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	Year	Reference	Coupling	Pathway	Preparation	Organism	Tissue;cell
Reutzel 2018 Oxid Med Cell Longev	2018	Reutzel M, Grewal R, Silaidos C, Zotzel J, Marx S, Tretzel J, Eckert GP (2018) Effects of long-term treatment with a blend of highly purified olive secoiridoids on cognition and brain ATP levels in aged NMRI mice. Oxid Med Cell Longev 2018:4070935.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Kauppila 2018 Thesis	2018	Kauppila JHK (2018) Generating mammalian mitochondrial disease models with mitochondrial DNA mutations. PhD Thesis p120.	LEAK OXPHOS ET	N S	Isolated mitochondria	Mouse	Heart Liver
Martins 2018 Oxid Med Cell Longev	2018	Martins IK, de Carvalho NR, Macedo GE, Rodrigues NR, Ziech CC, Vinadé L, Filho VMB, Menezes IA, Franco J, Posser T (2018) Anacardium microcarpum promotes neuroprotection dependently of AKT and ERK phosphorylation but does not prevent mitochondrial damage by 6-OHDA. Oxid Med Cell Longev 2018:2131895.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Chicken	Nervous system
Einer 2018 Cell Mol Gastroenterol Hepatol	2018	Einer C, Leitzinger C, Lichtmannegger J, Eberhagen C, Rieder T, Borchard S, Wimmer R, Denk G, Popper B, Neff F, Polishchuk EV, Polishchuk RS, Hauck SM, von Toerne C, Müller JC, Karst U, Baral BS, DiSpirito AA, Kremer AE, Semrau J, Weiss KH, Hohenester S, Zischka H (2018) A high calorie diet aggravates mitochondrial dysfunction and triggers severe liver damage in Wilson disease rats. Cell Mol Gastroenterol Hepatol 7:571-96.	LEAK OXPHOS ET	S	Isolated mitochondria	Rat	Liver
Goncalves 2018 Neurotoxicology	2018	Gonçalves DF, Courtes AA, Hartmann DD, da Rosa PC, Oliveira DM, Soares FAA, Dalla Corte CL (2018) 6-Hydroxydopamine induces different mitochondrial bioenergetics response in brain regions of rat. Neurotoxicology 70:1-11.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Rat	Nervous system
Marie 2018 Cell Death Dis	2018	Marie M, Bigot K, Angebault C, Barrau C, Gondouin P, Pagan D, Fouquet S, Villette T, Sahel JA, Lenaers G, Picaud S (2018) Light action spectrum on oxidative stress and mitochondrial damage in A2E-loaded retinal pigment epithelium cells. Cell Death Dis 9:287.	LEAK OXPHOS ET	N S NS	Permeabilized cells		Endothelial;epithelial;mesothelial cell
Bhaskaran 2018 EMBO Rep	2018	Bhaskaran S, Pharaoh G, Ranjit R, Murphy A, Matsuzaki S, Nair BC, Forbes B, Gispert S, Auburger G, Humphries KM, Kinter M, Griffin TM, Deepa SS (2018) Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance. EMBO Rep 19. pii: e45009.	LEAK OXPHOS	N S NS		Mouse	Fat
Chicco 2018 J Biol Chem	2018	Chicco AJ, Le CH, Gnaiger E, Dreyer HC, Muyskens JB, D'Alessandro A, Nemkov T, Hocker AD, Prenni JE, Wolfe LM, Sindt NM, Lovering AT, Subudhi AW, Roach RC (2018) Adaptive remodeling of skeletal muscle energy metabolism in high-altitude hypoxia: Lessons from AltitudeOmics. J Biol Chem 293:6659-71.	LEAK OXPHOS ET	F N S	Permeabilized tissue	Human	Skeletal muscle
Coleman 2018 Sci Rep	2018	Coleman V, Sa-Nguanmoo P, Koenig J, Schulz TJ, Grune T, Klaus S, Kipp AP, Ost M (2018) Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling. Sci Rep 8:2446.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Magnifico 2018 Oxid Med Cell Longev	2018	Magnifico MC, Xhani M, Popov M, Saso L, Sarti P, Arese M (2018) Nonylphenol and octylphenol differently affect cell redox balance by modulating the nitric oxide signaling. Oxid Med Cell Longev 2018:1684827.	ROUTINE OXPHOS	N S CIV ROX	Permeabilized cells Intact cells	Human	Liver Other cell lines
Doerrier 2018 Methods Mol Biol	2018	Doerrier C, Garcia-Souza LF, Krumschnabel G, Wohlfarter Y, Mészáros AT, Gnaiger E (2018) High-Resolution FluoRespirometry and OXPHOS protocols for human cells, permeabilized fibers from small biopsies of muscle, and isolated mitochondria. Methods Mol Biol 1782:31-70. https://doi.org/10.1007/978-1-4939-7831-1_3	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria Intact cells	Human Mouse Rat Saccharomyces cerevisiae	Heart Skeletal muscle Endothelial;epithelial;mesothelial cell Blood cells HEK Platelet
Scaini 2018 Eur Neuropsychopharmacol	2018	Scaini G, Quevedo J, Velligan D, Roberts DL, Raventos H, Walss-Bass C (2018) Second generation antipsychotic-induced mitochondrial alterations: Implications for increased risk of metabolic syndrome in patients with schizophrenia. Eur Neuropsychopharmacol 28:369-80.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Human	Other cell lines Lymphocyte
Arena 2018 Mol Cell	2018	Arena G, Cissé MY, Pyrdziak S, Chatre L, Riscal R, Fuentes M, Arnold JJ, Kastner M, Gayte L, Bertrand-Gaday C, Nay K, Angebault-Prouteau C, Murray K, Chabi B, Koechlin-Ramonatxo C, Orsetti B, Vincent C, Casas F, Marine JC, Etienne-Manneville S, Bernex F, Lombès A, Cameron CE, Dubouchaud H, Ricchetti M, Linares LK, Le Cam L (2018) Mitochondrial MDM2 regulates respiratory complex I activity independently of p53. Mol Cell 69:594-609.	OXPHOS	N S NS	Permeabilized cells	Human	Lung;gill Other cell lines
Bryant 2018 Thesis	2018	Bryant HJ (2018) The role of mitochondrial uncoupling in temperature responses in Atlantic killifish, Fundulus heteroclitus. Master's Thesis p126.	LEAK OXPHOS ET	F S	Isolated mitochondria	Fishes	Nervous system Liver Fat
Sokolov 2018 Mitochondrion	2018	Sokolov EP, Sokolova IM (2018) Compatible osmolytes modulate mitochondrial function in a marine osmoconformer Crassostrea gigas (Thunberg, 1793). Mitochondrion 45:29-37.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Molluscs	Lung;gill
Mills 2018 Nature	2018	Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA (2018) Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature 556:113-7.	ET	S	Isolated mitochondria	Rat	Liver
Fuhrmann 2018 Cell Mol Life Sci	2018	Fuhrmann DC, Wittig I, Dröse S, Schmid T, Dehne N, Brüne B (2018) Degradation of the mitochondrial complex I assembly factor TMEM126B under chronic hypoxia. Cell Mol Life Sci 75:3051-67.	LEAK ROUTINE OXPHOS ET	N S ROX	Isolated mitochondria Intact cells	Human
Logan 2018 Mol Metab	2018	Logan S, Pharaoh GA, Marlin MC, Masser DR, Matsuzaki S, Wronowski B, Yeganeh A, Parks EE, Premkumar P, Farley JA, Owen DB, Humphries KM, Kinter M, Freeman WM, Szweda LI, Van Remmen H, Sonntag WE (2018) Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes. Mol Metab 9:141-55.	LEAK OXPHOS	N S NS	Isolated mitochondria	Mouse	Nervous system
Tetri 2018 Front Physiol	2018	Tetri LH, Diffee GM, Barton GP, Braun RK, Yoder HE, Haraldsdottir K, Eldridge MW, Goss KN (2018) Sex-specific skeletal muscle fatigability and decreased mitochondrial oxidative capacity in adult rats exposed to postnatal hyperoxia. Front Physiol 9:326.	LEAK OXPHOS ET	N S CIV ROX	Permeabilized tissue	Rat	Skeletal muscle
Corrochano 2018 Hum Mol Genet	2018	Corrochano S, Blanco G, Williams D, Wettstein J, Simon M, Kumar S, Moir L, Agnew T, Stewart M, Landman A, Kotiadis VN, Duchen MR, Wackerhage H, Rubinsztein DC, Brown SDM, Acevedo-Arozena A (2018) A genetic modifier suggests that endurance exercise exacerbates Huntington's disease. Hum Mol Genet 27:1723-31.	OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Hsiao 2018 Anal Biochem	2018	Hsiao CP, Hoppel C (2018) Analyzing mitochondrial function in human peripheral blood mononuclear cells. Anal Biochem 549:12-20.	OXPHOS ET	F N S DQ CIV NS ROX	Intact cells	Human	Blood cells
Zhuang 2018 Thesis	2018	Zhuang Y (2018) Potential application of alternative oxidase (AOX) in neurodegenerative diseases. Master's Thesis p71.	OXPHOS	N S CIV ROX	Isolated mitochondria	Mouse	Nervous system
Van Erp 2018 Sci Rep	2018	Van Erp AC, Rebolledo RA, Hoeksma D, Jespersen NR, Ottens PJ, Nørregaard R, Pedersen M, Laustsen C, Burgerhof JGM, Wolters JC, Ciapaite J, Bøtker HE, Leuvenink HGD, Jespersen B (2018) Organ-specific responses during brain death: increased aerobic metabolism in the liver and anaerobic metabolism with decreased perfusion in the kidneys. Sci Rep 8:4405.	OXPHOS ET	F N S NS	Isolated mitochondria	Rat	Liver Kidney
Zimin 2018 Br J Anaesth	2018	Zimin PI, Woods CB, Kayser EB, Ramirez JM, Morgan PG, Sedensky MM (2018) Isoflurane disrupts excitatory neurotransmitter dynamics via inhibition of mitochondrial complex I. Br J Anaesth 120:1019-32.	OXPHOS LEAK	N S ROX	Isolated mitochondria	Mouse	Nervous system
Chen 2018 Hum Mol Genet	2018	Chen A, Tiosano D, Guran T, Baris HN, Bayram Y, Mory A, Shapiro-Kulnane L, Hodges CA, Coban Akdemir Z, Turan S, Jhangiani SN, van den Akker F, Hoppel CL, Salz HK, Lupski JR, Buchner DA (2018) Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency. Hum Mol Genet 27:1913-26.	OXPHOS ET	F N S DQ CIV NS	Isolated mitochondria	Human	Endothelial;epithelial;mesothelial cell Fibroblast
Mikulas 2018 Dent Mater	2018	Mikulás K, Hermann P, Gera I, Komlódi T, Horváth G, Ambrus A, Tretter L (2018) Triethylene glycol dimethacrylate impairs bioenergetic functions and induces oxidative stress in mitochondria via inhibiting respiratory Complex I. Dent Mater 34:e166-e181.	OXPHOS ET	N S	Isolated mitochondria	Guinea pig	Nervous system
Garcia-Roche 2018 Redox Biol	2018	García-Roche M, Casal A, Carriquiry M, Radi R, Celia Quijano C, Cassina A (2018) Respiratory analysis of coupled mitochondria in cryopreserved liver biopsies. Redox Biol 17:207-12.	LEAK OXPHOS ET	N NS ROX S	Permeabilized tissue	Rat Bovines	Liver
Chabi 2018 J Bioenerg Biomembr	2018	Chabi B, Fouret G, Lecomte J, Cortade F, Pessemesse L, Baati N, Coudray C, Lin L, Tong Q, Wrutniak-Cabello C, Casas F, Feillet-Coudray C (2018) Skeletal muscle overexpression of short isoform Sirt3 altered mitochondrial cardiolipin content and fatty acid composition. J Bioenerg Biomembr 50:131-42.	LEAK OXPHOS	N S CIV NS	Homogenate Isolated mitochondria	Mouse	Skeletal muscle
Becker 2018 EMBO Rep	2018	Becker C, Kukat A, Szczepanowska K, Hermans S, Senft K, Brandscheid CP, Maiti P, Trifunovic A (2018) CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis. EMBO Rep 19. pii: e45126.	LEAK OXPHOS ET	F N S NS ROX	Isolated mitochondria	Mouse	Liver Fat
Oemer 2018 Proc Nat Acad Sci U S A	2018	Oemer G, Lackner L, Muigg K, Krumschnabel G, Watschinger K, Sailer S, Lindner H, Gnaiger E, Wortmann SB, Werner ER, Zschocke J, Keller MA (2018) The molecular structural diversity of mitochondrial cardiolipins. Proc Nat Acad Sci U S A 115:4158-63.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS ROX	Intact cells Permeabilized cells	Human	HeLa
Weisz 2018 Hum Mol Genet	2018	Weisz ED, Towheed A, Monyak RE, Toth MS, Wallace DC, Jongens TA (2018) Loss of Drosophila FMRP leads to alterations in energy metabolism and mitochondrial function. Hum Mol Genet 27:95-106.	OXPHOS ET LEAK	N S NS ROX	Isolated mitochondria	Drosophila	Skeletal muscle
Goncalves 2018 Life Sci	2018	Gonçalves DF, de Carvalho NR, Leite MB, Courtes AA, Hartmann DD, Stefanello ST, da Silva IK, Franco JL, Soares FAA, Dalla Corte CL (2018) Caffeine and acetaminophen association: Effects on mitochondrial bioenergetics. Life Sci 193:234-41.	LEAK OXPHOS	N S NS ROX	Homogenate	Mouse	Liver
Jang 2018 Intensive Care Med Exp	2018	Jang DH, MD, Khatri UG, Shortal BP, Kelly M, Lambert DS, Hardy K, Eckmann DM (2018) Alterations in mitochondrial respiration and reactive oxygen species in patients poisoned with carbon monoxide treated with hyperbaric oxygen. Intensive Care Med Exp 6:4.	LEAK OXPHOS ET	N S Gp CIV NS ROX	Permeabilized cells	Human	Blood cells
Sirsat 2018 Comp Biochem Physiol A Mol Integr Physiol	2018	Sirsat SKG, Dzialowski EM (2018) Ontogeny of skeletal and cardiac muscle mitochondria oxygen fluxes in two breeds of chicken. Comp Biochem Physiol A Mol Integr Physiol 215:20-7.	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Birds	Heart Skeletal muscle
Allard 2018 J Clin Endocrinol Metab	2018	Allard NAE, Schirris TJJ, Verheggen RJ, Russel FGM, Rodenburg RJ, Smeitink JAM, Thompson PD, Hopman MTE, Timmers S (2018) Statins affect skeletal muscle performance: evidence for disturbances in energy metabolism. J Clin Endocrinol Metab 103:75-84.	OXPHOS	F N S Gp CIV NS	Permeabilized tissue	Human	Skeletal muscle
Petiz 2018 Chem Biol Interact	2018	Petiz LL, Pires ADRA, Echevarria A, Rodrigues-Santos CE, Eliane Merlin Rocha M, Acco A, Cadena SMSC (2018) Effects of a new antiprotozoal drug, N,N'-diphenyl-4-methoxy-benzamidine, on energy-linked functions of rat liver mitochondria. Chem Biol Interact 279:34-42.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Rat	Liver
Du 2018 Environ Sci Technol	2018	Du SNN, McCallum ES, Vaseghi-Shanjani M, Choi JA, Warriner TR, Balshine S, Scott GR (2018) Metabolic costs of exposure to wastewater effluent lead to compensatory adjustments in respiratory physiology in bluegill sunfish. Environ Sci Technol 52:801-11.	LEAK ET	N S NS	Isolated mitochondria	Fishes	Liver
Treberg 2018 Comp Biochem Physiol B Biochem Mol Biol	2018	Treberg JR, Braun K, Zacharias P, Kroeker K (2018) Multidimensional mitochondrial energetics: Application to the study of electron leak and hydrogen peroxide metabolism. Comp Biochem Physiol B Biochem Mol Biol 224:121-28.	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Mouse Rat	Skeletal muscle
Jang 2018 J Med Toxicol	2018	Jang DH, Khatri UG, Mudan A, Love JS, Owiredu S, Eckmann DM (2018) Translational application of measuring mitochondrial functions in blood cells obtained from patients with acute poisoning. J Med Toxicol 14:144-51.	LEAK ROUTINE OXPHOS ET	N S Gp CIV NS ROX	Intact cells Permeabilized cells	Human	Blood cells
Christen 2018 Free Radic Biol Med	2018	Christen F, Desrosiers V, Dupont-Cyr BA, Vandenberg GW, Le François NR, Tardif JC, Dufresne F, Lamarre SG, Blier PU (2018) Thermal tolerance and thermal sensitivity of heart mitochondria: Mitochondrial integrity and ROS production. Free Radic Biol Med 116:11-8.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Fishes	Heart
Setz 2018 Hear Res	2018	Setz C, Benischke AS, Pinho Ferreira Bento AC, Brand Y, Levano S, Paech F, Leitmeyer K, Bodmer D (2018) Induction of mitophagy in the HEI-OC1 auditory cell line and activation of the Atg12/LC3 pathway in the organ of Corti. Hear Res 361:52-65.	OXPHOS ET	F N S NS ROX	Permeabilized cells	Mouse	Other cell lines
Vinel 2018 Nat Med	2018	Vinel C, Lukjanenko L, Batut A, Deleruyelle S, Pradere JP, Le Gonidec S, Dortignac A, Geoffre N, Pereira O, Karaz S, Lee U, Camus M, Chaoui K, Mouisel E, Bigot A, Mouly V, Vigneau M, Pagano AF, Chopard A, Pillard F, Guyonnet S, Cesari M, Burlet-Schiltz O, Pahor M, Feige JN, Vellas B, Valet P, Dray C (2018) The exerkine apelin reverses age-associated sarcopenia. Nat Med 24:1360-71.	OXPHOS	N S	Permeabilized tissue	Mouse	Skeletal muscle
Hoffmann 2018 Sci Rep	2018	Hoffmann C, Höckele S, Kappler L, Hrabĕ de Angelis M, Häring HU, Weigert C (2018) The effect of differentiation and TGFβ on mitochondrial respiration and mitochondrial enzyme abundance in cultured primary human skeletal muscle cells. Sci Rep 8:737.	OXPHOS ET	F N S NS ROX	Permeabilized cells	Human	Skeletal muscle
Mavroudis 2018 Eur J Cardiothorac Surg	2018	Mavroudis CD, Karlsson M, Ko T, Hefti M, Gentile JI, Morgan RW, Plyler R, Mensah-Brown KG, Boorady TW, Melchior RW, Rosenthal TM, Shade BC, Schiavo KL, Nicolson SC, Spray TL, Sutton RM, Berg RA, Licht DJ, Gaynor JW, Kilbaugh TJ (2018) Cerebral mitochondrial dysfunction associated with deep hypothermic circulatory arrest in neonatal swine. Eur J Cardiothorac Surg 54:162-68.	LEAK ET OXPHOS	N S CIV NS ROX	Homogenate	Pig	Nervous system
Silva 2018 Nat Cell Biol	2018	Silva J, Aivio S, Knobel PA, Bailey LJ, Casali A, Vinaixa M, Garcia-Cao I, Coyaud É, Jourdain AA, Pérez-Ferreros P, Rojas AM, Antolin-Fontes A, Samino-Gené S, Raught B, González-Reyes A, Ribas de Pouplana L, Doherty AJ, Yanes O, Stracker TH (2018) EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation. Nat Cell Biol 20:162-74.	OXPHOS ET	N S NS ROX	Permeabilized tissue		Islet cell;pancreas;thymus
Isohanni 2018 Neurogenetics	2018	Isohanni P, Carroll CJ, Jackson CB, Pohjanpelto M, Lönnqvist T, Suomalainen A (2018) Defective mitochondrial ATPase due to rare mtDNA m.8969G>A mutation-causing lactic acidosis, intellectual disability, and poor growth. Neurogenetics 19:49-53.	OXPHOS ET	N S CIV NS	Permeabilized cells	Human	Skeletal muscle Blood cells Fibroblast
Woodman 2018 FASEB J	2018	Woodman AG, Mah R, Keddie D, Noble RMN, Panahi S, Gragasin FS, Lemieux H, Bourque SL (2018) Prenatal iron deficiency causes sex-dependent mitochondrial dysfunction and oxidative stress in fetal rat kidneys and liver. FASEB J 32:3254-63.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Rat	Liver Kidney
Smenes 2018 Interact Cardiovasc Thorac Surg	2018	Smenes BT, Bækkerud FH, Slagsvold KH, Hassel E, Wohlwend M, Pinho M, Høydal M, Wisløff U, Rognmo Ø, Wahba A (2018) Acute exercise is not cardioprotective and may induce apoptotic signalling in heart surgery: a randomized controlled trial. Interact Cardiovasc Thorac Surg 27:95-101.	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Human	Heart
Boutoual 2018 Sci Rep	2018	Boutoual R, Meseguer S, Villarroya M, Martín-Hernández E, Errami M, Martín MA, Casado M, Armengod ME (2018) Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARγ-UCP2-AMPK axis. Sci Rep 8:1163.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized cells Intact cells	Human	Fibroblast
Leckey 2018 FASEB J	2018	Leckey JJ, Hoffman NJ, Parr EB, Devlin BL, Trewin AJ, Stepto NK, Morton JP, Burke LM, Hawley JA (2018) High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans. FASEB J 32:2979-91.	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Song 2018 Proc Natl Acad Sci U S A	2018	Song E, Ramos SV, Huang X, Liu Y, Botta A, Sung HK, Turnbull PC, Wheeler MB, Berger T, Wilson DJ, Perry CGR, Mak TW, Sweeney G (2018) Holo-lipocalin-2-derived siderophores increase mitochondrial ROS and impair oxidative phosphorylation in rat cardiomyocytes. Proc Natl Acad Sci U S A 115:1576-81.	LEAK OXPHOS ET	N S NS	Intact cells	Rat	Heart
Holloway 2018 Cell Rep	2018	Holloway GP, Holwerda AM, Miotto PM, Dirks ML, Verdijk LB, van Loon LJC (2018) Age-associated impairments in mitochondrial ADP sensitivity contribute to redox stress in senescent human skeletal muscle. Cell Rep 22:2837–48.	OXPHOS ET LEAK	N S NS	Permeabilized tissue	Human	Skeletal muscle
Komlodi 2018 Methods Mol Biol	2018	Komlodi T, Sobotka O, Krumschnabel G, Bezuidenhout N, Hiller E, Doerrier C, Gnaiger E (2018) Comparison of mitochondrial incubation media for measurement of respiration and hydrogen peroxide production. Methods Mol Biol 1782:137-55.	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized cells Permeabilized tissue	Human Mouse	Skeletal muscle HEK
Silaidos 2018 Biol Sex Differ	2018	Silaidos C, Pilatus U, Grewal R, Matura S, Lienerth B, Pantel J, Eckert GP (2018) Sex-associated differences in mitochondrial function in human peripheral blood mononuclear cells (PBMCs) and brain. Biol Sex Differ 9:34.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Human	Nervous system Blood cells
Bricambert 2018 Nat Commun	2018	Bricambert J, Alves-Guerra MC, Esteves P, Prip-Buus C, Bertrand-Michel J, Guillou H, Chang CJ, Vander Wal MN, Canonne-Hergaux F, Mathurin P, Raverdy V, Pattou F, Girard J, Postic C, Dentin R (2018) The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity. Nat Commun 9:2092.	LEAK OXPHOS ET	N S	Homogenate	Mouse	Liver
Roy Chowdhury 2018 Mol Cell Neurosci	2018	Roy Chowdhury S, Djordjevic J, Thomson E, Smith DR, Albensi BC, Fernyhough P (2018) Depressed mitochondrial function and electron transport Complex II-mediated H₂O₂ production in the cortex of type 1 diabetic rodents. Mol Cell Neurosci 90:49-59.	OXPHOS ET	S		Mouse Rat	Nervous system
Mkrtchyan 2018 Biochim Biophys Acta	2018	Mkrtchyan GV, Üçal M, Müllebner A, Dumitrescu S, Kames M, Moldzio R, Molcanyi M, Schaefer S, Weidinger A, Schaefer U, Hescheler J, Duvigneau JC, Redl H, Bunik VI, Kozlov AV (2018) Thiamine preserves mitochondrial function in a rat model of traumatic brain injury, preventing inactivation of the 2-oxoglutarate dehydrogenase complex. Biochim Biophys Acta 1859:925-31.	OXPHOS	N S	Homogenate	Rat	Nervous system
Dejos 2018 Sci Rep	2018	Dejos C, Kuny S, Han WH, Capel H, Lemieux H, Sauvé Y (2018) Photoreceptor-induced RPE phagolysosomal maturation defects in Stargardt-like Maculopathy (STGD3). Sci Rep 8:5944.	OXPHOS	N S CIV NS ROX	Homogenate	Mouse	Endothelial;epithelial;mesothelial cell
Rodrigues 2018 Free Radic Biol Med	2018	Rodrigues NR, Macedo GE, Martins IK, Gomes KK, de Carvalho NR, Posser T, Franco JL (2018) Short-term sleep deprivation with exposure to nocturnal light alters mitochondrial bioenergetics in Drosophila. Free Radic Biol Med 120:395-406.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Drosophila
Chung 2018 J Exp Biol	2018	Chung DJ, Sparagna GC, Chicco AJ, Schulte PM (2018) Patterns of mitochondrial membrane remodeling parallel functional adaptations to thermal stress. J Exp Biol 221. pii: jeb174458.	LEAK OXPHOS ET	F N S CIV NS ROX	Isolated mitochondria	Fishes	Liver
Vatner 2018 Aging Cell	2018	Vatner DE, Zhang J, Oydanich M, Guers J, Katsyuba E, Yan L, Sinclair D, Auwerx J, Vatner SF (2018) Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14. Aging Cell 17:e12751.	LEAK OXPHOS	N S NS	Intact cells	Mouse	Fat
Monaco 2018b Diabetologia	2018	Monaco CMF, Hughes MC, Ramos SV, Varah NE, Lamberz C, Rahman FA, McGlory C, Tarnopolsky MA, Krause MP, Laham R, Hawke TJ, Perry CGR (2018) Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes. Diabetologia 61:1411-23.	OXPHOS	N S Gp NS ROX	Permeabilized tissue	Human	Skeletal muscle
Robb 2018 J Biol Chem	2018	Robb EL, Hall AR, Prime TA, Eaton S, Szibor M, Viscomi C, James AM, Murphy MP (2018) Control of mitochondrial superoxide production by reverse electron transport at complex I. J Biol Chem 293:9869-79. https://doi.org/10.1074/jbc.RA118.003647	ET	N S ROX	Isolated mitochondria	Rat	Heart
Clarke 2018 Methods Mol Biol	2018	Clarke KJ, Porter RK (2018) The importance of calcium ions for determining mitochondrial glycerol-3-phosphate dehydrogenase activity when measuring uncoupling protein 1 (UCP1) function in mitochondria isolated from brown adipose tissue. Methods Mol Biol 1782:325-36.	LEAK	S Gp	Isolated mitochondria	Rat	Fat
Tarpey 2018 Skelet Muscle	2018	Tarpey MD, Amorese AJ, Balestrieri NP, Ryan TE, Schmidt CA, McClung JM, Spangenburg EE (2018) Characterization and utilization of the flexor digitorum brevis for assessing skeletal muscle function. Skelet Muscle 8:14.	OXPHOS	N S CIV NS ROX		Mouse	Skeletal muscle
Ost 2018 Curr Opin Clin Nutr Metab Care	2018	Ost M, Doerrier C, Gama-Perez P, Moreno-Gomez S (2018) Analysis of mitochondrial respiratory function in tissue biopsies and blood cells. Curr Opin Clin Nutr Metab Care 21:336-42.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Permeabilized tissue Isolated mitochondria Intact cells		Blood cells Platelet Skeletal muscle Liver Fat
Boutoual 2018 Scientific Reports	2018	Boutoual, R., Meseguer, S., Villarroya, M., Martin-Hernandez, E., Errami, M., Martin, M. A., Casado, M., and Armengod, M. E. (2018) Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARgamma-UCP2-AMPK axis. Scientific reports 8, 1163	LEAK ROUTINE OXPHOS ET	F S Gp	Permeabilized cells Intact cells	Human	Other cell lines Fibroblast
Yang 2018 Cell Death Dis	2018	Yang F, Wu R, Jiang Z, Chen J, Nan J, Su S, Zhang N, Wang C, Zhao J, Ni C, Wang Y, Hu W, Zeng Z, Zhu K, Liu X, Hu X, Zhu W, Yu H, Huang J, Wang J (2018) Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation. Cell Death Dis 9:556.		N S CIV NS ROX	Intact cells	Mouse
Kappler 2018 Thesis	2018	Kappler L (2018) Method development for valid high‐resolution profiling of mitochondria and Omics investigation of mitochondrial adaptions to excess energy intake and physical exercise. Dissertation p181.	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized cells Homogenate Isolated mitochondria	Human Mouse	Skeletal muscle Liver Other cell lines
Salin 2018 Integr Comp Biol	2018	Salin K, Villasevil EM, Anderson GJ, Selman C, Chinopoulos C, Metcalfe NB (2018) The RCR and ATP/O indices can give contradictory messages about mitochondrial efficiency. Integr Comp Biol 58:486-94.	LEAK OXPHOS	N S NS ROX	Homogenate	Fishes	Liver
Kong 2018 Proteomics	2018	Kong D, Tian X, Li Y*, Zhang S, Cheng Y, Huo L, Ma H, Yang Z, Ren L, Zhang M, Zhang W (2018) Revealing the inhibitory effect of ginseng on mitochondrial respiration through synaptosomal proteomics. Proteomics 18:e1700354.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Homogenate	Rat	Nervous system
Martinez 2018 Arch Biochem Biophys	2018	Martínez JH, Fuentes F, Vanasco V, Alvarez S, Alaimo A, Cassina A, Coluccio Leskow F, Velazquez F (2018) Alpha-synuclein mitochondrial interaction leads to irreversible translocation and complex I impairment. Arch Biochem Biophys 651:1-12.	LEAK OXPHOS ET	N S ROX	Isolated mitochondria	Rat	Nervous system
Weber 2018 Int J Mol Sci	2018	Weber A, Klocker H, Oberacher H, Gnaiger E, Neuwirt H, Sampson N, Eder IE (2018) Succinate accumulation is associated with a shift of mitochondrial respiratory control and HIF-1α upregulation in PTEN negative prostate cancer cells. Int J Mol Sci 19:2129.	ROUTINE OXPHOS ET	F N S NS Other combinations ROX	Intact cells Permeabilized cells	Human	Genital
Tillmans 2018 Thesis	2018	Tillmans F (2018) Effect of normobaric hypoxia on leukemic vell lines in vitro. Dissertation p92.	LEAK ROUTINE ET	N S NS ROX	Intact cells Permeabilized cells	Human	Other cell lines Lymphocyte
Rodriguez-Nuevo 2018 EMBO J	2018	Rodríguez-Nuevo A, Díaz-Ramos A, Noguera E, Díaz-Sáez F, Duran X, Muñoz JP, Romero M, Plana N, Sebastián D, Tezze C, Romanello V, Ribas F, Seco J, Planet E, Doctrow SR, González J, Borràs M, Liesa M, Palacín M, Vendrell J, Villarroya F, Sandri M, Shirihai O, Zorzano A (2018) Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency. EMBO J 37.	LEAK ROUTINE OXPHOS ET	N S NS	Permeabilized tissue	Mouse	Skeletal muscle
Scott 2018 Integr Comp Biol	2018	Scott GR, Guo KH, Dawson NJ (2018) The mitochondrial basis for adaptive variation in aerobic performance in high-altitude deer mice. Integr Comp Biol 58:506-18. https://doi.org/10.1093/icb/icy056	OXPHOS ET	N S CIV NS	Permeabilized tissue Isolated mitochondria	Mouse	Heart Skeletal muscle
Wen 2018 PLOS Pathog	2018	Wen JJ, Yin YW, Garg NJ (2018) PARP1 depletion improves mitochondrial and heart function in Chagas disease: Effects on POLG dependent mtDNA maintenance. PLOS Pathog 14:e1007065.	OXPHOS	N S NS	Permeabilized tissue	Mouse	Heart Other cell lines
Durand 2018 Blood Purif	2018	Durand PY, Nicco C, Serteyn D, Attaf D, Edeas M (2018) Microbiota quality and mitochondrial activity link with occurrence of muscle cramps in hemodialysis patients using citrate dialysate: a pilot study. Blood Purif 46:301-8.	LEAK ROUTINE OXPHOS ET	S ROX	Intact cells	Human	Platelet Blood cells
Kauppila 2018 Nucleic Acids Res	2018	Kauppila JHK, Bonekamp NA, Mourier A, Isokallio MA, Just A, Kauppila TES, Stewart JB, Larsson NG (2018) Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice. Nucleic Acids Res 46:6642-69.	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Mouse
Bradley 2018 Biochim Biophys Acta	2018	Bradley RM, Bloemberg D, Aristizabal Henao JJ, Hashemi A, Mitchell AS, Fajardo VA, Bellissimo C, Mardian EB, Bombardier E, Paré MF, Moes KA, Stark KD, Tupling AR, Quadrilatero J, Duncan RE (2018) Lpaatδ/Agpat4 deficiency impairs maximal force contractility in soleus and alters fiber type in extensor digitorum longus muscle. Biochim Biophys Acta 1863:700-11.	LEAK OXPHOS ET	N S CIV NS	Permeabilized tissue	Mouse	Skeletal muscle
Wuest 2018 Cell Metab	2018	Wüst S, Dröse S, Heidler J, Wittig I, Klockner I, Franko A, Bonke E, Günther S, Gärtner U, Boettger T, Braun T (2018) Metabolic maturation during muscle stem cell differentiation is achieved by miR-1/133a-mediated inhibition of the Dlk1-Dio3 mega gene cluster. Cell Metab 27:1026-39.	OXPHOS	N S CIV	Intact cells	Mouse	Skeletal muscle
Zhang 2018 J Mol Cell Cardiol	2018	Zhang G, Sheng M, Wang J, Teng T, Sun Y, Yang Q, Xu Z (2018) Zinc improves mitochondrial respiratory function and prevents mitochondrial ROS generation at reperfusion by phosphorylating STAT3 at Ser⁷²⁷. J Mol Cell Cardiol 118:169-82.	LEAK ROUTINE OXPHOS ET	N S NS	Permeabilized cells Isolated mitochondria	Mouse	Heart
Logan 2018 Thesis	2018	Logan C (2018) Nitrate and nitrite differentially affect respiration in zebrafish during exercise. Honors Baccalaureate of Science in Nutrition p44.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Zebrafish	Skeletal muscle
Ahn 2018 Redox Biol	2018	Ahn B, Pharaoh G, Premkumar P, Huseman K, Ranjit R, Kinter M, Szweda L, Kiss T, Fulop G, Tarantini S, Csiszar A, Ungvari Z, Van Remmen H (2018) Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass. Redox Biol 17:47-58.	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Perks 2018 Cell Rep	2018	Perks KL, Rossetti G, Kuznetsova I, Hughes LA, Ermer JA, Ferreira N, Busch JD, Rudler DL, Spahr H, Schöndorf T, Shearwood AJ, Viola HM, Siira SJ, Hool LC, Milenkovic D, Larsson NG, Rackham O, Filipovska A (2018) PTCD1 is required for 16S rRNA maturation complex stability and mitochondrial ribosome assembly. Cell Rep 23:127-42.	LEAK OXPHOS ET	N Gp S	Isolated mitochondria	Mouse	Heart
Ravera 2018 Biol Cell	2018	Ravera S, Signorello MG, Bartolucci M, Ferrando S, Manni L, Caicci F, Calzia D, Panfoli I, Morelli A, Leoncini G (2018) Extramitochondrial energy production in platelets. Biol Cell 110:97-108.		N S	Permeabilized cells	Human	Blood cells Platelet
Varga 2017 Inflammopharmacology	2017	Varga G, Ugocsai M, Hartmann P, Lajkó N, Molnár R, Szűcs S, Jász DK, Érces D, Ghyczy M, Tóth G, Boros M (2017) Acetylsalicylic acid-tris-hydroxymethyl-aminomethane reduces colon mucosal damage without causing gastric side effects in a rat model of colitis. Inflammopharmacology 26:261-71.	OXPHOS LEAK	N S CIV NS ROX	Isolated mitochondria	Rat	Liver
Zhang 2017 J Biol Chem	2017	Zhang Y, Bharathi SS, Rardin MJ, Lu J, Maringer KV, Sims-Lucas S, Prochownik EV, Gibson BW, Goetzman ES (2017) Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain. J Biol Chem 292:10239-49.	OXPHOS ET	N S	Permeabilized cells Homogenate	Human	Liver HEK
Rademann 2017 Oxid Med Cell Longev	2017	Rademann P, Weidinger A, Drechsler S, Meszaros A, Zipperle J, Jafarmadar M, Dumitrescu S, Hacobian A, Ungelenk L, Röstel F, Kaszaki J, Szabo A, Skulachev VP, Bauer M, Bahrami S, Weis S, Kozlov AV, Osuchowski MF (2017) Mitochondria-targeted antioxidants SKQ1 and MitoTEMPO failed to exert a long-term beneficial effect in murine polymicrobial sepsis. Oxid Med Cell Longev 6412682.	OXPHOS	S	Homogenate	Mouse Rat	Liver
De Carvalho 2017 Toxicol Research	2017	de Carvalho NR, Rodrigues NR, Macedo GE, Boligon AA, de Campos MM, Posser T, Cunha FAB, Coutinho HD, Klamt F, Bristot IJ, Merritt TJS, Franco JL (2017) Eugenia uniflora leaves essential oil promotes mitochondrial dysfunction in Drosophila melanogaster through the inhibition of oxidative phosphorylation. Toxicol Research 6:526-34 .	LEAK OXPHOS ET	F N NS ROX S	Isolated mitochondria	Drosophila
Teplova 2017 Toxicol Lett	2017	Teplova VV, Belosludtsev KN, Kruglov AG (2017) Mechanism of triclosan toxicity: Mitochondrial dysfunction including complex II inhibition, superoxide release and uncoupling of oxidative phosphorylation. Toxicol Lett 275:108-17.	OXPHOS LEAK	N S CIV	Isolated mitochondria	Rat	Liver
Kake-Guena 2017 J Therm Biol	2017	Kake-Guena SA, Touisse K, Warren BE, Scott KY, Blier PU, Lemieux H (2017) Temperature-related differences in mitochondrial function among clones of the cladoceran Daphnia pulex. J Therm Biol 69:23-31.	LEAK OXPHOS	S Gp CIV NS ROX	Permeabilized tissue	Crustaceans
Ladd 2017 Brain Res	2017	Ladd AC, Brohawn DG, Thomas RR, Keeney PM, Berr SS, Khan SM, Portell FR, Shakenov MZ, Antkowiak PF, Kundu B, Tustison N, Bennett JP (2017) RNA-seq analyses reveal that cervical spinal cords and anterior motor neurons from amyotrophic lateral sclerosis subjects show reduced expression of mitochondrial DNA-encoded respiratory genes, and rhTFAM may correct this respiratory deficiency. Brain Res 1667:74-83.	LEAK OXPHOS	N CIV S	Homogenate	Rat	Nervous system
Correa 2017 Crit Care	2017	Corrêa TD, Pereira AJ, Brandt S, Vuda M, Djafarzadeh S, Takala J, Jakob SM (2017) Time course of blood lactate levels, inflammation, and mitochondrial function in experimental sepsis. Crit Care 21:105.	LEAK OXPHOS	N S CIV	Isolated mitochondria	Pig	Nervous system
Gruenig 2017 Toxicol In Vitro	2017	Grünig D, Felser A, Bouitbir J, Krähenbühl S (2017) The catechol-O-methyltransferase inhibitors tolcapone and entacapone uncouple and inhibit the mitochondrial respiratory chain in HepaRG cells. Toxicol In Vitro 42:337-47.	LEAK OXPHOS ET	N S CIV ROX	Isolated mitochondria Permeabilized cells	Human Mouse	Liver Other cell lines
Newsom 2017 Am J Physiol Endocrinol Metab	2017	Newsom SA, Miller BF, Hamilton KL, Ehrlicher SE, Stierwalt HD, Robinson MM (2017) Long-term rates of mitochondrial protein synthesis are increased in mouse skeletal muscle with high fat feeding regardless of insulin sensitizing treatment. Am J Physiol Endocrinol Metab 313:552-62.	LEAK OXPHOS ET	F N S NS ROX	Isolated mitochondria	Mouse	Skeletal muscle
Rodolphi 2017 Thesis	2017	Rodolphi MS (2017) Efeitos da nandrolona e da ceftriaxona na homeostasia glutamatérgica: uma busca por mecanismos interativos entre astrócitos e neurônios envolvidos no comportamento agressivo. Dissertation p58.	ROUTINE OXPHOS	S CIV ROX	Homogenate	Mouse	Nervous system
Kenny 2017 Diabetologia	2017	Kenny HC, Rudwill F, Breen L, Salanova M, Blottner D, Heise T, Heer M, Blanc S, O'Gorman DJ (2017) Bed rest and resistive vibration exercise unveil novel links between skeletal muscle mitochondrial function and insulin resistance. Diabetologia 60:1491-501.	LEAK OXPHOS ET	N S CIV NS F	Permeabilized tissue	Human	Skeletal muscle
Pecinova 2017 Oxid Med Cell Longev	2017	Pecinova A, Drahota Z, Kovalcikova J, Kovarova N, Pecina P, Alan L, Zima M, Houstek J, Mracek T (2017) Pleiotropic effects of biguanides on mitochondrial reactive oxygen species production. Oxid Med Cell Longev 7038603.	LEAK OXPHOS ET	N S Gp NS	Isolated mitochondria	Rat	Fat
Rekuviene 2017 Data Brief	2017	Rekuviene E, Ivanoviene L, Borutaite V, Morkuniene R (2017) Data on effects of rotenone on calcium retention capacity, respiration and activities of respiratory chain complexes I and II in isolated rat brain mitochondria. Data Brief 13:707-12.	LEAK OXPHOS	N S	Isolated mitochondria	Rat	Nervous system
Jang 2017 Biol Open	2017	Jang DH, Seeger SC, Grady ME, Shofer FC, Eckmann DM (2017) Mitochondrial dynamics and respiration within cells with increased open pore cytoskeletal meshes. Biol Open 6:1831-9.	LEAK ROUTINE ET	N S CIV NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell Fibroblast
Lopez 2017 PLOS ONE	2017	López A, Ortiz F, Doerrier C, Venegas C, Fernández-Ortiz M, Aranda P, Díaz-Casado ME, Fernández-Gil B, Barriocanal-Casado E, Escames G, López L, Acuña-Castroviejo D (2017) Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases. PLOS ONE 12:e0183090.	LEAK ROUTINE OXPHOS	N S NS	Isolated mitochondria	Mouse
Volani 2017 Metallomics	2017	Volani C, Doerrier C, Demetz E, Haschka D, Paglia G, Lavdas AA, Gnaiger E, Weiss G (2017) Dietary iron loading negatively affects liver mitochondrial function. Metallomics 9:1634-44.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Liver
Irgebay 2017 Breast	2017	Irgebay Z, Yeszhan B, Sen B, Tuleukhanov S, Brooks AD, Sensenig R, Orynbayeva Z (2017) Danazol alters mitochondria metabolism of fibrocystic breast Mcf10A cells. Breast 35:55-62.	ET	N S CIV NS ROX	Permeabilized cells	Human	Genital
Sharaf 2017 Biochim Biophys Acta	2017	Sharaf MS, Stevens D, Kamunde C (2017) Mitochondrial transition ROS spike (mTRS) results from coordinated activities of complex I and nicotinamide nucleotide transhydrogenase. Biochim Biophys Acta 1858:955-65.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse Fishes	Heart Liver
Luethi 2017 Toxicology	2017	Luethi D, Liechti ME, Krähenbühl S (2017) Mechanisms of hepatocellular toxicity associated with new psychoactive synthetic cathinones. Toxicology 387:57-66.	OXPHOS ET	NS N S DQ CIV ROX	Permeabilized cells	Human	Liver
Emmett 2017 Nature	2017	Emmett MJ, Lim HW, Jager J, Richter HJ, Adlanmerini M, Peed LC, Briggs ER, Steger DJ, Ma T, Sims CA, Baur JA, Pei L, Won KJ, Seale P, Gerhart-Hines Z, Lazar MA (2017) Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge. Nature 546:544-8.	LEAK OXPHOS	F N S CIV ROX	Homogenate	Mouse	Fat
Yeh 2017 Aquat Toxicol	2017	Yeh A, Marcinek DJ, Meador JP, Gallagher EP (2017) Effect of contaminants of emerging concern on liver mitochondrial function in Chinook salmon. Aquat Toxicol 190:21-31.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Fishes	Liver
Cardoso 2017 Biochim Biophys Acta	2017	Cardoso GMF, Pletsch JT, Parmeggiani B, Grings M, Glanzel NM, Bobermin LD, Amaral AU, Wajner M, Leipnitz G (2017) Bioenergetics dysfunction, mitochondrial permeability transition pore opening and lipid peroxidation induced by hydrogen sulfide as relevant pathomechanisms underlying the neurological dysfunction characteristic of ethylmalonic encephalopathy. Biochim Biophys Acta 1863:2192-2201.	LEAK OXPHOS ET	N S NS	Homogenate	Rat	Nervous system
Merz 2017 Intensive Care Med Exp	2017	Merz T, Vogt JA, Wachter U, Calzia E, Szabo C, Wang R, Radermacher P, McCook O (2017) Impact of hyperglycemia on cystathionine-γ-lyase expression during resuscitated murine septic shock. Intensive Care Med Exp 5:30.	LEAK OXPHOS ET	F N S NS ROX	Homogenate	Mouse	Liver
Miller 2017 PLOS ONE	2017	Miller B, Hamilton K, Boushel R, Williamson K, Laner V, Gnaiger E, Davis M (2017) Mitochondrial respiration in highly aerobic canines in the non-raced state and after a 1600-km sled dog race. PLOS ONE 12:e0174874.	OXPHOS ET LEAK	F N S NS ROX	Permeabilized tissue	Dog	Skeletal muscle
Van Schaardenburgh 2017 J Transl Med	2017	van Schaardenburgh M, Wohlwend M, Rognmo Ø, Mattsson EJR (2017) Exercise in claudicants increase or decrease walking ability and the response relates to mitochondrial function. J Transl Med 15:130.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Ounpuu 2017 Biochim Biophys Acta	2017	Ounpuu L, Klepinin A, Pook M, Teino I, Peet N, Paju K, Tepp K, Chekulayev V, Shevchuk I, Koks S, Maimets T, Kaambre T (2017) 2102Ep embryonal carcinoma cells have compromised respiration and shifted bioenergetic profile distinct from H9 human embryonic stem cells. Biochim Biophys Acta 1861:2146-54.	LEAK ROUTINE OXPHOS ET	N S NS ROX CIV	Permeabilized cells Intact cells	Human	Stem cells
Svensson 2017 Acta Physiol (Oxf)	2017	Svensson K, LaBarge SA, Martins VF, Schenk S (2017) Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis. Acta Physiol (Oxf) 221:193-203.	OXPHOS ET LEAK	F N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Paech 2017 Arch Toxicol	2017	Paech F, Messner S, Spickermann J, Wind M, Schmitt-Hoffmann AH, Witschi AT, Howell BA, Church RJ, Woodhead J, Engelhardt M, Krähenbühl S, Maurer M (2017) Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072. Arch Toxicol 91:3647-62.	LEAK OXPHOS ET	N S DQ CIV ROX	Permeabilized cells	Human	Liver Other cell lines
Kake 2017 J Therm Biol	2017	Kake Guena SA, Touisse K, Warren BE, Scott KY, Dufresne F, Blier PU, Lemieux H (2017) Temperature-related differences in mitochondrial function among clones of the cladoceran Daphnia pulex. J Therm Biol 69:23-31.	LEAK OXPHOS	N CIV NS S ROX	Permeabilized tissue	Crustaceans
Fink 2017 Am J Physiol Cell Physiol	2017	Fink BD, Bai F, Yu L, Sivitz WI (2017) Regulation of ATP production: dependence on calcium concentration and respiratory state. Am J Physiol Cell Physiol 313:C146-53.	LEAK OXPHOS	N S	Isolated mitochondria	Mouse	Skeletal muscle
Rekuviene 2017 Neurosci Lett	2017	Rekuviene E, Ivanoviene L, Borutaite V, Morkuniene R (2017) Rotenone decreases ischemia-induced injury by inhibiting mitochondrial permeability transition in mature brains. Neurosci Lett 653:45-50.		N S NS	Isolated mitochondria	Rat	Nervous system
Buso 2017 Thesis	2017	Buso A (2017) Mitochondrial oxidative phosphorylation plasticity/adaptation triggered by disturbances and stresses and targeted by therapies. PhD Thesis p110.	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Mouse	Skeletal muscle
Grassi 2017 J Appl Physiol (1985)	2017	Grassi B, Majerczak J, Bardi E, Buso A, Comelli M, Chlopicki S, Guzik M, Mavelli I, Nieckarz Z, Salvadego D, Tyrankiewicz U, Skórka T, Bottinelli R, Zoladz JA, Pellegrino MA (2017) Exercise training in Tgα_q*44 mice during the progression of chronic heart failure: cardiac vs. peripheral (soleus muscle) impairments to oxidative metabolism. J Appl Physiol (1985) 123:326-36.	LEAK OXPHOS ET	N NS S	Permeabilized tissue	Mouse	Skeletal muscle
Lalia 2017 Aging (Albany NY)	2017	Lalia AZ, Dasari S, Robinson MM, Abid H, Morse DM, Klaus KA, Lanza IR (2017) Influence of omega-3 fatty acids on skeletal muscle protein metabolism and mitochondrial bioenergetics in older adults. Aging (Albany NY) 9:1096-1129.	OXPHOS LEAK ET	F N NS ROX S	Isolated mitochondria	Human	Skeletal muscle
Khalifa 2017 Physiol Rep	2017	Khalifa AR, Abdel-Rahman EA, Mahmoud AM, Ali MH, Noureldin M, Saber SH, Mohsen M, Ali SS (2017) Sex-specific differences in mitochondria biogenesis, morphology, respiratory function, and ROS homeostasis in young mouse heart and brain. Physiol Rep 5. pii: e13125.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Mouse	Heart Nervous system
Lemieux 2017 Sci Rep	2017	Lemieux H, Blier PU, Gnaiger E (2017) Remodeling pathway control of mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers. Sci Rep 7:2840. doi:10.1038/s41598-017-02789-8	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Mouse	Heart
Horscroft 2017 Proc Natl Acad Sci U S A	2017	Horscroft JA, Kotwica AO, Laner V, West JA, Hennis PJ, Levett DZH, Howard DJ, Fernandez BO, Burgess SL, Ament Z, Gilbert-Kawai ET, Vercueil A, Landis BD, Mitchell K, Mythen MG, Branco C, Johnson RS, Feelisch M, Montgomery HE, Griffin JL, Grocott MPW, Gnaiger E, Martin DS, Murray AJ (2017) Metabolic basis to Sherpa altitude adaptation. Proc Natl Acad Sci U S A 114:6382–7. https://doi.org/10.1073/pnas.1700527114	LEAK OXPHOS ET	F N S NS Other combinations	Permeabilized tissue	Human	Skeletal muscle
Qi 2017 Ann Allergy Asthma Immunol	2017	Qi S, Cindy Barnig C, Charles AL, Poirot A, Meyer A, Clere-Jehl R, de Blay F, Geny B (2017) Nasal allergen challenge in allergic rhinitis induces mitochondrial dysfunction of peripheral blood mononuclear cells. Ann Allergy Asthma Immunol 118:367-9.	OXPHOS LEAK	N S CIV	Permeabilized cells	Human	Blood cells Lymphocyte
Komlodi 2017 Neuropharmacology	2017	Komlódi T, Tretter L (2017) Methylene blue stimulates substrate-level phosphorylation catalysed by succinyl-CoA ligase in the citric acid cycle. Neuropharmacology 123:287-98.	LEAK OXPHOS ET	N S	Isolated mitochondria	Guinea pig	Nervous system
Jespersen 2017 J Physiol	2017	Jespersen NR, Yokota T, Støttrup NB, Bergdahl A, Paelestik KB, Povlsen JA, Dela F, Bøtker HE (2017) Pre-ischaemic mitochondrial substrate constraint by inhibition of malate-aspartate shuttle preserves mitochondrial function after ischaemia-reperfusion. J Physiol 595:3765-80.	LEAK OXPHOS	F N NS ROX S	Permeabilized tissue	Rat	Heart
Tepp 2017 Mol Cell Biochem	2017	Tepp K, Puurand M, Timohhina N, Adamson J, Klepinin A, Truu L, Shevchuk I, Chekulayev V, Kaambre T (2017) Changes in the mitochondrial function and in the efficiency of energy transfer pathways during cardiomyocyte aging. Mol Cell Biochem 432:141-58.	OXPHOS LEAK	N S CIV ROX	Permeabilized cells	Rat	Heart
Chavanelle 2017 Sci Rep	2017	Chavanelle V, Boisseau N, Otero YF, Combaret L, Dardevet D, Montaurier C, Delcros G, Peltier SL, Sirvent P (2017) Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice. Sci Rep 7:204.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Ravasz 2017 Neurochem Int	2017	Ravasz D, Kacso G, Fodor V, Horvath K, Adam-Vizi V, Chinopoulos C (2017) Catabolism of GABA, succinic semialdehyde or gamma-hydroxybutyrate through the GABA shunt impair mitochondrial substrate-level phosphorylation. Neurochem Int 109:41-53.	OXPHOS	N S NS	Isolated mitochondria	Mouse	Nervous system Liver
Sidlauskas 2017 Neurosci Lett	2017	Sidlauskas K, Sidlauskiene R, Li N, Liobikas J (2017) 5-Hydroxy-1,4-naphthalenedione exerts anticancer effects on glioma cells through interaction with the mitochondrial electron transport chain. Neurosci Lett 639:207-14.	OXPHOS LEAK ROUTINE ET	N S	Intact cells Permeabilized cells	Rat	Nervous system Other cell lines
Harisseh 2017 Basic Res Cardiol	2017	Harisseh R, Pillot B, Gharib A, Augeul L, Gallo-Bona N, Ferrera R, Loufouat J, Delale T, Allas S, Abribat T, Crola Da Silva C, Ovize M (2017) Unacylated ghrelin analog prevents myocardial reperfusion injury independently of permeability transition pore. Basic Res Cardiol 112:4.	OXPHOS ET	N S CIV ROX	Permeabilized cells	Mouse	Heart
Mantilla 2017 PLOS Pathog	2017	Mantilla BS, Marchese L, Casas-Sánchez A, Dyer NA, Ejeh N, Biran M, Bringaud F, Lehane MJ, Acosta-Serrano A, Silber AM (2017) Proline metabolism is essential for Trypanosoma brucei brucei survival in the tsetse vector. PLOS Pathog 13:e1006158.	LEAK OXPHOS ET ROUTINE	S ROX N	Permeabilized cells Intact cells	Protists
Haegler 2017 PLOS ONE	2017	Haegler P, Grünig D, Berger B, Terracciano L, Krähenbühl S, Bouitbir J (2017) Hepatic effects of pharmacological doses of hydroxy-cobalamin[c-lactam] in mice. PLOS ONE 12:e0171026.	LEAK OXPHOS ET	N S CIV ROX DQ	Homogenate	Mouse	Liver
Van Schaardenburgh 2017 J Vasc Surg	2017	Van Schaardenburgh M, Wohlwend M, Rognmo Ø, Mattsson E (2017) Calf raise exercise increases walking performance in patients with intermittent claudication. J Vasc Surg 65:1473-82.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Ljones 2017 PLOS ONE	2017	Ljones K, Ness HO, Solvang-Garten K, Gaustad SE, Andre Høydal M (2017) Acute exhaustive aerobic exercise training impair cardiomyocyte function and calcium handling in Sprague-Dawley rats. PLOS ONE 12:e0173449.	OXPHOS ET LEAK	N S CIV NS ROX	Permeabilized tissue	Rat	Heart
Lee 2017 Am J Physiol Endocrinol Metab	2017	Lee S, Leone TC, Rogosa L, Rumsey J, Ayala J, Coen PM, Fitts RH, Vega RB, Kelly DP (2017) Skeletal muscle PGC-1β signaling is sufficient to drive an endurance exercise phenotype and to counteract components of detraining in mice. Am J Physiol Endocrinol Metab 312:E394-406.	LEAK OXPHOS	S	Permeabilized tissue	Mouse	Skeletal muscle
Makrecka-Kuka 2017 Toxicol Lett	2017	Makrecka-Kuka M, Volska K, Antone U, Vilskersts R, Grinberga S, Bandere D, Liepinsh E, Dambrova M (2017) Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria. Toxicol Lett 267:32-8.	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Mouse	Heart
Edgett 2017 Thesis	2017	Edgett B (2017) Regulation of SIRT1, SIRT3, PGC-1α, and LRP130 in response to energetic stress in human skeletal muscle. Doctoral Dissertation p145.	LEAK OXPHOS	F N NS S	Permeabilized tissue	Human	Skeletal muscle
Yang 2017 Cell Death Dis	2017	Yang N, Weinfeld M, Lemieux H, Montpetit B, Goping IS (2017) Photo-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosis. Cell Death Dis 8:e2587.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Saccharomyces cerevisiae Human	Lymphocyte
Nabben 2017 Am J Physiol Regul Integr Comp Physiol	2017	Nabben M, Schmitz JP, Ciapaite J, Le Clercq CM, van Riel NA, Haak HR, Nicolay K, de Coo IF, Smeets HJ, Praet SF, van Loon LJ, Prompers JJ (2017) Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in mitochondrial myopathy patients. Am J Physiol Regul Integr Comp Physiol 312:689-701.	LEAK OXPHOS ET	F N S	Permeabilized tissue	Human	Skeletal muscle
Mitroshina 2017 Mod Technol Med	2017	Mitroshina ЕV, Abogessimengane BZ, Urazov МD, Hamraoui I, Mishchenko ТА, Astrakhanova ТА, Shchelchkova NА, Lapshin RD, Shishkina ТV, Belousova II, Mukhina IV, Vedunova МV (2017) Adaptive role of glial cell line-derived neurotrophic factor in cerebral ischemia. Mod Technol Med 9:68-76.	OXPHOS LEAK	N S	Isolated mitochondria	Mouse	Nervous system
Vienne 2017 Anal Biochem	2017	Vienne JC, Cimetta C, Dubois M, Duburcq T, Favory R, Dessein AF, Fontaine M, Joncquel-Chevalier Curt M, Cuisset JM, Douillard C, Mention-Mulliez K, Dobbelaere D, Vamecq J (2017) A fast method for high resolution oxymetry study of skeletal muscle mitochondrial respiratory chain complexes. Anal Biochem 528:57-62.	LEAK OXPHOS ET	N CIV ROX S	Homogenate Permeabilized tissue	Pig	Skeletal muscle
Du 2017 Evolution	2017	Du SNN, Khajali F, Dawson NJ, Scott GR (2017) Hybridization increases mitochondrial production of reactive oxygen species in sunfish. Evolution 71:1643-52.	LEAK OXPHOS ET	N NS ROX S	Isolated mitochondria	Fishes	Liver
Mathers 2017 J Comp Physiol B	2017	Mathers KE, McFarlane SV, Zhao L, Staples JF (2017) Regulation of mitochondrial metabolism during hibernation by reversible suppression of electron transport system enzymes. J Comp Physiol B 187:227-34.	LEAK OXPHOS	N S CIV ROX DQ	Intact cells Isolated mitochondria	Other mammals	Liver
Tegelberg 2017 Orphanet J Rare Dis	2017	Tegelberg S, Tomašić N, Kallijärvi J, Purhonen J, Elmér E, Lindberg E, Nord DG, Soller M, Lesko N, Wedell A, Bruhn H, Freyer C, Stranneheim H, Wibom R, Nennesmo I, Wredenberg A, Eklund EA, Fellman V (2017) Respiratory chain complex III deficiency due to mutated BCS1L: a novel phenotype with encephalomyopathy, partially phenocopied in a Bcs1l mutant mouse model. Orphanet J Rare Dis 12:73.	LEAK ROUTINE OXPHOS ET	N NS ROX S	Permeabilized cells	Human Mouse	Blood cells Platelet
Koit 2017 Oxid Med Cell Longev	2017	Koit A, Shevchuk I, Ounpuu L, Klepinin A, Chekulayev V, Timohhina N, Tepp K, Puurand M,Truu L, Heck K, Valvere V, Guzun R, Kaambre T (2017) Mitochondrial respiration in human colorectal and breast cancer clinical material is regulated differently. Oxid Med Cell Longev 2017:1372640.	OXPHOS LEAK	N S CIV ROX NS	Permeabilized tissue	Human	Endothelial;epithelial;mesothelial cell
De Moura 2017 Neurotox Res	2017	de Moura Alvorcem L, da Rosa MS, Glänzel NM, Parmeggiani B, Grings M, Schmitz F, Wyse ATS, Wajner M, Leipnitz G (2017) Disruption of energy transfer and redox status by sulfite in hippocampus, striatum, and cerebellum of developing rats. Neurotox Res 32:264-75.	LEAK OXPHOS ET	N S NS	Homogenate	Rat	Nervous system
Jackson 2017 Cancer Res	2017	Jackson LE, Kulkarni S, Wang H, Lu J, Dolezal JM, Bharathi SS, Ranganathan S, Patel MS, Deshpande R, Alencastro F, Wendell SG, Goetzman ES, Duncan AW, Prochownik EV (2017) Genetic dissociation of glycolysis and the TCA cycle affects neither normal nor neoplastic proliferation. Cancer Res 77:5795-807.	LEAK OXPHOS	N S NS	Intact cells	Mouse	Liver
Dolezal 2017 J Biol Chem	2017	Dolezal JM, Wang H, Kulkarni S, Jackson L, Lu J, Ranganathan S, Goetzman ES, Bharathi SS, Beezhold K, Byersdorfer CA, Prochownik EV (2017) Sequential adaptive changes in a c-Myc-driven model of hepatocellular carcinoma. J Biol Chem 292:10068-86.	LEAK OXPHOS	N S NS	Intact cells	Mouse	Liver
Buck 2017 PLOS ONE	2017	Buck E, Zügel M, Schumann U, Merz T, Gumpp AM, Witting A, Steinacker JM, Landwehrmeyer GB, Weydt P, Calzia E, Lindenberg KS (2017) High-resolution respirometry of fine-needle muscle biopsies in pre-manifest Huntington's disease expansion mutation carriers shows normal mitochondrial respiratory function. PLOS ONE 12:e0175248.	LEAK OXPHOS ET	F N S NS ROX	Homogenate	Human Mouse	Heart Skeletal muscle Nervous system Liver
Kyhl 2017 Peptides	2017	Kyhl K, Lønborg J, Hartmann B, Kissow H, Poulsen SS, Ali HE, Kjær A, Dela F, Engstrøm T, Treiman M (2017) Lack of effect of prolonged treatment with liraglutide on cardiac remodeling in rats after acute myocardial infarction. Peptides 93:1-12.	OXPHOS LEAK	F N S NS ROX	Permeabilized tissue	Rat	Heart
Jeong 2017 Exp Mol Med	2017	Jeong JH, Cheol Kang Y, Piao Y, Kang S, Pak YK (2017) miR-24-mediated knockdown of H2AX damages mitochondria and the insulin signaling pathway. Exp Mol Med 49:e313.	OXPHOS	N S Gp CIV ROX	Permeabilized cells	Human	Liver
Krishnathas 2017 Med Chem Comm	2017	Krishnathas R, Bonke E, Dröse S, Zickermann V, Nasiri HR (2017) Identification of 4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine as a novel, highly potent and specific inhibitor of mitochondrial complex I. Med Chem Comm 8:657-61.	OXPHOS	N S	Isolated mitochondria	Rat	Heart
Boutant 2017 EMBO J	2017	Boutant M, Kulkarni SS, Joffraud M, Ratajczak J, Valera-Alberni M, Combe R, Zorzano A, Cantó C (2017) Mfn2 is critical for brown adipose tissue thermogenic function. EMBO J 36:1543-58.	ROUTINE LEAK OXPHOS ET	ROX N S NS	Intact cells Homogenate Isolated mitochondria	Mouse	Fat Fibroblast
Djafarzadeh 2017 J Vis Exp	2017	Djafarzadeh S, Jakob SM (2017) High-resolution respirometry to assess mitochondrial function in permeabilized and intact cells. J Vis Exp 8.doi: 10.3791/54985..	OXPHOS ET	N S CIV	Isolated mitochondria
Van den Berg 2017 Am J Respir Crit Care Med	2017	van den Berg M, Hooijman PE, Beishuizen A, de Waard MC, Paul MA, Hartemink KJ, van Hees HWH, Lawlor MW, Brocca L, Bottinelli R, Pellegrino MA, Stienen GJM, Heunks LMA, Wüst RCI, Ottenheijm CAC (2017) Diaphragm atrophy and weakness in the absence of mitochondrial dysfunction in the critically ill. Am J Respir Crit Care Med 196:1544-58.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Categories of SUIT protocols	2017	Gnaiger E (2017) Categories of SUIT protocols and ETS pathway control states. MiPNet 2017-03-12; original 2016-03-20; edited 2016-08-21.		F N S Gp CIV NS Other combinations ROX
Dahlke 2017 Glob Chang Biol	2017	Dahlke FT, Leo E, Mark FC, Pörtner HO, Bickmeyer U, Frickenhaus S, Storch D (2017) Effects of ocean acidification increase embryonic sensitivity to thermal extremes in Atlantic cod, Gadus morhua. Glob Chang Biol 23(4):1499-1510.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Fishes
Gusdon 2017 Exp Gerontol	2017	Gusdon AM, Callio J, Distefano G, O'Doherty RM, Goodpaster BH, Coen PM, Chu CT (2017) Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice. Exp Gerontol 90:1-13.	LEAK OXPHOS	N S	Isolated mitochondria	Mouse	Nervous system
Pamenter 2017 J Exp Biol	2017	Pamenter ME, Lau GY, Richards JG, Milsom WK (2017) Naked mole rat brain mitochondria electron transport system flux and H⁺ leak are reduced during acute hypoxia. J Exp Biol 221.	LEAK OXPHOS ET	N S CIV	Permeabilized cells	Other mammals	Nervous system
Parajuli 2017 PLOS ONE	2017	Parajuli N, Shrum S, Tobacyk J, Harb A, Arthur JM, MacMillan-Crow LA (2017) Renal cold storage followed by transplantation impairs expression of key mitochondrial fission and fusion proteins. PLOS ONE 12:e0185542.	OXPHOS	N S ROX	Permeabilized tissue	Rat	Kidney
Ho 2017 Thesis	2017	Ho DH (2017) The role of MLQ protein in structure and function of mammalian ATP synthase. Master's Thesis p84.	LEAK OXPHOS ET	N S CIV NS ROX	Intact cells Permeabilized cells	Human	Kidney
Fourcade 2017 Aging Cell	2017	Fourcade S, Morató L, Parameswaran J, Ruiz M, Ruiz-Cortés T, Jové M, Naudí A, Martínez-Redondo P, Dierssen M, Ferrer I, Villarroya F, Pamplona R, Vaquero A, Portero-Otín M, Pujol A (2017) Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance. Aging Cell 16:1404-13.	LEAK OXPHOS	N S NS ROX		Mouse
Cockova 2017 Thesis	2017	Čočková Z (2017) Modulation of RNA demethylase FTO function in SH-SY5Y cells: the effect on insulin signaling and mitochondrial respiration. Diploma Thesis p70.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells Isolated mitochondria	Human	Nervous system
Goedecke 2017 JMIR Res Protoc	2017	Goedecke JH, Mendham AE, Clamp L, Nono Nankam PA, Fortuin-de Smidt MC, Phiri L, Micklesfield LK, Keswell D, Woudberg NJ, Lecour S, Alhamud A, Kaba M, Lutomia FM, van Jaarsveld PJ, de Villiers A, Kahn SE, Chorell E, Hauksson J, Olsson T (2017) An exercise intervention to unravel the mechanisms underlying insulin resistance in a cohort of black South African women: Protocol for a randomized controlled trial. JMIR Res Protoc 03/10/2017:9098.	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle Fat
Radenkovic 2017 Biochem Pharmacol	2017	Radenkovic F, Holland OJ, Vanderlelie JJ, Perkins AV (2017) Selective inhibition of endogenous antioxidants with Auranofin causes mitochondrial oxidative stress which can be countered by selenium supplementation. Biochem Pharmacol 146:42-52.	ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Other cell lines
Gerber 2017 Brain	2017	Gerber S, Charif M, Chevrollier A, Chaumette T, Angebault C, Kane MS, Paris A, Alban J, Quiles M, Delettre C, Bonneau D, Procaccio V, Amati-Bonneau P, Reynier P, Leruez S, Calmon R, Boddaert N, Funalot B, Rio M, Bouccara D, Meunier I, Sesaki H, Kaplan J, Hamel CP, Rozet JM, Lenaers G (2017) Mutations in DNM1L, as in OPA1, result indominant optic atrophy despite opposite effects on mitochondrial fusion and fission. Brain 140:2586-96.	LEAK OXPHOS ET	N S NS	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell Fibroblast
Cavalcanti-de-Albuquerque 2017 Mol Neurobiol	2017	Cavalcanti-de-Albuquerque JP, de Souza Ferreira E, de Carvalho DP, Galina A (2017) Mitochondria-bound hexokinase (mt-HK) activity differ in cortical and hypothalamic synaptosomes: differential role of mt-HK in H₂O₂ depuration. Mol Neurobiol 55:5889-5900.	LEAK OXPHOS	N S Gp ROX	Intact cells	Rat	Nervous system
Yan 2017 BMC Genomics	2017	Yan X, Eynon N, Papadimitriou ID, Kuang J, Munson F, Tirosh O, O’Keefe L, Griffiths LR, Ashton KJ, Byrne N, Pitsiladis YP, Bishop DJ (2017) The gene SMART study: method, study design, and preliminary findings. BMC Genomics 18:821.	OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Lau 2017 Dissertation	2017	Lau G (2017) Adaptive variation of mitochondrial function in response to oxygen variability in intertidal sculpins (Cottidae, Actinopterygii). Dissertation p148.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Fishes	Nervous system
Darrell 2017 US Patent	2017	Neufer PD, Anderson EJ, Szeto HH (2017) Methods for preventing or treating insulin resistance. US Patent US20170100450 A1.	LEAK OXPHOS	F N S ROX	Permeabilized tissue	Human Rat	Skeletal muscle
Elmer 2017 US Patent	2017	Elmer E, Hansson MJ, Ehinger JK, Piel S, Moss S (2017) Succinate prodrugs for use in the treatment of lactic acidosis or drug-induced side-effects due to complex I-related impairment of mitochondrial oxidative phosphorylation. US Patent US20170100359 A1.	LEAK ROUTINE OXPHOS ET	S ROX	Intact cells	Human	Heart Blood cells Fibroblast Macrophage-derived Platelet
Koning 2017 J Cereb Blood Flow Metab	2017	Koning G, Leverin AL, Nair S, Schwendimann L, Ek J, Carlsson Y, Gressens P, Thornton C, Wang X, Mallard C, Hagberg H (2017) Magnesium induces preconditioning of the neonatal brain via profound mitochondrial protection. J Cereb Blood Flow Metab 39:1038-55.	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Rat
Knuppertz 2017 Aging Cell	2017	Knuppertz L, Osiewacz HD (2017) Autophagy compensates impaired energy metabolism in CLPXP-deficient Podospora anserina strains and extends healthspan. Aging Cell 16:704-15.	OXPHOS	N S CIV NS	Isolated mitochondria	Fungi
Duicu 2017 Can J Physiol Pharmacol	2017	Duicu OM, Privistirescu A, Wolf A, Petruş A, Dănilă MD, Raţiu CD, Muntean DM, Sturza A (2017) Methylene blue improves mitochondrial respiration and decreases oxidative stress in a substrate-dependent manner in diabetic rat hearts. Can J Physiol Pharmacol 95:1376-82.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Rat	Heart
Asseburg 2017 Thesis	2017	Asseburg H (2017) Untersuchungen zur nutritiven Prävention der Neurodegeneration – Wirkungen von Trauben- und Olivenpolyphenolen auf die mitochondriale und kognitive Dysfunktion bei der Gehirnalterung und Alzheimer-Erkrankung. Dissertation p296.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells Isolated mitochondria Intact cells	Mouse Rat	Nervous system Other cell lines
Tuboly 2017 Sci Rep	2017	Tuboly E, Molnár R, Tőkés T, Turányi RN, Hartmann P, Mészáros AT, Strifler G, Földesi I, Siska A, Szabó A, Mohácsi Á, Szabó G, Boros M (2017) Excessive alcohol consumption induces methane production in humans and rats. Sci Rep 7:7329.	OXPHOS	S	Homogenate	Rat	Nervous system Liver
Gifford 2017 J Appl Physiol (1985)	2017	Gifford JR, Trinity JD, Kwon OS, Layec G, Garten RS, Park SY, Nelson AD, Richardson RS (2017) Altered skeletal muscle mitochondrial phenotype in COPD: disease versus disuse. J Appl Physiol (1985) 124:1045-53.	OXPHOS	N S NS	Permeabilized tissue	Human	Skeletal muscle
Friederich 2017 Hum Mol Genet	2017	Friederich MW, Erdogan AJ, Coughlin CR 2nd, Elos MT, Jiang H, O'Rourke CP, Lovell MA, Wartchow E, Gowan K, Chatfield KC, Chick WS, Spector EB, Van Hove JLK, Riemer J (2017) Mutations in the accessory subunit NDUFB10 result in isolated complex I deficiency and illustrate the critical role of intermembrane space import for complex I holoenzyme assembly. Hum Mol Genet 26:702-16.	ROUTINE OXPHOS ET LEAK	N S CIV NS ROX	Permeabilized cells Intact cells	Human	Fibroblast
Polyzos 2017 Mech Ageing Dev	2017	Polyzos AA, McMurray CT (2017) The chicken or the egg: mitochondrial dysfunction as a cause or consequence of toxicity in Huntington's disease. Mech Ageing Dev 161:181-97. https://doi.org/10.1016/j.mad.2016.09.003		S
Xhani 2017 Thesis	2017	Xhani M (2017) Cellular redox homeostasis and environmental toxicity. Dissertation p110.	OXPHOS	N S CIV ROX	Permeabilized cells	Human	Liver Other cell lines
Nemeth 2017 Thesis	2017	Németh B (2017) The effect of itaconic acid on mitochondrial substrate-level phosphorylation. PhD Thesis p84.	LEAK OXPHOS	S	Isolated mitochondria	Mouse	Liver
Westerlund 2017 Pediatr Res	2017	Westerlund E, Marelsson SE, Ehinger JK, Sjövall F, Morota S, Åsander Frostner E, Oldfors A, Darin N, Lundgren J, Hansson MJ, Fellman V, Elmér E (2017) Oxygen consumption in platelets as an adjunct diagnostic method for pediatric mitochondrial disease. Pediatr Res 83:455-65.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Human	Platelet Blood cells
Nelskylae 2017 Resuscitation	2017	Nelskylä A, Nurmi J, Jousi M, Schramko A, Mervaala E, Ristagno G, Skrifvars MB (2017) The effect of 50% compared to 100% inspired oxygen fraction on brain oxygenation and post cardiac arrest mitochondrial function in experimental cardiac arrest. Resuscitation 116:1-7.	OXPHOS ET	F N S NS	Homogenate	Pig	Heart
Huang 2017 Sci Rep	2017	Huang L, Zhang K, Guo Y, Huang F, Yang K, Chen L, Huang K, Zhang F, Long Q, Yang Q (2017) Honokiol protects against doxorubicin cardiotoxicity via improving mitochondrial function in mouse hearts. Sci Rep 7:11989.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse	Heart
Nogueira 2017 Free Radic Biol Med	2017	Nogueira NP, Saraiva FMS, Oliveira MP, Mendonca APM, Inacio JDF, Almeida-Amaral EE, Menna-Barreto RF, Laranja GAT, Lopes Torres EJ, Oliveira MF, Paes MC (2017) Heme modulates Trypanosoma cruzi bioenergetics inducing mitochondrial ROS production. Free Radic Biol Med 108:183-91.	LEAK ROUTINE OXPHOS ET	S	Intact organism Permeabilized cells	Protists
Fisar 2017 Indian J Biochem Biophys	2017	Fišar Z, Hroudová J, Namrata S, Macečková D, Kopřivová A (2017) Protocols for high-resolution respirometry experiments to test the activity of electron transfer system of pig brain mitochondria. Indian J Biochem Biophys 54:258-72.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Pig	Nervous system
Sivitz 2017 Neuromethods	2017	Sivitz WI (2017) Techniques to investigate bioenergetics of mitochondria. In: Strack S, Usachev Y (eds) Techniques to investigate mitochondrial function in neurons. Neuromethods 123:67-94. Humana Press, New York. https://doi.org/10.1007/978-1-4939-6890-9_4	LEAK OXPHOS ET	F N S	Isolated mitochondria Intact cells
Wang 2017 J Am Heart Assoc	2017	Wang B, Xiong S, Lin S, Xia W, Li Q, Zhao Z, Wei X, Lu Z, Wei X, Gao P, Liu D, Zhu Z (2017) Enhanced mitochondrial transient receptor potential channel, canonical type 3-mediated calcium handling in the vasculature from hypertensive rats. J Am Heart Assoc 6. pii: e005812.	ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Rat	Endothelial;epithelial;mesothelial cell
Krylova 2017 Biomed Khim	2017	Krylova TD, Tsygankova PG, Itkis YS, Sheremet NL, Nevinitsyna TA, Mikhaylova SV, Zakharova EY (2017) High resolution respirometry in diagnostic of mitochondrial disorders caused by mitochondrial complex I deficiency. Biomed Khim 63:327-33.	ET	N S NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell Fibroblast
Jang 2017 Clin Toxicol (Phila)	2017	Jang DH, Kelly M, Hardy K, Lambert DS, Shofer FS, Eckmann DM (2017) A preliminary study in the alterations of mitochondrial respiration in patients with carbon monoxide poisoning measured in blood cells. Clin Toxicol (Phila) 55:579-84.	LEAK ROUTINE OXPHOS ET	F S CIV NS ROX	Intact cells		Blood cells
Djafarzadeh 2017b J Vis Exp	2017	Djafarzadeh S, Jakob SM (2017) Isolation of intact mitochondria from skeletal muscle by differential centrifugation for High-Resolution Respirometry measurements. J Vis Exp doi: 10.3791/55251.	LEAK OXPHOS	N S CIV NS	Isolated mitochondria		Skeletal muscle
Asping 2017 Eur J Clin Pharmacol	2017	Asping M, Stride N, Søgaard D, Dohlmann TL, Helge JW, Dela F, Larsen S (2017) The effects of 2 weeks of statin treatment on mitochondrial respiratory capacity in middle-aged males: the LIFESTAT study. Eur J Clin Pharmacol 73:679-87.	LEAK ET	F N S CIV NS ROX	Permeabilized tissue	Human
Schmidt 2017 J Vasc Surg	2017	Schmidt CA, Ryan TE, Lin CT, Inigo MM, Green TD, Brault JJ, Spangenburg EE, McClung JM (2017) Diminished force production and mitochondrial respiratory deficits are strain-dependent myopathies of subacute limb ischemia. J Vasc Surg 65:1504-1514.	OXPHOS ET LEAK	N S CIV NS	Permeabilized tissue Isolated mitochondria	Mouse	Skeletal muscle
Rowley 2017 J Nutr Biochem	2017	Rowley TJ, Bitner BF, Ray JD, Lathen DR, Smithson AT, Dallon BW, Plowman CJ, Bikman BT, Hansen JM, Dorenkott MR, Goodrich KM, Ye L, O'Keefe SF, Neilson AP, Tessem JS (2017) Monomeric cocoa catechins enhance β-cell function by increasing mitochondrial respiration. J Nutr Biochem 49:30-41.	OXPHOS ET	N S NS ROX	Permeabilized cells	Rat	Islet cell;pancreas;thymus
Abdurrachim 2017 Cardiovasc Res	2017	Abdurrachim D, Nabben M, Hoerr V, Kuhlmann MT, Bovenkamp P, Ciapaite J, Geraets IME, Coumans W, Luiken JJFP, Glatz JFC, Schäfers M, Nicolay K, Faber C, Hermann S, Prompers JJ (2017) Diabetic db/db mice do not develop heart failure upon pressure overload: a longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations. Cardiovasc Res 113:1148-60.	LEAK OXPHOS ET	N S	Isolated mitochondria	Mouse	Heart
Blecha 2017 Free Radic Biol Med	2017	Blecha J, Novais SM, Rohlenova K, Novotna E, Lettlova S, Schmitt S, Zischka H, Neuzil J, Rohlena J (2017) Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death. Free Radic Biol Med 112:253-66.	ROUTINE OXPHOS	S	Intact cells		Endothelial;epithelial;mesothelial cell
Han 2017 Invest Ophthalmol Vis Sci	2017	Han WH, Gotzmann J, Kuny S, Huang H, Chan CB, Lemieux H, Sauvé Y (2017) Modifications in retinal mitochondrial respiration precede type 2 diabetes and protracted microvascular retinopathy. Invest Ophthalmol Vis Sci 58:3826-39.	LEAK OXPHOS	N S CIV NS ROX	Homogenate	Rat	Nervous system
Zhou 2017 Biochim Biophys Acta	2017	Zhou L, Wang W, Hoppel C, Liu J, Zhu X (2017) Parkinson's disease-associated pathogenic VPS35 mutation causes complex I deficits. Biochim Biophys Acta 1863:2791-5.	OXPHOS ET	N S NS ROX	Isolated mitochondria	Human	Fibroblast
Xiong 2017 J Am Heart Assoc	2017	Xiong S, Wang B, Lin S, Zhang H, Li Y, Wei X, Cui Y, Wei X, Lu Z, Gao P, Li L, Zhao Z, Liu D, Zhu Z (2017) Activation of transient receptor potential melastatin subtype 8 attenuates cold-induced hypertension through ameliorating vascular mitochondrial dysfunction. J Am Heart Assoc 6. pii: e005495.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Mouse	Endothelial;epithelial;mesothelial cell
Permer 2017 Bachelor Thesis	2017	Permer M (2017) Respirometrische Charakterisierung kryopräservierter HEK 239T Zellen. Bachelor Thesis 1-56.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS ROX	Permeabilized cells Intact cells	Human	Other cell lines HEK
Djordjevic 2017 Neuroscience	2017	Djordjevic J, Thomson E, Chowdhury SR, Snow WM, Perez C, Wong TP, Fernyhough P, Albensi BC (2017) Brain region- and sex-specific alterations in mitochondrial function and NF-κB signaling in the TgCRND8 mouse model of Alzheimer's disease. Neuroscience 361:81-92.	ROUTINE OXPHOS ET	N S ROX	Isolated mitochondria	Mouse	Nervous system
Magnifico 2017 Oxid Med Cell Longev	2017	Magnifico MC, Oberkersch RE, Mollo A, Giambelli L, Grooten Y, Sarti P, Calabrese GC, Arese M (2017) VLDL induced modulation of nitric oxide signalling and cell redox homeostasis in HUVEC. Oxid Med Cell Longev 2017:2697364.	OXPHOS	N S CIV	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell
Briston 2017 Sci Rep	2017	Briston T, Roberts M, Lewis S, Powney B, M Staddon J, Szabadkai G, Duchen MR (2017) Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability. Sci Rep 7:10492.	OXPHOS ET	N S NS ROX	Isolated mitochondria	Rat	Liver
Dent 2017 Mol Metab	2017	Dent JR, Martins VF, Svensson K, LaBarge SA, Schlenk NC, Esparza MC, Buckner EH, Meyer GA, Hamilton DL, Schenk S, Philp A (2017) Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation. Mol Metab 6:1574-84.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Wollenman 2017 PLOS ONE	2017	Wollenman LC, Vander Ploeg MR, Miller ML, Zhang Y, Bazil JN (2017) The effect of respiration buffer composition on mitochondrial metabolism and function. PLOS ONE 12:e0187523.	LEAK OXPHOS ET	F N S NS	Isolated mitochondria	Guinea pig	Heart Liver
Zholobenko 2017 PLOS ONE	2017	Zholobenko AV, Mouithys-Mickalad A, Dostal Z, Serteyn D, Modriansky M (2017) On the causes and consequences of the uncoupler-like effects of quercetin and dehydrosilybin in H9c2 cells. PLOS ONE 12:e0185691.	LEAK OXPHOS ET ROUTINE	F N S NS ROX	Permeabilized cells Intact cells	Rat	Heart
Mueller 2017 Orphanet J Rare Dis	2017	Mueller SM, Gehrig SM, Petersen JA, Frese S, Mihaylova V, Ligon-Auer M, Khmara N, Nuoffer JM, Schaller A, Lundby C, Toigo M, Jung HH (2017) Effects of endurance training on skeletal muscle mitochondrial function in Huntington disease patients. Orphanet J Rare Dis 12:184.	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Nan 2017 Circ Res	2017	Nan J, Hu H, Sun Y, Zhu L, Wang Y, Zhong Z, Zhao J, Zhang N, Wang Y, Wang Y, Ye J, Zhang L, Hu X, Zhu W, Wang J (2017) TNFR2 stimulation promotes mitochondrial fusion via Stat3- and NF-kB-dependent activation of OPA1 expression. Circ Res 121:392-410.	OXPHOS ET	N S NS ROX	Intact cells	Mouse	Heart
Krischek 2017 Animal	2017	Krischek C, Wimmers K, Janisch S, Wicke M, Sharifi AR (2017) Temperature alterations during embryogenesis have a sex-dependent influence on growth properties and muscle metabolism of day-old chicks and 35-day-old broilers. Animal 12:1224-31.	OXPHOS	N S		Birds	Skeletal muscle
Hu 2017 Proc Natl Acad Sci U S A	2017	Hu H, Nan J, Sun Y, Zhu D, Xiao C, Wang Y, Zhu L, Wu Y, Zhao J, Wu R, Chen J, Yu H, Hu X, Zhu W, Wang J (2017) Electron leak from NDUFA13 within mitochondrial complex I attenuates ischemia-reperfusion injury via dimerized STAT3. Proc Natl Acad Sci U S A 114:11908-13.	OXPHOS	N S CIV NS ROX	Isolated mitochondria	Mouse
MiPNet21.14 Reference sample HRR	2016-10-19	Development of a reference sample for HRR.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Intact cells Permeabilized cells	Human	HEK
MiPNet21.13 Comparison mt-preparations	2016-10-18	O2k-Protocols: Mitochondrial preparations for HRR.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells Homogenate Isolated mitochondria	Mouse	Heart
MiPNet21.12 Comparison mt respiration media	2016-10-18	O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Intact cells Permeabilized cells	Human	HEK
MiPNet21.07 MitoFit DatLab PT	2016-07-20	MitoFit DatLab proficiency test.	LEAK OXPHOS ET	F N S Gp CIV Other combinations ROX	Permeabilized cells	Human
Assmann 2016 Cell Rep	2016	Assmann N, Dettmer K, Simbuerger JM, Broeker C, Nuernberger N, Renner K, Courtneidge H, Klootwijk ED, Duerkop A, Hall A, Kleta R, Oefner PJ, Reichold M, Reinders J (2016) Renal fanconi syndrome is caused by a mistargeting-based mitochondriopathy. Cell Rep 15:1423-9.	LEAK OXPHOS ET	F N S NS Other combinations ROX	Intact cells	Pig	Kidney Other cell lines
Heinonen 2016 Hum Exp Toxicol	2016	Heinonen JA, Schramko AA, Skrifvars MB, Litonius E, Backman JT, Mervaala E, Rosenberg PH (2016) The effects of intravenous lipid emulsion on hemodynamic recovery and myocardial cell mitochondrial function after bupivacaine toxicity in anesthetized pigs. Hum Exp Toxicol 36:365-75.	LEAK OXPHOS ET	F N S NS	Homogenate	Pig	Heart
Ryan 2016 J Mol Cell Cardiol	2016	Ryan TE, Schmidt CA, Alleman RJ, Tsang AM, Green TD, Neufer PD, Brown DA, McClung JM (2016) Mitochondrial therapy improves limb perfusion and myopathy following hindlimb ischemia. J Mol Cell Cardiol 97:191-6.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Skeletal muscle
Wijermars 2016 Am J Transplant	2016	Wijermars LG, Schaapherder AF, Kostidis S, Wüst RC, Lindeman JH (2016) Succinate accumulation and ischemia reperfusion injury: of mice but not men - A study in renal ischemia reperfusion. Am J Transplant 16:2741-6.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human Pig Mouse Rat	Kidney
Stepanova 2016 Biochim Biophys Acta	2016	Stepanova A, Shurubor Y, Valsecchi F, Manfredi G, Galkin A (2016) Differential susceptibility of mitochondrial complex II to inhibition by oxaloacetate in brain and heart. Biochim Biophys Acta 1857:1561-8.		S	Oxidase;biochemical oxidation	Mouse	Heart Nervous system
Wuest 2016 Cardiovasc Res	2016	Wüst RC, de Vries HJ, Wintjes LT, Rodenburg RJ, Niessen HW, Stienen GJ (2016) Mitochondrial complex I dysfunction and altered NAD(P)H kinetics in rat myocardium in cardiac right ventricular hypertrophy and failure. Cardiovasc Res 111:362-72.	LEAK OXPHOS	N S	Intact cells Permeabilized tissue	Rat	Heart
Rohlenova 2016 Antioxid Redox Signal	2016	Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork-Geleta A, Blecha J, Endaya B, Werner L, Cerny J, Zobalova R, Goodwin J, Spacek T, Alisadeh E, Yan B, Nguyen M, Vondrusova M, Sobol M, Jezek P, Hozak P, Truksa J, Rohlena J, Dong L, Neuzil J (2016) Selective disruption of respiratory supercomplexes as a new strategy to suppress Her2^high breast cancer. Antioxid Redox Signal 26:84-103.	LEAK ROUTINE ET	N S Other combinations	Permeabilized cells Homogenate	Human Mouse	Liver Genital Other cell lines
Morton 2016 Nat Med	2016	Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MT, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S (2016) Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. Nat Med 22:771-9.	LEAK OXPHOS	N S	Isolated mitochondria	Mouse	Liver
Iglesias-Gonzalez 2016 Mol Neurobiol	2016	Iglesias-González J, Sánchez-Iglesias S, Beiras-Iglesias A, Méndez-Álvarez E, Soto-Otero R (2016) Effects of aluminium on rat brain mitochondria bioenergetics: an in vitro and in vivo study. Mol Neurobiol 54:563-70.	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Rat	Nervous system
Kontro 2016 Thesis	2016	Kontro H (2016) Mitochondrial function and sirtuin expression in hippocampus of young and old high and low-capacity runner rats. Master's Thesis p35.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Nervous system
Reis 2016 Aging (Albany NY)	2016	Reis FC, Branquinho JL, Brandão BB, Guerra BA, Silva ID, Frontini A, Thomou T, Sartini L, Cinti S, Kahn CR, Festuccia WT, Kowaltowski AJ, Mori MA (2016) Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice. Aging (Albany NY) 8:1201-22.	LEAK	N S ROX	Permeabilized cells	Mouse	Fat
Sheremet 2016 Biochemistry (Moscow)	2016	Sheremet NL, Nevinitsyna TA, Zhorzholadze NV, Ronzina IA, Itkis YS, Krylova TD, Tsygankova PG, Malakhova VA, Zakharova EY, Tokarchuk AV, Panteleeva AA, Karger EM, Lyamzaev KG, Avetisov SE (2016) Previously unclassified mutation of mtDNA m.3472T>C: evidence of pathogenicity in Leber’s hereditary optic neuropathy. Biochemistry (Moscow) BM16-078.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell Fibroblast Platelet
Gehrig 2016 Orphanet J Rare Dis	2016	Gehrig SM, Mihaylova V, Frese S, Mueller SM, Ligon-Auer M, Spengler CM, Petersen JA, Lundby C, Jung HH (2016) Altered skeletal muscle (mitochondrial) properties in patients with mitochondrial DNA single deletion myopath. Orphanet J Rare Dis 11:105.	LEAK OXPHOS	F N S CIV NS Other combinations ROX	Permeabilized tissue	Human	Skeletal muscle
Radovic 2016 Diabetologia	2016	Radović B, Vujić N, Leopold C, Schlager S, Goeritzer M, Patankar JV, Korbelius M, Kolb D, Reindl J, Wegscheider M, Tomin T, Birner-Gruenberger R, Schittmayer M, Groschner L, Magnes C, Diwoky C, Frank S, Steyrer E, Du H, Graier WF, Madl T, Kratky D (2016) Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice. Diabetologia 59:1743-52.	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Mouse	Liver
Wijermars 2016 Kidney Int	2016	Wijermars LG, Schaapherder AF, de Vries DK, Verschuren L, Wuest RC, Kostidis S, Mayboroda OA, Prins F, Ringers J, Bierau J, Bakker JA, Kooistra T, Lindeman JH (2016) Defective postreperfusion metabolic recovery directly associates with incident delayed graft function. Kidney Int 90:181-91.	OXPHOS	N S NS ROX	Permeabilized tissue	Human	Kidney
Uecal 2016 J Neurotrauma	2016	Üçal M, Kraitsy K, Weidinger A, Paier-Pourani J, Patz S, Fink B, Molcanyi M, Schäfer U (2016) Comprehensive profiling of modulation of nitric oxide levels and mitochondrial activity in the injured brain: an experimental study based on the fluid percussion injury model in rats. J Neurotrauma 34:475-86.	LEAK OXPHOS	N S	Homogenate	Rat	Nervous system
Takahashi 2016 Exp Gerontol	2016	Takahashi K, Ohsawa I, Shirasawa T, Takahashi M (2016) Early-onset motor impairment and increased accumulation of phosphorylated α-synuclein in the motor cortex of normal aging mice are ameliorated by coenzyme Q. Exp Gerontol 81:65-75.	OXPHOS	N S ROX	Isolated mitochondria	Mouse	Nervous system
Cecatto 2016 Thesis	2016	Cecatto C (2016) Efeitos de acidos graxos hidroxilados de cadeia longa acumulados nas deficiencias da 3-hidroxiacil CoA desidrogenase de cadeia longa e da proteina trifunctional mitocondrial sobre a homeostase energetica mitochondrial nos musculos cardiaco e esqueletico de ratos jovens. Dissertation p103.	LEAK OXPHOS ET	N S	Permeabilized tissue Isolated mitochondria	Rat	Heart Skeletal muscle
Du 2016 Aquat Toxicol	2016	Du X, Crawford DL, Nacci DE, Oleksiak MF (2016) Heritable oxidative phosphorylation differences in a pollutant resistant Fundulus heteroclitus population. Aquat Toxicol 177:44-50.	LEAK OXPHOS ET	N S CIV Other combinations ROX	Permeabilized cells	Fishes	Liver
Sobotka 2016 J Bioenerg Biomembr	2016	Sobotka O, Endlicher R, Drahota Z, Kučera O, Rychtrmoc D, Raad M, Hakeem K, Červinková Z (2016) Impaired mitochondrial functions contribute to 3-bromopyruvate toxicity in primary rat and mouse hepatocytes. J Bioenerg Biomembr 48:363-73.	LEAK OXPHOS	N S CIV	Intact cells Permeabilized cells Homogenate Isolated mitochondria	Mouse Rat	Liver
Moon 2016 J Biol Chem	2016	Moon SH, Mancuso DJ, Sims HF, Liu X, Nguyen AL, Yang K, Guan S, Dilthey BG, Jenkins CM, Weinheimer CJ, Kovacs A, Abendschein D, Gross RW (2016) Cardiac myocyte-specific knock-out of calcium-independent phospholipase A2γ (iPLA2γ) decreases oxidized fatty acids during ischemia/reperfusion and reduces infarct size. J Biol Chem 291:19687-700.	LEAK OXPHOS	F N S NS Other combinations ROX	Isolated mitochondria	Mouse	Heart
Vevera 2016 Physiol Res	2016	Vevera J, Fišar Z, Nekovářová T, Vrablík M, Zlatohlávek L, Hroudová J, Singh N, Raboch J, Valeš K (2016) Statin-induced changes in mitochondrial respiration in blood platelets in rats and human with dyslipidemia. Physiol Res 65:777-88.	LEAK ROUTINE OXPHOS ET	N S NS Other combinations ROX	Intact cells Permeabilized cells	Human Rat	Blood cells Platelet
Ehinger 2016 Nat Commun	2016	Ehinger JK, Piel S, Ford R, Karlsson M, Sjövall F, Frostner EÅ, Morota S, Taylor RW, Turnbull DM, Cornell C, Moss SJ, Metzsch C, Hansson MJ, Fliri H, Elmér E (2016) Cell-permeable succinate prodrugs bypass mitochondrial Complex I deficiency. Nat Commun 7:12317. https://doi.org/10.1038/ncomms12317	OXPHOS ET	S	Intact cells Permeabilized tissue		Heart Blood cells Fibroblast
Teulier 2016 Proc Biol Sci	2016	Teulier L, Weber JM, Crevier J, Darveau CA (2016) Proline as a fuel for insect flight: enhancing carbohydrate oxidation in hymenopterans. Proc Biol Sci 283: 20160333.	OXPHOS	F N S Gp NS Other combinations ROX	Permeabilized tissue	Hexapods	Skeletal muscle
Hawley 2016 Diabetes	2016	Hawley SA, Ford RJ, Smith BK, Gowans GJ, Mancini SJ, Pitt RD, Day EA, Salt IP, Steinberg GR, Hardie DG (2016) The Na+/glucose cotransporter inhibitor canagliflozin activates AMPK by inhibiting mitochondrial function and increasing cellular AMP levels. Diabetes 65:2784-94.	OXPHOS	N S	Permeabilized cells	Human Mouse	Liver HEK
Hagl 2016 Neuromolecular Med	2016	Hagl S, Asseburg H, Heinrich M, Sus N, Blumrich EM, Dringen R, Frank J, Eckert GP (2016) Effects of long-term rice bran extract supplementation on survival, cognition and brain mitochondrial function in aged NMRI mice. Neuromolecular Med 18:347-63.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Moore 2016 Cryobiology	2016	Moore DS, Hand SC (2016) Cryopreservation of lipid bilayers by LEA proteins from Artemia franciscana and trehalose. Cryobiology 73:240-7.	LEAK OXPHOS ET	S	Isolated mitochondria	Rat	Liver
Schoenenberger 2016 Cancer Res	2016	Schönenberger D, Harlander S, Rajski M, Jacobs RA, Lundby AK, Adlesic M, Hejhal T, Wild PJ, Lundby C, Frew IJ (2016) Formation of renal cysts and tumors in Vhl/Trp53-deficient mice requires HIF1α and HIF2α. Cancer Res 76:2025-36.	OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Mouse	Nervous system
Christensen 2016 J Appl Physiol (1985)	2016	Christensen PM, Jacobs RA, Bonne T, Flück D, Bangsbo J, Lundby C (2016) A short period of high-intensity interval training improves skeletal muscle mitochondrial function and pulmonary oxygen uptake kinetics. J Appl Physiol (1985) 120:1319-27.	LEAK OXPHOS ET	F N S CIV NS Other combinations ROX	Permeabilized tissue	Human	Skeletal muscle
Barth 2016 Thesis	2016	Barth C (2016) Effekte einer intermittierenden Hyperoxie auf die mitochondriale Atmung in Alveolarmakrophagen. Dissertation p69.	LEAK ROUTINE OXPHOS	N S CIV NS ROX	Permeabilized cells Intact cells	Mouse	Lung;gill Macrophage-derived
Dias 2016 Neurobiol Aging	2016	Dias C, Lourenço CF, Ferreiro E, Barbosa RM, Laranjinha J, Ledo A (2016) Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation. Neurobiol Aging 46:84-95.	LEAK ET	N S ROX	Permeabilized tissue	Mouse	Nervous system
Franko 2016 Diabetes	2016	Franko A, Huypens P, Neschen S, Irmler M, Rozman J, Rathkolb B, Neff F, Prehn C, Dubois G, Baumann M, Massinger R, Gradinger D, Przemeck GK, Repp B, Aichler M, Feuchtinger A, Schommers P, Stöhr O, Sanchez-Lasheras C, Adamski J, Peter A, Prokisch H, Beckers J, Walch AK, Fuchs H, Wolf E, Schubert M, Wiesner RJ, Hrabě de Angelis M (2016) Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice. Diabetes 65:2540-52.	LEAK OXPHOS	N S CIV ROX	Permeabilized cells Permeabilized tissue	Human	Skeletal muscle Fibroblast
Edgett 2016 Exp Physiol	2016	Edgett BA, Hughes MC, Matusiak JB, Perry CG, Simpson CA, Gurd BJ (2016) SIRT3 gene expression but not SIRT3 subcellular localization is altered in response to fasting and exercise in human skeletal muscle. Exp Physiol 101:1101-13.	OXPHOS	F N S NS	Permeabilized tissue	Human	Skeletal muscle
Price 2016 J Thermal Biol	2016	Price ER, Sirsat TS, Sirsat SKG, Kang G, Keereetaweep J, Aziz M, Chapman KD, Dzialowski EM (2016) Thermal acclimation in American alligators: Effects of temperature regime on growth rate, mitochondrial function, and membrane composition. J Thermal Biol p11.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Reptiles	Heart Skeletal muscle

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