) - 08:40, 5 May 2020
• Hill 2015 Abstract MiPschool London 2015
  ...tial and depletion of ATP, leading to a cellular energetic crisis and cell death. ...demyelinating disease, the compound significantly improved clinical score and prevented deterioration of motor skills, suggesting significant neuroprotec
  3 KB (455 words) - 20:08, 7 March 2020
• Maddalena 2017 Biochim Biophys Acta
  ...azole substituted oleic acid 'TPP-IOA' affects mitochondrial bioenergetics and its protective efficacy in cells is influenced by cellular dependence on ae ...ne potential, caused extensive fragmentation of the mitochondrial network, and decreased apparent mitochondrial abundance within 3h of exposure. Many cult
  3 KB (332 words) - 12:55, 10 January 2017
• Lewis 2019 Int J Mol Sci
  ...19) Quantification of mitochondrial oxidative phosphorylation in metabolic disease: application to Type 2 diabetes. Int J Mol Sci 20:5271. https://doi.org/10. ...eutic interventions and drug development must move away from the organelle and toward the cardiovascular system.
  3 KB (369 words) - 07:31, 30 August 2023
• Ladd 2017 Brain Res
  ...ts show reduced expression of mitochondrial DNA-encoded respiratory genes, and rhTFAM may correct this respiratory deficiency. Brain Res 1667:74-83. ...mtDNA respiratory genes. In hNSC's rhTFAM increased mtDNA gene expression and stimulated mRNA metabolism by unclear mechanisms. rhTFAM may be useful in i
  3 KB (390 words) - 10:14, 27 June 2019
• Lee 2013 Abstract MiP2013
  ...2013) Building the mitochondrial medicine; need to define mtDNA variations and its function. Mitochondr Physiol Network 18.08. ...amaging mitochondrion [5,6]. This scheme could easily explain why diabetes and obesity are associated with enhanced cancer risk.
  3 KB (469 words) - 11:18, 28 April 2017
• Giordano 2018 Am J Respir Cell Mol Biol
  ...8) Alternative oxidase attenuates cigarette smoke-induced lung dysfunction and tissue damage. Am J Respir Cell Mol Biol 60:515-22. ...lated lung remodeling and potentially counteract CS-induced ROS production and cell damage.
  2 KB (362 words) - 10:12, 8 June 2020
• Aoun 2012 Br J Nutr
  ...neau MA, Coudray C (2012) Rat liver mitochondrial membrane characteristics and mitochondrial functions are more profoundly altered by dietary lipid quanti ...d impacts on the pathogenesis and development of non-alcoholic fatty liver disease.
  3 KB (435 words) - 16:48, 9 November 2017
• Maeda 2020 J Cell Mol Med
  ...e. Mitochondrial transfer into NRCMs resulted in anti-apoptotic capability and prevented the suppression of oxidative phosphorylation in mitochondria afte ...cular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.</small>
  3 KB (343 words) - 17:52, 1 July 2020
• Anderson 2009 J Am Coll Cardiol
  ...ufer PD (2009) Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart. J Am Coll C ...rom samples of the right atrial appendage obtained from nondiabetic (n=13) and diabetic (n=11) patients undergoing nonemergent coronary artery bypass graf
  3 KB (416 words) - 16:40, 14 October 2019
• Muntane Jordi
  Oncology Surgery, Cell Therapy and Transplant Organs group, ...in the scientific and/or other motivation for the STSM and what scientific and/or other outcomes you aim to accomplish with the STSM.
  6 KB (801 words) - 18:34, 16 March 2020
• Petrilli 2020 medRxiv
  ...th hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City. medRxiv doi: https://doi.org/10.1101/2020.04.08.20057794 ...=Background: Little is known about factors associated with hospitalization and critical illness in Covid-19 positive patients.
  3 KB (326 words) - 14:24, 5 May 2020
• No 2020 Pflugers Arch
  ...HB (2020) Effects of aging and exercise training on mitochondrial function and apoptosis in the rat heart. Pflugers Arch 472:179-93. ...rcise training prevents aging-induced impairment of mitochondrial function and mitochondria-mediated apoptosis in cardiac muscles.
  3 KB (414 words) - 06:13, 20 April 2020
• Pizzo 2020 JAMA
  ...21st century: renewing purpose, building and sustaining social engagement, and embracing a positive lifestyle. JAMA 2020 Jan 9. doi: 10.1001/jama.2019.210 ...cycle to optimally align life span with health span, compressing morbidity and sustaining high functionality through the arc of life?
  5 KB (686 words) - 03:34, 12 February 2020
• Yan 2015 BMC Cancer
  ...E succinate (MitoVES), a recently developed mitocan, for its ''in vitro'' and ''in vivo'' efficacy against TICs. ...eutic resistance. Cell susceptibility to MitoVES was assessed and the cell death pathway investigated. ''In vivo'' efficacy was studied by grafting NeuTL TI
  3 KB (381 words) - 16:34, 13 November 2017
• Santos 2019 MiPschool Coimbra
  ...ochondrial Physiology Society|MiPsociety]] Uncoupling Protein 1 inhibition and mitochondrial respiration in epicardial adipose tissue from hear failure pa ...fatty acid oxidation (FAO) and cardiac metabolism by modulating FA uptake and insulin action. Despite the important physiological role of EAT in cardiova
  3 KB (425 words) - 14:19, 24 June 2019
• Sonkar 2013 Abstract MiP2013
  |title=Sonkar VK, Dash D, Kulkarn PP (2013) Platelets, amyloid beta and mitochondrial respiration. Mitochondr Physiol Network 18.08. .... Exogenous Aβ25-35 was found to induce platelet aggregation, PAC-1binding and P-selectin exposure in washed human platelets, which was comparable to that
  3 KB (350 words) - 11:24, 28 April 2017
• Haslam 2007 Obes Rev
  ...know enough about the causes and how to manage it by diet, activity, drugs and surgery. The history of obesity is a history of failure. Looking back in ti ...ion and instinct, consciously countermanding the urge to eat for survival, and be as inactive as possible in order to conserve energy.
  3 KB (506 words) - 15:48, 27 December 2019
• Santos Bertolini 2018 Thesis
  |title=Santos Bertolini M (2018) Functional study of MICU1 and MICU2 proteins in calcium signaling of ''Trypanosoma cruzi''. Master's Thes ...ttps://bv.fapesp.br/en/dissertacoes-teses/155977/functional-study-of-micu1-and-micu2-proteins-in-calcium-sign Open Access]
  4 KB (523 words) - 14:01, 4 April 2019
• Giovarelli 2021 Pharmacol Res
  ...epigenetic profile of PGC-1α promoter, sustaining mitochondrial biogenesis and oxidative fiber type switch. We, therefore, demonstrate that givinostat exe
  3 KB (350 words) - 15:12, 20 October 2021
• He 2020 Clin Transl Med
  ...l 6 (TRPC6) is a potential therapeutic target for Alzheimer's disease (AD) and its expression is highly regulated by glucose concentration. ...nction can drive hypoglycemia‐associated cognitive impairment in diabetes, and reveal the underlying mechanism.
  3 KB (423 words) - 04:56, 21 November 2023
• Thayer 2005 Thesis
  |abstract=Type 1 diabetes (T1D), a disease characterized by the autoimmune-mediated ...f reactive oxygen species (ROS) contributing to both inflammation and cell death. While previous reports
  3 KB (415 words) - 16:14, 23 February 2015
• Andrade 2020 Nutr Metab Cardiovasc Dis
  ...al on cardiomyopathy and its relationship with the survival, proliferation and differentiation of CPC in Western diet-induced obesity. ...pathy improvement was accompanied by increased CPC survival, proliferation and newly cardiomyocytes formation related to increased pAkt/Akt ratio.
  3 KB (377 words) - 17:34, 23 April 2020
• Fumagalli 2019 JAMA Cardiol
  ...s with hypertrophic cardiomyopathy (HCM) are prone to body weight increase and obesity. Whether this predisposes these individuals to long-term adverse ou ...with HCM in terms of overall disease progression, heart failure symptoms, and arrhythmias.
  4 KB (556 words) - 03:33, 12 February 2020
• Horvath 2012 Abstract Bioblast
  ...l deaths in the world, with cardiovascular disease as the leading cause of death. New findings of the cardiac muscle mitochondria functions can be further u ...sbruck) combines optical measurement with [[high-resolution respirometry]] and with this new technology it is possible to detect changes in both parameter
  3 KB (408 words) - 02:15, 9 October 2019
• Dechandt 2017 J Bioenerg Biomembr
  ...IC, Curti C, Alberici LC (2017) Triacsin C reduces lipid droplet formation and induces mitochondrial biogenesis in primary rat hepatocytes. J Bioenerg Bio ...g the fatty acid consumption, which can in turn accelerate lipid oxidation and reverse NAFLD in long-term therapies.
  3 KB (389 words) - 11:16, 7 March 2020
• Magri 2022 Abstract Bioblast
  ...places HKs from mitochondria, promoting the organelle dysfunction and cell death [1-2]. ...ificative decrease of the LEAK respiration while increases net respiration and coupling efficiency linked to OXPHOS state [4]. This effect is probably due
  6 KB (902 words) - 15:44, 9 June 2023
• Siewiera 2016 Abstract IOC109
  ...Potential role of mitochondria as modulators of blood platelet activation and reactivity in diabetes. Mitochondr Physiol Network 21.01. ...d 2 diabetes mellitus. However, mechanisms of abnormal platelet activation and their hypersensitivity in diabetes are still far from complete understandin
  4 KB (517 words) - 16:17, 9 November 2016
• Tomasic 2019 Biochim Biophys Acta Mol Basis Dis
  ...ce responded largely normally to fasting by increasing hepatic respiration and switching to FA utilization, indicating that the mechanisms driving these a ...y to wild-type mice, suggesting largely normal systemic lipid mobilization and utilization mechanisms.
  3 KB (436 words) - 11:40, 3 March 2020
• Ghanim 2017 MiPschool Obergurgl
  ...ing more invasive therapies could greatly increase the comfort of patients and ideally increase the survival rate. ...he first identified protein that has a defined function in its native site and acquires a new beneficial function after partial unfolding. Other similar p
  3 KB (453 words) - 16:03, 12 January 2018
• Makrecka-Kuka 2017 MiP2017
  |title=[[File:MakreckaM.jpg|left|90px|Marina Makrecka-Kruka]] Heart, brain and kidneys: who will survive? Tissue-specific changes in mitochondrial functio ...The aim of the present study was to evaluate the dynamics of heart, brain and kidney mitochondrial function in the experimental model of endotoxemia.
  3 KB (453 words) - 12:17, 3 October 2017
• Pilot-Storck 2022 Abstract Bioblast
  ...delle J, Wintrebert M, Tiret L, <u>Pilot-Storck Fanny</u> (2022) ''Hacd1'' and ''Hacd2'' genes control mitochondrial energetic efficiency through the modu ...'' gene which cause a congenital myopathy characterized by muscle weakness and exercise intolerance [1].
  5 KB (701 words) - 08:32, 28 July 2022
• Gnaiger 2022 Abstract Bioblasts
  ...were called later: ‘Microorganisms and granula are at an equivalent level and represent elementary organisms, which are found wherever living forces are ...ent summary is a ''Living Communication'' with updates aimed at continuing and extending the discussion on bioblasts as the taxonomic unit of bioenergetic
  7 KB (977 words) - 08:24, 28 July 2022
• Owesny 2023 MiP2023
  ...le:Owesny P.jpg|left|100px|Owesny Patricia]]Impairment of cardiac function and mitochondrial energy metabolism through diet induced obesity in aging. ...re heart aging [3]. Therefore, our aim is to compare the impact of obesity and aging on heart function, as well as the cardiac energy metabolism, focusing
  3 KB (503 words) - 16:46, 12 July 2023
• Roy Chowdhury 2018 J Thorac Oncol
  ...elalisib will alter SCLC mitochondrial bioenergetic profiles and function, and that combination therapy may enable lower drug doses in clinical use. ...P glow and flow cytometry. Western blot analysis was used to evaluate cell death pathways.
  3 KB (497 words) - 16:42, 26 March 2019
• Gispert 2009 PLoS One
  |abstract=BACKGROUND: Parkinson's disease (PD) is an adult-onset movement disorder of largely unknown etiology. We ha ...of reduced expression of fission factor ''Mtp18'', we show reduced fission and increased aggregation of mitochondria only under stress in PINK1-deficient
  3 KB (418 words) - 13:50, 7 May 2019
• Silva-Rodrigues 2020 Free Radic Biol Med
  ...litus model causes a shift in mitochondria coupled-glucose phosphorylation and redox metabolism in rat brain. Free Radic Biol Med 160:796-806. ...ms against the development of cognitive degeneration and neurodegenerative disease, widely associated to mitochondrial CI deficits.
  4 KB (482 words) - 19:00, 6 December 2021
• Glaser 2014 Thesis
  ...ed increased oxygen consumption (basal respiration and respiring state IV) and reduced the mitochondrial respiratory control, indicating MG-induced uncoup ...ics and physiology in nerve cells. The phenomenon might induce cell death, and therefore, a higher predisposition for neurodegenerative disorders developm
  4 KB (508 words) - 14:19, 13 November 2017
• MiPschool 2010 Druskininkai LT Programme
  |Opening and get-together party ...e="width: 60em"|'''Friday, 11 June - Mitochondrial structural organization and respiration'''
  6 KB (785 words) - 16:37, 30 June 2017
• Petit 2017 MiP2017
  ...ome cardiolipin alterations linked to tafazzin mutations lead to apoptosis and mitophygy alterations. ...e clues to better understand the link between the Barth syndrome pathology and the mitochondrial dysfunctions exhibiting defects in oxidative phosphorylat
  3 KB (474 words) - 13:57, 16 October 2017
• Diaz-Casado 2014 Abstract SECF
  |title=Melatonin restores mitochondrial regulatory gene expression and function ...zed by the progressive loss of dopaminergic (DA) neurons. Oxidative stress and inflammation are two key processes in the pathophysiology of PD. Both
  4 KB (538 words) - 09:16, 30 May 2016
• Ekelund 2016 Lancet
  ...mortality? A harmonised meta-analysis of data from more than 1 million men and women. Lancet 388:1302-10. ...of prolonged sitting. We examined the associations of sedentary behaviour and physical activity with all-cause mortality.
  4 KB (656 words) - 14:49, 3 November 2016
• Renner-Sattler 2010 Mitochondr Physiol Network MiP2010
  ...dings, new methodological developments in measuring mitochondrial function and dysfunction are presented. ...istribution, and reproduction in any medium, provided the original authors and source are credited.
  7 KB (920 words) - 11:36, 18 January 2021
• Spielmann 2022 Mamm Genome
  ...) Knockout of the Complex III subunit Uqcrh causes bioenergetic impairment and cardiac contractile dysfunction. Mamm Genome 10.1007/s00335-022-09973-w ...lop a contractile dysfunction reflected by a decrease in ejection fraction and fractional shortening.
  4 KB (506 words) - 19:30, 5 March 2023
• MiPschool Druskininkai LT 2010
  ...ummer ''School, following the successful MiP''summer Schools'' 2007, 2008, and 2009. ...ecial emphasis this year will be given to mitochondria in brain health and disease.
  12 KB (1,536 words) - 16:38, 30 June 2017
• MiPschool Cambridge UK 2012
  |title=[[File:FEBS.jpg|right|120px|Mitochondrial Biochemistry, Physiology and Pathology]] ...ng of lectures, posters and discussion, for researchers, medics, post-docs and research students.</big>
  15 KB (2,112 words) - 15:37, 20 October 2017
• MiPschool 2012 Cambridge UK Programme
  ...ochondrial physiology and functional testing in diagnosis of mitochondrial disease (Lecture theatre) |Mitochondrial structure and respiratory function session
  14 KB (1,865 words) - 16:38, 30 June 2017
• Aid-Vanakova 2019 MiP2019
  ...erstood. We used Wfs1KO mice characterized with impaired glucose tolerance and an activated pathway characteristic for metabolic diseases [3]. ...es: oxidative heart and soleus muscle and glycolytic ''m. rectus femoris'' and ''m. gastrocnemius'' white.
  5 KB (679 words) - 09:31, 2 September 2019
• MtFOIE GRAS
  ...-invasive Profiling of Mitochondrial Function in Non-Alcoholic Fatty Liver Disease'''</big></big> ...lisation of knowledge, Grant Agreement No. 734719, Center for Neuroscience and Cell Biology
  13 KB (1,744 words) - 11:36, 4 March 2020
• Oroboros O2k-technology
  ...respiration at controlled oxygen levels, combined with redox biology (NADH and CoQ), ROS production, mitochondrial membrane potential, ATP production, Ca< ...itochondria, permeabilized tissues and permeabilized cells to living cells and tissues slices.
  14 KB (1,888 words) - 18:25, 29 March 2024
• Complex II ambiguities
  ...to secure scientific standards in current communications on bioenergetics and support adequate clinical applications. ...[[Ambiguity crisis]], [[:Category:Ambiguity crisis - NAD and H+ |Complex I and hydrogen ion ambiguities in the electron transfer system]]
  16 KB (2,064 words) - 08:21, 22 March 2024
• Bioblasts
  ...lony of bioblasts’. "Microorganisms and granula are at an equivalent level and represent elementary organisms, which are found wherever living forces are ...hungen zu den Zellen. Zweite vermehrte Auflage]] (The Elementary Organisms and Their Relationships to the Cells. Second Extended Edition).
  11 KB (1,575 words) - 23:27, 25 May 2016
• Pike 2011 Biochim Biophys Acta
  ...and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells. https://doi.org/10.1016/j.bbabio.2010.10.022 ...e NADPH for defense against oxidative stress and prevent ATP loss and cell death.
  11 KB (1,581 words) - 12:38, 21 April 2023
• O2k-Publications: Topics
  ...ications, which is updated by [[Bioblast editorial team|Bioblast editors]] and [[Special:CreateAccount|active wiki users]].''' → Contact: [mailto:mario. ...ublications - chronological: {{#ask:[[Category:Publications]][[Instrument and method::Oxygraph-2k]] |format=count
  62 KB (7,038 words) - 14:31, 22 August 2023
• MiPMap
  ...iology'''. Establishing a comprehensive database will require global input and cooperation. ...uation of altered mitochondrial respiratory control patterns in health and disease'' ([[Gnaiger 2009 Int J Biochem Cell Biol|Gnaiger 2009]]).
  7 KB (696 words) - 11:14, 20 October 2017
• Thomas 2017 Thesis
  ..., these results provide novel insights for the age-related decline in Nrf2 and identify new targets to maintain Nrf2-dependent detoxification with age. Ha ...atocytes from old before menadione resulted in a >2-fold reduction in cell death, suggesting that the age-related increase in menadione susceptibility likel
  7 KB (986 words) - 16:17, 13 November 2017
• PERICO
  <big><big>'''PERICO - Peroxisome Interactions and Communication'''</big></big> == PERICO: H2020-MSCA-ITN-2018 - Contents and Aims==
  10 KB (1,349 words) - 07:59, 31 January 2020
• Crisostomo 2017 MiP2017
  ...le=[[Image:CrisostomoL.JPG|left|90px|Luis Crisostomo]] Glycerol metabolism and mitochondrial function in human Sertoli cells - a preliminary study. ...olize glycerol [4], thus it might play a crucial role on their homeostasis and spermatogenesis.
  7 KB (946 words) - 11:44, 2 October 2017
• Mitochondrial Physiology Society
  ...the [https://www.ebe2024.org European Bioenergetics Conference - EBEC2024] and a free MiP''membership''. ...bioenergetics; integrating molecular, cellular and organismic physiology and pathology.
  16 KB (1,901 words) - 18:50, 6 March 2024
• Gnaiger 2010 Abstract MiP2010
  |title=Gnaiger E (2010) Seven years Mitochondrial Physiology Society and a welcome to MiP2010: Bioblasts – the aliens with permanent residence in ...ki Research Laboratory (Mitochondrial Physiology), Dept. General, Visceral and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria. – e
  17 KB (2,351 words) - 10:39, 14 June 2022
• MiPschool 2007 Schroecken AT Programme
  ...nto the basic concepts, advanced methodological and scientific approaches, and specific applications, with a focus on mitochondrial respiratory function l ::::Day 1: Mitochondrial respiratory capacity, coupling and respiratory control. Programme 1 - Abstracts 1
  12 KB (1,502 words) - 15:07, 22 March 2017
• Melatonin
  ...ectrum of action particularly at the level of mitochondria. » [[#Melatonin and protection from mitochondrial damage |'''MiPNet article''']] = Melatonin and protection from mitochondrial damage =
  15 KB (2,166 words) - 14:12, 24 September 2023
• Bioblast quiz
  :::: ''For tips&tricks and detailed instructions about how to make a quiz visit links below:'' ...repared for the [[MiPschool Tromso-Bergen 2018]]: ''The protonmotive force and respiratory control. 1. Coupling of electron transfer reactions to vectoria
  36 KB (5,157 words) - 12:10, 12 April 2024
• Brown 2020 MitoFit Preprint Arch
  ...A (2020) Vitamin D deficiency: a factor in COVID-19, progression, severity and mortality? – An urgent call for research. https://doi.org/10.26124/mitofi ...200001.pdf Vitamin D deficiency: a factor in COVID-19 progression severity and mortality? An urgent call for research]''' - '''2020-02-29 Published withou
  27 KB (3,615 words) - 08:19, 8 January 2023
• O2k-PublicationAlert2020 Archive
  ...mitochondrial respiration in platelets: A future biomarker for Alzheimer’s disease?'''<br> ...levels and platelet mitochondrial respiration in patients with Alzheimer's disease. Clin Biochem 72:71-80. [[Fisar 2019 Clin Biochem|»Bioblast link«]]
  45 KB (6,274 words) - 15:44, 7 January 2021
• Schoepf 2019 MitoFit Preprint Arch
  ...) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and a prognostic gene expression signature. https://doi.org/10.26124/mitofit:19 ...f OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and a prognostic gene expression signature]'''
  23 KB (3,225 words) - 08:30, 8 January 2023
• Oroboros Ecosystem Agenda 2022 Archive
  |'''What is the interaction between acylcarnitines and mitochondrial physiology?''' <br> ...h E (2022) Mitochondrial metabolites acylcarnitines: therapeutic potential and drug targets. Bioenerg Commun 2022.15. https://doi.org/10.26124/bec:2022-00
  87 KB (11,941 words) - 15:14, 16 November 2023
• Oroboros Ecosystem Agenda 2021 Archive
  ...chondrial electron transfer system transfers electrons from dehydrogenases and respiratory complexes downstream to Complex III. <br> - communicated by »[[Komlodi Timea]]« and »[[Schmitt Sabine]]« <br>
  85 KB (11,819 words) - 14:18, 10 January 2022
• Gnaiger 2024 J Biol Chem
  ...mplementing efforts to address the well-acknowledged issues of credibility and reproducibility. ...lex II ambiguities]], [[:Category:Ambiguity crisis - NAD and H+ |Complex I and hydrogen ion ambiguities in the electron transfer system]]
  135 KB (18,142 words) - 13:29, 1 May 2024
• Gnaiger 2019 MitoFit Preprints
  ...astroviejo D, Adiele RC, ''et al'' (2019) Mitochondrial respiratory states and rates. https://doi.org/10.26124/mitofit:190001.v6. — '''''Published''': 2 ...rint_Arch_doi_10.26124_mitofit_190001.pdf Mitochondrial respiratory states and rates]'''
  38 KB (5,252 words) - 08:27, 8 January 2023
• Oroboros Ecosystem Agenda 2020 Archive
  |'''Antioxidant supplementation: Effects of MitoQ and CoQ10 on ROS production and mitochondrial function'''<br> ...Narang R, Wang HW, Mori TA, Hickey AJR, Mitchell CJ, Merry TL (2020) MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydro
  126 KB (17,785 words) - 08:55, 13 August 2021
• BEC 2020.1 doi10.26124bec2020-0001.v1
  ...enclature facilitate effective transdisciplinary communication, education, and ultimately further discovery. ...n the hyperlinks (author names) to open the person pages with affiliations and addresses.
  59 KB (8,156 words) - 13:41, 1 May 2024